HARO Hirotaka 波呂浩孝

… Alternative Names

波呂浩孝ハロヒロタカ

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Researcher Number	10313264
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2023: 山梨大学, 大学院総合研究部, 教授 2017 – 2021: 山梨大学, 大学院総合研究部, 教授 2014 – 2017: 山梨大学, 総合研究部, 教授 2012 – 2013: 山梨大学, 医学工学総合研究部, 教授 2009 – 2010: University of Yamanashi, 大学院・医学工学総合研究部, 教授 … More 2007 – 2008: University of Yamanashi, Department of Orthopaedic Surgery,Interdiatfinary, graduate school of Medicine and Engineering, Assistant Professor 2006: 山梨大学, 大学院医学工学総合研究部, 助手 2001 – 2002: Tokyo Medical and Dental University, Graduate School, Research Associate, 大学院・医歯学総合研究科, 助手 2000: 東京医科歯科大学, 疾患遺伝子実験センター, 客員助教授 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Human genetics
Keywords	Principal Investigator 椎間板変性 / MMP-3 / トロンビン / マクロファージ / matrix degradation / inflammatory cytokine / 椎間板ヘルニア / VEGF / MCP-1 / TWEAK … More / 血管新生 / 椎間板穿刺モデル / 椎間板 / MMP3 / PAR1 / 抗サイトカイン療法 / 椎間板変性犬モデル / 炎症賦活メカニズム / 椎間板器官培養 / PAR-1 / Degeneration of intervertebral disc / TEWAK / angiogenesis inducing factor / spontaneous resorption / herniated disc / 生理的椎間板ヘルニア治療 / Matrix Metalloproteinase(MMP) / 血管内皮細胞増殖因子(VEGF) / 血行新生 / sequential expressions / MMPs / TNF-alpha / cascade / 血管新生誘導因子 / 自然退縮 / MMP / 脊椎脊髄病学 / 炎症性サイトカイン / P2X4 / ATP / 炎症 / 退縮 / angiogenesis / TNF-α … More Except Principal Investigator 骨肉腫 / 血小板 / Col / HAp / MMP / Tax / p51 / Smad / mTOR / 転移 / 骨軟部肉腫 / ＣＬＥＣ－２ / ポドプラニン / CLEC-2 / clinical / bone formation capability / Porous HAp / Sccaffold of MSC / MSC / サル・ヒト骨髄間葉系細胞 / BMP2担体 / 生体吸収性 / 多孔体HAp / 骨再生 / 細胞治療センター / β-TCP / ヒト骨髄培養細胞 / 企業化 / 連通孔 / 3元 / 多血小板血漿 / 霊長類 / アルカリフォスファターゼ / ヒト骨髄間葉系細胞 / 臨床治験 / 臨床応用 / 骨形成能 / 多孔質HAp / 細胞担体 / 骨髄間葉系細胞 / gene family / functional information / sequence information / 椎間板ヘルニア塊の消化 / マトリックス・メタロプロテアーゼ(MMP) / 間葉系細胞分化 / p51遺伝子 / p53関連遺伝子 / 遺伝子機能予測 / Furctional genomics / ファミリー遺伝子 / 近縁遺伝子群 / 機能情報 / 遺伝子情報 / 椎間板 / 組織因子 / 骨折 / migration / MCP-1 / PAR-1 / トロンビン / lung metastasis / LM8 / osteosarcoma / Gemcitabine / ゲムシタビン / ｍＴＯＲ / 骨・軟部腫瘍学 Less

Development of treatment for intervertebral disc degeneration by macrophage differentiation controlPrincipal Investigator
- Principal Investigator
  
  波呂浩孝
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Yamanashi
Novel Regulatory Factors of Intervertebral Disc Degeneration in the Mechanism by ThrombinPrincipal Investigator
- Principal Investigator
  
  HARO HIROTAKA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Yamanashi
Development of therapeutic methods targeting proliferation / metastasis induction by interaction between sarcoma and platelets and its molecular mechanism
- Principal Investigator
  
  Ichikawa Jiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Yamanashi
Clarification of age-related changes in intervertebral discs and development of new anti-cytokine therapyPrincipal Investigator
- Principal Investigator
  
