Ohtsubo Motoaki 大坪素秋

… Alternative Names

大坪素秋オオツボモトアキ

OHTSUBO Motoaki 大坪素秋

大坪基秋オオツボモトアキ

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Researcher Number	10211799
Other IDs
Affiliation (Current)	2025: 別府大学, 食物栄養科学部, 教授
Affiliation (based on the past Project Information) *help	2016: 別府大学, 公私立大学の部局等, 教授 2014 – 2015: 別府大学, 食物栄養科学部, 教授 2011 – 2012: 別府大学, 食物栄養科学部, 教授 2010: 広島大学, 原爆放射線医科学研究所, 非常勤講師 2007 – 2010: 広島大学, 原爆放射線医科学研究所, 助教 … More 2009: 広島大学, 原爆放射医科学研究所, 助教 2003 – 2006: 広島大学, 原爆放射線医科学研究所, 助手 2003 – 2005: 広島大学, 原爆放射線医学研究所, 助手 1996 – 2002: Kurume University, Assistant Professor, 分子生命科学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Molecular biology / Stem cell biology and medical science Except Principal Investigator Biological Sciences / Cell biology / General medical chemistry / General medical chemistry / Hematology / Bacteriology (including Mycology) / Functional biochemistry / Immunology / Eating habits / Stem cell biology and medical science
Keywords	Principal Investigator E6AP / CDK / 細胞がん化 / Cdk2 / サイクリンE / ユビキチンリガーゼ / E3 ubiquitin protein-ligase / cyclin E / cyclin-dependent kinase / cell cycle … More / Zincフィンガー / p21 / サイクリン依存性キナーゼ / 細胞周期 / DMA複製制御 / DNA複製制御 / Geminin / ポリコーム複合体 / 造血幹細胞 / 発生・分化 / 再生医学 … More Except Principal Investigator JAK / STAT / チロシンキナーゼ / サイトカイン / SH2ドメイン / Geminin / 情報伝達 / CIS / りん酸化 / 造血幹細胞 / ポリコーム遺伝子群 / ノックアウトマウス / tyrosine kinase / cytokine / Cdt1 / 自己複製 / エリスロポエチン / 転写因子 / knockout mice / シグナル伝達 / tyrosine phosphorylation / E3ユビキチンリガーゼ / レトロウイルスベクター / 分子基盤 / DNA複製ライセンス化 / 幹細胞性 / 幹細胞 / 細胞分化 / インターフェロン / 分化 / c-kit / ADAM / SREBP / 細胞周期 / サイクリン依存性キナーゼ / kinase inhibitor / チロシンりん酸化 / 胎児造血 / CISファミリー / SH2 domain / erythropoietin / ES細胞 / 造血幹細胞移植療法 / ポリコーム複合体 / 再生医学 / HOXB4 / ポリコーム複合体1 / 遺伝子改変マウス / 増幅 / DNA複製開始制御 / Cdtl / DNA複製制御 / p21 / エリスポエチン / 細胞増殖 / c-Cbl / EGF受容体 / retrovirus vector / genetically engineered mice / molecular basis / stemness / stem cells / Polycomb-group genes / 成体幹細胞 / cleavage of extracelular domain / lysophosphatidic acid / diphtheria toxin receptor / MAPKカスケード / ADAM12 / NAC / 細胞外領域切断 / リゾホスファチジン酸 / ジフテリア毒素レセプター / lipid metabolism / DNA replication / cell differentiation / cyclindependent kinase (cdk) / cyclin / cell cycle / CDKinhibitor / Cdk / LIM Kinase / p53 / Myc / Ceb / p57 / CDK阻害因子 / CDK / 脂質代謝 / DNA複製 / サイクリン / CDK阻害蛋白 / Clamp-Clamp loader / Nuclear Matrix Attachment / Cyclin-dependent kinase / Cdc7 kinase / MCM complex / prereplicative complex / E2F transcription factor / G1-S transition / マウス胚性幹細胞 / MCM2 / Cdc7-ASKキナーゼ / MCM / DNAヘリカーゼ / Cdcキナーゼ / DNA複製開始 / リン酸化 / G1-S期移行 / クランプ=クランプローダー / 核マトリックス付着 / Cdc7キナーゼ / MCMタンパク質 / DNA複製前複合体 / E2F転写因子 / G1-S期以降 / JAB / キナーゼ抑制因子 / interferon / APS / fetal liver hematopoiesis / エリスロポエチン受容体 / Ubiquitin / Knockout mouse / Transgenic mouse / Tyrosine Kinase / Cytokine / ユビキチン / トランスジェニックマウス / differentiation / transcription factor / signal transduction / プロモーター / サブトラクション / 転写調節 / インターロイキン / 脳機能 / 硫黄 / 硫黄食品 / 記憶力 / 内在性硫化ガス / 硫黄付加食品 / 硫化ガス / Hoxb4 / iPS細胞 / iPS 細胞 / 造血幹細胞移植学 / 活性操作 / ユビキチン化 / 慢性骨髄性白血病 / 白血病幹細胞 / 再生医療 / 幹細胞システム / PH / SH2 / アクチン / イメージング / 1分子 / FRET / GFP / 細胞内局在 / 一分子観察 / 蛍光顕微鏡 / Raf / Ras / チロキシンギナーゼ / STAT5 / JAK2 / SATA Less

