TSUJIUCHI Toshifumi 辻内俊文

Researcher Number	10254492
Other IDs
Affiliation *help	2011 – 2018 : 近畿大学, 理工学部, 教授 2008 – 2010 : 近畿大学, 理工学部, 准教授 2010 : 近畿大学, 理工学部・生命科学科, 教授 1994 – 1999 : 奈良県立医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Experimental pathology Except Principal Investigator Orthopaedic surgery / Biological pharmacy / Experimental pathology
Keywords	Principal Investigator リゾフォスファチジン酸 / 抗がん剤抵抗性 / LPA受容体 / 血管新生 / 浸潤・転移 / がん細胞 / がん培養細胞 / がん転移 / 抗がん剤耐性 / LPA … More Except Principal Investigator osteosarcoma / hepatocarcinogenesis / aspirin / リゾホスファチジン酸 / cirrhosis / arachidonic acid cascade / 分岐 / 発癌物質 / chemoprevention / 化学発癌 / 8-hydroxydeoxyguanosine / metastasis / mitochondria metabolism / 変異体 / PI3k/Akt/mTOR / c-myc inhibitor / ハムスター / carcinogen / 神経分岐 / sarcoma / 化学予防 / G蛋白質 / Pterostilbene / phytechemicals / nordihydroguaiaretic acid / ヘテロサイクリックアミン / 受容体 / がん細胞 / Osteosarcoma / mesenchymal stem cell / Colon cancer / Rnd2 / がん / hepatocyte injury / NF-kB / DNA repair / piroxicam / gene expression / creatinine kinase / hamster / リゾホスファジン酸 / glycolysis / choline deficinet diet / 神経軸索 / JAK/STAT / choline deficient diet / 卵巣がん細胞 / INK4a / LPA3 / heterocyclicamine / sarcosphere / drug resistance / 膵癌 / c-myc / stem cell niche / テロメラーゼ / Cancer stem cells / pancreatic carcinoma / 神経ネットワーク / cancer stem cell / 遺伝子異常 / honokiol / pterostilbene / glucose metabolism / 脂肪酸 Less

Roles of LPA receptors in the acquisition of malignant properties in cancer cells treated with anticancer drugsPrincipal InvestigatorOngoing
- Principal Investigator
  
  辻内俊文
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kinki University
Translational applications of broad spectrum natural compounds and phytochemicals or their derivatives to the novel treatment strategy against sarcomasOngoing
- Principal Investigator
  
  朴木寛弥
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nara Medical University
Abnormal LPA receptor signaling in cancer
- Principal Investigator
  
  FUKUSHIMA Nobuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kinki University
Functional analysis of LPA receptors in the acquisition of malignant properties in cancer cells.Principal Investigator
- Principal Investigator
  
  TSUJIUCHI Toshifumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kinki University
Molecular mechanisms for LPA_3-mediated neurite branch formation
- Principal Investigator
  
  FUKUSHIMA Nobuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kinki University
Isolation of cancer stem cells in bone and soft tissue tumors and novel molecular and cellular targeting therapy
- Principal Investigator
  
  HONOKI Kanya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nara Medical University
Basic Research on the Development and Progression of Pancreatic Duct Adenocarcinoma
- Principal Investigator
  
  KONISHI Yoichi
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nara Medical University
抗脂肪肝因子欠乏食によるラット肝発癌機構へのアラキドン酸カスケードの関与機構解析
- Principal Investigator
  
  傳田阿由美
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Medical University
抗脂肪肝因子欠乏食によるラット肝発癌機構へのアラキドン酸カスケードの関与機構解析
- Principal Investigator
  
  DENDA Ayumi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Medical University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Cancer Stem Cell Niche : The Role of Mesenchymal Stem Cells in Tumor Microenvironment. In : Cancer Stem Cells (ISBN 978-953-307-1454-5)2011
- Author(s)
  Honoki K, Fujii H, Tsujiuchi T.
- Publisher
  INTECH d.o.o., Rijeka, Croatia, in press
- Data Source
  KAKENHI-PROJECT-20591765
[Journal Article] Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells2018
- Author(s)
  Fukushima K, Takahashi K, Kurokawa A, Ishimoto K, Otagaki S, Minami K, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 496 Pages : 225-230
- DOI
  10.1016/j.bbrc.2018.01.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs2018
- Author(s)
  Takahashi K, Fukushima K, Otagaki S, Ishimoto K, Minami K, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  J Recept Signal Transduct Res.
  