  HARO Hirotaka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
Elucidation of proliferation and metastasis mechanism of platelet-dependent bone soft tissue sarcoma and development of novel therapeutic method
- Principal Investigator
  
  ICHIKAWA Jiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
Novel function of mTOR in inducing intervertebral disc degeneration
- Principal Investigator
  
  WAKO Masanori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
The development of minimally invasive treatment and the cause investigation of degenerative spondylosisPrincipal Investigator
- Principal Investigator
  
  HARO Hirotaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
Elucidation of the role of mTOR in murine osteosarcoma cell line
- Principal Investigator
  
  ANDO Takashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
Molecular biologic approach to elucidate intervertebral disc degeneration and establishment of new treatmentPrincipal Investigator
- Principal Investigator
  
  HARO Hirotaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
The mechanism of low back pain and establish for new strategy of treatmentPrincipal Investigator
- Principal Investigator
  
  HARO Hirotaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Yamanashi
Bone regeneration therapy using HAp/Cot with MSC.
- Principal Investigator
  
  SHINOMIYA Kenichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Research for angiogenesis mechanism in hemialed disc (HD) resorption process and development of new therapies for HD using the resorption processPrincipal Investigator
- Principal Investigator
  
  HARO Hirotaka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Identification of Gene Function from Sequence Information
- Principal Investigator
  
  YAMAMURA Yasuko, 井川洋二
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Medical and Dental University

[Book] 腰痛　疾患・症状別　疾患・症状別今日の治療と看護改訂第3版2013
- Author(s)
  波呂浩孝
- Total Pages
  1493
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24592191
[Journal Article] Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of lumbar disc herniation, third edition - secondary publication2022
- Author(s)
  Haro Hirotaka、Ebata Shigeto、Inoue Gen、Kaito Takashi、Komori Hiromichi、Ohba Tetsuro、Sakai Daisuke、Sakai Toshinori、Seki Shoji、Shiga Yasuhiro、Suzuki Hidenori、Toyota Hiromitsu、Watanabe Kazuyuki、Yamato Yu
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 27 Issue: 1 Pages: 31-78
- DOI
  10.1016/j.jos.2021.07.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Risk Factors and Assessment Using an Endoscopic Scoring System for Postoperative Respiratory Complications after Anterior Cervical Decompression and Fusion Surgery2021
- Author(s)
  Ohba Tetsuro、Akaike Hiroshi、Fujita Koji、Oda Kotaro、Tanaka Nobuki、Tomokazu Matsuoka、Sakurai Daiju、Haro Hirotaka
- Journal Title
  
  Spine Surgery and Related Research
  
  Volume: 5 Issue: 1 Pages: 10-15
- DOI
  10.22603/ssrr.2020-0104
- NAID
  130007975808
- ISSN
  2432-261X
- Year and Date
  2021-01-27
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Factors Affecting Pedicle Screw Insertional Torque in Spine Deformity Surgery2021
- Author(s)
  Oda Kotaro、Ohba Tetsuro、Hiroshi Yokomichi、Fujita Koji、Tanaka Nobuki、Koyma Kensuke、Haro Hirotaka
- Journal Title
  
  Spine
  
  Volume: 46 Issue: 17 Pages: 111530-111530
- DOI
  10.1097/brs.0000000000004021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09594, KAKENHI-PROJECT-18K17376
[Journal Article] Radiological Assessment of Postoperative Paraspinal Muscle Changes After Lumbar Interbody Fusion With or Without Minimally Invasive Techniques2021
- Author(s)
  Kameyama Keigo、Ohba Tetsuro、Endo Tomoka、Katsu Marina、Koji Fujita、Kensuke Koyama、Oda Kotaro、Tanaka Nobuki、Haro Hirotaka
- Journal Title
  
