Sada Kiyonao 定清直

… Alternative Names

SADA Kiyonao 定清直

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Researcher Number	10273765
Other IDs	https://orcid.org/0000-0001-6124-3100
External Links
Affiliation (Current)	2025: 福井大学, 学術研究院医学系部門, 教授
Affiliation (based on the past Project Information) *help	2025: 福井大学, 学術研究院医学系部門, 教授 2016 – 2023: 福井大学, 学術研究院医学系部門, 教授 2010 – 2015: 福井大学, 医学部, 教授 2006 – 2008: 福井大学, 医学部, 教授 2005: 神戸大学, 大学院医学系研究科, 助教授 … More 2004 – 2005: 神戸大学, 大学院・医学系研究科, 助教授 2001 – 2003: 神戸大学, 大学院・医学系研究科, 講師 1998: 神戸大, 医学部, 助手 1995 – 1998: Kobe University, School of Medicine Riserch Associate, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / Basic Section 49010:Pathological biochemistry-related / General medical chemistry / Functional biochemistry Except Principal Investigator Biological Sciences / Pathological medical chemistry / Pathological medical chemistry / Basic Section 52010:General internal medicine-related / Basic Section 48040:Medical biochemistry-related … More / Basic Section 49070:Immunology-related / Virology / General medical chemistry / General medical chemistry Less
Keywords	Principal Investigator チロシンキナーゼ / C型肝炎ウイルス / 3BP2 / ゲノム編集 / 感染宿主因子 / プロテオーム解析 / シグナル伝達 / Syk / アダプター蛋白質 / 蛋白質チロシンリン酸化反応 … More / 蛋白質チロシンリン酸化酵素 / 細胞骨格 / 血小板 / Abl / HCV / ウイルス / アダプタータンパク質 / proteome analysis / Svk / signal transduction / virus-host relationship / protein-tyrosine kinase / protein-tvrosine phosphorylation / hepatitis C virus / ウイルス-宿主間相互作用 / 糖尿病 / 分子病態学 / Cb1-b / I型糖尿病 / cherubism / Cbl-b / ユビキチンリガーゼ / スキャッフォールド蛋白質 / 細胞内情報伝達機構 / GTP結合蛋白質 / G蛋白質 / 蛋白質チロシン燐酸化酵素 … More Except Principal Investigator Syk / チロシンキナーゼ / Lyn / 3BP2 / protein-tyrosine kinase / C型肝炎ウイルス / Shc / 細胞骨格 / lysosomes / phagocytosis / ubiquitination / Cbl / Pak2 / ZAP-70 / CD45 / DT-40 cell / DT40細胞 / SH2 / 感染症 / 血小板 / 血管内皮細胞 / アルツハイマー病 / タウ / 免疫応答 / NF-κB / チロシンリン酸化 / ユビキチン化 / NF-kappa B / MALT1 / CARD9 / C型レクチン受容体 / 抗ウイルス応答 / 自然免疫 / ストレス応答 / ウイルス感染 / 二重鎖RNA / ウイルス-宿主相互作用 / インターフェロン / Japan / Indonesia / hepatocellular carcinoma / carcinogenic risk / mutant / sequence variation / hepatitis C virus / hepatitis B virus / 原発性肝癌 / 発癌リスク / 日本 / インドネシア / 原発性肝がん / 発がんリスク / 変異株 / 遺伝子多様性 / B型肝炎ウイルス / Signal transduction / Tyrosine kinase / Infection / Cancer / 食作用 / CXCR4 / 発がん抑制 / 白血病 / 発がん / 補体 / ファゴサイトーシス / 生体分子 / シグナル伝達 / がん / ユビチキン・プロテアソーム / 酸化ストレス / 細胞接着 / 非受容体型チロシンキナーゼ / 蛋白質チロシンリン酸化反応 / 蛋白質リン酸化反応 / CRAM / c-Cbl / Cbl-b / アダプター蛋白質 / non-hematopoietic cells / tyrosine phosphorylated / neurons / smooth muscle cells / vascular endothelial cells / Protein-tyrosine / 神経成長円錐 / 平滑筋細胞 / 血管 / チロシン燐酸化 / 血管平滑筋細胞 / 神経系 / 肝臓細胞 / oxidative stress / cortactin / Zap-70 / TPA / K562細胞 / ホスホリパーゼD / 活性酸素 / 過酸化水素 / チロシンホスファターゼ / コルタクチン / mast cell / FcgammaRIIIA / IgE receptor / B cell receptor / Protein-tyrosine kinase / トロンビン / B細胞受容体 / IgE受容体 / p72syk / PLCγ / PI3キナーゼ / GAP / RBL-2H3細胞 / 遺伝子 / ウイルス / 細胞内輸送 / ELKS蛋白 / トランスアクチベーション / NS5A / p53癌抑制蛋白 / セリンプロテアーゼ / NS3 / HCVレプリコン / c-Ab1 / リソソーム / 微小管 / 巨核球 / 血小板生成 / 細胞移動 / 細胞増殖 / 癌 / small G蛋白質 / Src / Grb2 Less

