Yamashita Atsuko 山下敦子

… Alternative Names

YAMASHITA Atsuko 山下敦子

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Researcher Number	10321738
Other IDs
Affiliation (Current)	2026: 大阪大学, 蛋白質研究所, 教授
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 蛋白質研究所, 教授 2021 – 2023: 岡山大学, 医歯薬学域, 教授 2017 – 2020: 岡山大学, 医歯薬学総合研究科, 教授 2015: 岡山大学, 医歯(薬)学総合研究科, 教授 2011: 独立行政法人理化学研究所, 播磨研究所・分子シグナリング研究チーム, チームリーダー … More 2008 – 2009: The Institute of Physical and Chemical Research, 分子シグナリング研究チーム, チームリーダー 2007: The Institute of Physical and Chemical Research, 分子シグナリング研究チーム, チームリーダー 2001 – 2003: 理化学研究所, 構造生物化学研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Transformative Research Areas, Section (II) / Science and Engineering / Molecular and Genome biology and related fields Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Biomolecular chemistry / Food science / 応用微生物学・応用生物化学 / Living organism molecular science
Keywords	Principal Investigator 味覚受容体 / 味覚 / 結晶構造解析 / 受容体 / ハロゲンイオン / 構造解析 / 示差走査蛍光測定法 / 一分子計測 / シミュレーション / 遺伝子編集 … More / 発生・分化 / 生殖 / 感覚受容 / 構造生物学 / 神経科学 / シグナル伝達 / タンパク質 / 結晶構造 / 機械刺激受容チャネル / TRPチャネル … More Except Principal Investigator モネリン / ファージディスプレイライブラリー / 組換えタンパク質 / 難発現タンパク質 / 人工タンパク質 / 一本鎖モネリン / ファージディスプレイ / コラーゲン / LDL受容体 / プライベートシャペロン / 分子シャペロン / GDSLリパーゼ / 生合成 / ピレスリン / 除虫菊 / 膜移行 / 情報伝達 / 構造機能 / Gタンパク質共役型受容体 / 甘味 / 味覚受容体 / 進化 / 構造機能解析 / 受容体 / 味覚 / Enzyme reaction / Structural biology / Protein crystallization / Laue diffraction / Membrane protein / Synchrotron radiation / Ultra-high resolution crystallography / Time-resolved crystallography / 時分割X線結晶構造解析 / 酵素反応 / 構造生物学 / タンパク質の結晶化 / ラウエ回折 / 膜タンパク質 / シンクロトロン放射光 / 超高分解能X線結晶構造解析 / 時間割X線結晶構造解析 / フォトアフィニティー標識 / マクロライド系化合物 / Xenopus laevis oocytes / Photoaffinity porbe / Patch-clamp electrophysiology / Binding assay / COS-1 / Sf9 / Glutamate-gated chloride channel / Milbemycin / Ivermectin / パッチクランプ / バインディングアッセイ / 大量発現 / 光親和性プローブ / 抑制性グルタミン酸受容体 / ミルベマイシン / イベルメクチン / マクロライド Less

Structural analysis of the recognition mechanism of diverse chemicals by taste receptorsPrincipal Investigator
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka University
  Okayama University
Analysis of molecular functions and physiological roles of halogen-ion sensing by T1r taste receptorsPrincipal Investigator
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka University
Analysis of physiological reactions caused by weak interactions between taste receptors and materialsPrincipal Investigator
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Okayama University
Reconstitution of artificial private chaperone systems and their application to the production of difficult-to-express proteins
- Principal Investigator
  
  Yasui Norihisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Okayama University
Structural biology of perception mechanisms of chemical signals by taste receptor type 1Principal Investigator
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Okayama University
Reverse structural biology of conformational dynamics and signal transduction mechanisms of taste receptorsPrincipal Investigator
- Principal Investigator
  
  Yamashita Atsuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Okayama University
Structural study of chemical communications through molecular interaction between T1r taste receptors and taste substancesPrincipal Investigator
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Okayama University
Involvement of taste receptor in oogenesis and early developmentPrincipal Investigator
- Principal Investigator
  
  Yamashita Atsuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Molecular and Genome biology and related fields
- Research Institution
  Okayama University
Structural and dynamical basis of taste receptor signaling mechanismPrincipal Investigator
- Principal Investigator
  
  Yamashita Atsuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Okayama University
Structural, functional, and evolutionary properties of sweet taste receptors
- Principal Investigator
  
  Kusakabe Yuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  National Agriculture and Food Research Organization
Elucidation of molecular mechanism of pyrethrin biosynthesis by a GDSL lipase and its application to creation of insect resistant plants
- Principal Investigator
  
  MATSUDA Kazuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kinki University
Molecular mechanism of persisting activation of glutamate-gated chloride channels by macrolide compounds
- Principal Investigator
  
  MATSUDA Kazuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kinki University
Crystallographic analyses of functional mechanisms of sensory receptorsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Atsuko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Forefront X-Ray Crystallography of Enzymes by using the third generation synchrotron radiation
- Principal Investigator
  
  KATO Hiroaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Kyoto University
  The Institute of Physical and Chemical Research

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All Journal Article Presentation Book Other

