Ishikawa Makoto 石川誠

… Alternative Names

ISHIKAWA Makoto 石川誠

石川誠イシカワマコト

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Researcher Number	10212854
Other IDs	https://orcid.org/0000-0002-1808-1799
Affiliation (Current)	2025: 東北大学, 医学系研究科, 大学院非常勤講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 医学系研究科, 大学院非常勤講師 2022: 東北大学, 医学系研究科, 准教授 2018 – 2020: 秋田大学, 医学系研究科, 准教授 2013 – 2017: 秋田大学, 医学(系)研究科(研究院), 准教授 2015: 秋田大学, 大学院医学系研究科, 准教授 … More 2012: 秋田大学, 医学部, 講師 1996: 秋田大学, 医学部, 助手 1992: Yamagata Univ. Sch.Med., Res. Assis., 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56060:Ophthalmology-related / General anatomy (including Histology/Embryology) / Ophthalmology / Ophthalmology
Keywords	Principal Investigator 神経保護 / 緑内障 / 眼圧上昇 / GABA受容体 / 神経ステロイド / 眼圧 / 興奮毒性 / グルタミン酸 / 免疫 / 神経保護効果 … More / 網膜神経節細胞 / ミクログリア / 緑内障動物実験モデル / 神経節細胞 / オートファジー / アロプログネノロン / 神経保護治療 / 相乗作用 / グルタミン酸受容体 / グルタミン酸代謝 / GABA / 加圧障害 / グルタミン合成酵素 / グルタミン酸輸送体 / グルタミン酸毒性 … More Except Principal Investigator 緑内障 / Gap junction / Deep-etching / Freeze-fracturing / Adranal chromaffin cell / Ciliary ganglion / Spinal cord / Synaptic receptor / ディ-プ・エッチング法 / シナプス構造 / 電気シナプス / ギャップ結合 / エッチング法 / 凍結割断レプリカ法 / 副腎クロマフィン細胞 / 毛様体神経節 / 脊髄 / シナプス受容体 / 視野進行 / 眼循環改善効果 / 緑内障治療薬 / 炭酸脱水酵素阻害 / 薬理学 / 血管平滑筋 / 眼循環 / Vogt-Koyama-Harada病 / 実験的自己免疫性ぶどう膜炎 / Tyrosinase related protein 2 / Tyrosinase related protein1 / Tyrosinase Less

ヒト緑内障GWASからの個別化創薬プラットフォーム構築研究
- Principal Investigator
  
  中澤徹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
Challenges for Breakthroughs in Social Implementation of Glaucoma Optic Nerve Regeneration Therapy
- Principal Investigator
  
  中澤徹
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tohoku University
眼圧上昇時のミクログリア起因性炎症反応の制御による神経保護の可能性Principal Investigator
- Principal Investigator
  
  石川誠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
The neurosteroid allopregnanolone and its enantiomer protects retinal neurons by effects on autophagy and GABAA receptors in rat glaucoma modelsPrincipal Investigator
- Principal Investigator
  
  Ishikawa Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Akita University
Neurosteroids modulate the effects of high pressure in a rat ex vivo glaucoma modelPrincipal Investigator
- Principal Investigator
  
  Ishikawa Makoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Akita University
Development of new glaucoma therapy other than decreasing intraocular pressure
- Principal Investigator
  
  Yoshitomi Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Akita University
Neuroprotection by enhancement of glutamate uptake against pressure-induced injury in a rat glaucoma modelPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Makoto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Akita University
VKH disease・原田病特異的抗原の検索-SDS不溶性成分の検索
- Principal Investigator
  
  山木邦比古
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Akita University
Ultrastructure of postsynaptic active zones associated with different type of receptors.
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Yamagata University

All 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] Excitotoxicity and glaucoma、"Ophthalmology; Current Clinical and Research Update" (Editor: PG. Davey)2014
- Author(s)
  Ishikawa M、 Yoshitomi T、 Izumi Y
- Publisher
  InTech Europe Publisher (Croatia)
- Data Source
  KAKENHI-PROJECT-24592666
[Book] 毛様体レーザーの治療「緑内障クローズアップ」編集：木内　良明2014
- Author(s)
  石川　誠
- Publisher
  メジカルレビュー社
- Data Source
  KAKENHI-PROJECT-24592666
[Book] Excitotoxicity as the pathogenesis of glaucoma and its neuroprotective strategies.2014
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, Yukitoshi Izumi.
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-24592666
[Journal Article] Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina.2023
- Author(s)
  Izumi Y, Ishikawa M, Nakazawa T, Kunikata H, Sato K, Covey DF, Zorumski CF.
- Journal Title
  
  Neural Regen Res.
  