  Volume : 38 Pages : 71-75
- DOI
  10.1080/10799893.2018.1426608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells.2017
- Author(s)
  Fukushima K, Takahashi K, Yamasaki E, Onishi Y, Fukushima N, Honoki K, Tsujiuchi T
- Journal Title
  
  Exp Cell Res
  
  Volume : 352 Pages : 139-145
- DOI
  10.1016/j.yexcr.2017.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells2017
- Author(s)
  Takahashi K, Fukushima K, Fukushima N, Honoki K, Tsujiuchi T
- Journal Title
  
  Mol Cell Biochem
  
  Volume : 431 Pages : 29-35
- DOI
  10.1007/s11010-017-2971-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells.2017
- Author(s)
  Takahashi K, Fukushima K, Onishi Y, Inui K, Node Y, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 483 Pages : 652-657
- DOI
  10.1016/j.bbrc.2016.12.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells.2017
- Author(s)
  Takahashi K, Fukushima K, Onishi Y, Node Y, Inui K, Fukushima N, Honoki K, Tsujiuchi T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 484 Pages : 675-680
- DOI
  10.1016/j.bbrc.2017.01.175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Crossroads of Hallmarks in Aging and Cancer: Anti-aging and anti-cancer target pathways can be shared?2016
- Author(s)
  Honoki K, Fujii H, Tsukamoto S, Kishi S, Tsujiuchi T, Tanaka Y.
- Journal Title
  
  Trends in Cancer Research
  
  Volume : 11 Pages : 39-59
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells.2016
- Author(s)
  Ishii S, Kitamura Y, Hirane M, Tomimatsu A, Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Mol Carcinog
  
  Volume : 55 Pages : 1553-1559
- DOI
  10.1002/mc.22408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.2016
- Author(s)
  Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 475 Pages : 25-30
- DOI
  10.1016/j.bbrc.2016.05.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10455
[Journal Article] Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells.2015
- Author(s)
  Ishii S, Hirane M, Kitamura Y, Mori S, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Mol Cell Biochem.
  
  Volume : 400 Pages : 145-151
- DOI
  10.1007/s11010-014-2270-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells.2015
- Author(s)
  Ishii S, Hirane M, Kato S, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 456 Pages : 135-138
- DOI
  10.1016/j.bbrc.2014.11.047
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Functional lysophosphatidic acid receptors expressed in Oryzias latipes.2014
- Author(s)
  Morimoto Y, Ishii S, Ishibashi J, Katoh K. Tsujiuchi T, Kagawa N, Fukushima N.
- Journal Title
  
  Gene
  
  Volume : 551 Pages : 189-200
- DOI
  10.1016/j.gene.2014.08.056
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590493, KAKENHI-PUBLICLY-25116721
[Journal Article] Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines.2014
- Author(s)
  Dong Y, Hirane M, Araki M, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Mol Cell Biochem.
  
  Volume : 393 Pages : 17-22
- DOI
  10.1007/s11010-014-2042-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells.2014
- Author(s)
  Araki M, Kitayoshi M, Dong Y, Hirane M, Ozaki S, Mori S, Fukushima N, Honoki K, Tsujiuchi T.
- Journal Title
  
  Growth Factors
  
  Volume : 32 Pages : 117-122
- DOI
  10.3109/08977194.2014.911294
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Multi-step lung carcinogenesis model induced by oral administration of N-nitrosobis(2-hydroxypropyl)amine in rats.2014
- Author(s)
  Tsujiuchi T, Nakae D, Konishi Y.
- Journal Title
  