  Global Spine Journal
  
  Volume: - Issue: 2 Pages: 295-303
- DOI
  10.1177/2192568221994794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Preoperative Thoracic Curve Magnitude and L4 end Vertebra were Risk Factors for Subjacent Disc Wedging after Selective Thoracolumbar/Lumbar Fusion with L3 as the Lowest Instrumented Vertebra in Lenke type 5 Curve Patients2021
- Author(s)
  Banno Tomohiro、Yamato Yu、Oba Hiroki、Ohba Tetsuro、Hasegawa Tomohiko、Yoshida Go、Arima Hideyuki、Oe Shin、Mihara Yuki、Ushirozako Hiroki、Takahashi Jun、Haro Hirotaka、Matsuyama Yukihiro
- Journal Title
  
  Spine
  
  Volume: Publish Ahead of Print Issue: 16 Pages: E878-E887
- DOI
  10.1097/brs.0000000000003961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Risk factors for subsequent vertebral fracture after acute osteoporotic vertebral fractures2021
- Author(s)
  Inose Hiroyuki、Kato Tsuyoshi、Ichimura Shoichi、Nakamura Hiroaki、Hoshino Masatoshi、Togawa Daisuke、Hirano Toru、Tokuhashi Yasuaki、Ohba Tetsuro、Haro Hirotaka、et al.
- Journal Title
  
  European Spine Journal
  
  Volume: - Issue: 9 Pages: 2698-2707
- DOI
  10.1007/s00586-021-06741-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Surgical Outcomes After Minimally Invasive Direct Lateral Corpectomy with Percutaneous Pedicle Screws for Osteoporotic Thoracolumbar Vertebral Collapse with Neurologic Deficits in the Thoracolumbar Spine Compared with Those After Posterior Spinal Fusion with Vertebroplasty2021
- Author(s)
  Ohba Tetsuro、Oba Hiroki、Oda Kotaro、Tanaka Nobuki、Haro Hirotaka
- Journal Title
  
  Spine
  
  Volume: 46 Issue: 18 Pages: 1271-1278
- DOI
  10.1097/brs.0000000000003988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Erratum for Risk Factors and Assessment Using an Endoscopic Scoring System for Postoperative Respiratory Complications after Anterior Cervical Decompression and Fusion Surgery2021
- Author(s)
  Ohba Tetsuro、Akaike Hiroshi、Fujita Koji、Oda Kotaro、Tanaka Nobuki、Tomokazu Matsuoka、Sakurai Daiju、Haro Hirotaka
- Journal Title
  
  Spine Surgery and Related Research
  
  Volume: 5 Issue: 3 Pages: 221-222
- DOI
  10.22603/ssrr.2020-0104-er
- NAID
  130008044482
- ISSN
  2432-261X
- Year and Date
  2021-05-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis2020
- Author(s)
  Ando Takashi、Ichikawa Jiro、Fujimaki Taro、Taniguchi Naofumi、Takayama Yoshihiro、Haro Hirotaka
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 11 Pages: 3097-3097
- DOI
  10.3390/cancers12113097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17995, KAKENHI-PROJECT-18K09060
[Journal Article] Clinical Importance, Incidence and Risk Factors for the Development of Postoperative Ileus Following Adult Spinal Deformity Surgery2020
- Author(s)
  Ohba Tetsuro、Koyama Kensuke、Oba Hiroki、Oda Kotaro、Tanaka Nobuki、Haro Hirotaka
- Journal Title
  
  Global Spine Journal
  
  Volume: _ Issue: 6 Pages: 1135-1140
- DOI
  10.1177/2192568220976562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma2020
- Author(s)
  Jiro Ichikawa, Takashi Ando, Tomonori Kawasaki, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Yujiro Kimura, Kaoru Aoki, Keiko Hayakawa, Katsue Suzuki-Inoue, Masao Saitoh, Hirotaka Haro
- Journal Title
  
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  
  Volume: in press Issue: 9 Pages: 1738-1750
- DOI
  10.1002/jbmr.4045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08654, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-20K08729, KAKENHI-PROJECT-18K06912, KAKENHI-PROJECT-18K09060, KAKENHI-PROJECT-16H06276
[Journal Article] ｢脊椎脊髄ジャーナル｣　第32巻　総目次2019
- Author(s)
  波呂浩孝
- Journal Title
  