To intake sulfur foods increase the ability of learning memory
- Principal Investigator
  
  Senba Kazuyo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits
- Research Institution
  Beppu University
Induction of hematopoietic stemcells from iPS cells and the molecular basis in the induction
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Analysis of Hematopoietic stem cell regulation through Polycomb-group complex 1Principal Investigator
- Principal Investigator
  
  OHTSUBO Motoaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Stem cell biology and medical science
- Research Institution
  Beppu University
  Hiroshima University
造血幹細胞の活性を支持するGemininの分子制御機構の解析
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Analysis of hematopoietic stem cell regulation through Geminin ubiquitination
- Principal Investigator
  
  YASUNAGA Shin'ichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Stem cell biology and medical science
- Research Institution
  Hiroshima University
Gemininを用いて造血幹細胞を増幅するための理論基盤の確立
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
がん幹細胞の活性制御におけるDNA複製ライセンス化の役割
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
ポリコーム複合体によるDNA複製ライセンス化制御の造血幹細胞における役割
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
ES細胞より造血幹細胞をex vivoで誘導する試み
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hiroshima University
Role of Polycomb-group genes in adult stem cells and their expansion
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSHIMA UNIVERSITY
ポリコーム遺伝子群による造血幹細胞の自己複製制御機構の研究
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
ポリコーム遺伝子群を用いた造血幹細胞増幅の試み
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hiroshima University
Study of the cleavage of diphtheria taxin receptor by ADAM12
- Principal Investigator
  
  UMATA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  University of Occupational and Environmental Health, Japan
Cdk Binding Protein
- Principal Investigator
  
  TOYOSHIMA Hideo
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
From G1 regulators to Replication machinery
- Principal Investigator
  
  MASAI Hisao
- Project Period (FY)
  2000 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
サイトカインシグナル伝達経路の可視化
- Principal Investigator
  
  MINOGUCHI Shigeru, 安川秀雄
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Kurume University
赤血球産生を制御するシグナル伝達分子の探索と機能解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Physiological function and Molecular mechanism of regulation by the CIS/JAB family members
- Principal Investigator
  
  YOSHIMURA Akihkio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  Kurume University
CISファミリーによるJAKシグナルの制御機構と生理機能
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
赤血球分化に関与するシグナル伝達分子の探索と機能解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Screening of signal transducing molecules by using transient expression
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kurume University
Molecular mechanism of negative regulation of JAK/STAT pathway by the CIS/JAB family members
- Principal Investigator
  
  YASUKAWA Hideo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kurume University
造血細胞の増殖と分化を制御するシグナル伝達分子群の解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
c-kitおよびJAKキナーゼの新規基質の単離と機能解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
サイクリンE-p21特異的なユビキチンリガーゼの解析Principal Investigator
- Principal Investigator
  
  大坪素秋
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
赤血球分化に関する情報伝達分子の探索と機能解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Physiological Function and Signal Transduction Mechanism of the STAT5-target genes
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Growth and differentiation signals of the erythropoietin receptor
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kurume university
Study of cyclin E-Cdk2 interacting proteinsPrincipal Investigator
- Principal Investigator
  