  Exp Toxicol Pathol
  
  Volume : 66 Pages : 81-88
- DOI
  10.1016/j.etp.2013.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Lysophosphatidic acid receptors in cancer pathobiology.2014
- Author(s)
  Tsujiuchi T, Araki M, Hirane M, Dong Y, Fukushima N.
- Journal Title
  
  Histol Histopathol
  
  Volume : 29 Pages : 313-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells.2014
- Author(s)
  Dong Y, Hirane M, Araki M, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 446 Pages : 585-589
- DOI
  10.1016/j.bbrc.2014.03.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Diverse effects of LPA receptors on cell motile activities of cancer cells.2014
- Author(s)
  Tsujiuchi, T., Hirane, M., Dong, Y. and Fukushima N.
- Journal Title
  
  J Recept Signal Transduct Res.
  
  Volume : 34 Pages : 149-153
- DOI
  10.3109/10799893.2013.876042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590129
[Journal Article] Lysophosphatidic acid receptors in cancer pathobiology.2014
- Author(s)
  Tsujiuchi T, Araki M, Hirane M, Dong Y, Fukushima N.
- Journal Title
  
  Histol Histopathol.
  
  Volume : 29 Pages : 313-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590129
[Journal Article] Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis.2014
- Author(s)
  Tanaka J, Yamaguchi K, Ishikura H, Tsubota M, Sekiguchi F, Seki Y, Tsujiuchi T, Murai A, Uemura T, Kawabata A.
- Journal Title
  
  Neuropharmacology
  
  Volume : 79 Pages : 112-118
- DOI
  10.1016/j.neuropharm.2013.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Inhibitory effects of LPA1 on cell motile activities stimulated by hydrogen peroxide and 2,3-dimethoxy-1,4-naphthoquinone in fibroblast 3T3 cells.2013
- Author(s)
  Hirane M, Araki M, Dong Y, Honoki K, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 441 Pages : 47-52
- DOI
  10.1016/j.bbrc.2013.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Extracellular lipid metabolism influences the survival of ovarian cancer cells.2013
- Author(s)
  Kuwata S, Ohkubo K, Kumamoto S, Yamaguchi N, Izuka N, Murota K, Tsujiuchi T,
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 439 Pages : 280-284
- DOI
  10.1016/j.bbrc.2013.08.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592465, KAKENHI-PROJECT-24570141, KAKENHI-PROJECT-24590129, KAKENHI-PROJECT-24590493
[Journal Article] Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cacner cells.2013
- Author(s)
  Yoshikawa K, Tanabe E, Shibata A, Inoue S, Kitayoshi M, Okimoto S, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Exp. Cell Res.
  
  Volume : 319 Pages : 105-112
- DOI
  10.1016/j.yexcr.2012.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of prosenescence therapy in sarcomas.2013
- Author(s)
  Honoki K, Tsujiuchi T.
- Journal Title
  
  Expert Rev Anticancer Ther
  
  Volume : 13 Pages : 983-996
- DOI
  10.1586/14737140.2013.820010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Negative regulation of cell motile and invasive activities by lysophosphatidic acid receptor-3 in colon cancer HCT116 cells.2012
- Author(s)
  Fukui R, Tanabe E, Kitayoshi M, Yoshikawa K, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Tumor Biol.
  
  Volume : 33 Pages : 1899-1905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Opposite roles of LPA1 and LPA3 on cell mitile and invasive activities of pancreatic cancer cells.2012
- Author(s)
  Kato K, Yoshikawa K, Tanabe E, Kitayoshi M, Fukui R, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Tumor Biol.
  
