TAKAYAMA Takuya 高山卓也

Researcher Number	10332579
Affiliation (based on the past Project Information) *help	2007: Japanese Foundation For Cancer Research, Cancer Institute, Division of Cancer Genome Research, Staff Scientist 2006: (財)癌研究会, がんゲノム研究部, 研究員 2005: The University of Tokyo, Institute of Medical Science, Advanced Clinical Research Center, Department of Surgery and Bioengineering, Associate Professor, 医科学研究所, 講師 2001 – 2005: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator General surgery / General surgery Except Principal Investigator General surgery / General surgery / Digestive surgery
Keywords	Principal Investigator dendritic cell / SLC / Flt3L / IL-18 / in vivo electroporation / chemokine / CCL21 / FIt3L / denderitic cell / in vitro electroporation … More / 腫瘍免疫 / CCR7 / ケモカイン / 樹状細胞 … More Except Principal Investigator CTL / HLA / 樹状細胞 / GMP / thymus / CD4+CD25+ / regulatory T cell / peptide / dendritic cells / 遺伝子治療 / ペプチド / Cancer vaccine / Epitope peptide / がんワクチン療法 / がんワクチン / p53 / neu / HER2 / エピトープペプチド / 免疫療法 / Flt3L / RNA / electroporation / マウス / 免疫寛容 / translational research / Inteleukin-12 / adenoviral vector / tumor immunology / gene Therapy / Interleukin-12 / 腫瘍免疫 / RCA / 臨床研究 / ウイルスベクター / HLA Loss / Tumor heterogenicity / 細胞障害性T細胞 / HLA欠損 / 腫瘍の多様性 / transgenic mouse / FoxP3 / 制御性T cell / CD4CD25 / 移植免疫 / 心移植 / CD4+CD25+T細胞 / 移植 / 胸腺 / トランスジェニックマウス / CD4陽性CD25陽性 / 調節性T細胞 / 組織適合性抗原 / genetherapy / immunotherapy / cancer / 骨髄非破壊的幹細胞移植 / 癌 / tolerance / ビタミンD / 骨髄移植 / 臓器移植 / アデノウィルスベクター / 樹上細胞 / IL-12 / 探索的医療 / アデノウイルスベクター Less

Novel gene therapy by modulation of dendritic cells in vivoPrincipal Investigator
- Principal Investigator
  
  TAKUYA Takayama
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Japanese Foundation For Cancer Research
Development of cancer immune-gene therapy using viral vector produced in Japanese academia
- Principal Investigator
  
  TAHARA Hideaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
The role of CD4+CD25+T cells for immunological tolerance induction in organ transplantation
- Principal Investigator
  
  BECK Yoshifumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Development for new cancer vaccine against heterogenicity and HLA-loss of tumor
- Principal Investigator
  
  TSUNODA Takuya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
NEW DEVELOPMENT OF DC IMMUNOTHERAPY TO UNIDENTIFIED CANCER ANTIGENPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Takuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Clinical development of cancer gene therapy using viral vectors
- Principal Investigator
  
  TAHARA Hideaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Analysis of tolerance induction using immunosuppresslve dendritic cells in transplantation
- Principal Investigator
  
  BECK Yoshifumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Cancer treatment by non-myeloablative hematopoietic stem cell transplant with Flt3L gene transfection.
- Principal Investigator
  
  ANDO Yuichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Development for new cancer vaccine using various kinds of epitope peptides
- Principal Investigator
  
  TSUNODA Takuya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Development of gene therapy using chemokine that regulates the mobilization of dendritic cells in situPrincipal Investigator
- Principal Investigator
  
  TAKAYAMA Takuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo

All 2008 2007 2006 2005 2003 2002

All Journal Article

[Journal Article] 「研究成果報告書概要(欧文)」より2008
- Author(s)
  Saito T, Takayama T, Osaki T, Nagai S, Suzuki T, Sato M, Kuwano H, Tahara H
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 2028-36
- Data Source
  KAKENHI-PROJECT-17209042
[Journal Article] Combined mobilization and stimulation of tumor-infiltrating dendritic cells and natural killer cells with Flt3 ligand and IL-18 in vivo induces systemic anti-tumor immunity.2008
- Author(s)
  Saito T, Takayama T, Osaki T, Nagai S, Suzuki T, Sato M, Kuwano H, Tahara H.
- Journal Title
  
