Hisatsune chihiro 久恒智博

… Alternative Names

HISATSUNE Chihiro 久恒智博

久恒智博ヒサツネチヒロ

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Researcher Number	10321803
Other IDs	https://orcid.org/0000-0001-7811-7784
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主席研究員 2021 – 2023: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 主席研究員 2020: 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 2019: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 2015 – 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 … More 2013 – 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2012: 独立行政法人理化学研究所, 発生神経生物研究チーム, 研究員 2008 – 2010: The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 研究員 2006: 東京大学, 医科学研究所, 助手 2005: 理研, 研究員 2003: 独立行政法人理化学研究所, 発生神経生物研究チーム, 研究員 2002: 理化学研究所, 発生神経生物研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology / Neuroscience in general / Neurophysiology and muscle physiology / General physiology Except Principal Investigator Otorhinolaryngology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator カルシウム / calcium / カルパイン / 骨格筋 / 筋ジストロフィー / 神経形態 / スパイン / neuron / dendritic spine / human iPS cells … More / 樹状突起スパイン / 細胞内カルシウム / TSC / 結節性硬化症 / てんかん / IP3 / Calcium / cerebellum / 小胞体 / 酸化還元 / Brain / Ca^<2+> signal / knockout mice / Inositol trisphosphate receptor / IP3 receptor / 運動 / 脳 / イノシトール3リン酸 / mice / knockout / conditional / dystonia / brain / IP_3R / signaling / taste / inositol / Src family kinase / Tyrosine phosphorylation / EGF receptor / single channel recording / tyrosine phosphorylation / Src family tyrosine kinase / TRPC channel … More Except Principal Investigator 血管条 / 蝸牛 / TRPチャンネル / 聴性脳幹反応 / 血管条辺縁細胞 / 内有毛細胞 / 内耳発生 / TRPM4 / IP3受容体 / カルシウム / miRNA / マイクロRNA Less

筋細胞でのカルパイン３の活性化機序の解明Principal Investigator
- Principal Investigator
  
  久恒智博
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Calpain３変異による肢帯型筋ジストロフィーの発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  久恒智博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of novel drugs for tuberous sclerosis complexPrincipal Investigator
- Principal Investigator
  
  HISATSUNE Chihiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Analysis of the relationship between abnormal organella and spinocerebellar ataxia 15Principal Investigator
- Principal Investigator
  
  Hisatsune Chihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Institute of Physical and Chemical Research
Analysis of the functional roles of TRPM4 in the mammalian cochlea
- Principal Investigator
  
  Murata Junko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Osaka University
  Juntendo University
Redox-dependent regulation of an endoplasmic reticulum resident protein in neural functionPrincipal Investigator
- Principal Investigator
  
  HISATSUNE Chihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research
Regulation of neuronal development by microRNAs
- Principal Investigator
  
  ANDO Hideaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of the role of IP_3 receptor in higher brain functionPrincipal Investigator
- Principal Investigator
  
  HISATSUNE Chihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
イノシトール3リン酸受容体の味覚シグナルにおける役割の解明Principal Investigator
- Principal Investigator
  
  久恒智博
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  The University of Tokyo
  The Institute of Physical and Chemical Research
TRP channelの活性制御機構の解明Principal Investigator
- Principal Investigator
  
  久恒智博
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Handbook of Neurochemistry and Molecular Neurobiology(Chapter25 : Signal molecules and Calcium : IP_3 receptor and Ca^<2+> signaling)2009
- Author(s)
  Chihiro Hisatsune, Katsuhiko Mikoshiba
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] 肢体型筋ジストロフィーR1/2Aと治療薬開発について2023
- Author(s)
  久恒智博　小野弥子
- Journal Title
  
  難病と在宅ケア
  
  Volume: vol.28 no10 Pages: 14-18
- Data Source
  KAKENHI-PROJECT-22K07014
[Journal Article] Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca 2+ Influx via L-Type Ca 2+ Channels2021
- Author(s)
  Hisatsune C, Shimada T, Miyamoto A, Lee A, Yamagata K
- Journal Title
  
  J Neurosci
  
  Volume: 41 Issue: 39 Pages: 8134-8149
- DOI
  10.1523/jneurosci.1930-20.2021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02536, KAKENHI-PROJECT-19K08334
[Journal Article] IP(3) receptor mutations and brain diseases in human and rodents2017
- Author(s)
  Hisatsune C, Mikoshiba K.
- Journal Title
  
  J Neurochem.
  