[Book] おいしさの科学とフードテック最前線2022
- Author(s)
  山下敦子（都甲潔監修）
- Total Pages
  435
- Publisher
  シーエムシー出版
- ISBN
  9784781316758
- Data Source
  KAKENHI-PROJECT-20H03195
[Book] おいしさの科学とフードテック最前線2022
- Author(s)
  山下敦子（都甲潔監修）
- Total Pages
  435
- Publisher
  シーエムシー出版
- ISBN
  9784781316758
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Journal Article] Receptor mechanism producing a sweet taste from plant aroma compounds2025
- Author(s)
  Horie Fuyumi、Sanematsu Keisuke、Yasumatsu Keiko、Hirokawa Takatsugu、Shigemura Noriatsu、Yamashita Atsuko、Kusakabe Yuko
- Journal Title
  
  Scientific Reports
  
  Volume: 15 Issue: 1 Pages: 6795-6795
- DOI
  10.1038/s41598-025-89711-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K02415, KAKENHI-PROJECT-23K27117, KAKENHI-PROJECT-24K02883, KAKENHI-PROJECT-24K08760
[Journal Article] Chemical range recognized by the ligand-binding domain in a representative amino acid-sensing taste receptor, T1r2a/T1r3, from medaka fish2024
- Author(s)
  Ishida Hikaru、Yasui Norihisa、Yamashita Atsuko
- Journal Title
  
  PLOS ONE
  
  Volume: 19 Issue: 3 Pages: e0300981-e0300981
- DOI
  10.1371/journal.pone.0300981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-23K27117
[Journal Article] Sweet/umami taste receptor-mediated chloride-sensation revealed by X-ray crystallographic analysis2024
- Author(s)
  Yamashita Atsuko
- Journal Title
  
  SPring-8/SACLA Research Frontiers 2023
  
  Volume: N/A Pages: 36-37
- Open Access
- Data Source
  KAKENHI-PROJECT-24K21272
[Journal Article] Sweet/umami taste receptor-mediated chloride-sensation revealed by X-ray crystallographic analysis2024
- Author(s)
  Yamashita Atsuko
- Journal Title
  
  SPring-8/SACLA Research Frontiers 2023
  
  Volume: N/A Pages: 36-37
- Open Access
- Data Source
  KAKENHI-PROJECT-23K27117
[Journal Article] Binding Analysis of Zinc Ions to the Ligand-Binding Domain of T1r2a/T1r3 from Medaka Fish2024
- Author(s)
  山下敦子、安井典久
- Journal Title
  
  SPring-8/SACLA Research Report
  
  Volume: 12 Issue: 5 Pages: 263-266
- DOI
  10.18957/rr.12.5.263
- ISSN
  2187-6886
- Year and Date
  2024-10-31
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27117
[Journal Article] Versatile chemical recognition by the ligand-binding domains of taste receptor type 1 addressed by structural biology and biophysics2024
- Author(s)
  山下敦子、石田光
- Journal Title
  
  The Japanese Journal of Taste and Smell Research
  
  Volume: 31 Issue: 1 Pages: 15-21
- DOI
  10.18965/tasteandsmell.31.1_15
- ISSN
  1340-4806, 2424-1326
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27117
[Journal Article] Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota2023
- Author(s)
  Jaunet-Lahary Titouan、Shimamura Tatsuro、Hayashi Masahiro、Nomura Norimichi、Hirasawa Kouta、Shimizu Tetsuya、Yamashita Masao、Tsutsumi Naotaka、Suehiro Yuta、Kojima Keiichi、Sudo Yuki、Tamura Takashi、Iwanari Hiroko、Hamakubo Takao、Iwata So、Okazaki Kei-ichi、Hirai Teruhisa、Yamashita Atsuko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1730-1730
- DOI
  10.1038/s41467-023-36883-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-20K21392, KAKENHI-PROJECT-20K21482, KAKENHI-PROJECT-18H02388, KAKENHI-PUBLICLY-21H00404, KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-22K20632, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H02414, KAKENHI-PROJECT-21H02446, KAKENHI-PROJECT-23K27415
[Journal Article] Investigating the Effect of Substituting a Single Cysteine Residue on the Thermal Stability of an Engineered Sweet Protein, Single-Chain Monellin2023
- Author(s)
  Ohnuma Kyosuke、Yamashita Atsuko、Yasui Norihisa
- Journal Title
  
  The Protein Journal
  
  Volume: 42 Issue: 6 Pages: 698-708
- DOI
  10.1007/s10930-023-10154-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-23K27117
[Journal Article] Direct binding of calmodulin to the cytosolic C-terminal regions of sweet/umami taste receptors2023
- Author(s)
  Yoshida Atsuki、Ito Ayumi、Yasui Norihisa、Yamashita Atsuko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 5 Pages: 451-459
- DOI
  10.1093/jb/mvad060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-23K27117
[Journal Article] Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors2023
- Author(s)
  Atsumi N, Yasumatsu K, Takashina Y, Ito C, Yasui N, Margolskee RF, Yamashita A
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.84291
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K02415, KAKENHI-PUBLICLY-21H05524, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-20H03855, KAKENHI-PROJECT-21K19084
[Journal Article] Development of Hidden Markov Modeling of Molecular Orientations and Structures from High-Speed Atomic Force Microscopy Time-Series Images2023
- Author(s)
  Tomonori Ogane, Daisuke Noshiro, Toshio Ando, Atsuko Yamashita, Yuji Sugita, Yasuhiro Matsunaga
- Journal Title
  
  PLoS Comp. Biol.
  