  OOTSUBO Motoaki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Kurume University
造血細胞の増殖と分化を制御するシグナル伝達分子群の解析
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
SH2ドメインを有する新規情報伝達分子CISの機能解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
免疫系におけるJAKキナーゼを介した情報伝達経路と標的遺伝子
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
サイトカイン受容体の情報伝達機構とその標的遺伝子の解析
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Growth and Differentiation through the Cytokine Receptors
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Life Science, Kurume University

All 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] 血液フロンティア・がん幹細胞研究の新たな展開・幹細胞における細胞周期制御2012
- Author(s)
  瀧原義宏、安永晋一郎、大野芳典、大坪素秋
- Total Pages
  11
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21602004
[Book] 血液フロンティア・がん幹細胞研究の新たな展開・幹細胞における細胞周期制御2012
- Author(s)
  瀧原義宏,安永晋一郎,大野芳典,大坪素秋
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.2013
- Author(s)
  Yasunaga, S., Ohtsubo, M., Ohno, Y., Tanaka-Okamoto, M., Ishizaki, H., Shirai, M., Mihara, K., Brock, W. H., Miyoshi, J., Takihara, Y.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 33 Pages: 644-660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] 幹細胞における細胞周期制御特集:がん幹細胞研究の新たな展開2012
- Author(s)
  瀧原義宏、安永晋一郎、大野芳典、大坪素秋
- Journal Title
  
  血液フロンティア(医薬ジャーナル社)
  
  Volume: 22 Pages: 33-43
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of surviving expression2012
- Author(s)
  Bhattacharyya, J., Mihara, K., Ohtsubo, M., Yasunaga, S., Takei, Y., Yanagihara, K., Sakai, A., Hishi, M., Takihara, Y., Kimura, A.
- Journal Title
  
  Cancer Science
  
  Volume: 103(1) Pages: 34-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Dominant-negative STAT1 mutations in the SH2 domain predispose to mycobacterial diseases.2012
- Author(s)
  Tsumura, M., Okada, S., Sakai, H., Yasunaga, S., Ohtsubo, M., Murata, T., Obata, H., Yasumi, T., Kong, X., Abhyankar, A., Heike, T., Nakahata, T., Nishikomori, R., Al-Muhsen, S., Boisson-Dupuis, S., Casanova, J.-L., AlSherhri, M., ElGhazali, G., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Hum. Mutat.
  
  Volume: 33 Pages: 1377-1387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency2011
- Author(s)
  Karakawa, S., Okada, S., Tsumura, M., Mizoguchi, Y., Ohno, N., Yasunaga, S., Ohtsubo, M., Kawai, T., Nishikomori, R., Sakaguchi, T., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 31(5) Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 21529-21534
- NAID
  40019027599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Molecular pathogenesis of novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.2010
- Author(s)
  Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Hum. Genet. 127(6)
  
  Pages: 619-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara Y
- Journal Title
  
  Proc.Natl.Acad.Sci. 107(50)
  
  Pages: 21529-21534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 21529-21534
- NAID
  40019027599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.2010
- Author(s)
  Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo, M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Hum.Genet.
  
  Volume: 127(6) Pages: 619-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] HOXB4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with growth potential.2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 21529-21534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency2010
- Author(s)
  Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo, M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Human Genetics
  
  Volume: 127(6) Pages: 619-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity2008
- Author(s)
  Ohtsubo, M.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 105
  
  Pages: 10396-10401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20058025
[Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.2008
- Author(s)
  Ohtsubo M., Yasunaga Y. & Takihara Y., et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. 105
  
  Pages: 10396-10401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Gerainin to sustain hematopoietic stem cell activity2008
- Author(s)
  Ohtsubo, M.
- Journal Title
  
  Proc. Nat1. Acad. Sci. USA 105
  
  Pages: 10396-10401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659152
[Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.2008
- Author(s)
  Ohtsubo, M., Yasunaga, S., Ohno, Y., Tsumura, M., Okada, S., Ishikawa, N., Shirao, K., Kikuchi, A., Nishitani, H., Kobayashi, M., Takihara Y
- Journal Title
  