  Volume: 印刷中 Issue: 6 Pages: 790-807
- DOI
  10.1111/jnc.13991
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06761, KAKENHI-PROJECT-25221002
[Journal Article] Astrocytic IP3Rs: Contribution to Ca2+ signalling and hippocampal LTP2017
- Author(s)
  Sherwood MW, Arizono M, Hisatsune C, Bannai H, Ebisui E, Sherwood JL, Panatier A, Oliet SH, Mikoshiba K
- Journal Title
  
  Glia
  
  Volume: 65 Issue: 3 Pages: 502-513
- DOI
  10.1002/glia.23107
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25250002, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-16K07316, KAKENHI-PROJECT-15K06761
[Journal Article] Regulation of spinogenesis in mature Purkinje cells via mGluR/PKC-mediated phosphorylation of CaMKIIβ2017
- Author(s)
  Sugawara Takeyuki、Hisatsune Chihiro、Miyamoto Hiroyuki、Ogawa Naoko、Mikoshiba Katsuhiko
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 114 Issue: 26
- DOI
  10.1073/pnas.1617270114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-15K06761, KAKENHI-PROJECT-15K09848
[Journal Article] A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns2017
- Author(s)
  Casey Jillian P.、Hirouchi Taisei、Hisatsune Chihiro、Lynch Bryan、Murphy Raymond、Dunne Aimee M.、Miyamoto Akitoshi、Ennis Sean、van der Spek Nick、O’Hici Bronagh、Mikoshiba Katsuhiko、Lynch Sally Ann
- Journal Title
  
  Journal of Neurology
  
  Volume: 264 Issue: 7 Pages: 1444-1453
- DOI
  10.1007/s00415-017-8545-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-15K06761
[Journal Article] Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice.2016
- Author(s)
  Staats KA, Humblet-Baron S, Bento-Abreu A, Scheveneels W, Nikolaou A, Deckers K, Lemmens R, Goris A, Van Ginderachter JA, Van Damme P, Hisatsune C, Mikoshiba K, Liston A, Robberecht W, Van Den Bosch L.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 5(16) Issue: 16 Pages: 3491-3499
- DOI
  10.1093/hmg/ddw190
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-15K06761
[Journal Article] IRBIT is novel determinant of catecholamine homeostasis through the TH phosphorylation by CaMKIIα2015
- Author(s)
  Katsuhiro Kawaai, Akihiro Mizutani, Hirotaka Shoji, Naoko Ogawa, Etsuko Ebisui, Yukiko Kuroda, Shigeharu Wakana, Tsuyoshi Miyakawa, Chihiro Hisatsune, Katsuhiko Mikoshiba
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 未定 Issue: 17 Pages: 5515-5520
- DOI
  10.1073/pnas.1503310112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-24590332, KAKENHI-PROJECT-15K06761, KAKENHI-PUBLICLY-15H01297, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-26250024, KAKENHI-PROJECT-25242078
[Journal Article] ERp44 exerts redox-dependent control of blood pressure at the ER2015
- Author(s)
  Chihiro Hisatsune, Etsuko Ebisui, Masaya Usui, Naoko Ogawa, Akio Suzuki, Nobuko Mataga, Hiromi Takahashi-Iwanaga, and Katsuhiko Mikoshiba
- Journal Title
  
  Molecular Cell
  
  Volume: 未定 Issue: 6 Pages: 1015-27
- DOI
  10.1016/j.molcel.2015.04.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-15K06761, KAKENHI-PROJECT-25221002
[Journal Article] Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.2014
- Author(s)
  Klar J, Hisatsune C, Baig SM, Tariq M, Johansson AC, Rasool M, Malik NA, Ameur A, Sugiura K, Feuk L, Mikoshiba K, Dahl N.
- Journal Title
  
  J Clin Invest.
  
