• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

MIURA Osamu  三浦 修

Researcher Number 10209710
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0981-3054
Affiliation (based on the past Project Information) *help 2016 – 2020: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2017: 東京医科歯科大学, 大学院医歯学総合研究科, 主任教授
2012 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授
2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2009: Tokyo Medical and Dental University, 医歯学総合研究科, 教授 … More
2007: Tokyo Medical and Dental University, Department of Hematology, Professor
2006: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2000 – 2003: Tokyo Medical and Dental University, Department of Hematology/Oncology, Professor, 大学院・医歯学総合研究科, 教授
1998 – 1999: Tokyo Medical and Dental University, Department of Medicine, Lecturer, 医学部, 講師
1992 – 1997: 東京医科歯科大学, 医学部, 助手
1993: Tokyo Medical & Dental Univ., Dept.of Medicine, Assistant, 医学部第一内科, 助手
1988 – 1990: Department of Medicine, Tokyo Medical and Dental University, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Hematology / Biological Sciences / Hematology / Basic Section 54010:Hematology and medical oncology-related
Except Principal Investigator
Hematology / 内科学一般 / Biological Sciences
Keywords
Principal Investigator
エリスロポエチン / CrkL / Lyn / Jak2 / シグナル伝達 / STAT5 / Rap1 / 受容体 / インターロイキン3 / チロシンリン酸化 … More / 造血器腫瘍 / チロシンキナーゼ / Erythropoietin / 分子標的療法 / ABL / BCR / 白血病 / Stat5 / レセプター / BCR/ABL / 血液腫瘍学 / インテグリン / JAK2 / JAK2-V617F / FLT3-ITD / Ask1 / Rottlerin / B-Raf / Rapl / Integrin / Rac / Interleukin 3 / 骨髄増殖性腫瘍 / 急性骨髄性白血病 / 悪性リンパ腫 / 化学療法剤 / アポトーシス / 細胞接着 / 細胞内シグナル伝達 / RSK / USP9X / プロテアソーム阻害薬 / Arsenic trioxide / Imatinib / Chronic myeloid leukemia / Askl / 亜ヒ酸 / イマチニブ / 慢性骨髄性白血病 / Signal Transduction / IL-3 / エリスロポエチレン / Interleukin3 / 造血細胞 / Receptor / Interleukin-3 / エリストポエチン / PECAM-1 / FLT3 / チロシンキナーゼ阻害薬 / chk1 / Mdm2阻害薬 / nutlin-3 / p53 / HSP90 / Chkl / etoposide / Jak2-V617F / sorafenib / Flt3-ITD / imatinib / p38 / 造血サイトカイン / 細胞周期停止 / 細胞周期 / サイトカイン / 薬剤反応性 / 内科 / 細胞・組織 / 癌 / C3G / チロシンフォスファターゼ / 細胞内刺激伝達 / JAK2キナーゼ / PI3キナーゼ … More
Except Principal Investigator
慢性関節リウマチ / 細胞内輸送 / 先天性欠損症 / 遺伝子変異 / アルファ2プラスミンインヒビター / Alpha 2 plasmin inhibitor / STAT4 / インターロイキン-12 / STAT / アルフア2プラスミンインヒビタ- / プロテインC / 細胞内輸送障害 / 分泌障害 / Congenital deficiency of alpha 2 plasmin inhibitor / Gene / Chromosome / cDNA / 遺伝子ファミリー / 血栓溶解 / 転写調節 / 線維素溶解 / アルファ2プラスミンインヒビター欠損症 / 遺伝子発現 / 染色体 / 遺伝子 / セリンプロテアーゼインヒビター / Impairement of Secretion / Gene Mutation / Intracellular Transport / Congenital Deficiency / alpha_2-plasmin inhibitor / α_2PIーOkinawa / 欠損症 / 失天性欠損症 / Frameshift / Intracellular transport / Hereditary deficiency / Fibrinolysis / フレ-ムシフト変異 / α_2PI-Nara / α_2PI-Okinawa / α_2PIーNara / アルファ2プラスミンインヒビタ- / アミノ酸欠失 / フレ-ムシフト / 遺伝性欠損症 / 線溶 / アルファ2プラスミンシンヒビタ- / シグナル伝達 / 細胞周期 / サイクリン依存性キナーゼ阻害因子 / Th1細胞 / 阻害薬 / 受容体 / JAKキナーゼ / インターロイキン12 / サイトカイン / サイクリン依存性キナーゼインヒビター / 遺伝子療法 / 転写因子 / PDGF / 滑膜細胞 / NFκB / PI3キナーゼ / MAPキナーゼ / JAK / TNFα / アルフア2プラスミンインヒビタ-欠損症 / プロテインC欠損症 / 変異遺伝子 Less
  • Research Projects