  Volume: 18 Issue: 5 Pages: 1004-1008
- DOI
  10.4103/1673-5374.355752
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09827
[Journal Article] The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury2023
- Author(s)
  Sato Kota、Ohno‐Oishi Michiko、Yoshida Masaaki、Sato Taimu、Aizawa Takaharu、Sasaki Yuto、Maekawa Shigeto、Ishikawa Makoto、Omodaka Kazuko、Kawano Chihiro、Ohue‐Kitano Ryuji、Kimura Ikuo、Nakazawa Toru
- Journal Title
  
  Glia
  
  Volume: 71 Issue: 11 Pages: 2609-2622
- DOI
  10.1002/glia.24442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09805, KAKENHI-PROJECT-22K09827
[Journal Article] Association between myopia and complications of glaucoma with retinal diseases: investigation of a large medical insurance database. Graefes2023
- Author(s)
  Ninomiya T, Kunikata H, Ishikawa M, Nakazawa T.
- Journal Title
  
  Arch Clin Exp Ophthalmol.
  
  Volume: - Issue: 8 Pages: 1-3
- DOI
  10.1007/s00417-023-06031-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09827, KAKENHI-PROJECT-20K09822, KAKENHI-PROJECT-23K09037
[Journal Article] 網膜神経節細胞でのオートファジー2023
- Author(s)
  石川　誠
- Journal Title
  
  眼科
  
  Volume: 65 Pages: 341-346
- Data Source
  KAKENHI-PROJECT-22K09827
[Journal Article] Glaucoma and microglia-induced neuroinflammation2023
- Author(s)
  Ishikawa M, Izumi Y, Sato-K, Sato T, Zorumski CF, Kunikata H, Nakazawa T.
- Journal Title
  
  Front. Ophthalmol.
  
  Volume: - Pages: 1-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09827
[Journal Article] Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma2023
- Author(s)
  Sato Kota、Takada Naoko、Fujioka Amane、Himori Noriko、Yokoyama Yu、Tsuda Satoru、Omodaka Kazuko、Kirihara Tomoko、Ishikawa Makoto、Kunikata Hiroshi、Nakazawa Toru
- Journal Title
  
  Journal of Glaucoma
  
  Volume: 32 Issue: 9 Pages: 734-737
- DOI
  10.1097/ijg.0000000000002257
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09827, KAKENHI-PROJECT-21K09736
[Journal Article] 緑内障のトランスレーショナルリサーチ2023
- Author(s)
  石川　誠
- Journal Title
  
  RETINA Medicine
  
  Volume: 12 Pages: 31-36
- Data Source
  KAKENHI-PROJECT-22K09827
[Journal Article] The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models.2020
- Author(s)
  Ishikawa M, Takaseki S, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.
- Journal Title
  
  Autophagy
  
  Volume: Feb 27 Pages: 1-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Journal Article] The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models2020
- Author(s)
  Ishikawa Makoto、Takaseki Sanae、Yoshitomi Takeshi、Covey Douglas F.、Zorumski Charles F.、Izumi Yukitoshi
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 3 Pages: 743-760
- DOI
  10.1080/15548627.2020.1731270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Journal Article] Clinical Assessment of Scleral Canal Area in Glaucoma Using Spectral Domain Optical Coherence Tomography.2020
- Author(s)
  Sawada Y, Araie M, Shibata H, Murata K, Ishikawa M, Yoshitomi T, Iwase T.
- Journal Title
  
  Am J Ophthalmol.
  
  Volume: Apr 9 Pages: 1-26
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09438
[Journal Article] Focal Lamina Cribrosa Defect in Myopic Eyes With Nonprogressive Glaucomatous Visual Field Defect2018
- Author(s)
  Sawada Yu、Araie Makoto、Kasuga Hitomi、Ishikawa Makoto、Iwata Toyoto、Murata Katsuyuki、Yoshitomi Takeshi
- Journal Title
  
  American Journal of Ophthalmology
  
  Volume: 190 Pages: 34-49
- DOI
  10.1016/j.ajo.2018.03.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888, KAKENHI-PROJECT-17K11417, KAKENHI-PROJECT-18K09438
[Journal Article] Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease.2018
- Author(s)
  Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.
- Journal Title
  
  Neuropsychiatry (London).
  