  Cancer Science 99
  
  Pages: 2028-2036
- NAID
  10024012190
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209042
[Journal Article] 樹状細胞を用いたがん免疫療法2007
- Author(s)
  高山卓也
- Journal Title
  
  アフェレーシス学会雑誌 26
  
  Pages: 228-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591434
[Journal Article] Systemic Administration of IL-23 Induces Potent Anti-tumor Immunity Primarily Mediated through Th1-type Response in Association with the Endogeno usiy Expressed IL-12.2007
- Author(s)
  Kaiga T, Sato M, Kaneda H, Iwakura Y, Takayama T, Tahara H.
- Journal Title
  
  J Immunology 178
  
  Pages: 7571-80
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209042
[Journal Article] Cancer Immunotherapy using Dendritic Cells2007
- Author(s)
  TAKUYA TAKAYAMA
- Journal Title
  
  Japanese Journal of Apheresis 26
  
  Pages: 228-231
- NAID
  110006285395
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591434
[Journal Article] Systemic Administration of IL-23 Induces Potent Anti-tumor Immunity Primarily Mediated through Th1-type Response in Association with the Endogenously Expressed IL-122007
- Author(s)
  Kaiga T, Sato M, Kaneda H, Iwakura Y, Takayama T, Tahara H
- Journal Title
  
  J Immunol 178
  
  Pages: 7571-7580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209042
[Journal Article] 「研究成果報告書概要(欧文)」より2007
- Author(s)
  Kaiga T, Sato M, Kaneda H, Iwakura Y, Takayama T, Tahara H
- Journal Title
  
  J Immunol 178
  
  Pages: 7571-7580
- Data Source
  KAKENHI-PROJECT-17209042
[Journal Article] 樹状細胞ワクチンのための樹状細胞のquality2006
- Author(s)
  高山卓也
- Journal Title
  
  BIO CLINICA 21
  
  Pages: 118-121
- Data Source
  KAKENHI-PROJECT-18591434
[Journal Article] Effect of imatinib (STI571) on metastatic gastrointestinal stromal tumors : report of a case.2005
- Author(s)
  Yuichi Ando, Takuya Tsunoda, et al.
- Journal Title
  
  Surg Today. 35
  
  Pages: 157-160
- NAID
  10014370499
- Data Source
  KAKENHI-PROJECT-16591297
[Journal Article] Dendritic cell might be one of key factors for eliciting antitumor effect by chemo-immunotherapy in vivo.2005
- Author(s)
  Hiroyuki Mushiake, Takuya Tsunoda, et al.
- Journal Title
  
  Cancer Immunology Immunotherapy 54
  
  Pages: 120-128
- Data Source
  KAKENHI-PROJECT-16591297
[Journal Article] Cancer gene therapy using in vivo electroporation of Flt3-Ligand.2005
- Author(s)
  Shimao K, Takayama T, Enomoto K, Saito T, Nagai S, Miyazaki J, Ogawa K, Tahara H.
- Journal Title
  
  Int.J Oncol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591330
[Journal Article] Cancer gene therapy using in vivo electroporation of Flt3-Ligand.2005
- Author(s)
  Shimao K, Takayama T, Enomoto K, Saito T, Nagai S, Miyazaki J, Ogawa K, Tahara H.
- Journal Title
  
  Int J Oncology 27
  
  Pages: 457-463
- Data Source
  KAKENHI-PROJECT-17209042
[Journal Article] Cancer gene therapy using in vivo electroporation of Flt3-Ligand.2005
- Author(s)
  Shimao K, Takayama T, et al.
- Journal Title
  