    (33 results)
  • Research Products

    (76 results)
  • Co-Researchers

    (10 People)
  •  Development of therapeutic strategies targeting molecular mechanisms underlying the therapy resistance endowed by activated tyrosine kinase mutants in hematological malignanciesPrincipal Investigator

    • Principal Investigator
      Miura Osamu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of therapeutic strategies targeting molecular mechanisms underlying the therapy resistance endowed by activated tyrosine kinase mutants in hematological malignanciesPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of combined molecular target therapy against hematopoietic malignancies expressing constitutively activated tyrosine kinasesPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Combined Anti-Leukemia Therapy Targeting Constitutively Activated Tyrosine Kinases and Checkpoint Activation MechanismsPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of novel therapeutic method to regulate chemoresistance of leukemic cells acquired through aberrantly activated intracellular signaling mechanismsPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  抗体アレイ法を応用した造血器腫瘍細胞におけるシグナル伝達因子異常の網羅的解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  造血器腫瘍細胞の化学療法剤誘導アポトーシスの制御機構の解明と新規制御法の開発Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  造血器腫瘍細胞の細胞周期停止とアポトーシス制御のシグナル伝達機構の解明Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Th1細胞分化とJAK、STATシグナル伝達機構の解析

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  化学療法剤による造血器腫瘍細胞のアポトーシス誘導機構の解明と新規制御法の開発Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  遺伝子導入滑膜細胞のシグナル伝達機構の解析―DNAアレイ法との比較検討

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Jak2- and Lyn-mediated Intracellular Signaling from the Erythropoietin ReceptorPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  造血細胞における細胞接着・増殖・細胞死調節のシグナル伝達統合機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  STATによるTh1細胞分化の分子機構-STAT4標的遺伝子の同定

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  サイクリン依存性キナーゼインヒビター遺伝子導入滑膜細胞のシグナル伝達機構の解析

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  白血病におけるJAK2・STAT5恒常的活性化の診断法開発と制御法へ向けての検討Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Medical and Dental University
  •  造血因子による細胞接着・増殖・細胞死調節のシグナル伝達機構Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Jak2-and Lyn-mediated Intracellular Signaling from the Erythropoietin ReceptorPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチン受容体からのチロシンキナーゼを介したシグナル伝達機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  慢性関節リウマチ滑膜細胞シグナル伝達機構の解明と人為的制御

    • Principal Investigator
      宮坂 信之
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチン受容体からのJAK2・STAT5活性化を介したシグナル伝達機構Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  Intracellular signaling mediated by the Jak2 tyrosine kinase in hematopoietic cellsPrincipal Investigator

    • Principal Investigator
      MIURA Osamu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチン受容体からのJAK2活性化を介した細胞内情報伝達機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチンによる増殖・分化誘導およびアポートシス抑制機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Jak2キナーゼ活性化によるエリスロポエチン受容体からの細胞内情報伝達機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチン受容体からのチロシンリン酸化を介した細胞内シグナル伝達機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  JAK2キナーゼを介したエリスロポエチンレセプターからの細胞内情報伝達機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチンレセプターからのチロシンリン酸化を介した細胞内情報伝達機構の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  エリスロポエチンレセプターからのチロシンリン酸化を介した細胞内刺激伝達経路の解析Principal Investigator