  Volume: 8 Issue: 01 Pages: 344-359
- DOI
  10.4172/neuropsychiatry.1000356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Journal Article] Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model.2018
- Author(s)
  Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 12851-12851
- DOI
  10.1038/s41598-018-31239-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Journal Article] Optic Disc Margin Anatomic Features in Myopic Eyes with Glaucoma with Spectral-Domain OCT.2018
- Author(s)
  Sawada Y, Araie M, Shibata H, Ishikawa M, Iwata T, Yoshitomi T.
- Journal Title
  
  Ophthalmology
  
  Volume: 125 Issue: 12 Pages: 1886-1897
- DOI
  10.1016/j.ophtha.2018.07.004
- NAID
  40022067115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11417, KAKENHI-PROJECT-18K09438
[Journal Article] Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer’s disease.2018
- Author(s)
  Ishikawa, M., Yoshitomi, T, Covey, D.F., Zorumski, C.F., Izumi, Y.
- Journal Title
  
  Neuropsychiatry
  
  Volume: 8 Pages: 344-359
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Journal Article] Multiple temporal lamina cribrosa defects in myopic eyes with glaucoma and their association with visual field defects.2017
- Author(s)
  Yu Sawada, Makoto Araie, Makoto Ishikawa, Takeshi Yoshitomi
- Journal Title
  
  Ophthalmology
  
  Volume: 124 Issue: 11 Pages: 1600-1611
- DOI
  10.1016/j.ophtha.2017.04.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11417, KAKENHI-PROJECT-15K10888
[Journal Article] 救急外来に今朝起きたら急に視力が落ちていたと訴えて患者が受診しました。鑑別すべき疾患と鑑別の方法を教えてください。2017
- Author(s)
  石川　誠
- Journal Title
  
  あたらしい眼科
  
  Volume: 34 Pages: 10-14
- Data Source
  KAKENHI-PROJECT-15K10888
[Journal Article] Association of Myopic Deformation of Optic Disc with Visual Field Progression in Paired Eyes with Open-Angle Glaucoma2017
- Author(s)
  Sawada Yu、Hangai Masanori、Ishikawa Makoto、Yoshitomi Takeshi
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 1 Pages: e0170733-e0170733
- DOI
  10.1371/journal.pone.0170733
- Data Source
  KAKENHI-PROJECT-15K10888
[Journal Article] Dorzolamide-induced relaxation of isolated rabbit ciliary arteries mediated by inhibition of extracellular calcium influx.2016
- Author(s)
  Dong, Y., Sawada, Y., Cui, J., Hayakawa, M., Ogino, D., Ishikawa, M., & Yoshitomi, T.
- Journal Title
  
  Japanese Journal of Ophthalmology
  
  Volume: 60(2) Issue: 2 Pages: 103-110
- DOI
  10.1007/s10384-015-0423-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462750
[Journal Article] The synthetic enantiomer of allopregnanolone effectively protects the ex vivo rat retina from injury by elevated hydrostatic pressure.2016
- Author(s)
  Ishikawa, M., Yoshitomi, T, Covey, D.F., Zorumski, C.F., Izumi, Y.
- Journal Title
  
  Neuropharmacology
  
  Volume: 111 Pages: 142-159
- DOI
  10.1016/j.neuropharm.2016.09.001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Journal Article] 24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.2016
- Author(s)
  Ishikawa, M., Yoshitomi ,T, Zorumski, C.F., Izumi, Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 6:3388 Issue: 1 Pages: 1-15
- DOI
  10.1038/srep33886
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Journal Article] 神経ステロイドは神経節細胞に軸索を加圧障害から防御する2015
- Author(s)
  石川　誠、吉冨　健志、Zorumski CF、和泉　幸俊
- Journal Title
  
  日眼会誌「外国誌要覧」
  
  Volume: 119 Pages: 308-308
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592666
[Journal Article] Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells2015
- Author(s)
  Ishikawa M、 Sawada Y、 Yoshitomi T
- Journal Title
  