  Volume : 33 Pages : 1739-1744
- DOI
  10.1007/s13277-012-0433-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Differential function of lysophosphatidic acid receptors in cell proliferation and migration of neuroblastoma cells2012
- Author(s)
  Hayashi, M., Okabe, K., Kato, K., Okumura, M., Fukui, R., Fukushima, N. and Tsujiuchi, T
- Journal Title
  
  Cancer Lett
  
  Volume : 316 Pages : 91-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590109
[Journal Article] Lysophosphatidic acid induces neurite branch formation through LPA_32012
- Author(s)
  Furuta, D., Yamane, M., Tsujiuchi, T., Moriyama, R. and Fukushima, N
- Journal Title
  
  Mol. Cell. Neurosci
  
  Volume : 50 Pages : 21-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590109
[Journal Article] Loss of lusophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells2012
- Author(s)
  Tanabe E, Kitayoshi M, Yoshikawa K, Shibata A, Honoki K, Fukushima N, Tsujiuchi T.
- Journal Title
  
  J. Recept. Signal Transduct. Res.
  
  Volume : 32 Pages : 328-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Regulation of ceoo motile activity through the different induction of LPA receptors by estrogens in liver epithelial WB-F344 cells.2012
- Author(s)
  Tanabe E, Shibata A, Inoue S, KItayoshi M, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 428 Pages : 105-109
- DOI
  10.1016/j.bbrc.2012.10.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Enhancement of endothelial cell migration by constitutively active LPA1-expressing tumor cells.2012
- Author(s)
  Kitayoshi M, Kato, K, Tanabe E, Yoshikawa K, Fukui R, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 422 Pages : 339-343
- DOI
  10.1016/j.bbrc.2012.05.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590493
[Journal Article] Coordinated interactions between actin and microtubules through crosslinkers in neurite retraction induced by lysophosphatidic acid2011
- Author(s)
  Fukushima, N., Furuta, D. and Tsujiuchi T
- Journal Title
  
  Neurochem. Intl
  
  Volume : 59 Pages : 109-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590109
[Journal Article] Induction of lysophosphatidic acid receptor-3 by 12-Otetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells2011
- Author(s)
  Okabe, K., Kato, K., Teranishi, M., Okumura, M., Fukui, R., Mori, T., Fukushima, N. and Tsujiuchi, T
- Journal Title
  
  Cancer Lett
  
  Volume : 309 Pages : 236-242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590109
[Journal Article] Genetic and epigenetic alterations of lysophosphatidic acid receptor genes in rodent tumors by experimental models2011
- Author(s)
  Tsujiuchi, T., et al
- Journal Title
  
  J.Toxicol.Pathol.
  
  Volume : 24 Pages : 143-148
- DOI
  10.1293/tox.24.143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590109
[Journal Article] Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance.2010
- Author(s)
  Honoki K, Fujii H, Kubo A, Kido A, Mori T, Tanaka Y, Tsujiuchi T.
- Journal Title
  
  Oncol.Rep 24
  
  Pages : 501-505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591765
[Journal Article] Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells.2010
- Author(s)
  Okabe K, Hayashi M, Fujii M, Honoki K, Mori T, Fukushima N, Tsujiuchi T.
- Journal Title
  
  Pathobiology 77(5)
  
  Pages : 278-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591765
[Journal Article] Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines.2009
- Author(s)
  Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y.
- Journal Title
  
  Int J Oncol 34
  
  Pages : 1381-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591765
[Journal Article] Growth inhibition and induction of apoptosis by 3-Methoxyestradiol in rat osteosarcoma and makignant fibrous histiocytoma cell lines.2008
- Author(s)
  Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y.
- Journal Title
  
  In vivo 22
  
  Pages : 21-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591765
[Journal Article] Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells
- Author(s)
  Okabe, K., Hayashi, M., Kato, K., Okumura, M., Fukui, R., Honoki, K., Fukushima, N. and Tsujiuchi, T
- Journal Title
  