    • Principal Investigator
      三浦 修
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  遺伝性凝固線溶系蛋白欠損症の発症機転としての変異蛋白の細胞内輸送障害

    • Principal Investigator
      AOKI Nobuo
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  Intracellular transport of Mutant alpha_2-plasmin inhibitor

    • Principal Investigator
      AOKI Nobuo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular Basis for Congenital Deficiency of Alpha_2-Plasmin Inhibitor

    • Principal Investigator
      AOKI Nobuo
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Studies on the genes of the regulatory proteins for blood coagulation and fibrinolysis.

    • Principal Investigator
      AOKI Nobuo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006 Other

All Journal Article Presentation

  • [Journal Article] Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells2020

    • Author(s)
      Akiyama Hiroki、Umezawa Yoshihiro、Watanabe Daisuke、Okada Keigo、Ishida Shinya、Nogami Ayako、Miura Osamu
    • Journal Title

      Cancers

      Volume: 12 Issue: 2 Pages: 406-406

    • DOI

      10.3390/cancers12020406

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Journal Article] Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway2019

    • Author(s)
      A. Nogami, K. Okada, S. Ishida, H. Akiyama, Y. Umezawa, O. Miura
    • Journal Title

      Translational oncology

      Volume: 12 Issue: 2 Pages: 336-349

    • DOI

      10.1016/j.tranon.2018.11.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08349, KAKENHI-PROJECT-19K17852
  • [Journal Article] Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress2019

    • Author(s)
      H. Akiyama, Y. Umezawa, S. Ishida, K. Okada, A. Nogami, O. Miura
    • Journal Title

      Cancer letters

      Volume: 453 Pages: 84-94

    • DOI

      10.1016/j.canlet.2019.03.046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08349, KAKENHI-PROJECT-19K17852
  • [Journal Article] FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM2019

    • Author(s)
      Watanabe、Nogami、Okada、Akiyama、Umezawa、Miura
    • Journal Title

      Cancers

      Volume: 11 Issue: 12 Pages: 1827-1827

    • DOI

      10.3390/cancers11121827

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Journal Article] FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway2018

    • Author(s)
      Okada Keigo、Nogami Ayako、Ishida Shinya、Akiyama Hiroki、Chen Cheng、Umezawa Yoshihiro、Miura Osamu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 10 Pages: 8870-86

    • DOI

      10.18632/oncotarget.22926

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Journal Article] Acute myeloid leukemia with t(3;21)(q26.2;q22) developing following low‐dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case report2017

    • Author(s)
      KEISUKE TANAKA, GAKU OSHIKAWA, HIROKI AKIYAMA, SHINYA ISHIDA, TOSHIKAGE NAGAO, MASAHIDE YAMAMOTO and OSAMU MIURA
    • Journal Title

      ONCOLOGY LETTERS

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Journal Article] Molecular mechanisms for enhancement of stromal cell-derived factor 1?induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1)2017

    • Author(s)
      Umezawa Yoshihiro、Akiyama Hiroki、Okada Keigo、Ishida Shinya、Nogami Ayako、Oshikawa Gaku、Kurosu Tetsuya、Miura Osamu
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 48 Pages: 19639-19655

    • DOI

      10.1074/jbc.m117.779603

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Journal Article] Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells2016

    • Author(s)
      Umezawa Y, Kurosu T, Akiyama H, Wu N, Nogami A, Nagao T and Miura O
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 28 Pages: 44448-44461

    • DOI

      10.18632/oncotarget.9844

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461416, KAKENHI-PROJECT-15K09467
  • [Journal Article] A novel MYD88 mutation, L265RPP, in Waldenström macroglobulinemia activates the NF-κB pathway to up regulate Bcl-xL expression and enhances cell survival2015

    • Author(s)
      Toshikage Nagao, Gaku Oshikawa, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Ayako Nogami, Tetsuya Kurosu, and Osamu Miura
    • Journal Title

