Nakamura Kazuhiro 中村和裕

… Alternative Names

NAKAMURA KAZUHIRO 中村和裕

NAKAMURA Kazuhiro 中村和裕

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Researcher Number	10327835
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院保健学研究科, 教授
Affiliation (based on the past Project Information) *help	2024: 群馬大学, 大学院保健学研究科, 教授 2016 – 2022: 群馬大学, 大学院保健学研究科, 教授 2014: 群馬大学, 大学院医学系研究科, 准教授 2012 – 2014: 群馬大学, 医学(系)研究科(研究院), 准教授 2001 – 2005: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52010:General internal medicine-related / Basic Section 48010:Anatomy-related / Human pathology / Psychiatric science Except Principal Investigator Basic Section 80040:Quantum beam science-related / Laboratory animal science / Neurochemistry/Neuropharmacology / Biological Sciences
Keywords	Principal Investigator 赤外自由電子レーザー / ポリグルタミン / ポリグルタミン病 / マウス / 蛋白質ミスフォールディング病 / 構造 / 赤外顕微鏡 / 中赤外自由電子レーザー / 中赤外光 / 脊髄小脳変性症 … More / Sensorimotor gating / 精神疾患 / ゲノム / prepulse inhibition / sensorimotor gating / 染色体 / 自己免疫疾患 / male-female interaction / aggressive behavior / フェロモン / 神経活動 / マウスフェロモン / 嗅覚 / 自己免疫 … More Except Principal Investigator AP-4 / 転写制御 / プロモーター領域多型 / 連鎖解析 / 感受性遺伝子 / 全身性エリテマトーデス / テラヘルツ自由電子レーザー / テレヘルツ / サブミリ波 / ジャイロトロン / アミロイドーシス / αヘリックス / βシート / テラヘルツ / 自由電子レーザー / アミロイド線維 / germinal center B cells / promoter region polymorphism / linkage analysis / hyper- IgG / FcyRIIB1 molecule / susceptibility gene / systemic lupus erythematosus / Ap-4 / Fc_γRIIB1分子 / 胚中心B細胞 / 高IgG血症 / FcγRIIB1分子 / 神経変性症 / 脊髄小脳変性症 / 神経変性疾患 / プルキンエ細胞 / 小脳 / NMDA受容体 / メマンチン / 脊髄小脳変性症1型 / gain-of-function型多型 / 制御領域多型 / 自己感応性B細胞 / FCγRIIB / PI3 kinase / LTK / New Zealandマウス / 主要組織適合遺伝子複合体 / recombinant congenic マウス / IL-4Rα / FcγRIIB / 遺伝子多型 / New Zealand マウス Less

蛋白質ミスフォールディング病全般に対するペプチドを用いた治療法開発Principal Investigator
- Principal Investigator
  
  中村和裕
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Gunma University
Study on irradiation effect of terahertz free electron laser on amyloid fibrils
- Principal Investigator
  
  Kawasaki Takayasu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 80040:Quantum beam science-related
- Research Institution
  High Energy Accelerator Research Organization
  Tokyo University of Science
Infrared microscopy analysis of polyglutamine-related brain sectionsPrincipal Investigator
- Principal Investigator
  
  NAKAMURA KAZUHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Gunma University
Therapy for dementia by free electron laser irradiationPrincipal Investigator
- Principal Investigator
  
  NAKAMURA KAZUHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Gunma University
Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.
- Principal Investigator
  
  IIZUKA Akira
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gunma University
Determination of common mechanisms shared by multiple types of spinocerebellar ataxiaPrincipal Investigator
- Principal Investigator
  
  NAKAMURA KAZUHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Gunma University
精神疾患におけるsensorimotor gating機能異常の分子機構の解明Principal Investigator
- Principal Investigator
  
  中村和裕
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Juntendo University
自己反応性B細胞の寛容破綻に関わる遺伝的機構とその制御
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
自己免疫疾患に伴う脳機能異常の分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  中村和裕
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Juntendo University
Establishment of knock-in mice for functional analysis of FcyRIIB regulatory region polymorphism
- Principal Investigator
  
  YI Jiang
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Juntendo University

All 2023 2022 2021 2018 2016 2015 2014 2013 2012 2005 2003 Other

All Journal Article Presentation Book

[Book] Methods in Enzymology2023
- Author(s)
  Hisashi Okumura, Takayasu Kawasaki, Kazuhiro Nakamura
- Total Pages
  31
- Publisher
  Elsevier
- ISBN
  9780323992640
- Data Source
  KAKENHI-PROJECT-20K12483
[Journal Article] Exogenous polyserine and polyleucine are toxic to recipient cells.2022
- Author(s)
  Owada R, Mitsui S, Nakamura K
- Journal Title
  
  Sci. Rep.
  