  Volume: 18 Issue: 12 Pages: e1010384-e1010384
- DOI
  10.1371/journal.pcbi.1010384
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05645, KAKENHI-PROJECT-22H00405, KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-20K21380
[Journal Article] 甘味受容体・うま味受容体を介した塩化物イオンの感知2023
- Author(s)
  山下敦子
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 81 Pages: 406-407
- Data Source
  KAKENHI-PROJECT-23K27117
[Journal Article] 放射光で視た甘味・うま味受容～味覚受容体T1rの構造解析～2023
- Author(s)
  山下敦子
- Journal Title
  
  SPring-8/SACLA利用者情報
  
  Volume: 28 Pages: 344-348
- Open Access
- Data Source
  KAKENHI-PROJECT-23K27117
[Journal Article] 食塩は甘味やうま味の受容体でも感知されている2023
- Author(s)
  山下敦子
- Journal Title
  
  明日の食品産業
  
  Volume: 539 Pages: 28-31
- Data Source
  KAKENHI-PROJECT-23K27117
[Journal Article] Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis2023
- Author(s)
  Okuda, K. et al.,
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 621-621
- DOI
  10.1038/s41467-023-36232-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19380, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-23K17374, KAKENHI-PROJECT-23K06482, KAKENHI-PROJECT-21K19084, KAKENHI-PROJECT-19H05640, KAKENHI-PUBLICLY-22H05568, KAKENHI-PROJECT-22H00356
[Journal Article] T1R2-mediated sweet sensing in a lizard2022
- Author(s)
  Liang Qiaoyi、Ko Meng-Ching、Ng Nathaniel S.R.、Reh Borja、Lee Jessica G.H.、Yamashita Atsuko、Nishihara Hidenori、Toda Yasuka、Baldwin Maude W.
- Journal Title
  
  Current Biology
  
  Volume: 32 Issue: 23 Pages: R1302-R1303
- DOI
  10.1016/j.cub.2022.10.061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0166, KAKENHI-PROJECT-22KK0079, KAKENHI-PROJECT-20H02941, KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-19H03272
[Journal Article] 受容体タンパク質を用いた味覚感知初反応の解析と応用2021
- Author(s)
  山下敦子, 芦川雄二, 南後恵理子, 安井典久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 79 Pages: 86-89
- NAID
  40022533057
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Journal Article] 味覚受容体の構造と働き2021
- Author(s)
  山下敦子
- Journal Title
  
  milsil
  
  Volume: 14 Pages: 6-8
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Journal Article] A sweet protein monellin as a non-antibody scaffold for synthetic binding proteins2021
- Author(s)
  Yasui N, Nakamura K, Yamashita A
- Journal Title
  
  J. Biochem.
  
  Volume: 169 Issue: 5 Pages: 585-599
- DOI
  10.1093/jb/mvaa147
- NAID
  120007182873
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04778, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-20H03195
[Journal Article] 受容体タンパク質を用いた味覚感知初反応の解析と応用2021
- Author(s)
  山下敦子, 芦川雄二, 南後恵理子, 安井典久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 79 Pages: 86-89
- NAID
  40022533057
- Data Source
  KAKENHI-PROJECT-20H03195
[Journal Article] 味覚受容体の構造と働き2021
- Author(s)
  山下敦子
- Journal Title
  
  milsil
  
  Volume: 14 Pages: 6-8
- Data Source
  KAKENHI-PROJECT-20H03195
[Journal Article] 味覚受容体の構造と働き2021
- Author(s)
  山下敦子
- Journal Title
  
  milsil
  
  Volume: 14 Pages: 6-8
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Journal Article] Current pivotal strategies leading a difficult target protein to a sample suitable for crystallographic analysis2020
- Author(s)
  Yamashita A
- Journal Title
  
  Biochem. Soc. Trans.
  
  Volume: 48 Issue: 4 Pages: 1661-1673
- DOI
  10.1042/bst20200106
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04778, KAKENHI-PROJECT-20H03195
[Journal Article] うま味受容体細胞外リガンド結合ドメインのX線結晶構造解析2019
- Author(s)
  細谷麻以子, 山下敦子
- Journal Title
  
  SPring-8/SACLA利用研究成果集
  
  Volume: 7
- NAID
  130007969583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03644
[Journal Article] 微生物TRPチャネルの機能と役割2019
- Author(s)
  魚住信之、山下敦子
- Journal Title
  
  医学のあゆみ
  
  Volume: 270 Pages: 970-976
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Journal Article] うま味受容体細胞外リガンド結合ドメインのX線結晶構造解析2019
- Author(s)
  細谷麻以子, 山下敦子
- Journal Title
  
  SPring-8/SACLA利用研究成果集
  
  Volume: 7
- NAID
  130007969583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19354
[Journal Article] 微生物TRPチャネルの機能と役割2019
- Author(s)
  魚住信之、山下敦子
- Journal Title
  
  医学のあゆみ
  
  Volume: 270 Pages: 970-976
- Data Source
  KAKENHI-PROJECT-17H03644
[Journal Article] うま味受容体細胞外リガンド結合ドメインのX線結晶構造解析2019
- Author(s)
  細谷麻以子, 山下敦子
- Journal Title
  