  脊椎脊髄ジャーナル
  
  Volume: 32 Issue: 12 Pages: 0
- DOI
  10.11477/mf.5002201278
- ISSN
  0914-4412
- Year and Date
  2019-12-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09594
[Journal Article] Role of Weekly Teriparatide Administration in Osseous Union Enhancement within Six Months After Posterior or Transforaminal Lumbar Interbody Fusion for Osteoporosis-Associated Lumbar Degenerative Disorders2017
- Author(s)
  Ebata Shigeto、Takahashi Jun、Hasegawa Tomohiko、Mukaiyama Keijiro、Isogai Yukihiro、Ohba Tetsuro、Shibata Yosuke、Ojima Toshiyuki、Yamagata Zentaro、Matsuyama Yukihiro、Haro Hirotaka
- Journal Title
  
  The Journal of Bone and Joint Surgery
  
  Volume: 99 Issue: 5 Pages: 365-372
- DOI
  10.2106/jbjs.16.00230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10393
[Journal Article] Comparison of serum markers for muscle damage, surgical blood loss, postoperative recovery, and surgical site pain after extreme lateral interbody fusion with percutaneous pedicle screws or traditional open posterior lumbar interbody fusion2017
- Author(s)
  Ohba Tetsuro、Ebata Shigeto、Haro Hirotaka
- Journal Title
  
  BMC Musculoskeletal Disorders
  
  Volume: 18 Issue: 1 Pages: 415-415
- DOI
  10.1186/s12891-017-1775-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10393
[Journal Article] 腰椎椎間板ヘルニアに対する低侵襲治療2015
- Author(s)
  波呂浩孝
- Journal Title
  
  椎脊髄ジャーナル
  
  Volume: 28（1） Pages: 51-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10393
[Journal Article] Characterization of symptomatic lumbar foraminal stenosis by conventional imaging.2015
- Author(s)
  Ohba T, Ebata S, Fujita K, Sato H, Devin CJ, Haro H
- Journal Title
  
  Eur Spine J
  
  Volume: 24(10) Issue: 10 Pages: 2269-2275
- DOI
  10.1007/s00586-015-3859-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10393
[Journal Article] 腰椎椎間板ヘルニアに対する化学的融解術2015
- Author(s)
  波呂浩孝
- Journal Title
  
  臨床整形外科
  
  Volume: 50（10） Pages: 981-985
- NAID
  40020601533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10393
[Journal Article] Autocrine VEGF/VEGFR1 Signaling in a Subpopulation of Cells Associates with Aggressive Osteosarcoma2014
- Author(s)
  Ohba T, Cates JM, Cole HA, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG
- Journal Title
  
  Mol Cancer Res
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791531
[Journal Article] High molecular weight hyaluronic acid increases the differentiation potential of the murine chondrocytic ATDC5 cell line.2014
- Author(s)
  Sato E, Ando T, Ichikawa J, Okita G, Sato N, Wako M, Ohba T, Ochiai S, Hagino T, Jacobson R, Haro H.
- Journal Title
  
  Journal of orthopaedic research
  
  Volume: 32 Issue: 12 Pages: 1619-1627
- DOI
  10.1002/jor.22691
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592191
[Journal Article] Pleiotropic effects of bisphosphonates on osteosarcoma2014
- Author(s)
  Ohba T, Cates JM, Cole HA, Slosky DA, Haro H, Ichikawa J, Ando T, Schwartz HS, Schoenecker JG
- Journal Title
  
  Bone
  
  Volume: 63 Pages: 110-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791531
[Journal Article] Bisphosphonates Inhibit Osteosarcoma-Mediated Osteolysis Via Attenuation of Tumor Expression of MCP-1 and RANKL2014
- Author(s)
  Ohba T, Cole HA, Cates JM, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG
- Journal Title
  
  J Bone Miner Res
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791531
[Journal Article] Translational research of herniated discs: current status of diagnosis and treatment.2014
- Author(s)
  Haro H
- Journal Title
  
  Journal of orthopaedic science
  
  Volume: 19 Issue: 4 Pages: 515-520
- DOI
  10.1007/s00776-014-0571-x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592191
[Journal Article] Endogenous TGF-beta activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-kappaB activation2013
- Author(s)
  Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A
- Journal Title
  