      Blood Cancer Journal

      Volume: 5

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Journal Article] A novel MYD88 mutation, L265RPP, in Waldenstrom macroglobulinemia activates the NF-kappaB pathway to upregulate Bcl-xL expression and enhances cell survival2015

    • Author(s)
      Nagao T, Oshikawa G, Ishida S, Akiyama H, Umezawa Y, Nogami A, Kurosu T and Miura O
    • Journal Title

      Blood cancer journal

      Volume: 5 Issue: 5 Pages: 315-317

    • DOI

      10.1038/bcj.2015.36

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09467, KAKENHI-PROJECT-26461416
  • [Journal Article] FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia.2015

    • Author(s)
      Nogami A, Oshikawa G, Okada K, Fukutake S, Umezawa Y, Nagao T, Kurosu T, Miura O
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 9189-9205

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Journal Article] FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia2015

    • Author(s)
      Nogami A, Oshikawa G, Okada K, Fukutake S, Umezawa Y, Nagao T, Kurosu T and Miura O
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 9189-205

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Journal Article] P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases2015

    • Author(s)
      Yoshimori M, Takada H, Imadome K, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O and Arai A
    • Journal Title

      Cancer medicine

      Volume: 4 Issue: 10 Pages: 1494-1504

    • DOI

      10.1002/cam4.494

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09467, KAKENHI-PROJECT-15K09468
  • [Journal Article] Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.2014

    • Author(s)
      Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, Yamamoto M, Miura O
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: e84746-e84746

    • DOI

      10.1371/journal.pone.0084746

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966, KAKENHI-PROJECT-26461416
  • [Journal Article] PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positiveleukemia cells2013

    • Author(s)
      Wu N, Kurosu T, Oshikawa G, Nagao T,Miura O
    • Journal Title

      Int J Oncol

      Volume: 42(2) Issue: 2 Pages: 419-28

    • DOI

      10.3892/ijo.2012.1729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591030, KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966
  • [Journal Article] CD137 Is Induced by the CD40Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation2013

    • Author(s)
      Nakaima Y, Watanabe K, Koyama T, Miura O, Fukuda T
    • Journal Title

      PLoS One

      Volume: 8(5) Issue: 5 Pages: e64425-e64425

    • DOI

      10.1371/journal.pone.0064425

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591031, KAKENHI-PROJECT-24591384
  • [Journal Article] Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis2013

    • Author(s)
      Kurosu T, Nagao T, Wu N, Oshikawa G, Miura O
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e79478-e79478

    • DOI

      10.1371/journal.pone.0079478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966
  • [Journal Article] DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3beta2011

    • Author(s)
      Nagao T, Oshikawa G, Wu N, Kurosu T, Miura O
    • Journal Title

      PLoS ONE

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] c-Cb1 and Cb1-b ligases mediate 17-allylaminodeniethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway2011

    • Author(s)
      Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 30263-30273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Clinical features of adult-onset chronic active Epstein-Barr virus infection : a retrospective analysis2011

    • Author(s)
      Arai A, Imadome K, Watanabe Y, Yoshimori M, Koyama T, Kawaguchi T, Nakaseko C, Fujiwara S, Miura O
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 602-609

    • NAID

      10029535036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Novel mouse xenograft models reveal a critical role of CD4+T cells in the proliferation of EBV-infected T and NK cells2011

    • Author(s)
      Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, OhgaS, Nakamura H, Ito M, Miura O, KomanoJ, Fujiwara S
    • Journal Title

      PLoS Pathog

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-in duced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway2011

    • Author(s)
      Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 30263-30273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway2010

    • Author(s)
      Kurosu T, Wu N, Oshikawa G, Kagechika H, Miura O
    • Journal Title

      Apoptosis

      Volume: 15 Pages: 608-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation2010

    • Author(s)
      Oshikawa G, Kurosu T, Arai A, Murakami N, Miura O
    • Journal Title

      Cancer Genet Cytogenet

      Volume: 199 Pages: 56-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement2010

