Kojima Hiroshi 小島寛

… Alternative Names

KOJIMA Hiroshi 小島寛

小島寛コジマヒロシ

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Researcher Number	10225435
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2021: 筑波大学, 医学医療系, 教授 2009: 筑波大, 人間総合科学研究科, 准教授 2007 – 2008: University of Tsukuba, 大学院・人間総合科学研究科, 准教授 2006: University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associated Professor, 大学院人間総合科学研究科, 助教授 2004 – 2005: 筑波大学, 大学院・人間総合科学研究科, 助教授 1995 – 1996: 筑波大学, 臨床医学系, 講師 1991 – 1992: 筑波大学, 臨床医学系, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Hematology / Hematology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Hematology / Basic Section 52040:Radiological sciences-related / Laboratory medicine
Keywords	Principal Investigator caspase-3 / CD226 / p38MAPK / Bcl-xL / bevacizumab / 血管新生因子 / バイオマーカー / 大腸癌 / 血小板産生 / アポトーシス … More / 巨核球 / トロンボポエチン / 膜表面応力センサ- / 早期発見 / がん早期診断 / 早期診断 / ガガスクロマトグラフ質量分析計 / 超小型膜型表面応力センサ / MSS / 膜表面応力センサ / 人工嗅覚センサ / がん検診 / ガスクロマトグラフ質量分析計 / 機械学習 / がん / 呼気 / 膜型表面応力センサ / 人工嗅覚センサー / Bevacizumab / Bevacitumab / 大腸がん / microRNA / Bevacixumab / 治療効果予測 / miRNA / サイトカイン / platelet production / thrombopoietin / megakaryocytes / 情報伝達系 / 胞体突起形成 / 血管内皮細胞 / Bc1-xL / VEGF / caspase / apoptosis / 造血幹細胞 / 細胞周期 / 幹細胞 / Bim / チロシンリン酸化 / Tec / 血小板 / マウス / SCF / IL-2 / NK細胞 … More Except Principal Investigator マイクロRNA / IL-3 / IL-2 / Stem Cell Factor / CD33 / CD34 / NK細胞 / 病理分類 / 化学療法 / 薬剤抵抗性 / micro RNA / 線量 / びまん性大細胞型B細胞リンパ腫 / 孤立線維性腫瘍 / ランゲハンス細胞組織球症 / 芽球性形質細胞様樹状細胞腫瘍 / 化学療法後の再発 / 放射線治療 / B細胞リンパ腫 / 化学療法抵抗性 / 放射線感受性 / 悪性リンパ腫 / リファレンス / 内在性コントロール遺伝子 / リンパ節 / ホルマリン固定パラフィン包埋 / 原発組織 / 原発不明がん / stroma cells / NK cells / Hematopoietic stem cells / stem cell factor / NK前駆細胞 / ストローマ細胞 / SCF / 造血幹細胞 / 分化 / ELISA / Major Basic Protein(MBP) / 好酸球 / 血管内皮細胞 / 分化・成熟 Less

A study of the diversity of radiosensitivity in chemoresistant malignant lymphomas
- Principal Investigator
  
  Tamaki Yoshio
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  University of Tsukuba
Exploration of the cancer screening method analyzing the exhaled breath through the membrane-type surface stress sensor (MSS)Principal Investigator
- Principal Investigator
  
  KOJIMA HIROSHI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Tsukuba
Global analysis of cancer-tissue-derived microRNA to improve treatment outcome of cancer of unknown primary
- Principal Investigator
  
  OKOSHI Yasushi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Tsukuba
Comprehensive analyses of biomarkers predicting therapeutic effect of an anti-angiogenetic agent against advanced colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Kojima Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
大腸癌血管新生阻害薬の効果予測を可能にするバイオマーカーの網羅的探索Principal Investigator
- Principal Investigator
  
  小島寛
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
アポトーシス関連遺伝子改変マウスを用いた巨核球成熟、血小板産生機構の系統的解析Principal Investigator
- Principal Investigator
  