Mechanisms of tyrosine kinase Syk-induced tau protein oligomerization
- Principal Investigator
  
  濱野忠則
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kanazawa Medical University
Regulation of anti-fungal immunity by adaptor protein 3BP2
- Principal Investigator
  
  千原一泰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  University of Fukui
Regulatory mechanism of virus particle production by protein-tyrosine kinase Abl.Principal Investigator
- Principal Investigator
  
  Sada Kiyonao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  University of Fukui
Processing of double-stranded RNA during recovery of the cell from the double-stranded RNA stress
- Principal Investigator
  
  Takeuchi Kenji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  University of Fukui
Novel function of tyrosine kinase Abl as a host factor against virus infectionPrincipal Investigator
- Principal Investigator
  
  Kiyonao Sada
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Tyrosine phosphorylation of a viral protein in the hepatitis C virus life cycle
- Principal Investigator
  
  Yamauchi Shota
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Role of the regulation of B cell protein-tyrosine kinase by hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  SADA Kiyonao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Influence on protein-tyrosine phosphorylation by hepatitis C virus in B cellsPrincipal Investigator
- Principal Investigator
  
  SADA Kiyonao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
C型肝炎ウイルスの増殖適応変異と病原性の研究
- Principal Investigator
  
  堀田博
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Effects of hepatitis C virus proteins on protein-tyrosine phosphorylation in liver cellsPrincipal Investigator
- Principal Investigator
  
  SADA Kiyonao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
レプリコンを用いたC型肝炎ウイルス・宿主間相互作用の分子機序に関する研究
- Principal Investigator
  
  HOTTA Hak
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
スキャッフォールド蛋白質の新しい機能Principal Investigator
- Principal Investigator
  
  定清直
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Research of the novel role of Syk
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Study on possible correlation between carcinogenic risk and genetic variation of hepatitis B and C viruses in Indonesia.
- Principal Investigator
  
  HOTTA Hak
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Kobe University
血小板生成の謎に迫る-巨核球から血小板放出へ至る分子メカニズムの解明-
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Research for regulation system and new function of tyrosine kinase Syk
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
細胞増殖およびがんの形成過程におけるチロシンキナーゼSykの機能解析
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
血球系以外の組織におけるチロシンキナーゼSykの機能解析Principal Investigator
- Principal Investigator
  
  定清直
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
血液細胞におけるSykの生理的機能の解析；活性化機構と標的分子の同定Principal Investigator
- Principal Investigator
  
  定清直
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
IDENTIFICATION AND CHARACTERIZATION OF Syk FAMIRY PROTEIN TYROSINE KINASE
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOBE UNIVERSITY
G蛋白質共役型受容体から蛋白質チロシン燐酸化酵素へのシグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  定清直
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
細胞質チロシンキナーゼp72^<syk>を介する細胞内情報伝達とG蛋白質
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Molecular basis of pathophysiological role of Syk in blood and immumecells
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOBE UNIVERSITY
Physiological role of protein-tyrosine kinase p72^<syk>
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kobe University
  福井医科大学

[Book] C型レクチンによるマスト細胞の活性化メカニズム、臨床免疫・アレルギー科2018
- Author(s)
  千原一泰，本定千知，木村幸弘，竹内健司，藤枝重治，石塚　全，定　清直
- Total Pages
  5
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-17K08656
[Journal Article] ケルビズム2023
- Author(s)
  定　清直
- Journal Title
  
  生化学
  
  Volume: 95 Pages: 117-117
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Novel roles of tyrosine kinase Abl as a host factor for microbial infection.2023
- Author(s)
  定清直、竹内健司、千原一泰
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 1 Pages: 96-99
- DOI
  10.14952/SEIKAGAKU.2023.950096
- ISSN
  0037-1017
- Year and Date
  2023-02-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation2022
- Author(s)
  Chihara Kazuyasu、Chihara Yuri、Takeuchi Kenji、Sada Kiyonao
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 4 Pages: 503-523
- DOI
  10.1042/bcj20210707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A2022
- Author(s)
  Miyamoto Daisuke、Takeuchi Kenji、Chihara Kazuyasu、Fujieda Shigeharu、Sada Kiyonao
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 4 Pages: 101804-101804
- DOI
  10.1016/j.jbc.2022.101804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum2021
- Author(s)
  Muramatsu Ikunobu、Uwada Junsuke、Chihara Kazuyasu、Sada Kiyonao、Wang Mao‐Hsien、Yazawa Takashi、Taniguchi Takanobu、Ishibashi Takaharu、Masuoka Takayoshi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 160 Issue: 3 Pages: 342-355
- DOI
  10.1111/jnc.15556
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-20K07354, KAKENHI-PROJECT-20K09814
[Journal Article] Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway.2021
- Author(s)
  Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, Iwasaki H.
- Journal Title
  