  Proc.Natl.Acad.Sci. 105(30)
  
  Pages: 10396-10401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Role for an Scmh1-mediated molecular network governing Geminin expression in hematopoiesis2012
- Author(s)
  Ohtsubo, M., Yasunaga, Y., Ohno, Y., Kawashima, A., Tetsuguchi, H., Saeki, K., Nakashima, Y., Takihara, Y.
- Organizer
  International Symposium 50^<th> Anniversary of RIRBM, Hiroshima University
- Place of Presentation
  広島国際会議場
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Hole for an Scmh1-mediated molecular network governing Geminin expression in hematopoiesis2012
- Author(s)
  Ohtsubo, M., Yasunaga, Y., Ohno, Y., Kawashima, A., Tetsuguchi, H., Saeki, K, Nakashima, Y., Takihara, Y.
- Organizer
  International Symposium 50^<th> Anniversary of RIRBM, Hiroshima University
- Place of Presentation
  広島国際会議場
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Novel molecular regulatory network governing Geminin maintains hematopoietic homeostasis.2012
- Author(s)
  Takihara, Y., Yasunaga, S., Ohno, Y., Saeki, K., Nakashima, Y., Ohtsubo, M.
- Organizer
  41st annual scientific meeting of the international society for hematology and stem cells
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-22390195
[Presentation] A new strategy for maintaining HSC activity through the modulation of Geminin expression2011
- Author(s)
  Yasunaga, Y., Ohno, Y., Ohtsubo, M., Furutani, T., Kawashima, A., Tetsuguchi, H., Saeki, K., Nakashima, Y., Takihara, Y.
- Organizer
  日本血液学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Scmhl deficiency up-regulates transcription of Hox genes to maintain the expression level of Geminin, that may play a crucial role for sustaining hematopoiesis.2011
- Author(s)
  Yasunaga S., Ohtsubo M., Ohno Y., Mori S., Furutani T., Kawashima A., Tetsuguchi H., Nakashima Y., Takihara Y.
- Organizer
  The First RIRBM International SymposiumBMB : Genome damage and non-cancerous diseases
- Place of Presentation
  Hiroshima, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Scmhl, a member of Polycomb complex 1, regulates hematopoiesis either through Geminin Ubiquitination or through repression of Hox genes.2010
- Author(s)
  Yasunaga S., Ohtsubo M., Ohno Y., Mori S., Furutani T., Kawashima A., Tetsuguchi H., Nakashima Y., Takihara Y.
- Organizer
  BMB (Biochemistry and Molecular Biology) 2010
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] A role for Geminin in sustaining activity of Haemopoietic stem and progenitor cells.2010
- Author(s)
  Yasunaga S., Ohno Y., Ohtsubo M., Tsumura M., Mori S., Nakashima Y., Kobayashi M., Takihara Y.
- Organizer
  The 72^<nd> Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Role for Geminin in hematopoietic stem cell regulation.2010
- Author(s)
  Yasunaga S., Ohno Y., Ohtsubo M, Tsumura, M., Kageyama Y., Mori S., Nakashima Y., Takihara Y.
- Organizer
  The 8^<th> Stem Cell Research Symposium
- Place of Presentation
  Awaji, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Study of a 5-FU-induced stabilization signal for Scmh1, a component of Polycomb-group complex 1 E3 ligase2009
- Author(s)
  Ohtsubo, M., Yasunaga, S., Ohno, Y., Tsumura, M., Kageyama, Y., Mori, S., Takihara, Y.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Molecular role of Scmhl, a member of Polycomb complex 1. Which plays a crucial role for governing the hematopoietic stem cell activity.2009
- Author(s)
  Yasunaga S., Ohtsubo M., Ohno Y., Tsumura, M., Kageyama Y., Mori S., Nakashima Y., Takihara Y.
- Organizer
  The 32^<nd> Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Molecular role of Scmhl, a member of Polycomb complex 1. Which plays a crucial role for governing the hematopoietic stem cell activity.2009
- Author(s)
  安永晋一郎, 大野芳典, 大坪素秋, 津村弥来, 影山由佳, 時元利恵, 瀧原義宏
- Organizer
  The 7^<th> Stem Cell Research Symposium
- Place of Presentation
  Tokyo, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] HSCの活性維持に必須なポリコーム複合体1の構成因子 Scmhl の機能ドメインの解析2009
- Author(s)
  大坪素秋
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Study of a 5-FU-induced stabilization signal for Scmhl, a component of Polycomb-group complex 1 E3 ligase2009
- Author(s)
  大坪素秋
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] HSCの活性維持に必須なポリコーム複合体1の構成因子Scmh1の機能ドメインの解析2009
- Author(s)
  大坪素秋
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] HSCの活性維持に必須なポリコーム複合体1の構成因子Scmhlの機能ドメインの解析2009
- Author(s)
  大坪素秋、安永晋一郎、津村弥来、大野芳典、影山由佳、森彩華、時元利恵、小林正夫、瀧原義宏
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Role of Scmh1 in the regulation of Polycomb-group complex 1, which acts as the E3 ubiquitin ligase for histone H2A and Geminin2009
- Author(s)
  Ohtsubo, M., Yasunaga, S., Tsumura, M., Ohno, Y., Kageyama, Y., Kimura, S., Tokimoto, R., Takihara, Y.
- Organizer
  The 7th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] 造血幹細胞制御におけるGemininの役割2008
- Author(s)
  安永晋一郎、大坪素秋、大野芳典、影山由佳、津村弥来、岡田賢、石川暢恒、白尾謙一郎、時元利恵、小林正夫、瀧原義宏
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Gemininによる造血幹細胞制御の分子基盤2008
- Author(s)
  安永晋一郎、大坪素秋、大野芳典、影山由佳、津村弥来、岡田賢、時元利恵、小林正夫、瀧原義宏
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20610003