  小島寛
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Comprehensive Analyses of Intracellular Signaling Mechanism Underlying Thrombopoietin-independent MegakaryopoiesisPrincipal Investigator
- Principal Investigator
  
  KOJIMA Hiroshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Thrombopoietin(TPO)による血小板活性化機構の解析Principal Investigator
- Principal Investigator
  
  小島寛
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
マウス骨髄前駆細胞からのNK細胞の分化の調節機構Principal Investigator
- Principal Investigator
  
  小島寛
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
好酸球顆粒Major Basic Proteinの産生・分泌機構に関する研究
- Principal Investigator
  
  阿部師
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
GENERATION OF NK CELLS FROM CD34+ HEMATOPOIETIC STEM CELLS
- Principal Investigator
  
  NAKAUCHI Hiromitsu, 渋谷彰
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  THE INSTITUTE OF PFYSICAL AND CHEMICAL RESEARCH
  University of Tsukuba
NK細胞の分化・成熟に及ぼす血管内皮細胞の影響
- Principal Investigator
  
  阿部帥
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba

All 2022 2021 2018 2017 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 図説血栓・止血。血管学(一瀬白帝編、分担執筆)2005
- Author(s)
  小島寛, 長澤俊郎
- Total Pages
  8
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] A Case Report of Radiotherapy for Skull Lesions of Langerhans Cell Histiocytosis With Dural Invasion2022
- Author(s)
  Hiroshima Y, Tamaki Y, Sawada T, Murakami M, Ishida T, Saitoh T, Kojima H, Okumura T, Sakurai H
- Journal Title
  
  Cancer Diagn Progn.
  
  Volume: 2(2) Issue: 2 Pages: 258-262
- DOI
  10.21873/cdp.10103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08219
[Journal Article] Statistical evaluation of total expiratory breath samples collected throughout a year: reproducibility and applicability toward olfactory sensor-based breath diagnostics.2021
- Author(s)
  Inada K, Kojima H, Cho-Isoda Y, Tamura R, Imamura G, Minami K, Nemoto T, Yoshikawa G
- Journal Title
  
  Sensors (Basel)
  
  Volume: 21(14) Pages: 4742-4742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07318
[Journal Article] Endogenous reference RNAs for microRNA quantitation in formalin-fixed, paraffin-embedded lymph node tissue2018
- Author(s)
  Inada K, Okoshi Y, Cho-Isoda Y, Ishiguro S, Suzuki H, Oki A, Tamaki Y, Shimazui T, Saito H, Hori M, Iijima T, Kojima H
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 5918-5927
- DOI
  10.1038/s41598-018-24338-7
- NAID
  120007134247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08640, KAKENHI-PROJECT-15K08963
[Journal Article] Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes.2009
- Author(s)
  Kozuma Y, Yuki S, Ninomiya H, Nagasawa T, Kojima H
- Journal Title
  
  Leukemia (In press)
- Data Source
  KAKENHI-PROJECT-19591094
[Journal Article] Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL.2007
- Author(s)
  Kozuma Y, Kojima H, et al.
- Journal Title
  
  J Thromb Haemost 5
  
  Pages: 1274-1282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] Review : Mechanism of platelet production from megakaryocytes. -Significance of proplatelet formation-(in Japanese)2007
- Author(s)
  Kojima H, Kozuma Y, et al.
- Journal Title
  
  Jpn J Thromb Haemost 17
  
  Pages: 261-271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL.2007
- Author(s)
  Kozuma Y, Kojima H, et al.
- Journal Title
  
  J Thromb Haemost 5(6)
  
  Pages: 1274-1282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Aktactivation, which prevents the cleavage of Bcl-xL.2007
- Author(s)
  Kozuma Y, Kojima H, et. al.
- Journal Title
  
  J Thromb Haemost 5
  
  Pages: 1274-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591094
[Journal Article] 血小板は如何にして産出されるか -血小板産生におけるproplatele formationの意義-(総説)2006
- Author(s)
  小島寛, 上妻行則, 長澤俊郎
- Journal Title
  