  Volume: 124 Issue: 11 Pages: 4773-80
- DOI
  10.1172/jci70720
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-25221002
[Journal Article] Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.2014
- Author(s)
  Hamada K, Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Hisatsune C, Nakamura T, Mikoshiba K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 38 Pages: 3966-3975
- DOI
  10.1073/pnas.1409730111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-26430048
[Journal Article] Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.2014
- Author(s)
  Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Ebisui E, Ogawa N, Matsui M, Takeuchi T, Mikoshiba K, Tsubota K.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 6 Pages: e99205-e99205
- DOI
  10.1371/journal.pone.0099205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-26462668
[Journal Article] Striatum-specific expression of Cre recombinase using the Gpr88 promoter in mice.2013
- Author(s)
  Hisatsune C, Ogawa N, Mikoshiba K.
- Journal Title
  
  Transgenic Res.
  
  Volume: 22 Issue: 6 Pages: 1241-7
- DOI
  10.1007/s11248-013-9711-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-25221002
[Journal Article] IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice.2013
- Author(s)
  Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui E, Ohshima T, Yamada M, Hensch TK, Hattori M, Mikoshiba K.
- Journal Title
  
  Front Neural Circuits.
  
  Volume: ７ Pages: 156-156
- DOI
  10.3389/fncir.2013.00156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-24621012, KAKENHI-PROJECT-25221002
[Journal Article] Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice.2013
- Author(s)
  Sugawara T, Hisatsune C, Le TD, Hashikawa T, Hirono M, Hattori M, Nagao S, Mikoshiba K.
- Journal Title
  
  J Neurosci.
  
  Volume: 33 Issue: 30 Pages: 12186-96
- DOI
  10.1523/jneurosci.0545-13.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-25221002
[Journal Article] Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy2012
- Author(s)
  Drawnel FM
- Journal Title
  
  J Cell Biology
  
  Volume: 199(5) Issue: 5 Pages: 783-98
- DOI
  10.1083/jcb.201111095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-24500451
[Journal Article] Cot Kinase Promotes Ca2+ Oscillation/Calcineurin-independent Osteoclastogenesis by Stabilizing NFATc1 Protein2012
- Author(s)
  Kuroda Y
- Journal Title
  
  Mol Cell Biology
  
  Volume: 32(14) Issue: 14 Pages: 2954-63
- DOI
  10.1128/mcb.05611-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-23790265, KAKENHI-PROJECT-24500451, KAKENHI-PROJECT-24590332
[Journal Article] Striatum-specific expression of Cre recombinase using the Gpr88 promoter in mice2012
- Author(s)
  Chihiro Hisatsune, Naoko Ogawa, and Katsuhiko Mikoshiba
- Journal Title
  
  Transgenic Research
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500451
[Journal Article] Regulation of hair shedding by the type 3 IP3 receptor2012
- Author(s)
  Sato-Miyaoka M
- Journal Title
  
  J Investigative Dermatology
  
  Volume: 132(9) Issue: 9 Pages: 2137-47
- DOI
  10.1038/jid.2012.141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-24500451
[Journal Article] Neuronal overexpression of IP3 receptor 2 is detrimental in mutant SOD1 mice2012
- Author(s)
  Staats KA
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 429(3-4) Issue: 3-4 Pages: 210-213
- DOI
  10.1016/j.bbrc.2012.10.094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-24500451
[Journal Article] Isolation of inositol 1,4,5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference.2010
- Author(s)
  Mizutani A, Kawaai K, Hisatsune C, Ando H, Michikawa T, Mikoshiba K
- Journal Title
  