  Experimental Eye Research
  
  Volume: 133 Pages: 3-18
- DOI
  10.1016/j.exer.2015.02.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592666, KAKENHI-PROJECT-25462750
[Journal Article] Experimentally Induced Mammalian Models of Glaucoma2015
- Author(s)
  Ishikawa M、 Yoshitomi T、 Zorumski CF、 Izumi Y
- Journal Title
  
  BioMed Research International
  
  Volume: 2015 Pages: 1-11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592666
[Journal Article] Experimentally Induced Mammalian Models of Glaucoma.2015
- Author(s)
  Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y.
- Journal Title
  
  Biomed Res
  
  Volume: 281214 Pages: 1-11
- DOI
  10.1155/2015/281214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462750
[Journal Article] Future therapies of wet age-related macular degeneration2015
- Author(s)
  Ishikawa M、 Jin D、 Sawada Y、 Abe S、 Yoshitomi T
- Journal Title
  
  Journal of Ophthalmology
  
  Volume: 2015 Pages: 1-10
- DOI
  10.1155/2015/138070
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592666
[Journal Article] Lamina Cribrosa Depth Variation Measured by Spectral-Domain Optical Coherence Tomography Within and Between Four Glaucomatous Optic Disc Phenotypes.2015
- Author(s)
  Sawada Y, Hangai M, Murata K, Ishikawa M, Yoshitomi T.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 56 Issue: 10 Pages: 5777-5784
- DOI
  10.1167/iovs.14-15942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462750
[Journal Article] Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model2014
- Author(s)
  ④ Ishikawa M、 Yoshitomi T、 Zorumski CF、 Izumi Y
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 55 Issue: 12 Pages: 8531-8541
- DOI
  10.1167/iovs.14-15624
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592666, KAKENHI-PROJECT-25462750
[Journal Article] Abnormalities in glutamate metabolism and excitotoxicity in the retinal diseases.2013
- Author(s)
  Makoto Ishikawa
- Journal Title
  
  Scientifica
  
  Volume: 2013 Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592666
[Journal Article] Abnormalities in glutamate metabolism and excitotoxicity in the retinal diseases.2013
- Author(s)
  Ishikawa M.
- Journal Title
  
  Scientifica (Cairo)
  
