Hatano Akihiko 幡野明彦

… Alternative Names

HATANO Akihiko 幡野明彦

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Researcher Number	10333163
Other IDs
Affiliation (Current)	2025: 芝浦工業大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 芝浦工業大学, 工学部, 教授 2014: 芝浦工業大学, 工学部, 教授 2012 – 2013: 芝浦工業大学, 工学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Chemistry related to living body
Keywords	Principal Investigator 蛍光色素 / チミジンホスホリラーゼ / 蛍光イメージング / 血管新生 / ピリミジンヌクレオシドホスホリラーゼ / 蛍光共鳴エネルギー移動 / 血管新生因子 / 非天然ヌクレオシド / プローブ / ヌクレオシド … More / 核酸代謝酵素 / 細胞選択 / 人工抗体 / 阻害剤集積型DNA / DNAオリガミ法 / 分子プローブ / 園頭反応 / 蛍光応答 / プローブ分子 / パイ平面拡張イミダゾール / ベンゾイミダゾール / 蛍光 / 早期発見 / 診断薬 / 癌 / 癌細胞 / 過リン酸分解 / 蛍光団 / 反応転換率 / ダンシル基 / 酵素活性 / ＴＰ応答型癌検出プローブ / 有機合成 / 癌マーカー / 癌診断 / 蛍光プローブ / 過リン酸分解反応 / イメージング / ドッキングスタディー / 有機溶媒効果 / 酵素合成 / 合成 / RNA / 薗頭カップリング / パラジウム触媒 / RNAプローブ / 塩基部位交換反応 Less

DNAオリガミ法を用いた集積化阻害剤による細胞特異的プローブの開発Principal Investigator
- Principal Investigator
  
  幡野明彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Shibaura Institute of Technology
Development of cancer cell-specific fluorescent probes targeting angiogenic factorsPrincipal Investigator
- Principal Investigator
  
  Hatano Akihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Shibaura Institute of Technology
Cancer cell-specific imaging with the fluorescent probe responding by thymidine phosphorylasePrincipal Investigator
- Principal Investigator
  
  Hatano Akihiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Shibaura Institute of Technology
Synthesis of the variety nucleostide probes produced by synchronization of the biocatalyst and the palladium catalystPrincipal Investigator
- Principal Investigator
  
  HATANO Akihiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Shibaura Institute of Technology

All 2023 2022 2021 2020 2019 2018 2015 2013 2012 Other

All Journal Article Presentation

[Journal Article] Supramolecular Conjugation between 18-Crown 6-Ether and Tannic Acid with Unique pH Responsiveness2023
- Author(s)
  Endo Saki、Sarai Mahiro、Hatano Akihiko、Niikura Kenichi
- Journal Title
  
  Chemistry Letters
  
  Volume: 52 Issue: 6 Pages: 455-458
- DOI
  10.1246/cl.230093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04878, KAKENHI-PROJECT-21K05315
[Journal Article] Introduction of pseudo-base benzimidazole derivatives into nucleosides via base exchange by a nucleoside metabolic enzyme2023
- Author(s)
  1)A. Hatano, R. Matsuzaka, G. Shimane, H. Wakana, K. Suzuki, C. Nishioka, A. Kojima, M.　Kidowaki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 91 Pages: 117411-117411
- DOI
  10.1016/j.bmc.2023.117411
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05315
[Journal Article] A disposable vancomycin sensor using molecularly imprinted carbon paste on a paper chip2021
- Author(s)
  Aaryashree; Ebisawa, Haruki; Azuma, Sayaka; Hatano, Akihiko; Yoshimi, Yasuo
- Journal Title
  
  Chemical Sensors
  
  Volume: 38 Pages: 76-78
- NAID
  40022727851
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Journal Article] Reagentless Sensing of Vancomycin Using an Indium Tin Oxide Electrode Grafted with Molecularly Imprinted Polymer including Ferrocenyl Group2021
- Author(s)
  Eguchi, Haruto; Hatano, Akihiko; Yoshimi, Yasuo
- Journal Title
  
  Sensors
  
  Volume: 24 Issue: 24 Pages: 8338-8338
- DOI
  10.3390/s21248338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05315
[Journal Article] Parallel motif triplex formation via a new, bidirectional hydrogen bonding pattern incorporating a synthetic cyanuryl nucleoside into the sense chain2020
- Author(s)
  Hatano, Akihiko; Shimazaki, Kei; Otsu, Maina; Kawai, Gota
- Journal Title
  