  Translational Research
  
  Volume: 227 Pages: 53-63
- DOI
  10.1016/j.trsl.2020.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08656
[Journal Article] Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells.2019
- Author(s)
  Uwada J, Yazawa T, Mikami D, Krug SM, Fromm M, Yoshiki H, Sada K, Muramatsu I, Taniguchi T.
- Journal Title
  
  Cell signal.
  
  Volume: 63 Pages: 109358-109358
- DOI
  10.1016/j.cellsig.2019.109358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794
[Journal Article] Novel regulatory systems for acetylcholine release in rat striatum and anti‐Alzheimer's disease drugs2019
- Author(s)
  Muramatsu Ikunobu、Uwada Junsuke、Yoshiki Hatsumi、Sada Kiyonao、Lee Kung‐Shing、Yazawa Takashi、Taniguchi Takanobu、Nishio Matomo、Ishibashi Takaharu、Masuoka Takayoshi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 印刷中 Issue: 5 Pages: 605-623
- DOI
  10.1111/jnc.14701
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-16K19023, KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K09794
[Journal Article] A New Aspect of Cholinergic Transmission in the Central Nervous System2018
- Author(s)
  Muramatsu Ikunobu、Masuoka Takayoshi、Uwada Junsuke、Yoshiki Hatsumi、Yazama Takashi、Lee Kung-Shing、Sada Kiyonao、Nishio Matomo、Ishibashi Takaharu、Taniguchi Takanobu
- Journal Title
  
  Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
  
  Volume: 1 Pages: 45-58
- DOI
  10.1007/978-981-10-8488-1_3
- ISBN
  9789811084874, 9789811084881
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012
[Journal Article] Tubulointerstitial Nephritis with IgM-Positive Plasma Cells.2017
- Author(s)
  Takahashi N,　Kimura H et al
- Journal Title
  
  J Am Soc　Nephrol.
  
  Volume: 28 Issue: 12 Pages: 3688-3698
- DOI
  10.1681/asn.2016101074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08931, KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-17K09692, KAKENHI-PROJECT-16K15232, KAKENHI-PROJECT-26293201, KAKENHI-PROJECT-15H04836, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K09252
[Journal Article] Development of a multiplex real-time PCR assay for detection of human enteric viruses other than norovirus using samples collected from gastroenteritis patients in Fukui Prefecture, Japan2017
- Author(s)
  Kowada Kazuaki、Takeuchi Kenji、Hirano Eiko、Toho Miho、Sada Kiyonao
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 90 Issue: 1 Pages: 67-75
- DOI
  10.1002/jmv.24926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08656
[Journal Article] Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells2017
- Author(s)
  Chihara Kazuyasu、Kato Yuji、Yoshiki Hatsumi、Takeuchi Kenji、Fujieda Shigeharu、Sada Kiyonao
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 11480-11480
- DOI
  10.1038/s41598-017-11915-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08656
[Journal Article] Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission2017
- Author(s)
  Muramatsu Ikunobu、Uwada Junsuke、Masuoka Takayoshi、Yoshiki Hatsumi、Sada Kiyonao、Lee Kung-Shing、Nishio Matomo、Ishibashi Takaharu、Taniguchi Takanobu
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 143 Issue: 1 Pages: 76-86
- DOI
  10.1111/jnc.14127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-16K19023, KAKENHI-PROJECT-15K08250
[Journal Article] Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK2017
- Author(s)
  Uwada Junsuke、Yazawa Takashi、Islam Md Tariqul、Khan Md Rafiqul Islam、Krug Susanne M.、Fromm Michael、Karaki Shin-ichiro、Suzuki Yuichi、Kuwahara Atsukazu、Yoshiki Hatsumi、Sada Kiyonao、Muramatsu Ikunobu、Taniguchi Takanobu
- Journal Title
  