  SPring-8/SACLA利用研究成果集
  
  Volume: 7
- NAID
  130007969583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Journal Article] 食行動と栄養摂取をむすぶ味覚受容体による味分子認識2019
- Author(s)
  山下敦子
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 531-535
- Data Source
  KAKENHI-PROJECT-17H03644
[Journal Article] 食行動と栄養摂取をむすぶ味覚受容体による味分子認識2019
- Author(s)
  山下敦子
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 531-535
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Journal Article] Differential scanning fluorimetric analysis of the amino-acid binding to taste receptor using a model receptor protein, the ligand-binding domain of fish T1r2a/T1r32019
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Yuko Kusakabe, Chiaki Ito ,Miki Akamatsu, Atsuko Yamashita
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 10 Pages: e0218909-e0218909
- DOI
  10.1371/journal.pone.0218909
- NAID
  120006860091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K02192, KAKENHI-PUBLICLY-18H04621, KAKENHI-PROJECT-17H03644, KAKENHI-PROJECT-19H02841, KAKENHI-PROJECT-17K19354
[Journal Article] Specific modification at the C-terminal lysine residue of the green fluorescent protein variant, GFPuv, expressed in Escherichia coli2019
- Author(s)
  Takahiro Nakatani, Norihisa Yasui, Issei Tamura & Atsuko Yamashita
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4722-4722
- DOI
  10.1038/s41598-019-41309-8
- NAID
  120006777526
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04621, KAKENHI-PROJECT-17H03644, KAKENHI-PROJECT-15H05370
[Journal Article] 食行動と栄養摂取をむすぶ味覚受容体による味分子認識2019
- Author(s)
  山下敦子
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 31-535
- Data Source
  KAKENHI-PROJECT-17K19354
[Journal Article] Structure-Function Relationships of Olfactory and Taste Receptors2018
- Author(s)
  Behrens Maik、Briand Loic、de March Claire A、Matsunami Hiroaki、Yamashita Atsuko、Meyerhof Wolfgang、Weyand Simone
- Journal Title
  
  Chemical Senses
  
  Volume: 43 Issue: 2 Pages: 81-87
- DOI
  10.1093/chemse/bjx083
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19354, KAKENHI-PROJECT-17H03644
[Journal Article] Distinct human and mouse membrane trafficking systems for sweet taste 1 receptors T1r2 and T1r32014
- Author(s)
  Shimizu M, Goto M, Kawai T, Yamashita A, Kusakabe, Y
- Journal Title
  