  Journal of orthopaedic research
  
  Volume: 31 Pages: 1144-1149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791531
[Journal Article] Experimental chemonucleolysis with recombinant human matrix metalloproteinase 7 in human herniated discs and dogs.2013
- Author(s)
  Haro H, Nishiga M, Ishii D, Shimomoto T, Kato T, Takenouchi O, Koyanagi S, Ohba T, Komori H.
- Journal Title
  
  Spine journal
  
  Volume: 13 Issue: 7 Pages: 1934-7
- DOI
  10.1016/j.spinee.2013.11.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592191
[Journal Article] 脊椎・脊髄疾患2012
- Author(s)
  波呂浩孝
- Journal Title
  
  整形外科
  
  Volume: 64 Pages: 81-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592191
[Journal Article] 腰椎変性疾患に対する低侵襲治療2012
- Author(s)
  波呂浩孝
- Journal Title
  
  Journal of Spine Research
  
  Volume: 3 Pages: 462-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592191
[Journal Article] TNF-alfa induced NF-kappaB signaling reversed age-related declines in VEGF induction and angiogenic activity in intervertebral disc tissues.2009
- Author(s)
  Ohba T, Haro H, Ando T, Wako M, Suenaga F, Aso Y, Koyama K, Hamada Y, Nakao A.
- Journal Title
  
  J Orthop Res 27
  
  Pages: 229-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591741
[Journal Article] Mechanism of signal transduction in TWEAK-induced matrix degradation by MMP-3 upregulationin disc tissues.2008
- Author(s)
  Masanori Wako, Hirotaka Haro
- Journal Title
  
  Spine 33
  
  Pages: 2489-2494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591741
[Journal Article] Mechanism of signal transduction in TWEAK-induced matrix degradation by MMP-3 upregulation in disc tissues.2008
- Author(s)
  Wako M, Ohba T, Ando T, Arai Y, Koyama K, Hamada Y, Nakao A, Haro H.
- Journal Title
  
  Spine 33
  
  Pages: 2489-2494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591741
[Journal Article] A potential role of TSLP in the recruitment of macrophages to mouse intervertebral disc cells via MCP-1 induction.2008
- Author(s)
  Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Katoh R, Ogawa H, Hamada Y, Nakao A.
- Journal Title
  
  Arthritis Res 58
  
  Pages: 3510-3519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591741
[Journal Article] A potential role of TSLP in the recruitment of macrophages to mouse interveretebral disc cells via MCP-1 induetion.2008
- Author(s)
  Tetsuro Ohba, Hirotaka Haro
- Journal Title
  
  Arthritis & Rheumatism 58
  
  Pages: 3510-3519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591741
[Journal Article] 椎間板変性と高齢者椎間板ヘルニアの病態2007
- Author(s)
  波呂浩孝、濱田良機
- Journal Title
  
  脊椎脊髄ジャーナル 20(5)
  
  Pages: 494-499
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591626
[Journal Article] Novel function of TWEAK in inducing intervertebral disc degeneration.2007
- Author(s)
  Hirotaka Haro et al.
- Journal Title
  
  Journal of Orthopaedic Research (In press)
- Data Source
  KAKENHI-PROJECT-18591626
[Journal Article] 椎間板変性と高齢者椎間板ヘルニアの病態2007
- Author(s)
  波呂浩孝他
- Journal Title
  
  脊椎脊髄ジャーナル (印刷中)
- Data Source
  KAKENHI-PROJECT-18591626
[Journal Article] Novel function of TWEAK in inducing intervertebral disc degeneration2007
- Author(s)
  Masanori, Wako, Hirotaka, Haro
- Journal Title
  
  No.25
  
  Pages: 1438-1446
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591626
[Journal Article] Novel function of TWEAK in inducing intervertebral disc degeneration2007
- Author(s)
  Masanori Wako, Hirotaka Haro
- Journal Title
  
  Journal of Orthopaedic Research 25
  
  Pages: 1438-1446
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591626
[Journal Article] Disc degeneration and the pathological mechanism of aged intervertebral disc2007
- Author(s)
  Hirotaka, Haro, Yoshiki, Hamada
- Journal Title
  
  No.20(5)
  