  Cellular Signalling
  
  Volume: 35 Pages: 188-196
- DOI
  10.1016/j.cellsig.2017.04.007
- NAID
  120006491645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-15K08182, KAKENHI-PROJECT-15K08250, KAKENHI-PROJECT-15K10654
[Journal Article] Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk2017
- Author(s)
  Honjoh Chisato、Chihara Kazuyasu、Yoshiki Hatsumi、Yamauchi Shota、Takeuchi Kenji、Kato Yuji、Hida Yukio、Ishizuka Tamotsu、Sada Kiyonao
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 46064-46064
- DOI
  10.1038/srep46064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-15K09213
[Journal Article] STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-lambda but not by interferon-alpha2016
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Honjoh, C., Kato, Y., Yoshiki, H., Hotta, H., and Sada, K.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 38336-38336
- DOI
  10.1038/srep38336
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19021
[Journal Article] Hepatitis C virus particle assembly involves phosphorylation of NS5A by the c-Abl tyrosine kinase2015
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 36 Pages: 21857-21864
- DOI
  10.1074/jbc.m115.666859
- NAID
  120005973616
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19021, KAKENHI-PROJECT-25460383
[Journal Article] Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with Vav3 in chicken DT40 cells2014
- Author(s)
  Chihara, K., Kimura, Y., Honjoh, C., Yamauchi, S., Takeuchi, K., Sada, K.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 322 Issue: 1 Pages: 99-107
- DOI
  10.1016/j.yexcr.2013.12.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591105, KAKENHI-PROJECT-25460383
[Journal Article] 関最新節リウマチ学 ―寛解・治癒を目指した研究と最新治療― Syk阻害薬2014
- Author(s)
  本定千知、千原一泰、木村幸弘、竹内健司、定　清直
- Journal Title
  
  日本臨牀増刊号「最新関節リウマチ学─寛解・治癒を目指した研究と最新治療」
  
  Volume: なし Pages: 521-524
- Data Source
  KAKENHI-PROJECT-25460383
[Journal Article] Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.2014
- Author(s)
  Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 45 Pages: 31565-75
- DOI
  10.1074/jbc.m114.581322
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293348, KAKENHI-PROJECT-25460383, KAKENHI-PROJECT-26293368
[Journal Article] Syk inhibitors2013
- Author(s)
  千原一泰、木村幸弘、本定千知、竹内健司、定　清直
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 36 Issue: 4 Pages: 197-202
- DOI
  10.2177/jsci.36.197
- NAID
  10031196416
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-25460383
[Journal Article] 関節リウマチ　ケアからキュアを目指した治療：Syk 阻害薬2013
- Author(s)
  木村幸弘、千原一泰、竹内健司、定　清直
- Journal Title
  
  日本臨牀
  
  Volume: 71(7) Pages: 1248-1252
- Data Source
  KAKENHI-PROJECT-25460383
[Journal Article] Syk 阻害薬-チロシンキナーゼSykの基礎と臨床-. 炎症疾患におけるキナーゼ阻害薬の進歩2012
- Author(s)
  定清直
- Journal Title
  
  医学のあゆみ
  
  Volume: 240(7) Pages: 567-570
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Syk阻害薬.2012
- Author(s)
  定　清直
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48(6) Pages: 1531-1534
- NAID
  120005463375
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Syk阻害薬-チロシンキナーゼSykの基礎と臨床-.炎症疾患におけるキナーゼ阻害薬の進歩2012
- Author(s)
  定清直
- Journal Title
  
  医学のあゆみ
  
  Volume: 240(7) Pages: 567-570
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Spleen tyrosine kinase (Syk)の生理的役割とその阻害薬の作用2012
- Author(s)
  千原一泰, 中島謙治, 竹内健司, 定清直
- Journal Title
  
  リウマチ科
  
  Volume: 47(6) Pages: 694-699
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] 次世代低分子化合物:Syk 阻害薬. 特集関節リウマチの最新情報-寛解を目指した診断と治療の新展開-2012
- Author(s)
  中島謙治, 千原一泰, 竹内健司, 定清直
- Journal Title
  
  最新医学
  
  Volume: 67(2) Pages: 101-106
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Syk 阻害薬. 特集リウマチ治療薬の新展開2012
- Author(s)
  定清直
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48(6) Pages: 1531-1534
- NAID
  40019349577
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
- Journal Title
  
  PLoS ONE
  
  Volume: 7(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells2011
- Author(s)
  Chihara, K., Nakashima, K., Takeuchi, K., and Sada, K
- Journal Title
  
  Genes Cells
  
  Volume: 16(12) Pages: 1133-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism2011
- Author(s)
  Ogi, K., Nakashima, K., Chihara, K., Takeuchi, K., Horiguchi, T., Fujieda, S., and Sada, K
- Journal Title
  
  Genes Cells
  
  Volume: 16(9) Pages: 951-960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation2011
- Author(s)
  Horiguchi, T., Ishiguro, N., Chihara, K., Ogi, K., Nakashima, K., Sada, K., and Hori-Tamura, N
- Journal Title
  
  J. Agric. Food. Chem
  
  Volume: 59(10) Pages: 5595-5601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
- Journal Title
  