  ＰＬＯＳＯＮＥ
  
  Volume: 9 Issue: 7 Pages: e100425-e100425
- DOI
  10.1371/journal.pone.0100425
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450194
[Presentation] Halogen ion-binding analysis of the ligand-binding domain of the taste receptor T1r1/T1r3 from pufferfish2025
- Author(s)
  Nagae Mana、Kuhara Yuri、Yamashita Atsuko
- Organizer
  The 21st International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21272
[Presentation] Halogen ion-binding site in fish taste receptor Tas1r32025
- Author(s)
  Yamashita Atsuko
- Organizer
  The 21st International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Halogen ion-binding analysis of the ligand-binding domain of the taste receptor T1r1/T1r3 from pufferfish2025
- Author(s)
  Nagae Mana、Kuhara Yuri、Yamashita Atsuko
- Organizer
  The 21st International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Structural basis of oxalate:formate antiport by a transporter in a gut bacterium: a physiological reaction at the 'inner outside' of the body2025
- Author(s)
  Yamashita Atsuko
- Organizer
  IPR International Conference 2025 in Awaji Island
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Halogen ion-binding site in fish taste receptor Tas1r32025
- Author(s)
  Yamashita Atsuko
- Organizer
  The 21st International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21272
[Presentation] Structural basis of diverse chemical recognition by type 1 taste receptors _ from organic compounds to ions2024
- Author(s)
  Yamashita Atsuko
- Organizer
  The International Symposium on Olfaction and Taste (ISOT2024)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] 構造生物学で探る味覚受容体T1rの多彩な味物質認識2024
- Author(s)
  山下敦子
- Organizer
  日本食品科学工学会第71回大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] メダカ Tas1r2a/Tas1r3 の L アミノ酸特異的認識における静電相互作用の影響について2024
- Author(s)
  山瀬裕子、山下敦子、武部克希、吉田竜介
- Organizer
  日本味と匂学会第58回大会
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] See the taste _ structures of taste receptors and their biological relevance2024
- Author(s)
  Yamashita Atsuko
- Organizer
  The 18th Conference of Asian Crystallographic Association (AsCA) 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K21272
[Presentation] Taste receptor type 1に見る構造と味物質認識機能の連関2024
- Author(s)
  山下敦子
- Organizer
  第７回感覚フロンティア研究シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-24K21272
[Presentation] フグ由来味覚受容体T1r1/T1r3 リガンド結合ドメインのハロゲンイオン結合解析2024
- Author(s)
  永江未奈、山下敦子
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Taste receptor type 1に見る構造と味物質認識機能の連関2024
- Author(s)
  山下敦子
- Organizer
  第７回感覚フロンティア研究シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] 特定のLDL受容体LAモジュールを選択的に認識する人工結合タンパク質の創製2024
- Author(s)
  中村祐介, 山下敦子, 安井典久
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] See the taste _ structures of taste receptors and their biological relevance2024
- Author(s)
  Yamashita Atsuko
- Organizer
  The 18th Conference of Asian Crystallographic Association (AsCA) 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Narrow taste receptor tuning to fructose in a vertebrate2024
- Author(s)
  Julia F. Cramer, Yasuka Toda, Atsuko Yamashita, Maude W. Baldwin
- Organizer
  The International Symposium on Olfaction and Taste (ISOT2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] フグ由来味覚受容体T1r1/T1r3 リガンド結合ドメインのハロゲンイオン結合解析2024
- Author(s)
  永江未奈、山下敦子
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24K21272
[Presentation] Different behavior of dissociation pathways of glutamine and glutamate in complex with Medaka Taste Receptor T1R2024
- Author(s)
  Duy Phuoc Tran, Vi Toan Lam, Hao Thai Nguyen, Atsuko Yamashita, Akio Kitao
- Organizer
  21st IUPAB Congress 2024 (IUPAB2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] ラット代謝型グルタミン酸受容体5の細胞外ドメインと甘味タンパク質の相互作用の解析2024
- Author(s)
  大谷　紗永、山下　敦子、安井　典久
- Organizer
  第63回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] 構造生物学で探る味覚受容体T1rの多彩な味物質認識2024
- Author(s)
  山下敦子
- Organizer
  日本食品科学工学会第71回大会
- Invited
- Data Source
  KAKENHI-PROJECT-24K21272
[Presentation] LDL受容体とそれを標的とする人工結合タンパク質の相互作用の構造基盤2023
- Author(s)
  安井　典久，中村　祐介，山下　敦子
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] Ligand-binding analysis of the ligand-binding domain of taste receptor T1r2a/T1r3 from medaka fish2023
- Author(s)
  Hikaru Ishida, Norihisa Yasui, Atsuko Yamashita
- Organizer
  The 20th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Chloride ion-binding to the extracellular ligand-binding domain of sweet/umami taste receptors evokes taste sensation2023
- Author(s)
  Atsuko Yamashita, Nanako Atsumi, Keiko Yasumatsu, Yuriko Takashina, Chiaki Ito, Norihisa Yasui, Robert F. Margolskee
- Organizer
  The 19th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Presentation] 受容体の構造から紐解く甘味・うま味2023
- Author(s)
  山下敦子
- Organizer
  日本農芸化学会中四国支部学会創立 100 周年記念第 37 回若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Chemical range recognized by the ligand-binding domain of medaka T1r2a/T1r32023
- Author(s)
  Hikaru Ishida, Yuri Kuhara, Atsuko Yamashita
- Organizer
  The 20th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] メダカ由来味覚受容体T1R2a/T1R3リガンド結合ドメインのアニオン結合特異性2023
- Author(s)
  久原侑莉,山下敦子
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] Chloride ion-binding to the extracellular ligand-binding domain of sweet/umami taste receptors evokes taste sensation2023
- Author(s)
  Atsuko Yamashita, Nanako Atsumi, Keiko Yasumatsu, Yuriko Takashina, Chiaki Ito, Norihisa Yasui, Robert F. Margolskee
- Organizer
  The 19th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] 甘味受容体・うま味受容体の構造生物学／逆構造生物学2023
- Author(s)
  山下敦子
- Organizer
  第９回 IPR Frontier Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] 甘味・うま味受容体に対する塩化物イオンの作用2023
- Author(s)
  山下敦子
- Organizer
  日本味と匂学会第５７回大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27117
[Presentation] システイン残基への変異導入がもたらす一本鎖モネリンの安定性変化2023
- Author(s)
  大沼　恭介, 山下　敦子, 安井　典久
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] メダカ由来味覚受容体T1r2a/T1r3リガンド結合領域に対する疎水性アミノ酸の作用解析および結合構造解析2022
- Author(s)
  新田　純矢, 安井　典久, 堤　尚孝, 山下　敦子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] LDL受容体リガンド結合領域を標的とする人工結合タンパク質の作製2022
- Author(s)
  安井　典久, 中村　祐介, 山下　敦子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] メダカ由来味覚受容体T1R2a/T1R3リガンド結合領域に対する疎_性アミノ酸の作_解析および結合構造解析2022
- Author(s)
  新田純矢、安井典久、堤尚孝、山下敦子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] メダカ由来味覚受容体T1R2a/T1R3リガンド結合領域に対する疎_性アミノ酸の作_解析および結合構造解析2022
- Author(s)
  新田純矢、安井典久、堤尚孝、山下敦子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Presentation] メダカ由来味覚受容体T1r2a/T1r3細胞外領域のリガンド結合解析2022
- Author(s)
  石田　光，安井　典久，山下　敦子
- Organizer
  日本味と匂学会第56回大会
- Data Source
  KAKENHI-PROJECT-21K19084
[Presentation] メダカ由来味覚受容体T1R2a/T1R3細胞外領域のリガンド結合解析2022
- Author(s)
  石田光，安井典久，山下敦子
- Organizer
  日本味と匂学会第56回大会
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] メダカ由来味覚受容体T1R2a/T1R3細胞外領域のリガンド結合解析2022
- Author(s)
  石田光，安井典久，山下敦子
- Organizer
  日本味と匂学会第56回大会