1. YOSHIMURA Akihiko (90182815)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
2. YASUNAGA Shin'ichiro (50336111)

# of Collaborated Projects: 11 results

# of Collaborated Products: 31 results
3. TAKIHARA Yoshihiro (60226967)

# of Collaborated Projects: 11 results

# of Collaborated Products: 31 results
4. YASUKAWA Hideo (60289361)

# of Collaborated Projects: 9 results

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5. MINOGUCHI Shigeru (60322757)

# of Collaborated Projects: 3 results

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6. 三澤宏之 (00289505)

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7. WAKIOKA Toru (40330873)

# of Collaborated Projects: 2 results

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8. OHNO Yoshinori (10548986)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
9. IHLE James

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10. JAMES Ihle

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# of Collaborated Products: 0 results
11. TSUJI Kohichiro (50179991)

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12. Senba Kazuyo (30381031)

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13. KAI Hisashi (60281531)

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14. MASAI Hisao (40229349)

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15. OHTANI Kiyoshi (30201974)

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16. FUJITA Masatoshi (30270713)

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17. MURAKAMI Yota (20260622)

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18. TSURIMOTO Toshiki (30163885)

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19. TOYOSHIMA Hideo (20197966)

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20. UMATA Toshiyuki (30213482)

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21. NISHITANI Hideo (40253455)

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22. TAKIHARA Keiko (70252640)

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23. 神薗慎太郎 (30261077)

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24. 三好淳 (80166214)

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25. 大賀恭 (60252508)

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26. 原口みさ子 (10244229)

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27. 住澤知之 (90206582)

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28. 佐藤憲子 (70280956)

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29. NEUMANN Drorit

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30. LODISH Harvey

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31. MATSUMOTO Akira

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32. 宮島篤

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33. MAYEUX Patri

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34. PATRICK Mayeux

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35. NEWMANN Dror

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36. KIM Jung?Min

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Ohtsubo Motoaki 大坪 素秋

大坪 素秋 オオツボ モトアキ

OHTSUBO Motoaki 大坪 素秋

大坪 基秋 オオツボ モトアキ

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Analysis of Hematopoietic stem cell regulation through Polycomb-group complex 1Principal Investigator

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Ohtsubo Motoaki 大坪素秋

大坪素秋オオツボモトアキ

OHTSUBO Motoaki 大坪素秋

大坪基秋オオツボモトアキ