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Hanajiri Ruri  花尻 瑠理 (木倉 瑠理)

ORCIDConnect your ORCID iD *help
… Alternative Names

花尻 瑠理  ハナジリ ルリ

木倉瑠理

HANAJIRI Ruri  花尻 瑠理

KIKURA Ruri  木倉 瑠理

花尻 瑠理(木倉瑠理)  ハナジリ ルリ

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Researcher Number 10224916
Affiliation (Current) 2025: 国立医薬品食品衛生研究所, 医薬安全科学部, 部長
Affiliation (based on the past Project Information) *help 2016 – 2023: 国立医薬品食品衛生研究所, 生薬部, 室長
2013: 国立医薬品食品衛生研究所, 生薬部, 室長
2012: 国立医薬品食品衛生研究所, 第3室, 室長
2011: 国立医薬品衛生研究所, 生薬第3部, 室長
Review Section/Research Field
Except Principal Investigator
Legal medicine / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords
Except Principal Investigator
合成カンナビノイド / 中毒 / 異常行動 / 薬物中毒 / 不整脈 / 心不全 / カンナビノイド受容体 / 突然死 / ゼブラフィッシュ / 危険ドラッグ … More / 法中毒学 / 心臓突然死 / 薬物代謝 / 学習 / 不安 / カンナビノイド / 行動薬理 / 病態生理学 / microRNA / 行動 / cannabinoid / forensic / caffeine / toxicity / drugs / mortality / behavior / zebrafish / ストレス / 行動薬理学 / カフェイン / セロトニン / 動物モデル / 病態 / カンナビノイド系薬物 / 薬毒物スクリーニング / セロトニン受容体 / 網羅的薬物分析 / 横紋筋融解症 / 行動異常 / 毒性 / 薬物スクリーニング / 分析化学 / 中毒学 / 法医学 / Q-TOF / Orbitrap / UPLC-MS-MS / 代謝物 / 飛行時間型 / タンデム質量分析 / ミフェプリストン / アマニチン / 自然毒 / 飛行時間型質量分析計 / オービトラップ / 質量分析 Less
  • Research Projects

    (3 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (12 People)
  •  Analytical research on pathogenesis of undetectable synthetic cannabinoids

    • Principal Investigator
      Yoshida Ken-ichi
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Tokyo Medical University
  •  Systematic analyses on the pathogenesis of neuro-psychoactive substances using zebrafish

    • Principal Investigator
      Yoshida Ken-ichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Legal medicine
    • Research Institution
      Tokyo Medical University
  •  Application of Fourier transformation-linear ion trap mass spectrometers to forensic medicine

    • Principal Investigator
      ISHII Akira
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Legal medicine
    • Research Institution
      Nagoya University

All 2018 2017 2014 2013 2012 2011

All Journal Article Presentation

  • [Journal Article] MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a cannabinoid receptor-1 (CB1)- and CB2-dependent manner in conscious rats2018

    • Author(s)
      Maeda H, Nagashima E, Hayashi K, Kikura-Hanajiri R, Yoshida K
    • Journal Title

      Forensic toxicology

      Volume: 36 Pages: 313-319

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19703
  • [Journal Article] MDMB-CHMICA induces thrashing behavior, bradycardia, and slow pressor response in a cannabinoid receptor-1 (CB1)- and CB2-dependent manner in conscious rats2018

    • Author(s)
      Maeda H, Nagashima E, Hayashi K, Kikura-Hanajiri R, Yoshida K
    • Journal Title

      Forensic toxicol.

      Volume: 36

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05274
  • [Journal Article] AB-CHMINACA-induced sudden death from non-cardiogenic pulmonary edema2018

    • Author(s)
      Hideyuki Maeda, Ruri Kikura-Hanajiri, Maiko Kawamura, Ken-ichi Yoshida
    • Journal Title

      Clinical Toxicology

      Volume: 56 Issue: 2 Pages: 143-145

    • DOI

      10.1080/15563650.2017.1340648

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09218, KAKENHI-PROJECT-16H05274
  • [Journal Article] The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae2017

    • Author(s)
      Kawahara G, Maeda H, Kikura-Hanajiri R, Yoshida K, Hayashi Y.
    • Journal Title

      Forensic Toxicol

      Volume: 印刷中 Issue: 2 Pages: 1-7

    • DOI

      10.1007/s11419-017-0366-9

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05274, KAKENHI-PROJECT-16K09218, KAKENHI-PROJECT-17H06112
  • [Journal Article] Changes in the prevalence of new psychoactive substances before and after the introduction of the generic scheduling of synthetic cannabinoids in Japan2014

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura, Y. Goda
    • Journal Title

      Drug Test. Anal

      Volume: in press Issue: 7-8 Pages: 832-839

    • DOI

      10.1002/dta.1584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Identification of two new-type designer drugs, a piperazine derivative MT-45 (I-C6) and a synthetic peptide Noopept (GVS-111), with a synthetic cannabinoid A-834735, a cathinone derivative 4-methoxy-α-PVP and a phenethylamine derivative 4-methylbuphedrine from illegal products2014