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Presentation] タイプ１型味覚受容体細胞外領域に対する１価カチオン結合の構造生物学・生物物理学的解析2021
- Author(s)
  山下敦子
- Organizer
  日本味と匂学会第55回大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] 受容体組換え発現タンパク質を用いたリガンド結合解析と味物質評価への可能性2021
- Author(s)
  山下敦子
- Organizer
  感覚研究コンソーシアム・第１回味覚ワーキンググループ
- Invited
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] メダカ受容体構造に見る味覚受容体の呈味分子認識2021
- Author(s)
  山下敦子
- Organizer
  第15 回食香粧研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] メダカ受容体構造に見る味覚受容体の呈味分子認識2021
- Author(s)
  山下敦子
- Organizer
  第15 回食香粧研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Presentation] メダカ由来味覚受容体T1R2a/3細胞外領域のリガンド非結合状態における立体構造解析2021
- Author(s)
  新田純矢、廣瀬未果、加藤貴之、山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] メダカ由来味覚受容体T1R2a/3細胞外領域のリガンド非結合状態における立体構造解析2021
- Author(s)
  新田純矢、廣瀬未果、加藤貴之、山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Presentation] フグ由来味覚受容体T1R1/T1R3リガンド結合領域の試料調製とリガンド結合解析2021
- Author(s)
  溝口楽人，吉田高志，細谷麻以子，伊藤千晶，芦川雄二，安井典久，山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] フグ由来味覚受容体T1R1/T1R3リガンド結合領域の試料調製とリガンド結合解析2021
- Author(s)
  溝口楽人，吉田高志，細谷麻以子，伊藤千晶，芦川雄二，安井典久，山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] タイプ１型味覚受容体細胞外領域に対する１価カチオン結合の構造生物学・生物物理学的解析2021
- Author(s)
  山下敦子
- Organizer
  日本味と匂学会第55回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] メダカ受容体構造に見る味覚受容体の呈味分子認識2021
- Author(s)
  山下敦子
- Organizer
  第15 回食香粧研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] フグ由来味覚受容体T1R1/T1R3リガンド結合領域の試料調製とリガンド結合解析2021
- Author(s)
  溝口楽人，吉田高志，細谷麻以子，伊藤千晶，芦川雄二，安井典久，山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H05524
[Presentation] 受容体組換え発現タンパク質を用いたリガンド結合解析と味物質評価への可能性2021
- Author(s)
  山下敦子
- Organizer
  感覚研究コンソーシアム・第１回味覚ワーキンググループ
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] メダカ由来味覚受容体T1R2a/3細胞外領域のリガンド非結合状態における立体構造解析2021
- Author(s)
  新田純矢、廣瀬未果、加藤貴之、山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] Structural and biophysical analysis of ion-binding to the extracellular ligand-binding domains of a fish taste receptor T1r2a/T1r32020
- Author(s)
  Atsuko Yamashita, Chiaki Ito, Yuriko Takashina, Nanako Atsumi, Norihisa Yasui
- Organizer
  International symposium on olfaction and taste (ISOT2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] 味覚受容体リガンド結合ドメイン－細胞外イオン相互作用の構造基盤2020
- Author(s)
  山下敦子
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] Structural and biophysical analysis of ion-binding to the extracellular ligand-binding domains of a fish taste receptor T1r2a/T1r32020
- Author(s)
  Atsuko Yamashita, Chiaki Ito, Yuriko Takashina, Nanako Atsumi, Norihisa Yasui
- Organizer
  International symposium on olfaction and taste (ISOT2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04778
[Presentation] 味覚受容体リガンド結合ドメイン－細胞外イオン相互作用の構造基盤2020
- Author(s)
  山下敦子
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03195
[Presentation] T1r1-T1r3味覚受容体味物質認識領域の構造生物学的解析2019
- Author(s)
  吉田高志、安井典久、伊藤千晶、山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第5回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 新規な非抗体分子骨格に基づく人工結合タンパク質のファージディスプレイライブラリーの作製2019
- Author(s)
  安井典久，山下敦子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 様々な組換え発現条件下でのGFPuv C末端Lys残基の翻訳後修飾2019
- Author(s)
  田村一晟，安井典久，守屋央朗，山下敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Structural basis of amino acid-perception by T1r taste receptors2019
- Author(s)
  Atsuko Yamashita
- Organizer
  The 9th Federation of Asian and Oceanian Physiological Societies Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 味覚受容体T1R2/T1R3リガンド結合領域カチオン結合部位の構造生物学的解析2019
- Author(s)
  伊藤千晶、安井典久、渥美菜奈子、山下敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 新規な非抗体分子骨格に基づく人工結合タンパク質のファージディスプレイライブラリーの作製2019
- Author(s)
  安井典久，山下敦子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Amino acid-binding characteristics of the ligand-binding domains of taste receptors analyzed by thermal shift assay2019
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Atsuko Yamashita
- Organizer
  The 1st International Symposium on Chemical Communication (ISCC2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 味覚受容体T1rへの1価カチオン結合の構造生物学的解析2019
- Author(s)
  伊藤千晶、高科百合子、安井典久、山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第6回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 食品成分と生体のインターフェース・味覚受容体による味物質認識の構造基盤2019
- Author(s)
  山下敦子
- Organizer
  日本生化学会北陸支部第37回大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 食品成分と生体のインターフェース・味覚受容体による味物質認識の構造基盤2019
- Author(s)
  山下敦子
- Organizer
  日本生化学会北陸支部第37回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 味覚受容体T1R2/T1R3の甘味物質応答に対する亜鉛イオンの作用2019
- Author(s)
  喜多志保子, 日下部裕子, 山下敦子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] T1r1-T1r3味覚受容体味物質認識領域の構造生物学的解析2019
- Author(s)
  吉田高志、安井典久、伊藤千晶、山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第5回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] T1r1-T1r3味覚受容体味物質認識領域の構造生物学的解析2019
- Author(s)
  吉田高志、安井典久、伊藤千晶、山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第5回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 一本鎖モネリンを非抗体分子骨格とするGFP結合タンパク質の作製と分子特性解析2019
- Author(s)
  安井典久，山下敦子
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 一本鎖モネリンを非抗体分子骨格とするGFP結合タンパク質の作製と分子特性解析2019
- Author(s)
  安井典久，山下敦子
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味覚受容体T1R2/T1R3の甘味物質応答に対する亜鉛イオンの作用2019
- Author(s)
  喜多志保子, 日下部裕子, 山下敦子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] Amino acid-binding characteristics of the ligand-binding domains of taste receptors analyzed by thermal shift assay2019
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Atsuko Yamashita
- Organizer
  The 1st International Symposium on Chemical Communication (ISCC2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味覚受容体T1R2/T1R3リガンド結合領域カチオン結合部位の構造生物学的解析2019
- Author(s)
  伊藤千晶、安井典久、渥美菜奈子、山下敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] Structural basis of amino acid-perception by T1r taste receptors2019
- Author(s)
  Atsuko Yamashita
- Organizer
  The 9th Federation of Asian and Oceanian Physiological Societies Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] A fish taste receptor opened the way for structural biology of taste perception2019
- Author(s)
  Atsuko Yamashita
- Organizer
  The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] Amino acid-binding characteristics of the ligand-binding domains of taste receptors analyzed by thermal shift assay2019
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Atsuko Yamashita
- Organizer
  The 1st International Symposium on Chemical Communication (ISCC2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 味覚受容体T1rへの1価カチオン結合の構造生物学的解析2019
- Author(s)
  伊藤千晶、高科百合子、安井典久、山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第6回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 味覚受容体T1R2/T1R3の甘味物質応答に対する亜鉛イオンの作用2019
- Author(s)
  喜多志保子, 日下部裕子, 山下敦子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味覚受容体T1R2/T1R3リガンド結合領域カチオン結合部位の構造生物学的解析2019
- Author(s)
  伊藤千晶、安井典久、渥美菜奈子、山下敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 味覚受容体T1rへの1価カチオン結合の構造生物学的解析2019
