AZUMA Hiroyuki 東博之

Researcher Number	10241275
Other IDs
Affiliation (based on the past Project Information) *help	2006: The University of Tokushima, Institute of Health Biosciences, Associated professor, 大学院ヘルスバイオサイエンス研究部, 助教授 2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教授 1999 – 2003: 徳島大学, 医学部, 助教授 1998: 徳島大学, 医学部, 講師 1998: University of Tokushima, University Hospital, Assistant Professor, 医学部附属病院, 講師 1993 – 1997: 徳島大学, 医学部・附属病院, 助手 1992 – 1993: 徳島大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Hematology / Circulatory organs internal medicine / 内分泌・代謝学 / Circulatory organs internal medicine Except Principal Investigator Hematology / Neurology / Circulatory organs internal medicine / Circulatory organs internal medicine / Metabolomics
Keywords	Principal Investigator 動脈硬化 / トロンビン / vascular smooth muscle cell / thrombin / atherosclerosis / heparin cofactor II / ノックアウトマウス / ヘパリンコファクターII / Smad / HHT … More / Sandwich assay / Growth hormone-releasing hormone / 高脂血症 / アポリポプロテイン(a) / リポプロテイン(a) / thrombin receptor / vascular remodeling / knockout mice / coronary intervention / PAR / PCI / トロンビン受容体 / 血管平滑筋細胞 / 血管リモデリング / 冠動脈インターベンション / knockout mouse / dermatan sulfate / デルマタン硫酸 / 血管平滑筋 / トロンピン / Endoglin / TGF-beta / 毛細血管 / 遺伝性出血性毛細血管拡張症 / HGF-β / エンドグリン / TGF-β / Biotin / Streptavidin / Urtrasensitive / Enzyme immunoassay / Somatostain / Growth hormone-releasing hormoe / ビオチン / アビジン / 超高感度 / 酵素免疫測定法 / Somatostatin / ATRA / IL-6 / 転写活性 / ニコチン酸 / ルシフェラーゼ / 転写 / 心筋梗塞 / 下肢静脈血栓症 / DIC / 合成ペプチド / ラジオイムノアッセイ / トロンビンレセプター … More Except Principal Investigator KLF2 / ERK5 / BMK1 / reactive oxygen species / 活性酸素 / ミトコンドリア障害 / aspirin / atherosclerosis / 血管内皮細胞 / アスピリン / 動脈硬化 / 遺伝子異常 / 先天性血栓性素因 / 先天性ヒスチジンリッチグリコプロテイン欠乏症 / pleiotropic effect / nitric oxide synthase / inflammation / statin / vascular endothelial function / VCAM-1 / PPARγ / 多面的作用 / 一酸化窒素合成酵素 / 炎症 / スタチン / 血管内皮機能 / apoptosis / mitochondrial dysfunction / superoxide dismutase / 筋細胞 / 神経細胞 / グルココルチコイド受容体 / グルココルチコイド / アポトーシス / スーパーオキサイドジスムターゼ / 活性酸素種 / repiratory chain / mitochondria / thrombin / vascular endothelial cells / 電子伝達系 / ミトコンドリア / トロンビン / Reactive oxigen species / Mitochondrial encephalomyopathy / Corticosteroid myopathy / Mitochondrial damage / ミトコンドリア脳筋症 / ステロイド筋症 / endothelial cell / hepatocyte / transcriptional factor / apolipoprotein (a) / lipoprotein (a) / 転写活性 / IL-6 / 血管内及細胞 / 肝細胞 / 転写因子 / アポ蛋白(a) / リポ蛋白(a) / 血栓症 / ヒスチジンリッチグリコプロテイン / 病態生理 / 発症機構 / 先天性プラスミノゲン欠乏症 / プラスミノゲン Less

Research Projects
(15 results)
Co-Researchers
(12 People)

Novel regulatory mechanism of vascular endothelial function mediated by BMK1/ERK5 and its application for anti-atherosclerosis therapy
- Principal Investigator
  
  AKAIKE Masashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokushima
Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor IIPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokushima
Mitochondrial dysfunction mediated by the activation of glucocorticoid receptor
- Principal Investigator
  
  TAKAO Mitsuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Mitochondrial damage mediated by reactive oxygen species : A study in corticosteroid myopathy and mitochondrial encephalomyopathies
- Principal Investigator
  
  MITSUI Takao
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Thrombin-induoed vascular injury through the overproduction of reactive oxygen species
- Principal Investigator
  
  AKAIKE Masashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokushima
Role and clinical significance of heparin cofactor II as an anti-atherosclerotic factorPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  University of Tokushima
Development of novel agents using the method of modulating the transcriptional activity of apo (a) gene
- Principal Investigator
  
  MATSUMOTO Toshio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  University of Tokushima
先天性ヒスチジンリッチグリコプロテイン欠乏症の病態生理，遺伝子異常および発症機構
- Principal Investigator
  
  重清俊雄
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Elucidation of genetic abnormality and molecular pathogenesis of hereditary hemorrhagic telangiectasiaPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tokushima
血栓症の危険因子である高Lp(a)血症の治療薬のスクリーニングと作用機序の解明Principal Investigator
- Principal Investigator
  
  東博之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
先天性プラスミノゲン欠乏症の遺伝子異常、発症機構および病態生理に関する研究
- Principal Investigator
  
  重清俊雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
高リポ蛋白(a)血症に対する治療薬の作用機序の解明と新しい治療薬のスクリーニングPrincipal Investigator
- Principal Investigator
  
  東博之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokushima
世界初の先天性ヒスチジンリッチグリコプロテイン欠乏症の遺伝子異常と病態生理
- Principal Investigator
  
  重清俊雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
トロンビンレセプター活性化放出ペプチドのラジオイムノアッセイの開発と臨床応用Principal Investigator
- Principal Investigator
  
  東博之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokushima
Development of urtrasensitive noncompetitive enzyme immunoassay for hypothalamic hormone and it's clinical applicationPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokushima

1. AKAIKE Masashi (90271080)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. MITSUI Takao (80294726)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. 重清俊雄 (50162582)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. SHUNTANI Yasumi (10235773)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MATSUMOTO Toshio (20157374)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. AIHARA Ken-ichi (70372711)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NISHIDA Toshinobu (50156080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOKOGOSAHI Yutaka (00253203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MIZUSHIMA Jyun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 白川光雄

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金川泰彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 池田康将

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AZUMA Hiroyuki 東 博之

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Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor IIPrincipal Investigator

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Role and clinical significance of heparin cofactor II as an anti-atherosclerotic factorPrincipal Investigator

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Elucidation of genetic abnormality and molecular pathogenesis of hereditary hemorrhagic telangiectasiaPrincipal Investigator

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血栓症の危険因子である高Lp(a)血症の治療薬のスクリーニングと作用機序の解明Principal Investigator

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高リポ蛋白(a)血症に対する治療薬の作用機序の解明と新しい治療薬のスクリーニングPrincipal Investigator

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トロンビンレセプター活性化放出ペプチドのラジオイムノアッセイの開発と臨床応用Principal Investigator

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Project Period (FY)

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Development of urtrasensitive noncompetitive enzyme immunoassay for hypothalamic hormone and it's clinical applicationPrincipal Investigator

Principal Investigator

AZUMA Hiroyuki 東博之