  Pages: 494-499
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591626
[Presentation] Strategy for treatment of osteoporosis associated with spinal disorders2019
- Author(s)
  Hirotaka Haro
- Organizer
  2019 Annual Meeting of Taiwan Spine Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09594
[Presentation] 事上磨錬　－ask what you can do for spinal disorders-2019
- Author(s)
  波呂浩孝
- Organizer
  第48回日本脊椎脊髄病学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09594
[Presentation] Chemonucleolysis with Recombinant Human MMP-72019
- Author(s)
  Hirotaka Haro
- Organizer
  34TH Annual Meeting of North American Spine Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09594
[Presentation] 骨肉腫ポドプラニンによる血小板凝集と活性化2017
- Author(s)
  市川二郎、安藤隆、佐藤信隆、大場哲郎、斉藤正憲、波呂浩孝
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K10436
[Presentation] 椎間板変性における炎症のメカニズム2016
- Author(s)
  波呂　浩孝
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-14
- Invited
- Data Source
  KAKENHI-PROJECT-15K10393
[Presentation] ヒトリコンビナントMMP-7を用いた椎間間版ヘルニア治療-非臨床研究-2015
- Author(s)
  波呂浩孝
- Organizer
  第34回運動器移植・再生医学研究会
- Place of Presentation
  ANAクラウンプラザホテル宇部（山口県・宇部市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-15K10393
[Presentation] 腰椎椎間板ヘルニアの病態と新規低侵襲治療2015
- Author(s)
  波呂浩孝
- Organizer
  第18回日本低侵襲脊椎外科学会学術集会
- Place of Presentation
  品川プリンスホテル（東京都・港区）
- Year and Date
  2015-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K10393
[Presentation] 腰椎椎間板ヘルニアの病態と治療戦略2015
- Author(s)
  波呂浩孝
- Organizer
  第23回日本腰痛学会
- Place of Presentation
  JPタワーホール&カンファレンス（東京都・千代田区）
- Year and Date
  2015-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-15K10393
[Presentation] Experimental chemonucleolysis with recombinant human matrix proteinase-72015
- Author(s)
  Haro H, Takenouchi I, Kato T, Koyanagi S, Komori H
- Organizer
  国際腰椎学会(ISSLS)2015
- Place of Presentation
  San Francisco（USA）
- Year and Date
  2015-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10393
[Presentation] rhMMP-7を用いた腰椎椎間板ヘルニアの新規治療2015
- Author(s)
  波呂浩孝
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K10393
[Presentation] Hylan G-F20 は軟骨細胞の分化を促進し, 変性を抑制する2014
- Author(s)
  安藤隆, 佐藤栄一, 市川二郎, 若生政憲, 大北弦樹, 佐藤信隆, 落合聡司, 萩野哲男, 波呂浩孝
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都医師会館(京都市)
- Data Source
  KAKENHI-PROJECT-24791531
[Presentation] 骨肉腫細胞株に対するmTOR阻害剤（Rapamycin）とDNA合成阻害剤（Gemcitabin）の併用による抗腫瘍効果についての検討2014
- Author(s)
  安藤隆、市川二郎、佐藤信隆、齋藤正憲、大場哲郎、波呂浩孝
- Organizer
  第47回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Data Source
  KAKENHI-PROJECT-24791531
[Presentation] 骨肉腫細胞でのトロンビン産生能とトロンビンへの応答性2014
- Author(s)
  市川二郎, Schoenecker Jonathan Schwartz Herbert, 安藤隆, 佐藤栄一, 波呂浩孝
- Organizer
  第87回日本整形外科学会学術集会
- Place of Presentation
  神戸国際会議場(神戸市)
- Data Source
  KAKENHI-PROJECT-24791531
[Presentation] 骨肉腫細胞株に対するmTOR 阻害剤(Rapamycin)とDNA 合成阻害剤(Gemcitabin)の併用による抗腫瘍効果についての検討2014
- Author(s)
  安藤隆, 市川二郎, 佐藤信隆, 大北弦樹, 若生政憲, 波呂浩孝
- Organizer
  第47回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  大阪国際会議場(大阪市)
- Data Source
  KAKENHI-PROJECT-24791531
[Presentation] Role of Weekly Administered Teriparatide in Bony Union Enhancement After Posterior Lumbar Degenerative Deformity: AProspective, Randmized Multi-Center Study2013
- Author(s)
  Haro H, Takahashi J, Matsuyama Y
- Organizer
  20th International Meeting on Advanced Spine Techniques
- Place of Presentation
  Vancouver Convention Center(Vancouver, Canada）
- Invited
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] マウス骨芽細胞へのThrombin刺激はMCP-1を発現させマクロファージの遊走を促進させる2013
- Author(s)
  安藤隆, 市川二郎, 大場哲郎, 佐藤信隆, 大北弦樹, 波呂浩孝
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ(千葉市)
- Data Source
  KAKENHI-PROJECT-24791531
[Presentation] 腰椎椎間板ヘルニアに対する治療法―未来への展望と取組み―2013
- Author(s)
  波呂浩孝
- Organizer
  第86回日本整形外科学会学術集会
- Place of Presentation
  広島リーガロイヤルホテル（広島県　広島市）
- Invited
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] 脊椎脊髄外科専門医制度の構築2013
- Author(s)
  波呂浩孝，中村博亮，紺野愼一，加藤真介，中村雅也，米延策雄，高橋和久，持田譲治
- Organizer