  Mol. Carcinog
  
  Volume : (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590109
[Presentation] Pterostilbene (3',5'-dimethoxyresveratrol) inhibits cell growth and augments the efficacy of doxorubicin through stem cell phenotype suppression in osteosarcoma cells in vitro2017
- Author(s)
  Kishi S, Honoki K, Tsujiuchi T, Kuniyasu H, et al.
- Organizer
  AACR Special Conference on Advances in Sarcomas: From Basic Science to Clinical Translation
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2017-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10455
[Presentation] Possible involvement of senescence bypass in mesenchymal stem cells for sarcomagenesis identified through a comparative gene expression profiling in rat sarcoma model2015
- Author(s)
  Honoki K, Fujii H, Kido A, Tsukamoto S, Mori T, Tanaka Y, Tsujiuchi T
- Organizer
  AACR annual meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10455
[Presentation] 脂肪酸による卵巣がん細胞HNOAの細胞死抑制機構2013
- Author(s)
  福嶋伸之、辻内俊文、岩森正男
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-24590129
[Presentation] Receptor type-specific role of lysophosphatidic acid signaling for migration and invasion in sarcoma cells.2013
- Author(s)
  Honoki K, Fujii H, Kido A, Tsukamoto S, Mori T, Tanaka Y, Tsujiuchi T.
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  パシフィコ横浜　(神奈川県)
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] 脂肪酸による卵巣がん細胞HNOAの細胞死抑制機構2013
- Author(s)
  福嶋伸之、辻内俊文、岩森正男
- Organizer
  第８６回日本生化学大会
- Place of Presentation
  パシフィコ横浜　(神奈川県)
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] LPA1の変異は小胞体への蓄積と情報伝達の異常を生じる2013
- Author(s)
  石井章一、辻内俊文、福嶋伸之
- Organizer
  第８６回日本生化学大会
- Place of Presentation
  パシフィコ横浜　(神奈川県)
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] LPA1の変異は小胞体への蓄積と情報伝達の異常を生じる2013
- Author(s)
  石井章一、辻内俊文、福嶋伸之
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-24590129
[Presentation] リゾフォスファチジン酸受容体阻害はヒト肉腫細胞の運動・浸潤能を抑制する2012
- Author(s)
  朴木寛弥、藤井宏真、城戸顕、塚本真治、辻内俊文
- Organizer
  第７１回日本癌学会総会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] ラットがん組織から見出されたLPA1変異体の機能解析2012
- Author(s)
  石井章一、辻内俊文、福嶋伸之
- Organizer
  第８５回日本生化学大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] 卵巣がん細胞の生存および増殖に対する種々の脂肪酸の作用2012
- Author(s)
  福嶋伸之、大久保慶、桑田聖平、辻内俊文、岩森正男
- Organizer
  第８５回日本生化学大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] ラットがん組織から見出されたLPA1変異体の機能解析2012
- Author(s)
  石井章一, 辻内俊文, 福嶋伸之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24590129
[Presentation] Possible involvement of stem-like population with elevated ALDH1 and DNA repair enzymes for drug resistance in human sarcoma.2010
- Author(s)
  Honoki K, Fujii H, Kido A, Tsukamoto S, Tanaka Y, Tsujiuchi T
- Organizer
  56^<th> Annual Meeting of Orthopedic Research Society
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] 間葉系幹細胞はラット肉腫モデルにおいて腫瘍細胞の早期正着および転移巣形成を促進する2010
- Author(s)
  朴木寛弥、藤井宏真、藤間保晶、森俊夫、城戸顕、辻内俊文
- Organizer
  第69回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] Human sarcoma cell lines contain drug-resistant shere forming stem-like cell populations with elevated aldehyde dehydrogenase 12009
- Author(s)
  Honoki K, Fujii H, Kubo A, Kido A, Yoshitani K, Mori T, Tsujiuchi T
- Organizer
  100^<th> Annual Meeting of American Association for Cancer Research
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] ヒト肉腫幹細胞様細胞はアルデヒドデヒドロゲナーゼ1およびDNA修復酵素を高発現し強い薬剤抵抗性を示す2009
- Author(s)
  朴木寛弥, 藤井宏真, 久保篤史、城戸顕, 森俊夫、辻内俊文
- Organizer
  第68回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] Stem-like sphere forming cell populations in sarcomas. Implications in chemo-resistance and possible therapeutic targets.2008
- Author(s)
  朴木寛弥, 藤井宏真, 高倉義典, 辻内俊文
- Organizer
  8^<th> International Conference of Anticancer Research
- Place of Presentation
  Kos, Greece
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] Human fibrosarcoma cell line HT1080lacking INK4a-ARF locus gene expression contains shere forming stem-like cells.2008
- Author(s)
  Honoki K, Fujii H, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y
- Organizer
  99^<th> Annual Meeting of American Association for Cancer Research
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] ユーイング肉腫細胞株HTB166における化学療法抵抗性幹細胞様細胞の単離2008
- Author(s)
  朴木寛弥, 藤井宏真, 城戸顕, 辻内俊文
- Organizer
  第67回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-20591765
[Presentation] 多価不飽和脂肪酸は活性酸素産生とMAPキナーゼ経路活性化を介して卵巣がん細胞死を引き起こす
- Author(s)
  福嶋伸之、田中亞以子、辻内俊文、岩森正男
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] ダカＬＰＡ受容体遺伝子の発現と機能
- Author(s)
  石井章一、森本祐司、石橋潤一、辻内俊文、加川尚、福嶋伸之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] メダカリゾホスファチジン酸受容体の発現と機能
- Author(s)
  福嶋伸之、石井章一、森本祐司、石橋潤一、辻内俊文、加川尚
- Organizer
  第37回日本神経科学大会　Neuro2014
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] メダカLPA受容体遺伝子の発現と機能
- Author(s)
  石井章一、辻内俊文、加川尚、福嶋伸之
- Organizer
  生体機能と創薬シンポジウム2014
- Place of Presentation
  近畿大学（大阪府）
- Year and Date
  2014-08-28 – 2014-08-29
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] 化学発がん物質により誘発されるラット肝細胞運動能へのＬＰＡシグナル伝達経路の関与
- Author(s)
  平根未来、董燕、朴木寛弥、辻内俊文
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24590493
[Presentation] 多価不飽和脂肪酸は活性酸素産生とMAPキナーゼ経路活性化を介して卵巣がん細胞死を引き起こす
- Author(s)
  福嶋伸之、田中亞以子、辻内俊文、岩森正男
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府、京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590129