  Volume: 2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462750
[Patent] The Enantiomer of Allopregnanolone for the Prevention and Treatment of Retinal Degeneration via Autophagy2019
- Inventor(s)
  石川誠, Douglas F. Covey他
- Industrial Property Rights Holder
  石川誠, Douglas F. Covey他
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] ラットex vivo緑内障モデルにおける眼圧上昇時のミクログリアによる網膜神経節細胞傷害のメカニズムについて2023
- Author(s)
  佐藤大夢、石川誠、大石路子、神位りえ子、俵山寛司、佐藤孝太、中澤徹
- Organizer
  第11 回わかもと先進眼科医療研究会（WACAMOTO）
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] 血漿プロテオーム解析による緑内障自己抗体の同定2023
- Author(s)
  高田菜生子、石川誠、佐藤孝太、國方彦志、福田枝里子、山口圭、小野千紘、桐原朋子、新谷千栄、五島直樹、中澤徹
- Organizer
  第34回日本緑内障学会
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] Induction of microglia-induced neuroinflammation in a rat ex vivo glaucoma model2023
- Author(s)
  Taimu Sato, Makoto Ishikawa, Kota Sato, Hiroshi Tawarayama and Toru Nakazawa
- Organizer
  10th World Glaucoma Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] ラットex vivo緑内障モデルにおける眼圧上昇時のNLRP3介在型炎症反応の誘導2023
- Author(s)
  佐藤大夢、石川誠、大石路子、神位りえ子、佐藤孝太、中澤徹
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] The neurosteroid allopregnanolone and its enantiomer protect retinal neurons by effects on autophagy in rat glaucoma models2023
- Author(s)
  Makoto Ishikawa, Taimu Sato, Kota Sato, Hiroshi Kunikata and Toru Nakazawa
- Organizer
  日中韓Joint meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] ラット ex vivo 緑内障モデルにおけるCSF1受容体拮抗薬(PLX5622)によるNLRP3介在型炎症反応抑制の検討2023
- Author(s)
  佐藤大夢、石川誠、大石路子、神位りえ子、佐藤孝太、中澤徹
- Organizer
  第34回日本緑内障学会
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] 学術展示ラット緑内障モデルにおけるNMDAチャンネル透過型プローブAGBによる神経保護メカニズムの検討2022
- Author(s)
  石川誠、佐藤大夢、大石路子、神位りえ子、佐藤孝太、中澤徹
- Organizer
  第33回日本緑内障学会
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] ラット緑内障モデルにおける神経ステロイド光学異性体の神経保護作用2022
- Author(s)
  石川誠, 佐藤大夢, 佐藤孝太, 國方彦志, 吉冨健志, 中澤徹
- Organizer
  第126回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] 学術奨励賞受賞講演：緑内障神経保護薬の新規開発神経ステロイドのオートファジー活性化に着目して2022
- Author(s)
  石川　誠
- Organizer
  第216回宮城県眼科集談会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] シンポジウム1：緑内障ゲノム研究の臨床応用老化遺伝子CDKN2Bと緑内障性視神経症との関連について2022
- Author(s)
  石川　誠
- Organizer
  第33回日本緑内障学会
- Data Source
  KAKENHI-PROJECT-22K09827
[Presentation] 緑内障実験モデルにおける神経ステロイドのオートファジー誘導と神経保護2020
- Author(s)
  石川　誠、柴田　直哉、渡辺　裕士、高関　早苗、岩瀬　剛、吉冨　健志、和泉　幸俊
- Organizer
  日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] Protective effects of tamoxifen against pressure-induced injury in a rat　ex vivo glaucoma model2019
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Yukitoshi Izumi
- Organizer
  8th WORLD GLAUCOMA CONGRESS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] Surgical repair of severe traumatic cyclodialysis by a circum- ferentially inserted 5-0 proline thread along the ciliary sulcus2019
- Author(s)
  Shohei Ito, Makoto Ishikawa, Yu Sawada, Takeshi Yoshitomi
- Organizer
  World Glaucoma Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] Protective effects of tamoxifen against pressure-induced injury in a rat ex vivo glaucoma model2019
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Yukitoshi Izumi
- Organizer
  World Glaucoma Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] Protective effects of tamoxifen against rat glaucoma model2019
- Author(s)
  石川誠、柴田直弥、吉冨健志、Zorumski Charles、和泉幸俊
- Organizer
  第123回　日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] Surgical repair of severe traumatic cyclodialysis by a circum- ferentially inserted 5-0 proline thread along the ciliary sulcus2019
- Author(s)
  Shohei Ito, Makoto Ishikawa, Yu Sawada, Takeshi Yoshitomi
- Organizer
  8th WORLD GLAUCOMA CONGRESS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] 神経ステロイドの光学異性体特異的な神経保護効果のメカニズム2018
- Author(s)
  柴田　直弥、石川　誠、吉冨　健志（秋田大）和泉　幸俊（ワシントン大）
- Organizer
  日本緑内障学会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] ex vivo緑内障モデルにおける神経ステロイドのオートファジー活性効果と神経保護ショートタイトル:　神経ステロイドと神経保護2018
- Author(s)
  石川　誠、柴田　直哉、吉冨　健志（秋田大）Douglas F. Covey、Charles F. Zorumski、和泉　幸俊（ワシントン大）
- Organizer
  第122回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] ex vivo緑内障モデルにおける神経ステロイドの相加的神経保護効果の機序2018
- Author(s)
  石川　誠、吉冨　健志（秋田大） Covey DF、Zorumski CF、和泉　幸俊（ワシントン大）
- Organizer
  日本緑内障学会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] 視神経低形成を認めた PAX2 PAX2 遺伝子変異を遺伝子変異を有した有した腎コロボーマ症候群の 1例2018
- Author(s)
  松井孝子、安田節子、坂本貴子、石川誠、吉冨健志
- Organizer
  日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] ex vivo緑内障モデルにおける神経ステロイドのオートファジー活性効果と神経保護2018
- Author(s)
  石川　誠、柴田　直哉、吉冨　健志（秋田大） Douglas F. Covey、Charles F. Zorumski、和泉　幸俊（ワシントン大）
- Organizer
  日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] ex vivo緑内障モデルにおける神経ステロイドの神経保護効果のメカニズム2018
- Author(s)
  1）石川　誠、柴田　直哉、吉冨　健志（秋田大眼科） 2）Douglas F. Covey、Charles F. Zorumski、和泉　幸俊（ワシントン大）
- Organizer
  日本眼薬理学会
- Data Source
  KAKENHI-PROJECT-18K09438
[Presentation] Synergistic protection from high pressure-induced injury by allopregnanolone and 24(S)-hydroxycholesterol in the ex vivo rat retina.2017
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Yukitoshi Izumi
- Organizer
  ARVO 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] Intraocular pressure elevation induces neurosteroid synthesis by NMDA receptors in a rat ex vivo retinal preparation.2017