  Methods Mol Biol. 645
  
  Pages: 133-41
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] Mechanism of ER stress-induced brain damage by IP(3) receptor.2010
- Author(s)
  Higo T, Hamada K, Hisatsune C, Nukina N, Hashikawa T, Hattori M, Nakamura T, Mikoshiba K.
- Journal Title
  
  Neuron
  
  Volume: 68 Pages: 865-878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] Mechanism of ER stress-induced brain damage by IP_3 receptor.2010
- Author(s)
  Higo T, Hamada K, Hisatsune C, Nukina N, Hashikawa T, Hattori M, Nakamura T, Mikoshiba K
- Journal Title
  
  Neuron. 68(5)
  
  Pages: 865-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by inositol 1,4,5-triphosphate receptor-mediated Ca^<2+> signal regulation.2009
- Author(s)
  Zhang S, Hisatsune C, Matsu-Ura T, Mikoshiba K
- Journal Title
  
  J Biol Chem. 284(42)
  
  Pages: 29158-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] 80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity.2009
- Author(s)
  Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 372-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] 80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity2009
- Author(s)
  Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K.
- Journal Title
  
  Journal of Biological Chemistry 284
  
  Pages: 372-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] IP_3 receptor and Ca^<2+> signaling2009
- Author(s)
  Hisatsune C, et al.
- Journal Title
  
  Handbook of Neurochemistry and Molecular Neurobiology (3^<rd> Edition)
  
  Pages: 566-575
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] Osteoblasts induce Ca^<2+> oscillation-independent NFATc1 activation during osteoclastogenesis.2008
- Author(s)
  Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K
- Journal Title
  
  Proc Natl Acad Sci U S A. 105(25)
  
  Pages: 8643-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis.2008
- Author(s)
  Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K.
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 8643-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] Predominant role of type 1 IP_3 receptor in aortic vascular muscle contraction.2008
- Author(s)
  Zhou H, Nakamura T, Matsumoto N, Hisatsune C, Mizutani A, Iesaki T, Daida H, Mikoshiba K
- Journal Title
  
  Biochem Biophys Res Commun. 369(1)
  
  Pages: 213-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] The role of Ca2+ signaling in cell function with special reference to exocrine secretion2008
- Author(s)
  Mikoshiba K, Hisatsune C, Futatsugi A, Mizutani A, Nakamura T, Miyachi K.
- Journal Title
  
  Cornea Suppl 1
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] The role of Ca^<2+> signaling in cell function with special reference to exocrine secretion.2008
- Author(s)
  Mikoshiba K, Hisatsune C, Futatsugi A, Mizutani A, Nakamura T, Miyachi K
- Journal Title
  
  Cornea. 27 Suppl 1(Review)
- Data Source
  KAKENHI-PROJECT-20500301
[Journal Article] Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production.2006
- Author(s)
  Hisatsune C, Kuroda Y, Akagi T, Torashima T, Hirai H, Hashikawa T, Inoue T, Mikoshiba K
- Journal Title
  