- Author(s)
  伊藤千晶、高科百合子、安井典久、山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第6回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] Structural basis of amino acid-perception by T1r taste receptors2019
- Author(s)
  Atsuko Yamashita
- Organizer
  The 9th Federation of Asian and Oceanian Physiological Societies Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] A fish taste receptor opened the way for structural biology of taste perception2019
- Author(s)
  Atsuko Yamashita
- Organizer
  The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] A fish taste receptor opened the way for structural biology of taste perception2019
- Author(s)
  Atsuko Yamashita
- Organizer
  The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 食品成分と生体のインターフェース・味覚受容体による味物質認識の構造基盤2019
- Author(s)
  山下敦子
- Organizer
  日本生化学会北陸支部第37回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 様々な組換え発現条件下でのGFPuv C末端Lys残基の翻訳後修飾2019
- Author(s)
  田村一晟，安井典久，守屋央朗，山下敦子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 表面プラズモン共鳴法による味覚受容体T1R細胞内C末端領域とカルシウム結合タンパク質の相互作用の速度論的解析2018
- Author(s)
  吉田涼希, 安井典久, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] Structural basis for recognition of preferable taste substances by T1r taste receptors2018
- Author(s)
  Atsuko Yamashita
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 一本鎖モネリンを分子骨格とする人工結合タンパク質ファージディスプレイライブラリーの構築2018
- Author(s)
  安井典久，山下敦子
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 分子骨格として一本鎖モネリンを用いたGFPを標的とする人工結合タンパク質の作製とその分子特性解析2018
- Author(s)
  安井典久, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味覚受容体による味物質応答の相関構造解析2018
- Author(s)
  山下敦子
- Organizer
  平成30年度第1回構造生物学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] サーマルシフトアッセイによる味覚受容体細胞外領域に対するアミノ酸の結合解析2018
- Author(s)
  吉田高志, 安井典久, 渥美菜奈子, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Protein thermal shift assay indicated a broad amino acid-binding capability of the ligand-binding domains of fish T1r taste receptor2018
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Nanako Atsumi, Yuko Kusakabe, Atsuko Yamashita
- Organizer
  The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 一本鎖モネリンを分子骨格とする人工結合タンパク質ファージディスプレイライブラリーの構築2018
- Author(s)
  安井典久，山下敦子
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 体外からの栄養素を感知する味覚受容体の構造基盤2018
- Author(s)
  山下敦子
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味物質-味覚受容体の構造生物学研究による化学コミュニケーションの理解2018
- Author(s)
  山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第3回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] Structural basis for recognition of preferable taste substances by T1r taste receptors2018
- Author(s)
  Atsuko Yamashita
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 表面プラズモン共鳴法による味覚受容体T1R細胞内C末端領域とカルシウム結合タンパク質の相互作用の速度論的解析2018
- Author(s)
  吉田涼希, 安井典久, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] Taste perception approached by biophysics and structural biology2018
- Author(s)
  Atsuko Yamashita
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] サーマルシフトアッセイによる味覚受容体細胞外領域に対するアミノ酸の結合解析2018
- Author(s)
  吉田高志, 安井典久, 渥美菜奈子, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] Protein thermal shift assay indicated a broad amino acid-binding capability of the ligand-binding domains of fish T1r taste receptor2018
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Nanako Atsumi, Yuko Kusakabe, Atsuko Yamashita
- Organizer
  The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 味覚受容体による味物質応答の相関構造解析2018
- Author(s)
  山下敦子
- Organizer
  平成30年度第1回構造生物学研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] サーマルシフトアッセイによる味覚受容体細胞外領域に対するアミノ酸の結合解析2018
- Author(s)
  吉田高志, 安井典久, 渥美菜奈子, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 味物質-味覚受容体の構造生物学研究による化学コミュニケーションの理解2018
- Author(s)
  山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味物質-味覚受容体の構造生物学研究による化学コミュニケーションの理解2018
- Author(s)
  山下敦子
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第3回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] Structural basis for recognition of preferable taste substances by T1r taste receptors2018
- Author(s)
  Atsuko Yamashita
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 表面プラズモン共鳴法による味覚受容体T1R細胞内C末端領域とカルシウム結合タンパク質の相互作用の速度論的解析2018
- Author(s)
  吉田涼希, 安井典久, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Taste perception approached by biophysics and structural biology2018
- Author(s)
  Atsuko Yamashita
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Protein thermal shift assay indicated a broad amino acid-binding capability of the ligand-binding domains of fish T1r taste receptor2018
- Author(s)
  Takashi Yoshida, Norihisa Yasui, Nanako Atsumi, Yuko Kusakabe, Atsuko Yamashita
- Organizer
  The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] 分子骨格として一本鎖モネリンを用いたGFPを標的とする人工結合タンパク質の作製とその分子特性解析2018
- Author(s)
  安井典久, 山下敦子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] 味覚受容体による味物質応答の相関構造解析2018
- Author(s)
  山下敦子
- Organizer
  平成30年度第1回構造生物学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19354
[Presentation] Taste perception approached by biophysics and structural biology2018
- Author(s)
  Atsuko Yamashita
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04621
[Presentation] X線結晶構造解析によるメダカT1r2a/T1r3細胞外領域への無機金属イオン結合解析2017
- Author(s)
  渥美菜奈子、安井典久、山下敦子
- Organizer
  日本味と匂学会第51回大会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味覚受容細胞で起こる味覚の初反応への構造生物学的アプローチ：味覚受容体細胞外領域の構造解析2017
- Author(s)
  山下敦子
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Crystal structures of the ligand-binding domains of taste receptor T1r heterodimer2017
- Author(s)
  Nipawan Nuemket, Norihisa Yasui, Yuko Kusakabe, Yukiyo Nomura, Nanako Atsumi & Atsuko Yamashita
- Organizer
  The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Expression, purification, and characterization of the entire heterodimeric extracellular regions of fish taste receptor2017
- Author(s)
  Hiroki Maruhashi, Daisuke Noshiro, Norihisa Yasui, Toshio Ando, Atsuko Yamashita
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 多様な化学シグナルを感知する味覚受容体味物質認識領域の構造と機能2017
- Author(s)
  山下敦子
- Organizer
  第５９回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] 味覚受容体細胞外領域による味物質認識の構造基盤2017
- Author(s)
  山下敦子
- Organizer
  大阪大学蛋白質研究所セミナー・SPring-8先端利用技術ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17H03644
[Presentation] Role of the C-terminal region of T1r3 in the membrane trafficking of taste receptor T1r2/T1r32016
- Author(s)
  日下部裕子、岡野正代、進藤由美子、山下敦子、河合崇行
- Organizer
  17th International Symposium on Olfaction and Taste
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450194
[Presentation] GFP融合技術を活用したタンパク質結晶構造解析のための発現コンストラクト設計2009
- Author(s)
  伊原誠、山下敦子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-19687006
[Presentation] GFP融合技術を活用したタンパク質結晶構造解析のための発現コンストラクト設計2009
- Author(s)
  伊原誠、山下敦子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  マリンメッセ福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19687006
[]