  第42回日本脊椎脊髄病学会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県　宜野湾市）
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] 腰椎椎間板ヘルニア融解治療法の開発:rhMMp-7を使用する根拠2013
- Author(s)
  波呂浩孝，竹之内修美，小柳　智，小森博達
- Organizer
  第21回日本腰痛学会
- Place of Presentation
  JPタワーホール&カンファレンス（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] Role of weekly administered teriparatide in bony union enhancement after posterior lumbar interbody fusion for osteoporosis-associated lumbar degenerative disorders:A prospective,randomized multicenter study2013
- Author(s)
  Haro H, Ebata S, Takahashi J, Hasegawa T, Hirabayashi H, Matsuyama Y
- Organizer
  International Society for Study of the Lumbar Spine
- Place of Presentation
  Fairmont Scottsdale Princess（Scottdale, USA）
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] 運動器の慢性疼痛研究･診療の最前線2012
- Author(s)
  波呂浩孝
- Organizer
  第61回東日本整形災害外科学会
- Place of Presentation
  高崎ビューホテル（高崎市）
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] Age-related sequences of MCP-1 and MMP-3 expression in degeneration of mouse intervertebral disc.2011
- Author(s)
  藤田康稚、安藤隆、大場哲郎、波呂浩孝
- Organizer
  Annual meeting of Orthopaedic Research Society
- Place of Presentation
  Long Beach, CA, USA
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] 炎症による椎間板性腰痛における加齢の影響2010
- Author(s)
  藤田康稚、安藤隆、大場哲郎、波呂浩孝
- Organizer
  第18回日本腰痛学会
- Place of Presentation
  札幌
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] 椎間板細胞における炎症性反応の加齢による変化2010
- Author(s)
  藤田康稚、安藤隆、大場哲郎、若生政憲、加藤良平、中尾篤人、波呂浩孝
- Organizer
  第29回日本運動器移植・再生医学研究会
- Place of Presentation
  京都
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] ヘルニア塊の退縮に対する加齢の影響について2010
- Author(s)
  藤田康稚、大場哲郎、安藤隆、若生政憲、中尾篤人、波呂浩孝
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] TSLPは、腰椎椎間板ヘルニアの自然退縮機序において、ヘルニア塊へのマクロファージの浸潤に作用している2009
- Author(s)
  大場哲郎、若生政憲、小山賢介、藤田康稚、波呂浩孝
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  横浜
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] 椎間板由来のサイトカイン産生におけるTNF-αのシグナル伝達経路の解析2008
- Author(s)
  大場哲郎, 波呂浩孝
- Organizer
  日本整形外科学会
- Place of Presentation
  京都
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] Novel function of TWEAK in inducing intervertebral disc degeneration2007
- Author(s)
  Masanori, Wako, Hirotaka, Haro
- Organizer
  the Japanese Orthopaedic Association
- Place of Presentation
  Hamamatu Shizuoka Japan
- Year and Date
  2007-10-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591626
[Presentation] Novel function of TWEAK in inducing intervertebral disc degeneration2007
- Author(s)
  若生政憲、波呂浩孝
- Organizer
  Journal of Orthopaedic Research
- Place of Presentation
  浜松
- Year and Date
  2007-10-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591626
[Presentation] Novel function of TWEAK in inducing intervertebral disc degeneration.2007
- Author(s)
  若生政憲、波呂浩孝
- Organizer
  日本整形外科学会
- Place of Presentation
  浜松
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18591626
[Presentation] 椎間板由来のサイトカイン産生におけるTNF-αのシグナル伝達経路の解析2007
- Author(s)
  大場哲郎、波呂浩孝、安藤隆、若生政憲、中尾篤人、浜田良機
- Organizer
  第22回日本整形外科学会基礎学術集会
- Place of Presentation
  浜松
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-20591741
[Presentation] 炎症と椎間板変性のメカニズム
- Author(s)
  波呂浩孝
- Organizer
  第29回　日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島県・鹿児島市
- Year and Date
  2014-10-09 – 2014-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] Analysis of deglutition after occipitocervical arthrodesis for cervical deformity in rheumatoid arthritis
- Author(s)
  Haro H, Fujita K, Ohba T, Ebata S
- Organizer
  21st International Meeting on Advanced Spine Techniques
- Place of Presentation
  Valencia, Spain
- Year and Date
  2014-07-16 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-24592191
[Presentation] 椎間板ヘルニアに対する新規治療―rhMMP-7を用いた経皮的融解術
- Author(s)
  波呂浩孝
- Organizer
  第87回日本整形外科学会学術集会
- Place of Presentation
  兵庫県・神戸市
- Year and Date
  2014-05-22 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-24592191

