Petr Gruz ＰｅｔｒＧｒｕｚ

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GRUZ Petr グルーズピーター

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Researcher Number	10321853
Other IDs	https://orcid.org/0000-0003-4627-6611
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, ゲノム安全科学部, 主任研究官
Affiliation (based on the past Project Information) *help	2013: 国立医薬品食品衛生研究所, 変異遺伝部, 主任研究官
Review Section/Research Field	Except Principal Investigator Risk sciences of radiation/Chemicals
Keywords	Except Principal Investigator DNA損傷 / 突然変異 / DNAポリメラーゼζ / トランスリージョンDNA合成 / 遺伝毒性発がん物質 / 閾値

Studies on mechanisms underlying genotoxic thresholds through genetic modification of DNA polymerase zeta
- Principal Investigator
  
  NOHMI Takehiko
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Health Sciences

All 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] in vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase2014
- Author(s)
  A. Sassa, T. Suzuki, Y. Kanemaru, N. Niimi, H. Fujimoto, A. Katafuchi, P. Gruz, M. Yasui, R.C. Gupta, F. Johnson, T. Ohta, M. Honma, N. Adachi and T. Nohmi
- Journal Title
  
  DNA Repair
  
  Volume: 15 Pages: 21-28
- DOI
  10.1016/j.dnarep.2013.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-24659035, KAKENHI-PROJECT-25281022, KAKENHI-PROJECT-25340044
[Journal Article] DNA polymerase kappa-dependent DNA synthesis at stalled replication forks is important for CHK1 activation2013
- Author(s)
  R. Betous, M.J. Pillaire, L. Pierini, S. van der Laan, B. Recolin, E. Ohl-Seguy, C. Guo, N. Niimi, P. Gruz, T. Nohmi, E. Friedberg, C. Cazaux, D. Maiorano and J.S. Hoffmann
- Journal Title
  
  EMBO J.
  
  Volume: 32 Issue: 15 Pages: 2172-2185
- DOI
  10.1038/emboj.2013.148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016
[Journal Article] Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains2012
- Author(s)
  M. Yamada, M. Shimizu, A. Katafuchi, P. Gruz, S. Fujii, Y. Usui, R.P. Fuchs and T. Nohmi
- Journal Title
  
  Mol. Microbiol.
  
  Volume: 86 Issue: 6 Pages: 1364-1375
- DOI
  10.1111/mmi.12061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016
[Journal Article] Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa2011
- Author(s)
  A. Sassa, N. Niimi, H. Fujimoto, A. Katafuchi, P. Gruz, M. Yasui, R. C. Gupta, F. Johnson, T. Ohta and T. Nohmi
- Journal Title
  
  Mutat. Res.
  
  Volume: 718 Issue: 1-2 Pages: 10-17
- DOI
  10.1016/j.mrgentox.2010.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-22710068
[Presentation] Mitomycin C によるDNA二本鎖切断誘発に対するDNA polymerase kappaのin vivoにおける役割2013
- Author(s)
  本山茂樹，竹入章，松尾沙織里，和田直子，寺社下浩一，三島雅之，新見直子，Petr Gruz，増村健一，山田雅巳，能美健彦
- Organizer
  日本環境変異原学会第42回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] Phenylalanine 171 of human DNA polymerase kappa is a molecular brake for translesion DNA synthesis across benzo[a]pyrene adducts2013
- Author(s)
  A.Sassa, T. Suzuki, Y. Kanemaru, N. Niimi, H. Fujimoto, A. Katafuchi, P. Gruz, M. Yasui, R. C. Gupta, F. Johnson, T. Ohta, M. Honma, N. Adachi and T. Nohmi
- Organizer
  44th Environmental Mutagenesis and Genomics Society
- Place of Presentation
  Monterey, California, U.S.A.
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] Partial restration of UV-mutagenesis in a umuDC-deletion mutant of Escherichia coli with human DNA polymerase eta2013
- Author(s)
  P. Gruz and T. Nohmi
- Organizer
  日本環境変異原学会第42回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] DNAポリメラーゼゼータはBPDE-N2-dGの損傷乗り越え合成後の伸長時にエラーを誘発する2013
- Author(s)
  鈴木哲矢，佐々　彰，ピーターグルーズ，足立典隆，本間正充，能美健彦
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] Genotoxic thresholds : identification of mutations in vivo and mechanistic studies in vitro2011
- Author(s)
  T. Nohmi, K. Masumura, P Gruz, N. Toyoda-Hokaiwado, M. Takamune, N. Niimi, T. Suzuki, Y. Kanemaru, M. Yasui, M. Yamada, M. Honma, N. Adachi and A. Nishikawa
- Organizer
  2nd International Symposium on Genotoxic and Carcinogenic Thresholds
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-22241016

1. NOHMI Takehiko (30150890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. MASUMURA Kenichi (40291116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. YASUI Manabu (50435707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. SAJI Tetsuya (20573950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. TOYODA Naomi (70381853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Petr Gruz Ｐｅｔｒ Ｇｒｕｚ

GRUZ Petr グルーズ ピーター

Research Projects

Research Products

Co-Researchers

Studies on mechanisms underlying genotoxic thresholds through genetic modification of DNA polymerase zeta

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] in vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA polymerase kappa-dependent DNA synthesis at stalled replication forks is important for CHK1 activation2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] Mitomycin C によるDNA二本鎖切断誘発に対するDNA polymerase kappaのin vivoにおける役割2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Phenylalanine 171 of human DNA polymerase kappa is a molecular brake for translesion DNA synthesis across benzo[a]pyrene adducts2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Partial restration of UV-mutagenesis in a umuDC-deletion mutant of Escherichia coli with human DNA polymerase eta2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] DNAポリメラーゼゼータはBPDE-N2-dGの損傷乗り越え合成後の伸長時にエラーを誘発する2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Genotoxic thresholds : identification of mutations in vivo and mechanistic studies in vitro2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Petr Gruz ＰｅｔｒＧｒｕｚ

GRUZ Petr グルーズピーター