  International Journal of Oncology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591330
[Journal Article] Identification of Immunoglobulin superfamily 11 (IGSF11) as a Novel Target for Cancer Immunotherapy of Gastro-intestinal and Hepatocellular Carcinomas.2005
- Author(s)
  Takeshi Watanabe, Takako Suda, Takuya Tsunoda, et al.
- Journal Title
  
  Cancer Sci 96
  
  Pages: 498-506
- Data Source
  KAKENHI-PROJECT-16591297
[Journal Article] Rationale for anti-angiogenic cancer therapy with vaccination using epitope peptides derived from human vascular endothelial growth factor receptor 2 (VEGFR2).2005
- Author(s)
  Satoshi Wada, Takuya Tsunoda, et al.
- Journal Title
  
  Cancer Res 65
  
  Pages: 4939-4946
- Data Source
  KAKENHI-PROJECT-16591297
[Journal Article] Generation of Mature Dendritic Cells Fully Capable of T Helper Type 1 Polarization Using OK-432 Combined with Prostaglandin E22003
- Author(s)
  Sato M, Takayama T, et al.
- Journal Title
  
  Cancer Science 94
  
  Pages: 1091-1098
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591330
[Journal Article] Generation of Mature Dendritic Cells Fully Capable of T Helper Type 1 Polarization Using OK-432 Combined with Prostaglandin E2.2003
- Author(s)
  Sato M, Takayama T, Tanaka H, Konishi J, Suzuki T, Kaiga T, Tahara H.
- Journal Title
  
  Cancer Sci 94
  
  Pages: 1091-1098
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591330
[Journal Article] Retroviral delivery of transforming growth factor-β1 to myeloid dendritic cells ; inhibition of T cell priming ability and influence on allograft survival.2002
- Author(s)
  Takayama T, Tahara H.他4名
- Journal Title
  
  Transplantation 74
  
  Pages: 112-119
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207047
[Journal Article] Retroviral delivery of transforming growth factor-β 1 to myeloid dendritic cells ; inhibition of T cell priming ability and influence on allograft survival.2002
- Author(s)
  Takayama T, Tahara H, et al.
- Journal Title
  
  Transplantation 74
  
  Pages: 112-119
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207047

1. TAHARA hideaki (70322071)

# of Collaborated Projects: 10 results

# of Collaborated Products: 10 results
2. TSUNODA Takuya (30275359)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
3. BECK Yoshifumi (70199454)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KITAMURA Yoshihiro (10202037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ANDO Yuichi (00262080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TOJYO Arinobu (00211681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 谷憲三郎 (00183864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 市川直哉 (60251451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐々木勝則 (60336394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UCHIDA Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAYAMA Takuya 高山 卓也

Research Projects

Research Products

Co-Researchers

Novel gene therapy by modulation of dendritic cells in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cancer immune-gene therapy using viral vector produced in Japanese academia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of CD4+CD25+T cells for immunological tolerance induction in organ transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development for new cancer vaccine against heterogenicity and HLA-loss of tumor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NEW DEVELOPMENT OF DC IMMUNOTHERAPY TO UNIDENTIFIED CANCER ANTIGENPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical development of cancer gene therapy using viral vectors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of tolerance induction using immunosuppresslve dendritic cells in transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cancer treatment by non-myeloablative hematopoietic stem cell transplant with Flt3L gene transfection.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development for new cancer vaccine using various kinds of epitope peptides

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of gene therapy using chemokine that regulates the mobilization of dendritic cells in situPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 「研究成果報告書概要(欧文)」より2008

Author(s)

Journal Title

Data Source

[Journal Article] Combined mobilization and stimulation of tumor-infiltrating dendritic cells and natural killer cells with Flt3 ligand and IL-18 in vivo induces systemic anti-tumor immunity.2008

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] 樹状細胞を用いたがん免疫療法2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Systemic Administration of IL-23 Induces Potent Anti-tumor Immunity Primarily Mediated through Th1-type Response in Association with the Endogeno usiy Expressed IL-12.2007

TAKAYAMA Takuya 高山卓也