1. ANDO Takashi (10377492)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. NAKAO Atsushito (80317445)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. HARA Yasushi (00228628)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TEKADA Shu (30376727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KOMORI Hiromichi (60262169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HAMADA Yoshiki (80096544)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. SATO Nobutaka (00418716)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. YAMAMURA Yasuko (50146809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. ICHIKAWA Jiro (00456469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 大場哲郎 (70456490)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. NAKAO Atsuhito (80318445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. WAKO Masanori (30402077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHTANI Kiyoshi (30201974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHINAKA Yoshiyuki (30024657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAMURA Masataka (30180392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHINOMIYA Kenichi (20111594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KURODA Hiroshi (70282746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ITO Soichiro (10242190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ASOU Yoshinori (50345279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKAYAMA Yoshihiro (20596994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. INOUE Katsue (10324211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 井川洋二 (40085618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 小柳津直樹 (00282773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 高橋淳 (60345741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 小山勝弘 (30313779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. KAWASAKI Tomonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARO Hirotaka 波呂 浩孝

波呂 浩孝 ハロ ヒロタカ

Research Projects

Research Products

Co-Researchers

Development of treatment for intervertebral disc degeneration by macrophage differentiation controlPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Novel Regulatory Factors of Intervertebral Disc Degeneration in the Mechanism by ThrombinPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of therapeutic methods targeting proliferation / metastasis induction by interaction between sarcoma and platelets and its molecular mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of age-related changes in intervertebral discs and development of new anti-cytokine therapyPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Elucidation of proliferation and metastasis mechanism of platelet-dependent bone soft tissue sarcoma and development of novel therapeutic method

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Novel function of mTOR in inducing intervertebral disc degeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of minimally invasive treatment and the cause investigation of degenerative spondylosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the role of mTOR in murine osteosarcoma cell line

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Molecular biologic approach to elucidate intervertebral disc degeneration and establishment of new treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of low back pain and establish for new strategy of treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Bone regeneration therapy using HAp/Cot with MSC.

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Research for angiogenesis mechanism in hemialed disc (HD) resorption process and development of new therapies for HD using the resorption processPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Gene Function from Sequence Information

Principal Investigator

Project Period (FY)

HARO Hirotaka 波呂浩孝

波呂浩孝ハロヒロタカ

[Book] 腰痛　疾患・症状別　疾患・症状別今日の治療と看護改訂第3版2013