    • Author(s)
      Nakauchi Y, Takase H, Sugita S, Mochizuki M, Shibata S, Ishiwata Y, Shibuya Y, Yasuhara M, Miura O, AraiNakauchi Y, Takase H, Sugita S, Mochizuki M, Shibata S, Ishiwata Y, Shibuya Y, Yasuhara M, Miura O, Arai A
    • Journal Title

      Int J Hematol

      Volume: 92 Pages: 179-185

    • NAID

      10026512401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation.2010

    • Author(s)
      Oshikawa G, Kurosu T, AraiA, Murakami N, Miura O.
    • Journal Title

      Cancer Genet Cytogenet

      Volume: 199 Pages: 56-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway.2010

    • Author(s)
      Kurosu T, Wu N, Oshikawa G, Kagechika H, Miura O.
    • Journal Title

      Apoptosis

      Volume: 15 Pages: 608-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Role for protein geranylgeranylation in adult T-cell leukemia cell survival2009

    • Author(s)
      Nonaka M, Uota S, Saitoh Y, Takahashi M, Sugimoto H, Amet T, Arai A, Miura O, Yamamoto N, Yamaoka S
    • Journal Title

      Exp Cell Res

      Volume: 315 Pages: 141-150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway2009

    • Author(s)
      Kurosu T, Ohki M, Wu N, Kagechika H, Miura O
    • Journal Title

      Cancer Res

      Volume: 69 Pages: 3927-3936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy2009

    • Author(s)
      Wakabayashi S, Arai A, Oshikawa G, Araki A, Watanabe M, Uchida N, Taniguchi S, Miura O
    • Journal Title

      Int J Hematol

      Volume: 90 Pages: 605-610

    • NAID

      10026110013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.2009

    • Author(s)
      Kurosu T, Ohki M, Wu N, Kagechika H, Miura O.
    • Journal Title

      Cancer Res 69

      Pages: 3927-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Journal Article] ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis.2007

    • Author(s)
      Yan W, Arai A, Aoki M, Ichijo H, Miura O
    • Journal Title

      Biochem Biophys Res Commun 355

      Pages: 1038-1044

    • Data Source
      KAKENHI-PROJECT-18591046
  • [Journal Article] Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells2007

    • Author(s)
      Kida A, Kakihana K, Kotani S, Kurosu T, Miura O.
    • Journal Title

      Oncogene 26

      Pages: 6630-6640

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591046
  • [Journal Article] Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta2007

    • Author(s)
      Kurosu T, Tsuji K, Kida A, Koyama T, Yamamoto M, Miura O.
    • Journal Title

      Oncogene 26

      Pages: 2975-2987

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591046
  • [Journal Article] IRF4 negatively regulates proliferation of germinal center B cell-derived Burkitt's lymphoma cell lines and induces differentiation toward plasma cells2007

    • Author(s)
      Teng Y, Takahashi Y, Yamada M, Kurosu T, Koyama T, Miura O, Miki T.
    • Journal Title

      Eur J Cell Biol 86

      Pages: 581-589

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591046
  • [Journal Article] CrkL plays a role in SDF-1-indused activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells. Cell Signal2006

    • Author(s)
      Arai A, Aoki M, Weihua Y, Jin A, Miura O
    • Journal Title

      Cell Signaling 18

      Pages: 2162-2171

    • Data Source
      KAKENHI-PROJECT-18591046
  • [Journal Article] BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion2006

    • Author(s)
      Jin A, Kurose T, Tsuji K, Mizuchi D, Arai A, Fujita H, Hattori M, Minato N, Miura O
    • Journal Title

      Oncogene 25

      Pages: 4332-4340

    • Data Source
      KAKENHI-PROJECT-18591046
  • [Presentation] FLT3-ITD activates RSK1 to upregulate mTORC1 and eIF4B and to inhibit BAD and BIM2020

    • Author(s)
      Daisuke Watanabe, Ayako Nogami, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Toshikage Nagao, Osamu Miura
    • Organizer
      第 82 回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Presentation] Overexpression of MPL causes ruxolitinib-resistance in MPN with CALR frame-shift mutations2020