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Yukitoshi Izumi
- Organizer
  World Glaucoma Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] シンポジウム13「薬物治療」神経保護治療2017
- Author(s)
  石川　誠
- Organizer
  第28回日本緑内障学会
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] TSPO modulates retinal axonal swelling in a rat ex vivo glaucoma model2016
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, Charles F. Zorumski, Douglas F. Covey, and Yukitoshi Izumi
- Organizer
  ARVO2016
- Place of Presentation
  Seattle
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] Pressure elevateon induces upregulation of allopregnanolone synthesizing enzyme in an ex　vivo rat glaucoma model.2016
- Author(s)
  Ishikawa, M., Yoshitomi, T., Zorumski C.F., Izumi, Y.
- Organizer
  The 31th Asia-Pacific Academy of Ophthalmology Congress. Taipei.
- Place of Presentation
  Taipei
- Year and Date
  2016-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] 圧傷害モデル研究の実践2016
- Author(s)
  石川　誠
- Organizer
  第27回日本緑内障学会
- Place of Presentation
  横浜
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] 神経ステロイド24S-hydroxycholesterol のex vivo 緑内障モデルにおける神経保護効果2016
- Author(s)
  石川誠、吉冨健志、Chales Zorumsk)、和泉幸俊
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台市
- Year and Date
  2016-04-07
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] TSPO modulates retinal axonal swelling in a rat ex vivo glaucoma model2016
- Author(s)
  Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y.
- Organizer
  ARVO2016
- Place of Presentation
  Seattle (USA)
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] 神経ステロイド24S-hydroxycholesterol のex vivo 緑内障モデルにおける神経保護効果.2016
- Author(s)
  石川誠, 吉冨健志, Chales Zorumski, 和泉幸俊.
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台市
- Year and Date
  2016-04-07
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] Upregulation of neurosteroid synthesizing enzyme in an ex vivo rat glaucoma model.2015
- Author(s)
  Ishikawa M, Yoshitomi T, Izumi Y
- Organizer
  The 6th world glaucoma congress.
- Place of Presentation
  Hong Kong
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462750
[Presentation] 眼圧上昇と24S-hydroxycholesterol の発現上昇の関連について.2015
- Author(s)
  石川誠, 吉冨健志, 和泉幸俊.
- Organizer
  第35回日本眼薬理学会
- Place of Presentation
  東京都
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] 眼圧上昇時の神経ステロイドの誘導メカニズム.2015
- Author(s)
  石川誠, 吉冨健志, 和泉幸俊.
- Organizer
  第26回日本緑内障学会
- Place of Presentation
  名古屋市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] Upregulation of neurosteroid synthesizing enzyme in an ex vivo rat glaucoma model.2015
- Author(s)
  Ishikawa, M., Yoshitomi, T., Izumi, Y.
- Organizer
  World Glaucoma Congress 2015.
- Place of Presentation
  Hong Kong
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10888
[Presentation] Lamina cribrosa anterior surface depth and morphology in normal eyes.2015
- Author(s)
  Sawada Y, Ishikawa M, Fujiwara K, Yoshitomi T
- Organizer
  The 6th world glaucoma congress.
- Place of Presentation
  Hong Kong
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462750
[Presentation] Pressure-dependent changes of GLT-1 splice variants in the isolated rat retinal preparation.2013
- Author(s)
  Ishikawa, M., Yoshitomi, T., Izumi, Y.
- Organizer
  World Glaucoma Congress
- Place of Presentation
  Vancouver Canada
- Data Source
  KAKENHI-PROJECT-25462750
[Presentation] Pressure-dependent changes of glutamate transporters in the ex vivo rat retinal preparation.
- Author(s)
  Ishikawa M, Yoshitomi T, Izumi Y.
- Organizer
  World Ophthalmology Congress 2014.
- Place of Presentation
  Tokyo
- Year and Date
  2014-04-02 – 2014-04-06
- Data Source
  KAKENHI-PROJECT-24592666
[Presentation] Pressure-dependent changes of glutamate transporters in the ex vivo rat retinal preparation
- Author(s)
  Makoto Ishikawa, Takeshi Yoshitomi, and Yukitoshi Izumi
- Organizer
  World Ophthalmology Congress 2014－APAO2014－118ｔｈ　JOS
- Place of Presentation
  東京
- Year and Date
  2014-04-04 – 2014-04-07
- Data Source
  KAKENHI-PROJECT-25462750
[Presentation] Lamina cribrosa anterior surface depth and morphology in normal eyes
- Author(s)
  Sawada Y, Ishikawa M, Yoshitomi-T
- Organizer
  World Glaucoma Congress 2015
- Place of Presentation
  Hong Kong
- Year and Date
  2015-06-06 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-24592666
[Presentation] 緑内障の基礎と臨床
- Author(s)
  石川　誠
- Organizer
  第３６回東北ブロック眼科講習会
- Place of Presentation
  秋田
- Year and Date
  2014-08-30 – 2014-08-31
- Invited
- Data Source
  KAKENHI-PROJECT-24592666
[Presentation] ラットex vivo加圧モデルにおけるアロプレグナノロンの発現
- Author(s)
  石川　誠、吉冨　健志、和泉　幸俊
- Organizer
  第25回日本緑内障学会
- Place of Presentation
  大阪
- Year and Date
  2014-09-19 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-24592666
[Presentation] Upregulstion of neurosteroid synthesizing enzyme in an ex vivo rat glaucoma model
- Author(s)
  Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y
- Organizer
  World Glaucoma Congress 2015
- Place of Presentation
  Hong Kong
- Year and Date
  2015-06-06 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-24592666

