Hara Isao 原勲

… Alternative Names

HARA Isao 原勲

Less

Researcher Number	10263378
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 和歌山県立医科大学, 医学部, 教授 2007 – 2018: Wakayama Medical University, 医学部, 教授 2006: 神戸大学, 医学研究科, 助教授 2006: Kobe University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 2003 – 2005: 神戸大学, 大学院・医学系研究科, 助教授 … More 2002: 神戸大学, 医学部附属病院, 講師 2002: Kobe University Graduate School of Medicine Lecturer, 大学院・医学系研究科, 講師 2001: 神戸大学, 大学院・医学系研究科, 助手 1995 – 2000: 神戸大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Urology / Urology / Basic Section 56030:Urology-related Except Principal Investigator Urology / Urology
Keywords	Principal Investigator 腫瘍免疫 / 腎細胞癌 / 癌幹細胞 / CD44 / IL-18 / 遺伝子治療 / 遺伝子導入 / 制御性B細胞 / 乳酸 / 腫瘍浸潤リンパ球 … More / 腫瘍内浸潤マクロファージ / iPS細胞 / 腫瘍免疫学 / 樹状細胞 / adhesion molecule / bladder cancer / 浸潤能 / 接着分子 / 接着因子 / 膀胱癌 / renal cell carcinoma / Immune gene therapy / 泌尿器科悪性腫瘍 / 免疫寛容 / 泌尿器悪性腫瘍 / 卵巣癌 / 免疫学 / 癌 / 遺伝子 / IL6 / ホルモン依存性 / 前立腺癌 / マウス / Interleukin12 / 免疫療法 / heat shock protein / BCG … More Except Principal Investigator CD44 / 遺伝子治療 / CT / 再発予防 / 尿路結石 / Clinical Application / Gene Therapy / Adenovirus / Thymidine Kinase(TK) / promoter / tissue specific / Prostate Specific Antigen(PSA) / Prostate cancer / 癌抑制遺伝子 / P53 / ホルモン不応 / ベクター / PSA / 臨床応用 / アデノウイルス / TK / プロモーター / 臓器特異性 / 前立腺特異抗原(PSA) / 前立腺癌 / COMPETITIVE RT-PCR / URINE / UROLOGIC CANCER / CD44遺伝子 / 泌尿器科癌 / Competitive RT-PCR / competitive RT-PCR / 尿 / 泌尿器癌 / direct instillation / trans-uretheral / mouse urinary bladder / in vivo gene transfer / 膀胱内注入 / invivo DNA導入 / ラット膀胱 / マウス膀胱 / 膀胱注入 / in vivo遺伝子導入 / 国際情報交換 / 多施設共同研究 / 化学療法 / バイオマーカー / 膀胱癌 / 尿路上皮癌」 Less

高乳酸環境を標的とした新規腫瘍免疫療法の開発Principal Investigator
- Principal Investigator
  
  原勲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Wakayama Medical University
Development of novel treatment for renal cell carcinoma targeting tumor associated macrophagePrincipal Investigator
- Principal Investigator
  
  Hara Isao
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Wakayama Medical University
Immunotherapy using dendritic cell targeting cancer stem cellPrincipal Investigator
- Principal Investigator
  
  Hara Isao
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Wakayama Medical University
Development of predictive tool for urinary stone recurrence using renal papillary CT value
- Principal Investigator
  
  Kohjimoto Yasuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Wakayama Medical University
Establishment of the biomarker in urothelial cancer patients treated with systemic combination chemotherapy.
- Principal Investigator
  
  MATSUMURA Nagahide
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Wakayama Medical University
Development of novel immunotherapy targeting immunosuppressant IDO in urinary tract cancerPrincipal Investigator
- Principal Investigator
  
  HARA Isao
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Wakayama Medical University
Biological change of androgen dependent prostate cancer cell line by interleukin 6 gene transductionPrincipal Investigator
- Principal Investigator
  
  HARA Isao
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Wakayama Medical University
How does CD44v8-10 isoform effect the invasion and metastatic ability of bladder cancer cell?Principal Investigator
- Principal Investigator
  