    • Author(s)
      Shunichiro Yasuda, Satoru Aoyama, Ryoto Yoshimoto, Daisuke Watanabe, Kouhei Yamamoto, Takeo Fujiwara,Yoko Edahiro, Misa Imai, Marito Araki, Norio Komatsu, Osamu Miura, Norihiko Kawamata
    • Organizer
      第 82 回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Presentation] FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim.2019

    • Author(s)
      Ayako Nogami, Daisuke Watanabe, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Toshikage Nagao, Shuji Tohda, Osamu Miura
    • Organizer
      2019 American Society of Hematology Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Presentation] Deubiquitinase Inhibitor WP1130 Exerts Anti-leukemic Effect by Causing Aggresomal Translocation of FLT3-ITD and Oxidative Stress to Induce Apoptosis2019

    • Author(s)
      Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Daisuke Watanabe, Shinya Ishida, Ayako Nogami, Osamu Miura
    • Organizer
      The 9th JSH International Symposium 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Presentation] Proteasome Inhibitors Downregulate the mTORC1/4EBP1/S6K/Mcl-1 Pathway Cooperatively with Inhibitors for The STAT5/Pim Kinase Pathway to Induce Apoptosis in FLT3-ITD-positive AML Cells2018

    • Author(s)
      Ayako Nogami, Keigo Okada, Daisuke Watanabe, Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida, Gaku Oshikawa, Shuji Tohda, Osamu Miura
    • Organizer
      The 9th JSH International Symposium 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08349
  • [Presentation] Deubiquitinase inhibitor WP1130 blocks JAK2-V617F to induce apoptosis in leukemic cells2017

    • Author(s)
      Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Shinya Ishida, Ayako Nogami, Toshikage Nagao, Osamu Miura
    • Organizer
      第 79 回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Modulation of the mTORC1 pathway by ubiquitin-proteasome system via REDD1 in AML with FLT3-ITD2017

    • Author(s)
      Ayako Nogami, Keigo Okada, Cheng Chen, Maho Kawakami, Hiroki Akiyama, Yoshihiro Umezawa, Gaku Oshikawa, Shinya Ishida, Tetsuya Kurosu, Osamu Miura
    • Organizer
      第 79 会日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] FLT3-ITD confers resistance to PI3K/Akt inhibitors by enhancing mTORC1/Mcl- 1 pathway via Pim kinase2017

    • Author(s)
      Keigo Okada, Ayako Nogami, Cheng Chen, Maho kawakami, Hiroki Akiyama, Shinya Ishida, Yoshihiro Umezawa, Osamu Miura
    • Organizer
      第 79 回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells2017

    • Author(s)
      Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Shinya Ishida, Ayako Nogami, and Osamu Miura
    • Organizer
      The 59th American Society of Hematology Annual Meeting & Exposition
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Autophagy and Bcl-2 family members protect JAK2-V617F-expressing leukemic cells from ruxolitinib2017

    • Author(s)
      Shinya Ishida, Gaku Oshikawa, Toshikage Nagao, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Ayako Nogami, and Osamu Miura
    • Organizer
      第 79 回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] PECAM-1 による PI3K/Akt/mTORC1 経路を介した SDF-1 誘導性走化能の亢進機構2016

    • Author(s)
      梅澤 佳央、秋山 弘樹、岡田 啓吾、石田 信也、野上 彩子、押川 学、黒須 哲也、三浦 修
    • Organizer
      第 78 回日本血液学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Deubiquitinase inhibitor WP1130 blocks JAK2-V617F and FLT3-ITD to induce apoptosis in leukemic cells2016

    • Author(s)
      Hiroki Akiyama,Yoshihiro Umezawa,Keigo Okada,Shinya Ishida,Ayako Nogami,Gaku Oshikawa, Osamu Miura
    • Organizer
      第 78 回日本血液学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Pim キナーゼによる mTOR 経路促進を介した FLT3-ITD による Bortezomib 抵抗性獲得機構2016