  RSC Advances
  
  Volume: 10 Issue: 38 Pages: 22766-22774
- DOI
  10.1039/d0ra03889j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05360
[Journal Article] A single-use ceramic-based electrochemical sensor chip using molecularly imprinted carbon paste electrode2020
- Author(s)
  Aaryashree; Takeda, Yuuto; Kanai, Momoe; Hatano, Akihiko; Yoshimi, Yasuo; Kida, Masahito
- Journal Title
  
  Sensors
  
  Volume: 20 Issue: 20 Pages: 5847-5847
- DOI
  10.3390/s20205847
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05360, KAKENHI-PROJECT-17H02088
[Journal Article] Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes2019
- Author(s)
  Akihiko Hatano, Yuichi Kanno, Yuya Kondo, Yuta Sunaga, Hatsumi Umezawa, Koji Fukui
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 5 Pages: 859-864
- DOI
  10.1016/j.bmc.2019.01.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05360
[Journal Article] Bio-catalytic synthesis of unnatural nucleosides possessing a large functional group such as a fluorescent molecule by purine nucleoside phosphorylase,2019
- Author(s)
  A. Hatano, H. Wakana, N. Terado, A.Kojima, C. Nishioka, Y. Iizuka, T. Imaizumi, S. Uehara,
- Journal Title
  
  Catalysis Science & Technolog
  
  Volume: 9 Issue: 18 Pages: 5122-5129
- DOI
  10.1039/c9cy01063g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05360
[Journal Article] Synthesis of a protected ribonucleoside phosphoramidite-linked spin label via an alkynyl chain at the 5′ position of uridine2019
- Author(s)
  A. Hatano, N, Terado, Y. Kanno, T. Nakamura, G. Kawai
- Journal Title
  
