Hashizume Hideki 橋爪秀樹

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HASHIZUME Hideki 橋爪秀樹

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Researcher Number	10311276
Other IDs	https://orcid.org/0009-0008-1218-3461
Affiliation (Current)	2026: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 2016 – 2018: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 2012 – 2013: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry / Living organism molecular science
Keywords	Principal Investigator MRSA / 感染症薬 / mode of action / synergy / 作用機序解析 / 薬剤耐性菌 / 相乗的抗菌活性 / クロプトシン / メチシリン耐性黄色ブドウ球菌 / 新規抗菌薬 … More / 動物実験 / 黄色ブドウ球菌 / 相乗性 / L-156,602 / chloptosin / 薬剤併用 / 耐性菌克服 / 医薬品探索 / reverse resistance / in vivo efficacy / beta-lactam / 感染症 / 機序解析 / 耐性克服 / βラクタム剤 / tripropeptin C / ペプチド系化合物 / 抗菌剤 / 細胞壁合成 / リポペプチド / トリプロペプチンC / バンコマイシン / トリプロペプチン / 院内感染 Less

MOA study and efficacy evaluation of the synergistic activity of Chloptosin and L-156,602 against MRSAPrincipal Investigator
- Principal Investigator
  
  Hashizume Hideki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Microbial Chemistry Research Foundation
the mechanism study of reverse beta-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin CPrincipal Investigator
- Principal Investigator
  
  HASHIZUME Hideki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Microbial Chemistry Research Foundation
Mode of action study of tripropeptin C, which exhibits excellent in vivo efficacy superior to vancomycinPrincipal Investigator
- Principal Investigator
  
  HASHIZUME Hideki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Microbial Chemistry Research Foundation

All 2018 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C2018
- Author(s)
  Hideki Hashizume, Yoshiaki Takahashi, Tohru Masuda, Shun-ichi Ohba, Tomokazu Ohishi, Manabu Kawada & Masayuki Igarashi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 71 Issue: 1 Pages: 79-85
- DOI
  10.1038/ja.2017.88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08338
[Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びベータラクタム系抗生物質の抗菌活性増強剤2013
- Inventor(s)
  橋爪秀樹
- Industrial Property Rights Holder
  （公財）微生物化学研究会
- Industrial Property Rights Type
  特許
- Filing Date
  2013
- Data Source
  KAKENHI-PROJECT-24710254
[Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びβラクタム系抗生物質の抗菌活性増強剤2013
- Inventor(s)
  橋爪秀樹
- Industrial Property Rights Holder
  公益財団法人微生物化学研究会
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-249729
- Filing Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-24710254
[Presentation] 新規抗 MRSA 抗生物質トリプロペプチンの作用機序解析におけるSPR を利用した低分子ー低分子間相互作用解析2013
- Author(s)
  橋爪秀樹
- Organizer
  第13回　日本蛋白質科学会
- Place of Presentation
  とりぎん文化会館（鳥取）
- Invited
- Data Source
  KAKENHI-PROJECT-24710254
[Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析- SPRを利用した低分子-低分子間相互作用解析の一例-2013
- Author(s)
  橋爪秀樹
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-24710254
[Presentation] In Vitro Antimicrobial Activity and In Vivo Efficacy In a Mouse Staphylococcal-Septicemia Model of Water-soluble Tripropeptin C Analogs2012
- Author(s)
  S. Hirosawa, H. Hashizume, Y. Kobayashi, R. Watabe, K. Inoue, Y. Takahashi, S. Harada, S. Ohba*2, T. Masuda, R. Sawa, Y. Takahashi, T. Miyake, A. Nomoto and M. Shibasaki
- Organizer
  52nd Interscience conference of antimicrobial agents and chemotherapy
- Place of Presentation
  Moscone Convension center, SanFrancisco, USA
- Data Source
  KAKENHI-PROJECT-24710254
[Presentation] In Vitro Antimicrobial Activity and In Vivo Efficacy In a Mouse Staphylococcal-Septicemia Model of Water-soluble Tripropeptin C Analogs2012
- Author(s)
  Sehei Hirosawa, Hideki Hashizume, Yoshihiko Kobayashi, Ryo Watabe, Kunio Inoue, Yuko Takahashi, Shigeko Harada, Syunichi Ohba, Tohru Masuda, Ryuichi Sawa, Yoshiaki Takahashi, Toshiaki Miyake, Akio Nomoto, Masakatsu Shibasaki
- Organizer
  52^<nd> ICAAC
- Place of Presentation
  Moscone Convension Center (San Francisco, USA)
- Year and Date
  2012-09-11
- Data Source
  KAKENHI-PROJECT-24710254
[Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析　- SPR を利用した低分子-低分子間相互作用解析の一例 -
- Author(s)
  橋爪秀樹
- Organizer
  第13回　日本蛋白質科学会
- Place of Presentation
  とりぎん文化会館（鳥取市）
- Data Source
  KAKENHI-PROJECT-24710254

1. HARADA Shigeko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hashizume Hideki 橋爪 秀樹

HASHIZUME Hideki 橋爪 秀樹

Research Projects

Research Products

Co-Researchers

MOA study and efficacy evaluation of the synergistic activity of Chloptosin and L-156,602 against MRSAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

the mechanism study of reverse beta-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin CPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mode of action study of tripropeptin C, which exhibits excellent in vivo efficacy superior to vancomycinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びベータラクタム系抗生物質の抗菌活性増強剤2013

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びβラクタム系抗生物質の抗菌活性増 強剤2013

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 新規抗 MRSA 抗生物質トリプロペプチンの作用機序解析におけるSPR を利用した低分子ー低分子間相互作用解析2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析- SPRを利用した低分子-低分子間相互作用解析の一例-2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] In Vitro Antimicrobial Activity and In Vivo Efficacy In a Mouse Staphylococcal-Septicemia Model of Water-soluble Tripropeptin C Analogs2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] In Vitro Antimicrobial Activity and In Vivo Efficacy In a Mouse Staphylococcal-Septicemia Model of Water-soluble Tripropeptin C Analogs2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析 - SPR を利用した低分子-低分子間相互作用解析の一例 -

Author(s)

Organizer

Place of Presentation

Data Source

Hashizume Hideki 橋爪秀樹

HASHIZUME Hideki 橋爪秀樹

[Patent] 併用抗メチシリン耐性黄色ブドウ球菌薬、及びβラクタム系抗生物質の抗菌活性増強剤2013

[Presentation] 新規抗MRSA抗生物質トリプロペプチンの作用機序解析　- SPR を利用した低分子-低分子間相互作用解析の一例 -