    • Author(s)
      野上 彩子、岡田 啓五、押川 学、石田 信也、秋山 弘樹、梅澤 佳央、黒須 哲也、三浦 修
    • Organizer
      第 78 回日本血液 学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Roles for BTK in JAK2-V617F-positive PVTL-1 cells resistant to the Jak kinase inhibitor ruxolitinib2015

    • Author(s)
      Ishida S, Oshikawa G, Nogao T, Okada K, Akiyama H, Umezawa Y, NOgami A, Miura O
    • Organizer
      第 77 回日本血液 学会学術集会
    • Place of Presentation
      石川県金沢市石川県立音楽堂
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] Mechanisms of resistance to TKIs in novel JAK2-V617F-positive AML cell line, PVTL-2 and PVTL-12015

    • Author(s)
      Ishida S, Oshikawa G, Nogao T, Okada K, Akiyama H, Umezawa Y, Nogami A, Miura O .
    • Organizer
      第 77 回日本血液 学会学術集会
    • Place of Presentation
      石川県金沢市石川県立音楽堂
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] FLT3-ITD による STAT5、Pim-1 と mTOR 経路を介した Bortezomib 耐性誘導機構2015

    • Author(s)
      野上 彩子、岡田 啓五、押川 学、石田 信也、秋山 弘樹、梅澤 佳央、黒須 哲也、三浦 修
    • Organizer
      第 77 回日本血液学会学術集会
    • Place of Presentation
      石川県金沢市石川県立音楽堂
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] FLT3-ITD confers resistance to PI3K/Akt inhibitors by inducing Pim kinases through STAT5 activation2015

    • Author(s)
      Keigo Okada, Ayako Nogami, Gaku Oshikawa, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miura
    • Organizer
      第 77 回日本血液 学会学術集会
    • Place of Presentation
      石川県金沢市石川県立音楽堂金沢
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K09467
  • [Presentation] PECAM-1 enhances SDF-1-induced chemotaxis mediated through activation of the PI3K/Akt/mTORC1 pathway2014

    • Author(s)
      Yoshihiro Umezawa, Hiroki Akiyama, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miura
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-31
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] Flt3-ITD confers resistance to PI3K/Akt inhibitors by protecting mTOR/eIF4F/Mcl-1 pathway via STAT52014

    • Author(s)
      Ayako Nogami, Gaku Oshikawa, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miura
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-31
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] Molecular basis for differential responses of FlT3-ITD and TKD to P13K/Akt and proteasome inhibitors.2013

    • Author(s)
      Nogami A, Oshikawa G, Fukutake S, Nagao T, Umezawa Y, Kurosu T, Miura O.
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] Roles of tyrosine kinases in B-cell receptor signaling regulating survival of CLL B cells2013

    • Author(s)
      Kato M, Watanabe K, Suwa S, Iida M, Tohda S, Miura O, Fukuda T.
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] Molecular biological analysis of a novel MYD88 mutation, L265-RPP, in Waldenstrom macroglobulinemia2013

    • Author(s)
      Nagao T, Umezawa Y, Nogami A, Kurosu T, Miura O.
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] BCR/ABL発現細胞におけるChk1とp53を介した細胞周期チェックポイント活性化の相互調節機構2012

    • Author(s)
      黒須 哲也、呉 楠、野上 彩子、押川 学、長尾 俊景、三浦 修
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] Flt3-ITD及びFlt3-TKD発現細胞の分子標的薬への感受性の差違とその分子基盤2012

    • Author(s)
      押川 学、長尾 俊景、野上 彩子、呉 楠、黒須 哲也、三浦 修
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24591384
  • [Presentation] Inhibition of Jak2-V617F under DNA-damage stress induces its degradation and synergistic apoptosis2011

    • Author(s)
      Nagao T, Oshikawa G, Wu N, Kurosu T, Miura O.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] PECAM-1 possibly mediates BCR/ABL signaling and modulates imatinib sensitivity of Ph+leukemic cells2011