  Synthetic Communications
  
  Volume: 49 Issue: 1 Pages: 136-145
- DOI
  10.1080/00397911.2018.1545033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05360
[Journal Article] Improved synthesis of mercapto C-nucleoside possessing p-phenyl thiol as base using a lithiated coupling reaction2015
- Author(s)
  A. Hatano,* M. Okada, K. Dezaki, S. Hirai
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Issue: 7 Pages: 1095-1100
- DOI
  10.1016/j.tet.2014.12.085
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24550193
[Journal Article] One-pot approach to functional nucleosides possessing fluorescent group using nucleobase-exchange reaction by thymidine phosphorylase2013
- Author(s)
  A. Hatano, M. Kurosu, S. Yonaha, M. Okada, S. Uehara
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 11 Issue: 40 Pages: 6900-6905
- DOI
  10.1039/c3ob41605d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] Chemoenzymatic synthesis of unnatural nucleoside with stable isotopes2023
- Author(s)
  Genki SHIMANE, Nanae Terado, Akihiko HATANO
- Organizer
  rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Development of the one-dimensional integrated inhibitor of deoxynojirimycin using DNA sequences2023
- Author(s)
  Ryu MAYUMI, Akihiko HATANO
- Organizer
  SEATUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Synthesis of spin-labeled RNAs to elucidate the function of reverse transcriptase2023
- Author(s)
  Nagihiro Miyahara, Nanae Terado, Saki Kaneko, Akihiko Hatano
- Organizer
  SEATUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] ynthesis of spin-labeled RNAs to elucidate the function of reverse transcriptase2023
- Author(s)
  Genki SHIMANE, Akihiko HATANO, Nanae TERADO
- Organizer
  SEATUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Effects of Functional Groups Recognition of Nucleoside Structure for Phosphorolysis with Pyrimidine Nucleoside Phosphorylase PyNP2023
- Author(s)
  Rei HAMANO, Koichi OTSUKIi, Akihiko HATANO
- Organizer
  SEATUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Examination of chemical enzyme synthesis method to introduce multiple stable isotopes into nucleoside molecular structure2023
- Author(s)
  Genki SHIMANE, Akihiko HATANO, Nanae TERADO
- Organizer
  SEATUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Introduction of Benzimidazole as Purine Analog into Nucleoside Structure by Base-Exchange Reaction of Nucleoside Metabolism Enzyme2023
- Author(s)
  Riki MATSUSAKA, Akihiko HATANO
- Organizer
  SEATUC 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Synthesis of pentostatin precursor with pyrimidine nucleoside phosphorylase2023
- Author(s)
  Rai Hamano, Akihiko Hatano, Riki Matsuzaka
- Organizer
  3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Examination of chemical enzyme synthesis method to introduce multiple stable isotopes into uridine molecular structure2022
- Author(s)
  Genki SHIMANE, Akihiko HATANO
- Organizer
  Active Enzyme Molecules, 2022, in Toyama
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] ピリミジンヌクレオシドホスホリラーゼによるリボース部位修飾ヌクレオシドの反応性2022
- Author(s)
  間弓利勇・大槻晃一・幡野明彦
- Organizer
  日本化学会第102春季年会(2022)
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 核酸代謝酵素PyNPによるヌクレオシドへのプリン類似体ベンゾイミダゾール化合物の導入2022
- Author(s)
  松坂理希・幡野明彦
- Organizer
  本化学会第102春季年会(2022)
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] レーザーマイクロダイセクション装置によるがん細胞特異的に見られる核内封入体構成成分の同定2022
- Author(s)
  水口　海，八谷　如美，幡野　明彦
- Organizer
  本化学会第102春季年会(2022)
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] レーザーマイクロダイセクション装置によるがん細胞特異的に見られる核内封入体構成成分としての液滴オルガネラの単離2022
- Author(s)
  水口海, 幡野明彦, 八谷如美
- Organizer
  日本化学会第102春季年会(2022)
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] Effects of Functional Groups Recognition of Nucleoside substrate for Phosphorolysis with Nucleoside Metabolic Enzyme PyNP2022
- Author(s)
  Ryu MAYUMI, Koichi OTSUKI, Akihiko HATANO
- Organizer
  Active Enzyme Molecules, 2022, in Toyama
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] Base Exchange Effects of Benzimidazole as Pseudo Purine Base into Nucleoside Structure with Nucleoside Metabolic Enzyme2022
- Author(s)
  Riki MATSUSAKA, Takumi HAYASHIDA, Akihiko HATANO
- Organizer
  Active Enzyme Molecules, 2022, in Toyama
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] 核酸代謝酵素PyNPによるヌクレオシドへのプリン類似体ベンゾイミダゾール化合物の導入2022
- Author(s)
  松坂理希・林田拓巳・幡野明彦
- Organizer
  日本化学会第102春季年会(2022)
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] ピリミジンヌクレオシドホスホリラーゼPyNP によるリボース部位修飾ヌクレオシドの反応性2022
- Author(s)
  間弓利勇・大槻晃一・幡野明彦
- Organizer
  本化学会第102春季年会(2022)
- Data Source
  KAKENHI-PROJECT-21K05315
[Presentation] SYNTHESIS OF UNNATURAL NUCLEOSIDES LINKED FLUORESCENT GROUP BY NUCLEOSIDE METABOLIC ENZYME2020
- Author(s)
  Hiroyuki Wakana, Akihiko Hatano
- Organizer
  14th South East Asian Technical University Consortium Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 核酸代謝酵素類を用いた蛍光部位を持つ非天然ヌクレオシドの合成と反応性の評価2019
- Author(s)
  若菜浩幸、鈴木康、幡野明彦
- Organizer
  生体触媒シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 蛍光部位を持つ非天然ヌクレオシドの核酸代謝酵素を用いた合成と反応性の評価2019
- Author(s)
  若菜浩幸，鈴木康，寺戸那奈恵，幡野明彦
- Organizer
  バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] Development of the imaging probe targeting for thymidine phosphorylase as angiogenic factor of cancer2018
- Author(s)
  Wakana, Hiroyuki, Hatano, Akihiko
- Organizer
  生体触媒シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 血管新生因子であるチミジンホスホリラーゼに応答する蛍光プローブの開発2018
- Author(s)
  若菜浩幸、幡野明彦
- Organizer
  酵素工学研究会
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 核酸代謝酵素を用いた蛍光部位導入非天然ヌクレオシドの合成2018
- Author(s)
  若菜浩幸，幡野明彦
- Organizer
  第12回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] Synthesis of unnatural nucleosides containing fluorescent group by using nucleic acid metabolic enzyme2018
- Author(s)
  H. Wakana, N. Terado, A. Hatano
- Organizer
  15th Japan-China-Korea Joint Symposium on Enzyme Engineering
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 核酸代謝酵素を用いた修飾プリンのヌクレオシドへの導入2018
- Author(s)
  鈴木康、若菜浩幸、飯塚佑、幡野明彦
- Organizer
  生体触媒シンポジウム
- Data Source
  KAKENHI-PROJECT-18K05360
[Presentation] 安定同位体を有したヌクレオシドの酵素合成2015
- Author(s)
  寺戸那奈恵 , 藤井映美 , 福田健治 , 幡野明彦
- Organizer
  第95回日本化学会春季年会
- Place of Presentation
  日本大学船橋
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] 蛍光色素を有した非天然ヌクレオシドの酵素合成2013
- Author(s)
  幡野明彦、黒須優幸、川端耕平、相川未来、平井誠太郎
- Organizer
  第7回バイオ関連化学シンポジウム2013
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] Synthesis of nucleosides possessing fluorescent group via nucleobase-exchange reaction of thymidine phosphorylase2013
- Author(s)
  Akihiko Hatano, Masayuki Kurosu
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] 核酸代謝酵素の塩基部位交換反応を利用した蛍光色導入ヌクレオシド合成2013
- Author(s)
  川端耕平、相川未来、藤井絵美、黒須博幸、幡野明彦
- Organizer
  第4回CSJ化学フェスタ2014
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] 核酸代謝酵素の基質拡張のためのドッキングシミュレーション2013
- Author(s)
  幡野明彦、黒須優幸、須永裕太、出崎健太郎、藤井映美
- Organizer
  第17回生体触媒化学シンポジウム
- Place of Presentation
  岡山理科大学
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] 蛍光プローブ含有ヌクレオシドを合成可能にする分子フラスコとしてのチミジンホスホリラーゼ2012
- Author(s)
  須永裕太，黒須優幸，出崎健太郎，与那覇奨，幡野明彦
- Organizer
  第16回生体触媒化学シンポジウム
- Place of Presentation
  富山県民会館
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] Enzymatic synthesis of nucleosides with the introduction of a stable isotope into the base moiety
- Author(s)
  Nanae Terado, Fujii Emi, Kenji Fukuda and Akihiko Hatano
- Organizer
  Active Enzyme Molecule
- Place of Presentation
  Toyama
- Year and Date
  2014-12-17 – 2014-12-19
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] 核酸代謝酵素を用いた塩基部位に安定同位体を含むリボヌクレオシドの合成
- Author(s)
  寺戸那奈恵 , 藤井映美 , 福田健治 , 幡野明彦
- Organizer
  第4回CSJ化学フェスタ2014
- Place of Presentation
  タワーホール船堀
- Year and Date
  2014-10-14 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-24550193
[Presentation] 安定同位体を有したヌクレオシドの酵素合成
- Author(s)
  寺戸那奈恵 , 藤井映美 , 福田健治 , 幡野明彦
- Organizer
  第8回バイオ関連化学シンポジウム
- Place of Presentation
  岡山大学津島キャンパス
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24550193

