Niki Yasuo 二木康夫

… Alternative Names

NIKI Yasuo 二木康夫

二木康夫ニキヤスオ

Less

Researcher Number	10276298
Other IDs
External Links
Affiliation (Current)	2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2020: 慶應義塾大学, 医学部(信濃町), 准教授 2016: 慶應義塾大学, 医学部(信濃町), 講師 2009 – 2015: Keio University, 医学部, 講師 2007 – 2008: 慶應義塾大学, 医学部, 助教 2001: 慶應大, 医学部, 助手 2000: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator メカニカルストレス / 変形性関節症 / Toll様受容体 / 関節リウマチ / インターロイキン32 / TLR / TRPV4 / IL-1 / 三次元軟骨モデル / インターロイキン３２ … More / 三次元培養 / 炎症性関節炎 / TNF-α / 炎症性サイトカイン / リウマチ病学 / インターフェロン-γ / 慢性関節リウマチ / NKT細胞 / トランスジェニックマウス / インターロイキン-1 … More Except Principal Investigator パンヌス / 骨棘 / 変形性関節症 / 軟骨変性 / 血管新生 / 軟骨 / 変形性膝関節症 Less

Establishment of mechanical load-induced OA model and analysis of articular cartilage destruction modePrincipal Investigator
- Principal Investigator
  
  Niki Yasuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Keio University
IL-1 and TLR signals play an important role in mechanical stress-induced osteoarthritisPrincipal Investigator
- Principal Investigator
  
  NIKI Yasuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Potential role of Interleukin-32 for joint disease and elucidation of the downstream signalingPrincipal Investigator
- Principal Investigator
  
  NIKI Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
The role of interleukin-32 on inflammatory arthritis and the possibility of being a therapeutic target.Principal Investigator
- Principal Investigator
  
  NIKI Yasuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Involvement of Vascular Endothelial Factor in the remodeling process of Osteoarthritic Cartilage
- Principal Investigator
  
  ENOMOTO Hiroyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
IL-1α過剰発現トランスジェニックマウスにおけるNKT細胞の解析Principal Investigator
- Principal Investigator
  
  二木康夫
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University

All 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis.2013
- Author(s)
  Nakayama M, Niki Y, Kawasaki T, Takeda Y, Ikegami H, Toyama Y, Miyamoto T.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 2960-2960
- DOI
  10.1038/srep02960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24592280
[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012
- Author(s)
  Nakayama M., Niki Y., Kawasaki T., Takeda Y., Horiuchi K., Sasaki A., Okada Y., Umezawa K., Ikegami H., Toyama Y. and Miyamoto T.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14 Issue: 3
- DOI
  10.1186/ar3850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24592280
[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012
- Author(s)
  M. Nakayama, Y. Niki, et al
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: (投稿中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591959
[Journal Article] Accuracy of center of femoral head and talocrural joint calculated by navigation system2008
- Author(s)
  Enomoto H., Matsuzaki K., Matsumoto H., Otani T., Niki Y., Suda Y.
- Journal Title
  