1. HONOKI Kanya (40336863)

# of Collaborated Projects : 4results

# of Collaborated Products : 32results
2. DENDA Ayumi (90110858)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
3. FUKUSHIMA Nobuyuki (10254161)

# of Collaborated Projects : 3results

# of Collaborated Products : 34results
4. TOHMA Yasuaki (60448777)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
5. TANAKA Yasuhito (30316070)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
6. MORIYAMA Ryutaro (30411573)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
7. KONISHI Yoichi (00075061)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. TSUTSUMI Masahiro (00207416)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. NAKAE Dai (90207712)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 藤井宏真 (00625791)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 岩森正男

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

TSUJIUCHI Toshifumi 辻内 俊文

Research Projects

Research Products

Co-Researchers

Roles of LPA receptors in the acquisition of malignant properties in cancer cells treated with anticancer drugsPrincipal InvestigatorOngoing

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Translational applications of broad spectrum natural compounds and phytochemicals or their derivatives to the novel treatment strategy against sarcomasOngoing

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Abnormal LPA receptor signaling in cancer

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Functional analysis of LPA receptors in the acquisition of malignant properties in cancer cells.Principal Investigator

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Molecular mechanisms for LPA_3-mediated neurite branch formation

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Isolation of cancer stem cells in bone and soft tissue tumors and novel molecular and cellular targeting therapy

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Basic Research on the Development and Progression of Pancreatic Duct Adenocarcinoma

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抗脂肪肝因子欠乏食によるラット肝発癌機構へのアラキドン酸カスケードの関与機構解析

Principal Investigator

Project Period (FY)

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抗脂肪肝因子欠乏食によるラット肝発癌機構へのアラキドン酸カスケードの関与機構解析

Principal Investigator

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[Book] Cancer Stem Cell Niche : The Role of Mesenchymal Stem Cells in Tumor Microenvironment. In : Cancer Stem Cells (ISBN 978-953-307-1454-5)2011

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[Journal Article] Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells2018

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[Journal Article] Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs2018

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[Journal Article] Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells.2017

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[Journal Article] Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells2017

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TSUJIUCHI Toshifumi 辻内俊文