  Volume: 12 Issue: 1 Pages: 1685-1685
- DOI
  10.1038/s41598-022-05720-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07242
[Journal Article] Application study of infrared free-electron lasers towards the development of amyloidosis therapy2022
- Author(s)
  Jindo Mikiko、Nakamura Kazuhiro、Okumura Hisashi、Tsukiyama Koichi、Kawasaki Takayasu
- Journal Title
  
  Journal of Synchrotron Radiation
  
  Volume: 29 Issue: 5 Pages: 1133-1140
- DOI
  10.1107/s1600577522007330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12483
[Journal Article] Role of Water Molecules and Helix Structure Stabilization in the Laser-Induced Disruption of Amyloid Fibrils Observed by Nonequilibrium Molecular Dynamics Simulations.2021
- Author(s)
  Okumura H, Itoh SG, Nakamura K, Kawasaki T.
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: in press Issue: 19 Pages: 2361-2368
- DOI
  10.1021/acs.jpcb.0c11491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07242, KAKENHI-PROJECT-21K06118, KAKENHI-PROJECT-21K06040
[Journal Article] Toxicity of internalized polyalanine to cells depends on aggregation.2021
- Author(s)
  Iizuka Y, Owada R, Kawasaki T, Hayashi F, Sonoyama M, Nakamura K.
- Journal Title
  
  Sci. Rep.
  
  Volume: 11 Issue: 1 Pages: 23441-23441
- DOI
  10.1038/s41598-021-02889-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07242, KAKENHI-PROJECT-20K06573
[Journal Article] Dissociation of β-Sheet Stacking of Amyloid β Fibrils by Irradiation of Intense, Short-Pulsed Mid-infrared Laser.2018
- Author(s)
  Kawasaki T, Yaji T, Ohta T, Tsukiyama K, Nakamura K.
- Journal Title
  
  Cell Mol Neurobiol.
  
  Volume: in press Issue: 5 Pages: 1039-1049
- DOI
  10.1007/s10571-018-0575-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15553, KAKENHI-PROJECT-17K05763
[Journal Article] Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.2015
- Author(s)
  Akira Iizuka, Kazuhiro Nakamura, Hirokazu Hirai
- Journal Title
  
  Neuroscience letters
  
  Volume: 592 Pages: 37-41
- DOI
  10.1016/j.neulet.2015.02.055
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830046
[Journal Article] Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 12014
- Author(s)
  Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H
- Journal Title
  
  Cerebellum
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590407
[Journal Article] Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar purkinje cells2014
- Author(s)
  Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
- Journal Title
  
  Cerebellum
  
  Volume: 13 Issue: 1 Pages: 29-41
- DOI
  10.1007/s12311-013-0516-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PUBLICLY-24111545, KAKENHI-PROJECT-24590407, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-24700394, KAKENHI-PROJECT-24800008, KAKENHI-PROJECT-25640040
[Journal Article] Cranial Irradiation Induces Bone Marrow-derived Microglia to the Adult Mouse Brain Tissue2014
- Author(s)
  Noriyuki OKONOGI,,　Kazuhiro NAKAMURA,　Yoshiyuki SUZUKI, MD, PhD1; Nana SUTO2; Kazutomo SUZUE, Takuya KAMINUMA, Takashi NAKANO and Hirokazu HIRAI
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590407
[Journal Article] cis phosphorylated tau as the earliest detectable pathogenic conformation in Alzheimer disease, offering novel diagnostic and therapeutic strategies.2013
- Author(s)
  Nakamura K, Zhou XZ, Lu KP
- Journal Title
  
  Prion
  
  Volume: 7 Issue: 2 Pages: 117-120
- DOI
  10.4161/pri.22849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590407
[Journal Article] Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.2013
- Author(s)
  Takechi Y, Mieda T, Iizuka A, Toya S, Suto N, Takagishi K, Nakazato Y, Nakamura K, Hirai H.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 535 Pages: 67-72
- DOI
  10.1016/j.neulet.2012.12.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590407
[Journal Article] Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1.2013
- Author(s)
  Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
- Journal Title
  
  Cerebellum
  
  Volume: epub Issue: 3 Pages: 323-330
- DOI
  10.1007/s12311-013-0536-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25830046, KAKENHI-PUBLICLY-26111701
[Journal Article] Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.2012
- Author(s)
  Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP.
- Journal Title
  
  Mol. Cell Biol.
  
  Volume: 32 Issue: 15 Pages: 2966-78
- DOI
  10.1128/mcb.05688-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590407, KAKENHI-PUBLICLY-23117526
[Journal Article] Correlation of aggression with serum IgM level in autoimmune-prone NZB mice.2005
- Author(s)
  K.Nakamura, et al.
- Journal Title
  
  Developmental Brain Research1 59
  
  Pages: 145-148
- Data Source
  KAKENHI-PROJECT-13140205
[Journal Article] Genetic dissection of anxiety in autoimmune disease.2003
- Author(s)
  Nakamura et al.
- Journal Title
  