  HARA Isao
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kobe University
Secreted type of modified interleukin-18 gene transduced into mouse renal cell carcinoma cells induces systemic tumor immunityPrincipal Investigator
- Principal Investigator
  
  HARA Isao
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kobe University Graduate School of Medicine
Basic Research into Clinical Application of Gene Therapy for Prostate Cancer
- Principal Investigator
  
  GOTOH Akinobu
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kobe University School of Medicine
IL12遺伝子導入による癌免疫療法の基礎的研究Principal Investigator
- Principal Investigator
  
  原勲
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Urology
- Research Institution
  Kobe University
BCG65kDa蛋白抗原の遺伝子導入による癌免疫療法Principal Investigator
- Principal Investigator
  
  原勲
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Urology
- Research Institution
  Kobe University
IN VIVO GENE TRANSFER ON RAT URINARY BLADDER EPITHELIAL CELL
- Principal Investigator
  
  KAMIDONO Sadao
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  KOBE UNIVERSITY SCHOOL OF MEDICINE
THE ANALYSIS OF CD44 ALTERNATIVE SPLICING PATTERN IN UROLOGIC CANCER
- Principal Investigator
  
  MATUI Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  KOBE UNIVERSITY

All 2018 2017 2004

All Journal Article

[Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018
- Author(s)
  Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 741-750
- DOI
  10.1111/cas.13501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17H01540
[Journal Article] Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB82017
- Author(s)
  Nishizawa S, Hirohashi Y, Kusumoto H, Wakamiya T, Iguchi T, Yamashita S, Iba A, Kikkawa K, Kohjimoto Y, Torigoe T, Hara I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 494 Issue: 3-4 Pages: 693-699
- DOI
  10.1016/j.bbrc.2017.10.146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17K16811, KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-17H01540
[Journal Article] Over expression of CD44v8-10 in human bladder cancer cells decreases their interaction with hyaluronic acid and potentiates their malignant progression.2004
- Author(s)
  Muramaki, Mototsugu Miyake, Hideaki Kamidono, Sadao Hara, Isao
- Journal Title
  
  Journal of Urology 171(1)
  
  Pages: 426-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591687

1. MATSUMURA Nagahide (30316103)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. INO Kazuhiko (60303640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KODAMA Yoshiki (90347584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKAMURA Yasushi (60275352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAMIDONO Sadao (30030935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ARAKAWA Soichi (70159490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MATUI Takashi (70252781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAYA Hideyuki (80264282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. GOTOH Akinobu (70283885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OKADA Hiroshi (00177057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGAI Hiroshi (80335447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Kohjimoto Yasuo (50295820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IBA Akinori (00423939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 江藤弘 (90213553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 郷司和男 (50195921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山上裕機 (20191190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 尾島敏康 (60448785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 若宮崇人 (50794400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 井上徳光 (80252708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 村岡聡 (90773945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HIROHASHI Yoshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Isao 原 勲

HARA Isao 原 勲

Research Projects

Research Products

Co-Researchers

高乳酸環境を標的とした新規腫瘍免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel treatment for renal cell carcinoma targeting tumor associated macrophagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immunotherapy using dendritic cell targeting cancer stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of predictive tool for urinary stone recurrence using renal papillary CT value

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the biomarker in urothelial cancer patients treated with systemic combination chemotherapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel immunotherapy targeting immunosuppressant IDO in urinary tract cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological change of androgen dependent prostate cancer cell line by interleukin 6 gene transductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

How does CD44v8-10 isoform effect the invasion and metastatic ability of bladder cancer cell?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Secreted type of modified interleukin-18 gene transduced into mouse renal cell carcinoma cells induces systemic tumor immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Research into Clinical Application of Gene Therapy for Prostate Cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL12遺伝子導入による癌免疫療法の基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BCG65kDa蛋白抗原の遺伝子導入による癌免疫療法Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IN VIVO GENE TRANSFER ON RAT URINARY BLADDER EPITHELIAL CELL

Principal Investigator

Project Period (FY)

Hara Isao 原勲

HARA Isao 原勲