  Journal of Neuroscience 26
  
  Pages: 10916-10924
- Data Source
  KAKENHI-PROJECT-17700373
[Presentation] TSC inactivation increases neuronal network activity by enhancing Ca2+ influx via L-type Ca2+ channels2022
- Author(s)
  Chihiro Hisatsune, Tadayuki Shimada, Akitoshi Miyamoto, Amy Lee, Kanato Yamagata
- Organizer
  第４５回　日本神経科学学会　Neuro 2022
- Data Source
  KAKENHI-PROJECT-22K07014
[Presentation] TSC inactivation increases neuronal network activity by enhancing Ca2+ influx via L-type Ca2+ channels2022
- Author(s)
  Chihiro Hisatsune, Tadayuki Shimada, Akitoshi Miyamoto, Amy Lee, and Kanato Yamagata
- Organizer
  第45回　日本神経科学学会 Neuro2022
- Data Source
  KAKENHI-PROJECT-19K08334
[Presentation] TSC欠損型ヒト神経細胞はmTOR依存的にL-typeカルシウムチャネルのカルシウム流入増加を引き起こす2021
- Author(s)
  久恒智博、島田忠之、宮本章歳、Amy Lee, 山形要人
- Organizer
  第44回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08334
[Presentation] TSC2欠損型ヒト神経細胞における細胞内カルシウム動態の解析2020
- Author(s)
  久恒智博、島田忠之、宮本章歳、山形要人
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K08334
[Presentation] TSC2欠損型ヒトiPS細胞由来の神経細胞にみられる神経ネットワーク異常2019
- Author(s)
  久恒智博、島田忠之、宮本章歳、山形要人
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K08334
[Presentation] mGluR/PKCシグナルによるCaMKIIβのリン酸化は成熟小脳プルキンエ細胞の樹状突起スパインの形成を制御する2017
- Author(s)
  菅原健之、久恒智博、宮本浩行、小川直子、御子柴克彦
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K06761
[Presentation] 脊髄小脳変性症２９型家系より新たに発見したIP3R1ミスセンス変異によるCa2+シグナルの変化2017
- Author(s)
  廣内大成、Casey Jillian P. 、久恒智博、宮本章歳、御子柴克彦
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K06761
[Presentation] 小胞体内腔タンパク質ERp44による酸化還元依存的な分泌制御2016
- Author(s)
  久恒智博
- Organizer
  解剖学会・生理学会合同シンポジウム
- Place of Presentation
  ビッグパレットふくしま　(福島県郡山市)
- Year and Date
  2016-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K06761
[Presentation] 小胞体内腔タンパク質ERp44による血圧制御2016
- Author(s)
  久恒智博
- Organizer
  Molecular Cardiovascular conference II
- Place of Presentation
  東京ドームホテル（東京都文京区）
- Year and Date
  2016-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K06761

1. ANDO Hideaki (50373262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SUGAWARA Takeyuki (70584522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FURUTA Toshiaki (90231571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Murata Junko (80332740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Okada Hiroko (20433774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 坂内博子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山形要人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 御子柴克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Hisatsune chihiro 久恒 智博

HISATSUNE Chihiro 久恒 智博

久恒 智博 ヒサツネ チヒロ

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筋細胞でのカルパイン３の活性化機序の解明Principal Investigator

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Calpain３変異による肢帯型筋ジストロフィーの発症メカニズムの解明Principal Investigator

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Development of novel drugs for tuberous sclerosis complexPrincipal Investigator

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Analysis of the relationship between abnormal organella and spinocerebellar ataxia 15Principal Investigator

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Analysis of the functional roles of TRPM4 in the mammalian cochlea

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Redox-dependent regulation of an endoplasmic reticulum resident protein in neural functionPrincipal Investigator

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Regulation of neuronal development by microRNAs

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Analysis of the role of IP_3 receptor in higher brain functionPrincipal Investigator

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イノシトール3リン酸受容体の味覚シグナルにおける役割の解明Principal Investigator

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TRP channelの活性制御機構の解明Principal Investigator

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[Book] Handbook of Neurochemistry and Molecular Neurobiology(Chapter25 : Signal molecules and Calcium : IP_3 receptor and Ca^<2+> signaling)2009

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[Journal Article] 肢体型筋ジストロフィーR1/2Aと治療薬開発について2023

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[Journal Article] Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca 2+ Influx via L-Type Ca 2+ Channels2021

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[Journal Article] IP(3) receptor mutations and brain diseases in human and rodents2017

Author(s)

Hisatsune chihiro 久恒智博

HISATSUNE Chihiro 久恒智博

久恒智博ヒサツネチヒロ