  Microbiol. Immunol
  
  Volume: 55(11) Pages: 774-782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] C 型肝炎ウイルスの病原性発現機構2010
- Author(s)
  定清直
- Journal Title
  
  小児感染免疫
  
  Volume: 22(1) Pages: 35-41
- NAID
  10026419798
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] 関節リウマチ治療におけるSyk阻害薬の可能性を探る. 特集次世代の低分子量化合物は生物学的製剤を超えることができるか2010
- Author(s)
  千原一泰, 定清直
- Journal Title
  
  分子リウマチ治療
  
  Volume: 3(4) Pages: 186-189
- NAID
  40017367198
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] C型肝炎ウイルスの病原性発現機構2010
- Author(s)
  定清直
- Journal Title
  
  小児感染免疫
  
  Volume: 22(1) Pages: 35-41
- NAID
  10026419798
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Adaptor protein 3BP2 and cherubism2008
- Author(s)
  Hatani, T., Sada, K
- Journal Title
  
  Curr. Med. Chem 15(6)
  
  Pages: 549-554
- NAID
  120000807824
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS32006
- Author(s)
  Tanaka, M., Nagano-Fujii, M., Deng, L., Ishido, S., Sada, K., Hotta, H
- Journal Title
  
  Biochem. Biophys. Res. Commun 340(3)
  
  Pages: 792-799
- NAID
  120000943971
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] The NS3 protein of hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner2006
- Author(s)
  Deng, L., Nagano-Fujii, M., Tanaka, M., Nomura-Takigawa, Y., Ikeda, M., Kato, N., Sada. K., Hotta, H
- Journal Title
  
  J. Gen. Virol 87(6)
  
  Pages: 1703-1713
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] A novel mitochondria ubiquitin ligase plays a critical role in mitochondria] dynamics2006
- Author(s)
  Yonashiro, R., Ishido, S., Kyo, S., Fukuda, T., Goto, E., Matsuki, Y., Ohmura-Hashimoto, M., Sada. K., Hotta, H., Yamamura, H., Inatome, R., Yanagi, S
- Journal Title
  
  EMBO J 25(15)
  
  Pages: 3618-3626
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference2006
- Author(s)
  Otaki, M., Sada, K., Kadoya, H., Nagano-Fujii, M., Hotta, H
- Journal Title
  
  Antiviral Res 70(3)
  
  Pages: 105-111
- NAID
  120000945629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway2006
- Author(s)
  Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S., Sada, K., Hotta, H
- Journal Title
  
  J. Gen. Virol 87(7)
  
  Pages: 1935-1945
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE2006
- Author(s)
  Hotta, H., Nihei, K., Abe, Y., Kato, S., Jiang D. P., Nagano-Fujii, M., Sada, K
- Journal Title
  
  Microbiol. Immunol 50(7)
  
  Pages: 525-534
- NAID
  10017991849
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Journal Article] 肥満細胞におけるFcεレセプターIからのシグナル伝達:3BP2とCbl-bによる肥満細胞活性化制御2005
- Author(s)
  定清直
- Journal Title
  
  臨床免疫 44(1)
  
  Pages: 63-70
- Data Source
  KAKENHI-PROJECT-16790170
[Journal Article] マスト細胞活性化シグナルを制御する分子.特集マスト細胞とアレルギー.2005
- Author(s)
  定清直
- Journal Title
  
  Molecular Medicine 42(10)
  
  Pages: 1107-1112
- Data Source
  KAKENHI-PROJECT-16790170
[Journal Article] Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2γ-PAK.2004
- Author(s)
  Miah, S.M.S., Sada, K., Tuazon, P.T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J.A., Yamamura, H.
- Journal Title
  
  Mol.Cell.Biol. 24
  
  Pages: 71-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Journal Article] マスト細胞学の分子生物学-IgEシグナルを中心に-2004
- Author(s)
  定清直
- Journal Title
  
  アレルギーの臨床 24・10
  
  Pages: 781-785
- Data Source
  KAKENHI-PROJECT-16790170
[Journal Article] マスト細胞の負の活性制御因子2004
- Author(s)
  定清直
- Journal Title
  
  アレルギー科 17・3
  
  Pages: 220-227
- Data Source
  KAKENHI-PROJECT-16790170
[Journal Article] Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk
- Author(s)
  Inubushi, S., Nagano-Fujii, M., Kitayama, K., Tanaka, M., An, C., Yokozaki, H., Yamamura, H., Nuriya, H., Kohara, M., Sada, K., Hotta, H
- Journal Title
  