1. Kusakabe Yuko (90353937)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. MATSUDA Kazuhiko (00199796)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HIRATAKE Jun (80199075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OZOE Yoshihisa (80112118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKAJIMA Toshihide (10247968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATO Hiroaki (90204487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMATSU Toru (50293949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ABE Keiko (10151094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. IMAI Hiroo (60314176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. EBIHARA Mitsuru (80232974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUI Kenji (90199729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IHARA Makoto (30466031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Yasui Norihisa (90467514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
14. 松本崇 (80333350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 市山進 (00333336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 清中茂樹 (90422980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 北尾彰朗 (30252422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 堤尚孝 (70963495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YASUMATSU Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. YU Isseki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 杉田有治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 戸田安香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Atsuko 山下 敦子

YAMASHITA Atsuko 山下 敦子

Research Projects

Research Products

Co-Researchers

Structural analysis of the recognition mechanism of diverse chemicals by taste receptorsPrincipal Investigator

Principal Investigator

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Analysis of molecular functions and physiological roles of halogen-ion sensing by T1r taste receptorsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Analysis of physiological reactions caused by weak interactions between taste receptors and materialsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Reconstitution of artificial private chaperone systems and their application to the production of difficult-to-express proteins

Principal Investigator

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Review Section

Research Institution

Structural biology of perception mechanisms of chemical signals by taste receptor type 1Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Reverse structural biology of conformational dynamics and signal transduction mechanisms of taste receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of chemical communications through molecular interaction between T1r taste receptors and taste substancesPrincipal Investigator

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Involvement of taste receptor in oogenesis and early developmentPrincipal Investigator

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Structural and dynamical basis of taste receptor signaling mechanismPrincipal Investigator

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Structural, functional, and evolutionary properties of sweet taste receptors

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Elucidation of molecular mechanism of pyrethrin biosynthesis by a GDSL lipase and its application to creation of insect resistant plants

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Molecular mechanism of persisting activation of glutamate-gated chloride channels by macrolide compounds

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Crystallographic analyses of functional mechanisms of sensory receptorsPrincipal Investigator

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Yamashita Atsuko 山下敦子

YAMASHITA Atsuko 山下敦子