  Hum.Mol.Genet. 12
  
  Pages: 1079-1086
- Data Source
  KAKENHI-PROJECT-15790636
[Presentation] 分子振動励起によるアミロイド線維のβシートからαヘリックスへの構造変換2022
- Author(s)
  川﨑平康, 　神藤美貴子, 　奥村久士,　中村和裕,　築山光一
- Organizer
  第9回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K12483
[Presentation] Dissociation of b2-microglobulin peptide fibril by infrared free electron laser: theoretical and experimental evidences2022
- Author(s)
  Mikiko Jindo, Kazuhiro Nakamura, Hisashi Okumura, Koichi Tsukiyama, and Takayasu Kawasaki
- Organizer
  The 59th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-20K12483
[Presentation] テラヘルツ自由電子レーザーによるアミロイド線維の凝集解離2021
- Author(s)
  川崎平康、中村和裕、入澤明典
- Organizer
  第８回日本アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K12483
[Presentation] 中赤外光による神経変性疾患関連アミロイドの解離と形態異常改善2021
- Author(s)
  中村和裕
- Organizer
  第２７回　FELとHigh Power Radiation研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07242
[Presentation] Targeting beta-sheet stacking of Alzheimer’s amyloid beta peptide by mid-infrared free-electron laser2018
- Author(s)
  Takayasu Kawasaki, Toyonari Yaji, Toshiaki Ohta, Koichi Tsukiyama, Kazuhiro Nakamura
- Organizer
  Alzheimers Research UK conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15553
[Presentation] 赤外自由電子レーザーの神経変性疾患治療への応用2016
- Author(s)
  中村和裕
- Organizer
  第６３回北関東医学会総会特別講演
- Place of Presentation
  群馬大学医学部刀城会館
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K15553
[Presentation] 脊髄小脳変性症１型モデルマウス中枢および末梢神経障害に対する間葉系幹細胞の治療効果2014
- Author(s)
  中村和裕、平井宏和
- Organizer
  日本生理学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24590407
[Presentation] 頭部への局所照射とBone Marrow Derived Microglia(BMDM)の誘導2013
- Author(s)
  小此木範之、中村和裕、鈴木義行、神沼拓也、須藤奈々、中野隆史、平井宏和
- Organizer
  第３回国際放射線神経生物学会
- Place of Presentation
  名護、沖縄
- Data Source
  KAKENHI-PROJECT-24590407
[Presentation] 遺伝性脊髄小脳変性症１型ノックインマウスにおける末梢神経障害2013
- Author(s)
  中村　和裕、平井　宏和
- Organizer
  第３回国際放射線神経生物学会
- Place of Presentation
  名護、沖縄
- Data Source
  KAKENHI-PROJECT-24590407
[Presentation] Cranial Irradiation Induces Migration of Bone Marrow Derived Microglia (BMDM) to the Cerebellum in Adult C57BL/6 Mice.2012
- Author(s)
  Okonogi N, Nakamura K, Suzuki Y, Suto N, Kaminuma T, Nakano T and Hirai H.
- Organizer
  The American Society for Therapeutic Radiology and Oncology 54th annual meeting.
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-24590407
[Presentation] Mesenchymal stem cell therapy of spinocerebellar ataxia type 1 model mice
- Author(s)
  Kazuhiro Nakamura
- Organizer
  日本生理学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24590407
[Presentation] NMDA受容体拮抗薬メマンチンの長期経口投与によるSCA1モデルマウス病態の改善
- Author(s)
  Akira Iizuka, Kazuhiro Nakamura, Hirokazu Hirai
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2015-07-28 – 2015-07-31
- Data Source
  KAKENHI-PROJECT-25830046

1. Kawasaki Takayasu (00363268)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. IKOTA Hayato (90420116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IIZUKA Akira (10466683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. HIRAI Hirokazu (70291086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. KONNO Ayumu (40509048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YI Jiang (50276466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 広瀬幸子 (00127127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中優子 (00533233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中里洋一 (10106908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 入澤明典 (90362756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 奥村久士 (80360337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三宅弘一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamura Kazuhiro 中村 和裕

NAKAMURA KAZUHIRO 中村 和裕

NAKAMURA Kazuhiro 中村 和裕

Research Projects

Research Products

Co-Researchers

蛋白質ミスフォールディング病全般に対するペプチドを用いた治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on irradiation effect of terahertz free electron laser on amyloid fibrils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Infrared microscopy analysis of polyglutamine-related brain sectionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapy for dementia by free electron laser irradiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determination of common mechanisms shared by multiple types of spinocerebellar ataxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

精神疾患におけるsensorimotor gating機能異常の分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

自己反応性B細胞の寛容破綻に関わる遺伝的機構とその制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己免疫疾患に伴う脳機能異常の分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of knock-in mice for functional analysis of FcyRIIB regulatory region polymorphism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Methods in Enzymology2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Exogenous polyserine and polyleucine are toxic to recipient cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application study of infrared free-electron lasers towards the development of amyloidosis therapy2022

Author(s)

Journal Title

Nakamura Kazuhiro 中村和裕

NAKAMURA KAZUHIRO 中村和裕

NAKAMURA Kazuhiro 中村和裕