1. 福井浩二 (80399807)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 新倉謙一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hatano Akihiko 幡野 明彦

HATANO Akihiko 幡野 明彦

Research Projects

Research Products

Co-Researchers

DNAオリガミ法を用いた集積化阻害剤による細胞特異的プローブの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cancer cell-specific fluorescent probes targeting angiogenic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cancer cell-specific imaging with the fluorescent probe responding by thymidine phosphorylasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthesis of the variety nucleostide probes produced by synchronization of the biocatalyst and the palladium catalystPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Supramolecular Conjugation between 18-Crown 6-Ether and Tannic Acid with Unique pH Responsiveness2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Introduction of pseudo-base benzimidazole derivatives into nucleosides via base exchange by a nucleoside metabolic enzyme2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A disposable vancomycin sensor using molecularly imprinted carbon paste on a paper chip2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Reagentless Sensing of Vancomycin Using an Indium Tin Oxide Electrode Grafted with Molecularly Imprinted Polymer including Ferrocenyl Group2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parallel motif triplex formation via a new, bidirectional hydrogen bonding pattern incorporating a synthetic cyanuryl nucleoside into the sense chain2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A single-use ceramic-based electrochemical sensor chip using molecularly imprinted carbon paste electrode2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bio-catalytic synthesis of unnatural nucleosides possessing a large functional group such as a fluorescent molecule by purine nucleoside phosphorylase,2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of a protected ribonucleoside phosphoramidite-linked spin label via an alkynyl chain at the 5′ position of uridine2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improved synthesis of mercapto C-nucleoside possessing p-phenyl thiol as base using a lithiated coupling reaction2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] One-pot approach to functional nucleosides possessing fluorescent group using nucleobase-exchange reaction by thymidine phosphorylase2013

Hatano Akihiko 幡野明彦

HATANO Akihiko 幡野明彦

[Presentation] ピリミジンヌクレオシドホスホリラーゼによるリボース部位修飾ヌクレオシドの反応性2022

[Presentation] レーザーマイクロダイセクション装置によるがん細胞特異的に見られる核内封入体構成成分としての液滴オルガネラの単離2022

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