1. YOSHITOMI Takeshi (60191623)

# of Collaborated Projects: 4 results

# of Collaborated Products: 52 results
2. 佐藤孝太 (50732327)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 中澤徹 (30361075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. TAKASEKI Sanae

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. WATANABE Hiroshi (80004662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TONOSAKI Akira (90004572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山木邦比古 (20125751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 近藤功 (50234927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小池数与 (80234657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 杉江淳 (50777000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 津田聡 (60791093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大石路子 (80454875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 國方彦志 (40361092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OHNO Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 澤田有

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ishikawa Makoto 石川 誠

ISHIKAWA Makoto 石川 誠

石川 誠 イシカワ マコト

Research Projects

Research Products

Co-Researchers

ヒト緑内障GWASからの個別化創薬プラットフォーム構築研究

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Review Section

Research Institution

Challenges for Breakthroughs in Social Implementation of Glaucoma Optic Nerve Regeneration Therapy

Principal Investigator

Project Period (FY)

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Review Section

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眼圧上昇時のミクログリア起因性炎症反応の制御による神経保護の可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The neurosteroid allopregnanolone and its enantiomer protects retinal neurons by effects on autophagy and GABAA receptors in rat glaucoma modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neurosteroids modulate the effects of high pressure in a rat ex vivo glaucoma modelPrincipal Investigator

Principal Investigator

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Research Institution

Development of new glaucoma therapy other than decreasing intraocular pressure

Principal Investigator

Project Period (FY)

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Research Institution

Neuroprotection by enhancement of glutamate uptake against pressure-induced injury in a rat glaucoma modelPrincipal Investigator

Principal Investigator

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Research Institution

VKH disease・原田病特異的抗原の検索-SDS不溶性成分の検索

Principal Investigator

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Research Institution

Ultrastructure of postsynaptic active zones associated with different type of receptors.

Principal Investigator

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Research Institution

[Book] Excitotoxicity and glaucoma、"Ophthalmology; Current Clinical and Research Update" (Editor: PG. Davey)2014

Author(s)

Publisher

Data Source

[Book] 毛様体レーザーの治療「緑内障クローズアップ」編集：木内 良明2014

Author(s)

Publisher

Data Source

[Book] Excitotoxicity as the pathogenesis of glaucoma and its neuroprotective strategies.2014

Author(s)

Publisher

Data Source

[Journal Article] Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury2023

Author(s)

Journal Title

Ishikawa Makoto 石川誠

ISHIKAWA Makoto 石川誠

石川誠イシカワマコト

[Book] 毛様体レーザーの治療「緑内障クローズアップ」編集：木内　良明2014