  Comp Assisted Orthop Surg 8
  
  Pages: 339-340
- Data Source
  KAKENHI-PROJECT-19591766
[Presentation] proteoglycan lossがOA変化の初期のトリガーである可能性についての検討2019
- Author(s)
  福原悠介、二木康夫、菊地寿幸、宇田川和彦、武田勇樹、松本守雄、中村雅也
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09120
[Presentation] 軟骨基質の消失そのものがOA変化を惹起する可能性についての検討2019
- Author(s)
  福原悠介、二木康夫、菊地寿幸、宇田川和彦、武田勇樹、松本守雄、中村雅也
- Organizer
  第38回日本運動器移植・再生医学研究会
- Data Source
  KAKENHI-PROJECT-18K09120
[Presentation] Excessive Cyclic Compression Stress Increases Susceptibility to IL-1 in 3D-cultured Chondrocytes2018
- Author(s)
  Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Toshiyuki Kikuchi, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura
- Organizer
  2018 Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10492
[Presentation] Excessive Cyclic Compression Stress Increases Susceptibility to IL-1 in 3D-cultured Chondrocytes2017
- Author(s)
  Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Toshiyuki Kikuchi, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura
- Organizer
  2017 American college of Rheumatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10492
[Presentation] ATDC5を用いた三次元培養軟骨モデルの確立とメカニカルストレスの応答性2016
- Author(s)
  武田勇樹　二木康夫　福原悠介　福田良嗣　宇田川和彦　菊地寿幸　宮本健史　松本守雄　中村雅也
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広仁会館（広島県広島市）
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-15K10492
[Presentation] ATDC5を用いたコラーゲンスポンジ三次元培養軟骨モデルとメカニカルストレスの影響2015
- Author(s)
  武田勇樹　二木康夫　福原悠介　福田良嗣　宇田川和彦　菊地寿幸　宮本健史　松本守雄　中村雅也
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K10492
[Presentation] IL-32の下流シグナルはToll様受容体4下流のTRIFを刺激しTNFαとI型インターフェロンの産生に関与する2013
- Author(s)
  中山政憲　二木康夫　武田勇樹　宇田川和彦　戸山芳昭　宮本健史
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24592280
[Presentation] Interleukin-32 induces TNFalpha and type IInterferon via Proteinase 3-Protease activated receptor 2-TIR-domain-containing adapter-inducing interferon-beta axis2013
- Author(s)
  Masanori Nakayama, Yasuo Niki, Yoshiki Kawasaki, Yuki Takeda, Yoshiaki Toyama, Takeshi Miyamoto
- Organizer
  The European League against Rheumatism (EULAR) Congress
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-24592280
[Presentation] Interleuikin-32 developed inflammatory arthritis with TNFalpha induction via Protease 3 and Protease activated receptor 2-TIR-domain-containing adapter-inducing interferon-be-ta axis.2013
- Author(s)
  Masanori Nakayama, Yasuo Niki, Toshiki Kawasaki, Yuki Takeda, Hiroyasu Ikegami, Yoshiaki Toyama, Takeshi Miyamoto
- Organizer
  Orthopaedic Research Society annual meeting,2013
- Place of Presentation
  San Antonio,USA
- Data Source
  KAKENHI-PROJECT-24592280
[Presentation] The effects of interleukin-32 alpha on development of inflammatory arthritis and endotoxin shock in mice2012
- Author(s)
  M. Nakayama, Y. Niki, et al
- Organizer
  Orthopaedic Research Society 2012 annual meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21591959
[Presentation] IL-32αはNFκB/ERKシグナルを介してTNFαを誘導し関節炎の病態に関与する2012
- Author(s)
  中山政憲、二木康夫, 他
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-21591959
[Presentation] インターロイキン32αはToll様受容体シグナルを介してサイトカインを誘導し関節炎の病態に関与する。2012
- Author(s)
  中山政憲　二木康夫　武田勇樹　宇田川和彦　池上博泰　戸山芳昭　宮本健史
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24592280
[Presentation] IL-32αのマウスにおける関節炎ならびに敗血症性ショックの誘導効果について2011
- Author(s)
  中山政憲、二木康夫, 他
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  群馬
- Data Source
  KAKENHI-PROJECT-21591959
[Presentation] IL-32αのマウスにおける関節炎誘導効果について2010
- Author(s)
  中山政憲、二木康夫, 他
- Organizer
  第54回日本リウマチ学会学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591959
[Presentation] Clinical significance of cytokines in synovial fluid as predictive markers of joint destruction2009
- Author(s)
  Enomoto H, Kobayashi S, Saito S, Momohara S, Niki Y, Inoue K, Toyama Y, Suda Y
- Organizer
  In Annual Meetings of American Academy of Orthopaedic Surgeon
- Place of Presentation
  Las Vegas, USA
- Year and Date
  2009-02-25
- Data Source
  KAKENHI-PROJECT-19591766
[Presentation] Clinical significance of cytokines in synovial fluid as predictive markers of joint destruction2009
- Author(s)
  Enomoto H, Kobayashi S, Saito S, Momohara S, Niki Y, Inoue K, Toyama Y, Suda Y
- Organizer
  Annual Meetings of American Academy of Orthopaedic Surgeon
- Place of Presentation
  Las Vegas, NV, USA
- Year and Date
  2009-02-25
- Data Source
  KAKENHI-PROJECT-19591766
[Presentation] The effects of interleuikin-32 alpha on development of inflammatory synovitis and cartilage destruction in mice2009
- Author(s)
  M. Nakayama, Y. Niki, et al
- Organizer
  American College of Rheumatology 2009 scientific meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-21591959

1. NAKAYAMA Masanori (70528249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. ENOMOTO Hiroyuki (10256315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. KAWASAI Toshiki (30365291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKEDA Yuki (20445307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 福原悠介 (60594645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 宇田川和彦 (70528364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. MIYAMOTO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岡田保典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niki Yasuo 二木 康夫

NIKI Yasuo 二木 康夫

二木 康夫 ニキ ヤスオ

Research Projects

Research Products

Co-Researchers

Establishment of mechanical load-induced OA model and analysis of articular cartilage destruction modePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IL-1 and TLR signals play an important role in mechanical stress-induced osteoarthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Potential role of Interleukin-32 for joint disease and elucidation of the downstream signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of interleukin-32 on inflammatory arthritis and the possibility of being a therapeutic target.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of Vascular Endothelial Factor in the remodeling process of Osteoarthritic Cartilage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-1α過剰発現トランスジェニックマウスにおけるNKT細胞の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012

Author(s)

Journal Title

Data Source

[Journal Article] Accuracy of center of femoral head and talocrural joint calculated by navigation system2008

Author(s)

Journal Title

Data Source

[Presentation] proteoglycan lossがOA変化の初期のトリガーである可能性についての検討2019

Author(s)

Organizer

Data Source

[Presentation] 軟骨基質の消失そのものがOA変化を惹起する可能性についての検討2019

Author(s)

Organizer

Data Source

[Presentation] Excessive Cyclic Compression Stress Increases Susceptibility to IL-1 in 3D-cultured Chondrocytes2018

Author(s)

Organizer

Data Source

[Presentation] Excessive Cyclic Compression Stress Increases Susceptibility to IL-1 in 3D-cultured Chondrocytes2017

Author(s)

Organizer

Data Source

[Presentation] ATDC5を用いた三次元培養軟骨モデルの確立とメカニカルストレスの応答性2016

Author(s)

Organizer

Place of Presentation

Niki Yasuo 二木康夫

NIKI Yasuo 二木康夫

二木康夫ニキヤスオ