  日本血栓止血学会誌 17
  
  Pages: 261-271
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] 総説:血小板は如何にして産生されるか2006
- Author(s)
  小島寛, 上妻行則, 長澤俊郎
- Journal Title
  
  日本血栓止血学会誌 (in press)
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] 血小板は如何にして産生されるか -血小板産生におけるproplatele formationの意義- (総説)2006
- Author(s)
  小島寛, 上妻行則, 長澤俊郎
- Journal Title
  
  日本血栓止血学会誌 17
  
  Pages: 261-271
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] Mechanism of platelet production (in Japanese)2005
- Author(s)
  Kojima H, Nagasawa T
- Journal Title
  
  Thrombosis, Hemostasis, and Vascular Sciences (Ed : Ichinose A)(Chugai Igakusya, Tokyo)
  
  Pages: 131-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590922
[Journal Article] Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation,which prevents the cleavage of Bcl-xL.
- Author(s)
  Kozume Y, Kojima H, et al.
- Journal Title
  
  J Thromb Haemost (in press)
- Data Source
  KAKENHI-PROJECT-16590922
[Presentation] Reference gene selection for microRNA quantitation in lymph node tissue2017
- Author(s)
  Inada K, Okoshi Y, Cho Y, Iijima T, Hori M, Kojima H
- Organizer
  第76回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08640
[Presentation] Functional Analysis of CD9 during Megakaryopoiesis.2008
- Author(s)
  Kono T, Mukai H, Kozuma Y, Kojima H, Ninomiya H.
- Organizer
  50th annual meeting of the American Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19591094
[Presentation] 巨核球造血におけるcaspase活性化の役2008
- Author(s)
  上妻行則,河野智子,二宮治彦,小島寛
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19591094
[Presentation] Role of the proapoptotic BH3-only protein Bim in megakaryopoiesis and platelet production.2007
- Author(s)
  Kozuma Y, Kojima H, et. al.
- Organizer
  21st Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Geneva, Switzerland
- Year and Date
  2007-07-08
- Data Source
  KAKENHI-PROJECT-19591094

1. NAKAUCHI Hiromitsu (40175485)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OKOSHI Yasushi (10400673)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 阿部帥 (80014215)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Tamaki Yoshio (60188422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 渋谷彰 (80216027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 二宮治彦 (10198533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 長澤俊郎 (70014298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鈴川和己 (50334066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 金子新 (40361331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 島居徹 (80235613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 沖明典 (60334067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 鈴木久史 (40750740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 水本斉志 (20512388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. INADA Katsushige

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Kojima Hiroshi 小島 寛

KOJIMA Hiroshi 小島 寛

小島 寛 コジマ ヒロシ

Research Projects

Research Products

Co-Researchers

A study of the diversity of radiosensitivity in chemoresistant malignant lymphomas

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of the cancer screening method analyzing the exhaled breath through the membrane-type surface stress sensor (MSS)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Global analysis of cancer-tissue-derived microRNA to improve treatment outcome of cancer of unknown primary

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analyses of biomarkers predicting therapeutic effect of an anti-angiogenetic agent against advanced colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

大腸癌血管新生阻害薬の効果予測を可能にするバイオマーカーの網羅的探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アポトーシス関連遺伝子改変マウスを用いた巨核球成熟、血小板産生機構の系統的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive Analyses of Intracellular Signaling Mechanism Underlying Thrombopoietin-independent MegakaryopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Thrombopoietin(TPO)による血小板活性化機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウス骨髄前駆細胞からのNK細胞の分化の調節機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

好酸球顆粒Major Basic Proteinの産生・分泌機構に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

GENERATION OF NK CELLS FROM CD34+ HEMATOPOIETIC STEM CELLS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NK細胞の分化・成熟に及ぼす血管内皮細胞の影響

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 図説 血栓・止血。血管学(一瀬白帝編、分担執筆)2005

Author(s)

Kojima Hiroshi 小島寛

KOJIMA Hiroshi 小島寛

小島寛コジマヒロシ

[Book] 図説血栓・止血。血管学(一瀬白帝編、分担執筆)2005