  J. Gen. Virol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] アダプター蛋白質3BP2によるCARD9の機能調節機構の解析2023
- Author(s)
  坪川亜優美、千原一泰、千原悠里、竹内健司、藤枝重治、定清直
- Organizer
  日本生化学会北陸支部第４１回大会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] アダプター蛋白質3BP2によるCARD9シグナル伝達機構の調節2023
- Author(s)
  坪川亜優美、千原一泰、千原悠里、竹内健司、藤枝重治、定清直
- Organizer
  第９６回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] アダプター蛋白質3BP2はC型レクチン受容体dectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2022
- Author(s)
  千原一泰, 坪川亜優美, 千原悠里, 竹内健司, 藤枝重治, 定　清直
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] ウイルス感染・免疫応答を制御する宿主因子の新しい役割Ⅲ2022
- Author(s)
  定　清直
- Organizer
  2022年度北陸腸内細菌研究会・研究発表会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] チロシンキナーゼAblはウイルス基質活性化因子NS5Aとの相互作用によりC型肝炎ウイルス粒子形成を促進する2022
- Author(s)
  宮本大輔, 竹内健司, 千原一泰, 藤枝重治, 定　清直
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] 福井大学における感染症医療人材養成事業（UF-IDEEP）と特色あるカリキュラム「感染症」の新設2022
- Author(s)
  定清直, 酒巻一平, 岩﨑博道
- Organizer
  第65回日本感染症学会中日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] チロシンキナーゼAblはウイルス基質活性化因子NS5Aとの相互作用によりC型肝炎ウイルス粒子形成を促進する2022
- Author(s)
  宮本大輔, 竹内健司, 千原一泰, 藤枝重治, 定　清直
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] アダプター蛋白質3BP2はC型レクチン受容体dectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2022
- Author(s)
  千原一泰, 坪川亜優美, 千原悠里, 竹内健司, 藤枝重治, 定　清直
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] Covid-19 epidemic in Fukui Prefecture2021
- Author(s)
  Hasegawa T, Sada, K., and Hasegawa M.
- Organizer
  UNAIR The 12th International Nursing Conference “Reframing Nursing Education, Research and Practice: COVID-19 as Catalyst for Innovation”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] アダプター蛋白質3BP2はC型レクチンDectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2021
- Author(s)
  千原一泰，千原悠里，竹内健司，定　清直
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] 感染症教育と国際交流2021
- Author(s)
  定　清直
- Organizer
  第128回関西形成外科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] 感染免疫を制御する宿主因子の新しい役割：チロシンキナーゼAblとSyk2019
- Author(s)
  定　清直.
- Organizer
  高分子学会　バイオ・高分子研究会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] 非受容体型チロシンキナーゼAblとC型肝炎ウイルスの相互作用2019
- Author(s)
  宮本大輔，竹内健司，千原一泰，定　清直
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] ゲノム編集マウスを利用したB細胞におけるアダプタータンパク質3BP2の機能解析2018
- Author(s)
  千原一泰, 竹内健司, 千原悠里, 宮本大輔, 定　清直
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] Syk阻害薬：基礎的背景と病態への展望2018
- Author(s)
  定　清直
- Organizer
  第61回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] アダプター蛋白質3BP2による貪食細胞の機能調節メカニズム2017
- Author(s)
  千原一泰, 加藤雄士, 竹内健司, 藤枝重治, 定　清直
- Organizer
  日本生化学会北陸支部第35回大会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] マスト細胞におけるC型レクチンMincleの機能解析2015
- Author(s)
  本定千知, 千原一泰, 吉木はつみ, 山内翔太, 竹内健司, 飛田征男, 岩野正之, 石塚全, 定清直
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] Role of c-Abl in hepatitis C virus particle assembly2015
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K19021
[Presentation] C型肝炎ウイルス粒子形成におけるc-Ablの役割2015
- Author(s)
  山内翔太, 竹内健司, 千原一泰, 孫雪東, 本定千知, 吉木はつみ, 堀田博, 定清直
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] マスト細胞におけるC型レクチンMincleの機能解析2015
- Author(s)
  本定千知, 千原一泰, 吉木はつみ, 山内翔太, 竹内健司, 飛田征男, 岩野正之, 石塚全, 定清直
- Organizer
  日本生化学会北陸支部第33回大会
- Place of Presentation
  富山
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] チロシンキナーゼによるHCV複製の制御機構2015
- Author(s)
  山内翔太, 竹内健司, 千原一泰, 孫雪東, 本定千知, 吉木はつみ, 堀田博, 定清直
- Organizer
  日本生化学会北陸支部第33回大会, シンポジウム「病原性ウイルス・免疫応答研究の最前線」
- Place of Presentation
  富山
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] Role of NS5A tyrosine phosphorylation in hepatitis C virus particle assembly2015
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-23
- Data Source
  KAKENHI-PROJECT-15K19021
[Presentation] アダプター蛋白質3BP2は分化したAML細胞においてSrc型チロシンキナーゼの活性化を促進する2015
- Author(s)
  千原一泰，吉木はつみ，加藤雄士，本定千知，山内翔太，竹内健司，定清直
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] マスト細胞におけるDectin-1の機能解析：真菌感染防御におけるマスト細胞の新たな役割．2014
- Author(s)
  千原一泰，木村幸弘，本定千知，吉木はつみ，山内翔太，竹内健司，定　清直．
- Organizer
  日本生化学会北陸支部第32回大会
- Place of Presentation
  富山大学杉谷キャンパス
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] Syk阻害薬2013
- Author(s)
  定　清直
- Organizer
  第57回日本リウマチ学会・学術集会
- Place of Presentation
  国立京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] C型レクチンDectin-1を介するマスト細胞の活性化機構2013
- Author(s)
  木村幸弘, 千原一泰, 竹内　健司, 本定千知, 藤枝重治, 定　清直
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] C型肝炎ウイルス非構造蛋白質NS5AにおけるFyn-SH2ドメインとの結合に重要なチロシン残基同定の試み2013
- Author(s)
  竹内健司, 孫　雪東, 千原一泰, Lin Deng, 勝二郁夫, 堀田　博, 定　清直
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] ニワトリDT40細胞におけるアダプター蛋白質3BP2のチロシンリン酸化とVav3との会合メカニズム2013
- Author(s)
  千原一泰, 木村幸弘, 本定千知, 竹内　健司, 定　清直
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] Syk 標的治療2012
- Author(s)
  定清直
- Organizer
  第40回日本臨床免疫学会
- Place of Presentation
  東京
- Year and Date
  2012-09-27
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] 第60回日本ウイルス学会学術集会2012
- Author(s)
  定　清直
- Organizer
  C型肝炎ウイルスNS5AはB細胞のチロシンキナーゼFynを活性化する.
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
- Organizer
  IUBMB&FEBS
- Place of Presentation
  Sevilla, Spain
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C 型肝炎ウイルス研究の今日的話題2012
- Author(s)
  定清直
- Organizer
  第2回医学教育アフリカ支援国際セミナー
- Place of Presentation
  福井
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] 第35回日本分子生物学会年会2012
- Author(s)
  定　清直
- Organizer
  C型肝炎ウイルスNS5A蛋白質のSrc homology 2/3ドメイン結合能とB細胞での発現によるSrcファミリーキナーゼFynの活性化.
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C型肝炎ウイルスNS5A蛋白質のSrc homology 2/3ドメイン結合能とB細胞での発現によるSrcファミリーキナーゼFynの活性化2012
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀口朋子, 孫雪東, Lin Deng, 勝二郁夫, 堀田博, 定清直
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.2012
- Author(s)
  Sada, K.
- Organizer
  IUBMB&FEBS
- Place of Presentation
  Sevilla, Spain
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C型肝炎ウイルス研究の今日的話題2012
- Author(s)
  定清直
- Organizer
  第2回医学教育アフリカ支援国際セミナー
- Place of Presentation
  福井(招待講演)
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Syk標的治療.2012
- Author(s)
  定　清直
- Organizer
  第40回日本臨床免疫学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Syk阻害薬.2012
- Author(s)
  定　清直
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Syk 阻害薬. SLE の新規治療2012
- Author(s)
  定清直
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C型肝炎ウイルスNS5AはB細胞のチロシンキナーゼFynを活性化する2012
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀口朋子, 孫雪東, Lin Deng, 勝二郁夫, 堀田博, 定清直
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] 次世代低分子化合物を用いた治療-Syk 阻害薬-2011
- Author(s)
  定清直
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
- Organizer
  IUMS 2011
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Sykの基礎と臨床新しい標的分子と疾患制御2011
- Author(s)
  定清直
- Organizer
  第39回日本臨床免疫学会総会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT2011
- Author(s)
  Sada, K.
- Organizer
  Immunology 2011
- Place of Presentation
  San Francisco
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C 型肝炎ウイルス複製におけるエネルギーセンサーAMPKの役割2011
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  日本生化学会北陸支部第29回大会
- Place of Presentation
  金沢
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] 次世代低分子化合物を用いた治療-Syk阻害薬-.Next Decade Symposium 3「新しい病因・病態・治療法を探る-あらたな関節リウマチ治療標的分子-」2011
- Author(s)
  定清直
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT2011
- Author(s)
  Sada, K., Nakashima, K., Ogi, K., and Chihara, K
- Organizer
  Immunology 2011
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF- in RBL-2H3 cells2011
- Author(s)
  千原一泰, 中島謙治, 竹内健司, 定清直
- Organizer
  第34回日本分子生物学会年会(MBSJ2011)
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Syk の基礎と臨床新しい標的分子と疾患制御2011
- Author(s)
  定清直
- Organizer
  第39回日本臨床免疫学会総会(免疫疾患学会連合2011)
- Place of Presentation
  東京
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C 型肝炎ウイルスの病原性発現機構2010
- Author(s)
  定清直
- Organizer
  第84回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2010-04-05
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達の増強2010
- Author(s)
  扇和弘, 羽溪朋子, 中島謙治, Upasana Shukla, 千原一泰, 藤枝重治, 定清直
- Organizer
  日本生化学会北陸支部第28回大会
- Place of Presentation
  福井
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] ハスカップ果実によるマスト細胞の脱顆粒抑制機構の解析2010
- Author(s)
  石黒奈穂子, 堀口朋子, 福本菜奈子, 定清直, 田村(堀)奈緒子
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達への影響2010
- Author(s)
  扇和弘, 中島謙治, シュクラウパサナ, 千原一泰, 藤枝重治, 定清直
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C型肝炎ウイルスの病原性発現機構2010
- Author(s)
  定清直
- Organizer
  第84回日本感染症学会総会
- Place of Presentation
  京都招待講演
- Year and Date
  2010-04-05
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Syk阻害剤2010
- Author(s)
  定清直
- Organizer
  第54回日本リウマチ学会総会
- Place of Presentation
  神戸招待講演
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Syk 阻害剤2010
- Author(s)
  定清直
- Organizer
  第54回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Glucose uptake and GLUTI/2 expression are down -regulated in Huh-7.5 cells harboring an HCV subgenomic RNA replicon and full-genomic RNA replicon2007
- Author(s)
  Kasai, D., Nagano-Fujii, M., Bungyoku, Y., Sasayama, M., Sada. K., Hotta, H
- Organizer
  14th International Symposium on Hepatitis Virus and Related Viruses
- Place of Presentation
  Glasgow, UK
- Year and Date
  2007-09-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] Kinase activity of the non-receptor tyrosine kinase Syk is down-regulated in Huh-7.5 cells harboring an HCV RNA subgenomic replicon2006
- Author(s)
  Inubushi, S., Nagano-Fujii, M., Kitayama, K., Yamamura, H., Sada, K., Hotta, H
- Organizer
  13th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Sydney, Australia
- Year and Date
  2006-08-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293
[Presentation] A high degree of sequence variation of HCV NS5A and the presence of anti-NS5A antibodies in the pretreatment sera are associated with efficient viral clearance by combination therapy using pegylated interferon and ribavirin2006
- Author(s)
  El-Shamy, A., Sasayama, M., Nagano-Fujii, M., Sada, K., Kim, S. R., Hotta, H
- Organizer
  13th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Sydney, Australia
- Year and Date
  2006-08-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590293

1. YAMAMURA Hirohei (90030882)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
2. HOTTA Hak (40116249)

# of Collaborated Projects: 7 results

# of Collaborated Products: 26 results
3. CHIHARA Kazuyasu (00314948)

# of Collaborated Projects: 7 results

# of Collaborated Products: 50 results
4. TAKEUCHI Kenji (40236419)

# of Collaborated Projects: 7 results

# of Collaborated Products: 46 results
5. YANAGI Shigeru (60252003)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. NAGANO Motoko (90304089)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. TOHYAMA Yumi (70362770)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. TAKANO Tomoko (30226807)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YAMAUCHI Shota (00728941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
10. MINAMI Yasuhiro (70229772)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 扇本真治 (80292853)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. YAMAMOTO Tadashi (40134621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HATANI Tomoko (60452124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 勝二郁夫 (40356241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 足達哲也 (60345014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 竹内郁登 (70262623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 丸山晋吾 (90262633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 稲津哲也 (00242587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 谷口隆信 (60217130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 濱野忠則 (40334817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 榎本崇一 (40569117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KUROSAKI Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KINET Jean-pierre

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TOMOHIRO Kur

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. UWADA Junsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 木村秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 乙葉基子

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
28. 矢澤隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 益岡尚由

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 藤枝重治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sada Kiyonao 定 清直

SADA Kiyonao 定 清直

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Regulatory mechanism of virus particle production by protein-tyrosine kinase Abl.Principal Investigator

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Novel function of tyrosine kinase Abl as a host factor against virus infectionPrincipal Investigator

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Role of the regulation of B cell protein-tyrosine kinase by hepatitis C virusPrincipal Investigator

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Influence on protein-tyrosine phosphorylation by hepatitis C virus in B cellsPrincipal Investigator

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Effects of hepatitis C virus proteins on protein-tyrosine phosphorylation in liver cellsPrincipal Investigator

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スキャッフォールド蛋白質の新しい機能Principal Investigator

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Sada Kiyonao 定清直

SADA Kiyonao 定清直