    • Author(s)
      N. Uchiyama, S. Matsuda, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      forensic Toxicology

      Volume: 32 Issue: 1 Pages: 9-18

    • DOI

      10.1007/s11419-013-0194-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Two new synthetic cannabinoids, AM-2201 benzimidazole analog (FUBIMINA) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM), and three phenethylamine derivatives, 25H-NBOMe 3,4,5-trimethoxybenzyl analog, 25B-NBOMe, and 2C-N-NBOMe, identified in illegal products2014

    • Author(s)
      N. Uchiyama, Y. Shimokawa, S. Matsuda, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 32 Issue: 1 Pages: 105-115

    • DOI

      10.1007/s11419-013-0217-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] URB-754 : a new class of designer drug and 12 synthetic cannabinoids detected in illegal products2013

    • Author(s)
      N. Uchiyama, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Sci. Int

      Volume: 227 Pages: 21-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannnabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative, α-PVT, and an opioid receptor agonist, AH-7921, in illegal products2013

    • Author(s)
      N. Uchiyama, S. Matsuda, M. Kawamura, R. Kikura-Hanjiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 2 Pages: 223-240

    • DOI

      10.1007/s11419-013-0182-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products2013

    • Author(s)
      N. Uchiyama, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      10.1016/j.forsciint.2012.08.047

      Volume: 227 Pages: 21-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Changes in the prevalence of synthetic cannabinoids and cathinone derivatives in Japan until early 20122013

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 44-53

    • DOI

      10.1007/s11419-012-0165-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Prevalence of new designer drugs and their legal status in Japan2013

    • Author(s)
      Kikura-Hanajiri R, Uchiyama N, Kawamura M, Ogata J, Goda Y
    • Journal Title

      Yakugaku Zasshi

      Volume: 122 Pages: 31-40

    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Prevalence of new designer drugs and their legal status in Japan2013

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura, J. Ogata, Y. Goda
    • Journal Title

      Yakugaku Zasshi

      Volume: 133 Pages: 31-40

    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA), identified as designer drugs in illegal products2013

    • Author(s)
      N. Uchiyama, S. Matsuda, D. Wakana, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 93-100

    • DOI

      10.1007/s11419-012-0171-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Identification and quantitation of JWH-213, a cannabimimetic indole, as a designer drug in an herbal product.2013

    • Author(s)
      K. Takahashi, N. Uchiyama, T. Fukiwake, T. Hasegawa, M. Saijou, Y. Motoki, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 145-150

    • DOI

      10.1007/s11419-012-0161-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Identification of a novel cannabimimetic phenylacetylindole, cannabi- piperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB1 and CB2 receptors2011

    • Author(s)
      Uchiyama N, Kikura-Hanajiri R and Goda Y
    • Journal Title

      Chem. Pharm. Bull

      Volume: 59 Pages: 1203-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Pages: 165-174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Survey of current trends in the abuse of psychotropic substances and plants in Japan2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Journal Title

      Legal Med

      Volume: 13 Pages: 109-115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Journal Article] Chiral analyses of dextromethorphan/ levomethorphan and their metabolites in rat and human samples using LC-MS/MS2011

    • Author(s)
      Kikura-Hanajiri R, Kawamura M, Miyajima A, Sunouchi M, Goda Y
    • Journal Title

      Anal Bioanal Chem

      Volume: 400(1) Pages: 165-174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] 25B-NBOMeはゼブラフィッシュに横紋筋融解症を惹起する2017

    • Author(s)
      川原玄理 前田秀将 花尻(木倉)瑠理 吉田謙一 林由起子
    • Organizer
      日本筋学会第3回学術集会
    • Data Source
      KAKENHI-PROJECT-16H05274
  • [Presentation] 5B-NBOMeはゼブラフィッシュに横紋筋融解症を惹起する2017

    • Author(s)
      川原玄理  前田秀将  花尻(木倉)瑠理  林由起子 ○吉田謙一
    • Organizer
      日本法中毒学会 第36年会
    • Data Source
      KAKENHI-PROJECT-16H05274
  • [Presentation] 合成カンナビノイド系薬物MDMB-CHMICAは、ラットに徐脈・昇圧作用と行動異常を惹起する2017

    • Author(s)
      前田秀将 永嶋瑛利香 川原玄理 花尻(木倉)瑠理 林由起子 吉田謙一
    • Organizer
      日本法中毒学会 第36年会
    • Data Source
      KAKENHI-PROJECT-16H05274
  • [Presentation] wo new designer drugs, MT-45 (I-C6) and Noopept (GVS-111), detected with a synthetic cannabinoid A-834735 in illegal products2013

    • Author(s)
      N. Uchiyama, S. Matsuda, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Funchal, Portugal
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Effects of cannabinoids on the neuronal responses in the mouse amygdala analyzed by voltage-sensitive dye imaging2013

    • Author(s)
      K. Hara, Tomomi Fujieda, T. Irie, H. Miwa, J. Oka, T. Shirao, R. Kikura-Hanajiri, Y. Goda, M. Kurihara, Y. Sekino
    • Organizer
      Neuro 2013
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Determination of MAM-2201 and its metabolites in a fatal case and the binding affinities of MAM-2201 at the cannabinoid CB1 and CB2 receptors. 51th Annual Meeting of the International Association of Rorensic Toxicologists2013

    • Author(s)
      R. Kikura-Hanajiri, M. Kawamura, S. Kanno, T. Nagai, M. Takada, T. Mukai and Y. Goda
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] A fatal case after smoking herb containing a synthetic cannabinoid MAM-22012013

    • Author(s)
      S. Kanno, R. Kikura-Hanajiri, M. Sagi, T. Nagai, S. Chiba, H. Takeshita, M. Takada, M. Kawamura, Y. Goda, T. Mukai
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] 2012 年度に実施した違法ドラッグ製品の流通実態調査結果について2013

    • Author(s)
      内山 奈穂子,松田 諭,花尻(木倉)瑠理,合田 幸広
    • Organizer
      日本法中毒学会第 32 年会
    • Place of Presentation
      さわやかちば県民プラザ、柏市
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] urvey of the emergence of erectile dysfunction medicines and their related compounds adulterated to health food products in Japan for the last decade2013

    • Author(s)
      K. Saisho, R. Kikura-Hanajiri, Y. Goda
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] The emerging of new synthetic cannabinoids and their binding affinities at the cnnnabinoid CB1 and CB2 receptors2013

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura and Y. Goda
    • Organizer
      SOFT 2013 Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2013-10-30
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Determination of MAM-2201 and its metabolites in a fatal case and the binding affinities of MAM-2201 at the cannabinoid CB1 and CB2 receptors2013

    • Author(s)
      R. Kikura-Hanajiri, M. Kawamura, S. Kanno, T. Nagai, M. Takada, T. Mukai and Y. Goda
    • Organizer
      51th Annual Meeting of the International Association of Rorensic Toxicologists
    • Place of Presentation
      Funchal, Portugal
    • Year and Date
      2013-09-03
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] いわゆる「脱法ハーブ」使用者生体試料からの薬物分析例2013

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] 指定薬物制度と違法ドラッグ流通実態の変化について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      第49回全国衛生化学技術協議会
    • Place of Presentation
      環境保健センター(高松)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Survey of the trend in the abuse of designer drugs in Japan from 2002 to 20112012

    • Author(s)
      Kikura-Hanajiri R, Kawamura M, Uchiyama N, Goda Y
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Changes in the trends of the abuse of designer drugs and their legal status in Japan2012

    • Author(s)
      Ruri Kikura-Hanajiri
    • Organizer
      2012 NIDA International Forum
    • Place of Presentation
      PalmSprings, CA (USA)
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Changes in the trends of the abuse of designer drugs and their legal status in Japan2012

    • Author(s)
      Kikura-Hanajiri R, Uchiyama N, Kawamura M, Goda Y
    • Organizer
      2012 NIDA International Forum -New and Emerging Psychoactive Substances : Second Interdisciplinary Forum-
    • Place of Presentation
      Palm Springs, California, USA
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] 違法ドラッグを取り巻く国内外における現状と規制について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      日本薬学会第132年会一般シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] The trends of the abuse of designer drugs and their legal status in Japan2012

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      The first International Conference on Novel Psychoactive Compounds
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2012-03-12
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] 「脱法ドラッグ」の流通実態と指定薬物制度について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      平成24年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Survey of the trend in the abuse of designer drugs in Japan from 2002 to 20112012

    • Author(s)
      Ruri Kikura-Hanajiri
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] 指定薬物について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      第49回全国薬事指導協議会総会
    • Place of Presentation
      鯉城会館(広島)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Survey of current trends in the abuse of psychotropic substances and plants in Japan2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      First international multidisciplinary forum on new drugs
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2011-05-12
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Determination of a synthetic cannabinoid, JWH-018 and its metabolites in raturine and hair samples using UPLC-MS/MS2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      SOFT-TIAFT 2011
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2011-09-30
    • Data Source
      KAKENHI-PROJECT-23390183
  • [Presentation] Drug Control in Japan-Designated Substances-2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      First international multidisciplinary forum on new drugs
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2011-05-11
    • Data Source
      KAKENHI-PROJECT-23390183
  • 1.  Yoshida Ken-ichi (40166947)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 2.  川原 玄理 (40743331)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  林 由起子 (50238135)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 4.  前田 秀将 (60407963)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 5.  ISHII Akira (30252175)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ZAITSU Kei (30700546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NASU Tamie (10020794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SENO Hiroshi (50236113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  HATTORI Hideki (30107817)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OGAWA Tadashi (50559937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KANEKO Rina (70367697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  原 修一 (70208651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results

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この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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