    • Author(s)
      Wu N, Kurosu T, Oshikawa G, Nagao T, Miura O.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] c-Cbl and Cbl-b mediate 17-AAG-induced Flt3-ITD degradation through the ubiquitin proteasome pathway2011

    • Author(s)
      Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O.
    • Organizer
      第73回日本血液学会総
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Inhibition of BCR/ABL downregulates Chk1 to induce apoptosis synergistically with chemotherapeutics2011

    • Author(s)
      Kurosu T, Wu N, Oshikawa G, Nagao T, Miura O.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Roles for PECAM-1(CD31) in signaling from and leukemogenesis by BCR/ABL2010

    • Author(s)
      Wu N, Kurosu T, Suzuki T, Oshikawa G, Nagao T, Miura O.
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Roles for PECAM-1(CD31)in signaling from and leukemogenesis by BCR/ABL2010

    • Author(s)
      呉楠, 黒須哲也, 鈴木隆之, 押川学, 長尾俊景, 三浦修
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Chemotherapy resistance through enhanced Chk1 activation by BCR/ABL, Flt-ITD and Jak2-V617F2010

    • Author(s)
      Kurosu T, Wu N, Suzuki T, Oshikawa G, Nagao T, Miura O.
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Molecular mechanisms regulating DNA damage-induced degradation of Jak2-V617F and apoptosis2010

    • Author(s)
      Nagao T, Wu N, Oshikawa G, Suzuki T, Kurosu T, Miura O.
    • Organizer
      第72回日本血液学会総
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] c-Cbl-mediated ubiquitination of Flt3-ITD and cellular mechanisms regulating its degradation2010

    • Author(s)
      Oshikawa G, Wu N, Nagao T, Suzki T, Kurosu T, Miura O.
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Chemotherapy resistance through enhanced Chkl activation by BCR/ABL, Flt3-ITD and Jak2-V617F2010

    • Author(s)
      黒須哲也, 呉楠 , 鈴木隆之, 拝長尾俊景, 三浦修
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] c-Cbl-mediated ubiquitination of Flt3-ITD and cellular mechanismsregulating its degradation2010

    • Author(s)
      押川学, 呉楠., 長尾俊景, 黒須哲也, 三浦 修
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] Molecular mechanisms regulating DNA damage-induced degradation of Jak2-V617F and apoptosis2010

    • Author(s)
      長尾俊景, 呉楠, 押川学, 鈴木隆之, 黒須哲也, 三浦修
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] BCR/ABL発現細胞におけるimatinib誘導性アポトーシスのnutlin-3aによるp53活性化を介した相乗的亢進機構2009

    • Author(s)
      黒須哲也、呉楠、大木学、押川学、長尾俊景、鈴木隆之、三浦修
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21591194
  • [Presentation] MDM2阻害薬nutlin-3aとBCL2阻害薬ABT-737によるBCR/ABL発現細胞のimatinib誘導性アポトーシスの相乗的亢進2007

    • Author(s)
      黒須 哲也, 大木 学、呉 楠、三浦 修
    • Organizer
      第69回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591046
  • [Presentation] Simvastatin Induces Apoptosis in EBV-Positive T- or NK-Cell Lymphoproliferative Disorders and Anti-Tumor Effects in Xenograft Models.

    • Author(s)
      Arai A, Horino M, Wang L, Imadome K, Hamasaki K, Kurata M, Ichikawa A, Fujiwara S, Miura O.
    • Organizer
      The 4th JSH International Symposium
    • Place of Presentation
      松山
    • Data Source
      KAKENHI-PROJECT-24591384
  • 1.  YAMAMOTO Kou (00281717)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  宮坂 信之 (30157622)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  AOKI Nobuo (20048937)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  KATO Atsushi (50183265)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  HIROSAWA Shinsaku (50143574)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  上阪 等 (00251554)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  福田 哲也 (70332624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  新井 文子 (70359678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  三木 徹 (90242180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  黒須 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi