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SAKAMOTO NAOYA  坂本 直哉

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SAKAMOTO Naoya  坂本 直哉

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Researcher Number 10334418
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Affiliation (Current) 2020: 北海道大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help 2017 – 2020: 北海道大学, 医学研究院, 教授
2016: 北海道大学, 医学研究科, 教授
2012 – 2015: 北海道大学, 医学(系)研究科(研究院), 教授
2014: 北海道大学, 医学研究科, 教授
2014: 北海道大学, 大学院医学研究科, 教授 … More
2012: 北海道大学, 医学系研究科, 教授
2012: 北海道大学, 大学院・医学研究科, 教授
2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 寄付講座教員
2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員(准教授)
2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員
2009: 東京医科歯科大学, 医歯学総合研究科, 寄附講座准教授
2009: Tokyo Medical and Dental University, 医歯学総合研究科, 寄附講座教員
2008 – 2009: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座准教授
2008: 東京医科歯科大学, 医歯学総合研究科, 准教授
2007: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座教員
2006: Tokyo Medical and Dental University, Department of Gastroenerology and Hepatology, Associate Professor, 大学院医歯学総合研究科, 助教授
2006: 東京医科歯科大学, 大学院医歯学総合研究科, 寄付講座教員
2006: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教員
2005: 東京医科歯科大学, 医学部付属病院, 助手
2005: Tokyo Medical and Dental University, Graduate school, Research associate, 大学院・医歯学総合研究科, 寄附講座教員
2002 – 2005: 東京医科歯科大学, 医学部附属病院, 助手
2004: Tokyo Medical and Dental Univ., Dept.of Gastroenteorology and Hepatology, Instructor, 医学部・附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Medium-sized Section 53:Organ-based internal medicine and related fields / Biological Sciences / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords
Principal Investigator
C型肝炎 / HCV-JFH1培養系 / 抗ウイルス療法 / 肝線維化 / HCVレプリコン / 肝炎ウイルス / ウイルス肝炎 / 医学 / ウイルス学 / RNA interference … More / small interfering RNA / 遺伝子導入療法 / HCV replicon system / 内科 / suppression subtractive hybridization / 胃腺腫 / 胃癌 / 原発性胆汁性肝硬変 / HVC-JFH1培養系 / レプリコンシステム / HCV-Feoレプリコン / 小分子ライブラリー / HCV / CD81 / 医療 / 感染症 / ウイルス / 基礎研究 / B型肝炎 / 分子動力学シミュレーション / 薬剤耐性変異 / C型肝炎ウイルス / レプリコン・システム / アデノウイルスベクター / 分子標的治療 / hepatitis Ci virus / adenovirus vector / molecular targeted drug / antiviral therapy / gene therapy / レプリコン / サイクロスポリン / 発現ライブラリー / インターフェロン / スクリーニング / サイクロフィリン / HCVレプリコン・システム / サイクロスポリンA / siRNA / Hepatitis C virus / Cyclosporin A / Interferon-stimulated genes / type-I interferon / high-throughput screening / 消化器内科 / 肝硬変 / 肝線維症 / 間葉系幹細胞 / 間葉系 幹細胞 / 薬剤耐性 / DAA薬剤耐性 … More
Except Principal Investigator
肝細胞 / 再生医学 / C型肝炎ウイルス / インターフェロン / 細胞移植 / 幹細胞 / 発生・分化 / HCV / レプリコン・システム / 分子標的治療 / 抗ウイルス療法 / HCVレプリコン / 肝幹細胞 / FACS / レプリコン / 慢性肝炎 / Cardif / HCV-JFH1培養系 / プラークアッセイ / 細胞障害効果 / 小胞体ストレス / RNAポリメラーゼ / ＨＣＶ / 肝癌 / IRF-1 / replicon / interferon / 臍帯血 / 細胞生物学 / HBV / HBx / B型肝炎ウイルス / ウイルスベクター / Small interfering RNA / 感染レセプター / 肝癌細胞 / siRNA / 遺伝子導入療法 / shRNA / 細胞外マトリクス / 細胞 / HCV レプリコン / RIG-I / HCV-NS4B / STING / 生体発光共鳴エネルギー転移(Bioliminescence Resonance Energy ransfer) / ヒト肝臓キメラマウス / 肝臓学 / 肝細胞移植 / CD13 / 治療抵抗性機序 / C型慢性肝炎 / インターロイキン6 / 治療抵抗性 / 肝発癌 / インターロイキン６ / コア変異株 / コア変異 / DAA製剤 / 移植 / 肝疾患治療 / 細胞・組織 / ＮＳ4Ｂ / ＩＬ28Ｂ / IFNλ / IL-6 / ＩＦＮ / 薬剤耐性ウイルス / HSF1 / Heat shock factor / ストレス関連遺伝子 / 酸化ストレス / 脂肪性肝炎 / NS5A蛋白 / 自然免疫 / interferon regulatory factor 1 / interferon sensitivity determining region / interferon regulatory factor 3 / NS5A領域 / microarray / NS5A / NF-KB / Hepatitis C Virus / NS5A protein / innate immunity / サイクロスポリンA / レトロウイルスベクター / サイクロフィリン / small interfering RNA / Cyclosporin A / HCV replicon system / cyclophilin / 肝障害 / ヒト臍帯血由来細胞 / アルブミン / CD45 / linege marker / NOD / SCIDマウス / umbilical cord blood / hepatocytes / stem cells / cell transplantation / liver injury / regenerative medicine / cell biology / 移植・再生医療 / 再生医療 / 傷害肝 / Regenerative medicine / Development ＆ Differentiation / Transplantation / Stem cells / Umbilical cord blood / Cell therapy / Cell biology / Hepatocytes / 肝脂肪化 / カルニチン / HCC / truncated HBx / 肝細胞癌 / HBｘ / インテグレーション / CSCｓ / 肝癌幹細胞 / 癌 / ＨＢｘ / cccDNA / DDB1 / 完全排除 / ドラッグスクリーニング / レポーター / NASH / 糖鎖 / バイオマーカー / 宿主制限因子 / HBs抗原 / HBc抗原 / HBx蛋白 / GVHD / VOD/SOS / R-Spondin Less

  • Research Projects

    (38 results)

  • Research Products

    (604 results)

  • Co-Researchers

    (97 People)

  •  非アルコール性脂肪肝炎、新規診断マーカー・治療標的としての糖鎖修飾解析Ongoing

    • Principal Investigator
      小川 浩司
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hokkaido University

  •  Development of novel antiviral therapy targeting hepatitis B virus host restriction factorOngoing

    • Principal Investigator
      森川 賢一
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hokkaido University

  •  肝組織間質蛋白の糖鎖修飾構造を標的とした肝線維化に対する糖鎖創薬の基盤形成Principal InvestigatorOngoing

    • Principal Investigator
      坂本 直哉
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Hokkaido University

  •  R-Spondinによる肝幹細胞を標的とした造血幹細胞移植後肝傷害の治療開発Ongoing

    • Principal Investigator
      豊嶋 崇徳
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Hokkaido University

  •  Comprehensive screening of miviroenvirinmental factors that affect liver fibrosisPrincipal InvestigatorOngoing

    • Principal Investigator
      坂本 直哉
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hokkaido University

  •  レポーターアッセイによる新規・大規模抗HBV薬スクリーニング系を用いた薬剤開発Ongoing

    • Principal Investigator
      須田 剛生
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hokkaido University

  •  Development of drugs targeting liver fibrosis by modulation of protein/lipid glycosylationPrincipal InvestigatorOngoing

    • Principal Investigator
      坂本 直哉
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Hokkaido University

  •  A new development of antivirals for eradication of HBV cccDNAOngoing

    • Principal Investigator
      森川 賢一
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  Search for new cell- or small molecule-based therapies to promote regression of liver cirrohsisPrincipal Investigator

    • Principal Investigator
      Sakamoto Naoya
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  Effect of truncated Hepatitis B virus X protein integration on malignant potential of HCC

    • Principal Investigator
      Goki Suda
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  Application of molecular dynamics simulation to construct of virtual assay system of antiviral drug resistancePrincipal Investigator

    • Principal Investigator
      Sakamoto Naoya
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  Anti-Adipogenic and Antiviral Effects of L-Carnitine on Hepatitis C Virus Infection

    • Principal Investigator
      koji ogawa
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  Investigation of the HSF1 signaling pathway as the molecular targeted therapies for hepatocellular carcinoma.

    • Principal Investigator
      Makoto Chuma
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Yokohama City University

  •  Establishment of virtual assay system by molecular dynamic simulation of HCV antiviral resistancePrincipal Investigator

    • Principal Investigator
      Sakamoto Naoya
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  To analyze the mechanisms of HCV drug resistance by using chimeric HCV cell culture system

    • Principal Investigator
      SUDA Goki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  High throughput screening of chemical library for antiviral compounds for hepatitis virusesPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  Analysis of IL-6-mediated drug-resistance of hepatitis C virus infection

    • Principal Investigator
      NAKAGAWA Mina
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Study on establishment of experimental animal model for chimeric liver with hepatitis C virus infection using induced hepatocyte-like cells

    • Principal Investigator
      AZUMA Seishin
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Impaired host response and HCV disturbance of type I/III IFN signaling are closely associated with non-response to IFN-based anti-HCV treatment

    • Principal Investigator
      OOKA Shinya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Development of drugs targeting hepatitis B x-proteinPrincipal Investigator

    • Principal Investigator
      SAKAMOTO NAOYA
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

  •  細胞障害性HCV培養系を用いた重症C型肝炎発症機構の解析

    • Principal Investigator
      筬島 裕子
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Establishment of mouse-directed HCV infection modelsPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  High-throughput screening of virus-and host-targeted suppressors of HCV infectionPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  FRET/ BRET analysis of interaction between HCV protein and interferon signaling

    • Principal Investigator
      FUJITA Megumi (TASAKA Megumi)
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Development of plaque assay to isolate cytopathic HCV clones

    • Principal Investigator
      OOOKA Shinya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Analysis on molecular mechanisms of liver reconstitution by transplanted hepatic cells

    • Principal Investigator
      AZUMA Seishin (CHEN Cheng-Hsin)
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Research on molecular mechanism of hepatic stem cell proliferation and development of mouse models for stem cell transplantation

    • Principal Investigator
      KAKINUMA Sei
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo

  •  Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factorsPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Research on transplantation of hepatic stem cells and development of experimental mouse models for hepatitis C virus

    • Principal Investigator
      CHEN Cheng-hsin
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  C型肝炎ウイルス発現モデル動物を用いたsiRNAによる感染抑制系の開発

    • Principal Investigator
      OOOKA Shinya
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Suppression subraction法による消化器癌の分子病態の解析Principal Investigator

    • Principal Investigator
      坂本 直哉
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University

  •  Study on hepatic differentiation of mesenchymal stem cells derived from human umbilical cord blood, and cell therapy for liver disease by use of mesenchymal stem cells.

    • Principal Investigator
      CHEN Cheng-Hsin
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Comprehensive screening of host proteins that suppress replication of HCV repliconPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Suppression of hepatitis C virus replication by cyclosporine A

    • Principal Investigator
      OOOKA Shinya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Identification of human cord blood-derived hepatic stem cells, and establishment of cell therapy for lethal liver disease

    • Principal Investigator
      KAKINUMA Sei
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
      Tokyo Medical and Dental University

  •  Therapeutic application of RNA interference to suppress hepatitis C virus replicationPrincipal Investigator

    • Principal Investigator
      SAKAMOTO Naoya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  HCV VectorによるHCV感染過程の制御分子の同定

    • Principal Investigator
      ENOMOTO Nobuyuki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University

  •  Analysis of anti-interferon mechanism by HCV NS5A protein using HCV replicon system

    • Principal Investigator
      ENOMOTO Nobuyuki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Yamanashi
      Tokyo Medical and Dental University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] C型慢性肝炎・C型肝硬変. 日常診療に活かす診療ガイドラインUP-TO-DATE2018→2019.2018
    • Author(s)
      森川賢一、坂本直哉.
    • Total Pages
      1037
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Book] C型肝炎-新薬開発の展望. B型・C型肝炎の抗ウイルス療法-最前線の治療エッセンス.2017
    • Author(s)
      森川賢一、坂本直哉.
    • Total Pages
      195
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Book] 分子標的薬 その作用機序と効果予測(肝細胞及び肝幹・前駆細胞移植におけるMatrix Metalloproteinaseの関与)2010
    • Author(s)
      柿沼晴, 坂本直哉, 渡辺守, 他, 分著(小俣政男編集)
    • Total Pages
      239
    • Publisher
      アークメデイア
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Book] siRNAによるC型肝炎遺伝子治療.バイオ医薬品の開発技術とシーズ2009
    • Author(s)
      坂本直哉、横田隆〓
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Book] 肝疾患レビュー 2□I : 肝炎ウイルスと自然免疫2006
    • Author(s)
      坂本 直哉(分担)
    • Publisher
      日本メディカルセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Book] 肝疾患レビュー2006-2007:肝炎の基礎(4):肝炎ウイルスと自然免疫2006
    • Author(s)
      坂本直哉(共著)
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Book] 肝疾患レビュー 2-I : 肝炎ウイルスと自然免疫2006
    • Author(s)
      坂本直哉(分担)
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Book] 肝疾患Review20042004
    • Author(s)
      坂本直哉, 榎本信幸
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Book] 肝疾患Review20042004
    • Author(s)
      坂本直哉, 榎本信幸
    • Publisher
      HCV治療の基礎的戦略
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] The Successful Retreatment with Glecaprevir and Pibrentasvir of Genotype 1 or 2 HCV-infected Hemodialysis Patients who Failed to Respond to NS5A and Protease Inhibitor Treatment2019
    • Author(s)
      Suda Goki、Nakai Masato、Sho Takuya、Kimura Megumi、Shimazaki Tomoe、Maehara Osamu、Shigesawa Taku、Suzuki Kazuharu、Nakamura Akihisa、Ohara Masatsugu、Umemura Machiko、Kawagishi Naoki、Baba Masaru、Natsuizaka Mitsuteru、Morikawa Kenichi、Ogawa Koji、Sakamoto Naoya、for the NORTE Study Group
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 7 Pages: 943-947

    • DOI

      10.2169/internalmedicine.2077-18

    • NAID

      130007622183

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K09334

  • [Journal Article] Glecaprevir and Pibrentasvir for Japanese Patients with Human Immunodeficiency Virus and Genotype 3 Hepatitis C Virus Coinfection: A Report of Three Cases2019
    • Author(s)
      Sho Takuya、Suda Goki、Kimura Megumi、Shimazaki Tomoe、Maehara Osamu、Shigesawa Taku、Suzuki Kazuharu、Nakamura Akihisa、Ohara Masatsugu、Umemura Machiko、Izumi Takaaki、Kawagishi Naoki、Baba Masaru、Nakai Masato、Natsuizaka Mitsuteru、Morikawa Kenichi、Ogawa Koji、Sakamoto Naoya、for the NORTE Study Group
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 6 Pages: 797-802

    • DOI

      10.2169/internalmedicine.1856-18

    • NAID

      130007611402

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K19324

  • [Journal Article] Mesenchymal stem cell therapy for acute and chronic pancreatitis.2018
    • Author(s)
      Kawakubo K, Ohnishi S, Kuwatani M, Sakamoto N
    • Journal Title

      J Gastroenterol

      Volume: 53 Pages: 1-5

    • DOI

      10.1007/s00535-017-1363-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05282

  • [Journal Article] Regulation of interferon signaling and HCV-RNA replication by extracellular matrix.2018
    • Author(s)
      Kuwashiro T, Iwane S, Jinghe X, Matsuhashi S, Eguchi Y, Anzai K, Fujimoto K, Mizuta T, Sakamoto N, Ikeda M, Kato N, Ozaki I.
    • Journal Title

      Int J Mol Med

      Volume: 42 Pages: 957-965

    • DOI

      10.3892/ijmm.2018.3693

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-16H05282

  • [Journal Article] Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats2018
    • Author(s)
      Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N
    • Journal Title

      Frontiers in Pharmacology

      Volume: 9 Pages: 709-709

    • DOI

      10.3389/fphar.2018.00709

    • NAID

      120006522665

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434

  • [Journal Article] L-Carnitine Suppresses Loss of Skeletal Muscle Mass in Patients With Liver Cirrhosis2018
    • Author(s)
      Ohara Masatsugu、Ogawa Koji、Suda Goki、Kimura Megumi、Maehara Osamu、Shimazaki Tomoe、Suzuki Kazuharu、Nakamura Akihisa、Umemura Machiko、Izumi Takaaki、Kawagishi Naoki、Nakai Masato、Sho Takuya、Natsuizaka Mitsuteru、Morikawa Kenichi、Ohnishi Shunsuke、Sakamoto Naoya
    • Journal Title

      Hepatology Communications

      Volume: 2 Pages: 906-918

    • DOI

      10.1002/hep4.1207

    • NAID

      120006585791

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K19324, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-16K09334

  • [Journal Article] Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.2018
    • Author(s)
      Cai C, Koch B, Morikawa K, Suda G, Sakamoto N, Rueschenbaum S, Akhras S, Dietz J, Hildt E, Zeuzem S, Welsch C, Lange CM
    • Journal Title

      Front Immunol

      Volume: 9 Pages: 723-723

    • DOI

      10.3389/fimmu.2018.00723

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05282

  • [Journal Article] Increased serum C-reactive protein and decreased urinary aquaporin 2 levels are predictive of the efficacy of tolvaptan in patients with liver cirrhosis2018
    • Author(s)
      3.Nakai M, Ogawa K, Takeda R, Ohara M, Kawagishi N, Izumi T, Umemura M, Ito J, Sho T, Suda G, Morikawa K, Sakamoto N
    • Journal Title

      Hepatol Res

      Volume: in press

    • DOI

      10.1111/hepr.12988

    • NAID

      120006551584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K19324, KAKENHI-PROJECT-16H05282

  • [Journal Article] Safety and efficacy of elbasvir and grazoprevir in Japanese hemodialysis patients with genotype 1b hepatitis C virus infection2018
    • Author(s)
      Suda Goki、Morikawa Kenichi、Ogawa Koji、Sakamoto Naoya、他
    • Journal Title

      Journal of Gastroenterology

      Volume: 54 Pages: 78-86

    • DOI

      10.1007/s00535-018-1495-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K19324

  • [Journal Article] Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis.2018
    • Author(s)
      Sugiura R, Ohnishi S, Ohara M, Ishikawa M, Miyamoto S, Onishi R, Yamamoto K, Kawakubo K, Kuwatani M, Sakamoto N
    • Journal Title

      Am J Transl Res

      Volume: 10 Pages: 2102-2114

    • NAID

      120006528265

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05282

  • [Journal Article] Treatment of hepatitis C in special populations2018
    • Author(s)
      Suda G, Ogawa K, Morikawa K, Sakamoto N
    • Journal Title

      J Gastroenterol

      Volume: in press

    • DOI

      10.1007/s00535-017-1427-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15K08980

  • [Journal Article] Sialic Acid Linkage Specific Derivatization of Glycosphingolipid Glycans by Ring-Opening Aminolysis of Lactones2018
    • Author(s)
      Hanamatsu H, Nishikaze T, Miura N, Piao J, Okada K, Sekiya S, Iwamoto S, Sakamoto N, Tanaka K, Furukawa JI
    • Journal Title

      Analytical Chemistry

      Volume: 90 Pages: 13193-13199

    • DOI

      10.1021/acs.analchem.8b02775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19530, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-16K05804

  • [Journal Article] Cecum ulcer is a reliable endoscopic finding in cytomegalovirus colitis concomitant with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.2018
    • Author(s)
      Matsuda Kana、Ono Shoko、Ishikawa Marin、Miyamoto Shuichi、Abiko Satoshi、Tsuda Momoko、Yamamoto Keiko、Kudo Takahiko、Shimizu Yuichi、Hayase Eiko、Hashimoto Daigo、Teshima Takanori、Matsuno Yoshihiro、Sakamoto Naoya
    • Journal Title

      Ann Hematol

      Volume: 97 Pages: 877-883

    • DOI

      10.1007/s00277-018-3241-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09945, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17H04206

  • [Journal Article] Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence2018
    • Author(s)
      Morikawa Kenichi、Nakamura Akihisa、Shimazaki Tomoe、Sakamoto Naoya
    • Journal Title

      Drug Design, Development and Therapy

      Volume: Volume 12 Pages: 2749-2756

    • DOI

      10.2147/dddt.s133697

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Journal Article] Conditioned Medium Obtained from Amnion-Derived Mesenchymal Stem Cell Culture Prevents Activation of Keloid Fibroblasts.2018
    • Author(s)
      Sato C, Yamamoto Y, Funayama E, Furukawa H, Oyama A, Murao N, Hosono H, Kawakubo K, Sakamoto N, Ohnishi S
    • Journal Title

      Plast Reconstr Surg

      Volume: 141 Pages: 390-398

    • DOI

      10.1097/prs.0000000000004068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19530, KAKENHI-PROJECT-16H05282

  • [Journal Article] Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.2018
    • Author(s)
      Ohara Masatsugu、Ohnishi Shunsuke、Hosono Hidetaka、Yamamoto Koji、Yuyama Kohei、Nakamura Hideki、Fu Qingjie、Maehara Osamu、Suda Goki、Sakamoto Naoya
    • Journal Title

      Stem Cells Int

      Volume: 2018 Pages: 1-15

    • DOI

      10.1155/2018/3212643

    • NAID

      120006585982

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06456, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-16K09334

  • [Journal Article] Increased serum C-reactive protein and decreased urinary aquaporin 2 levels are predictive of the efficacy of tolvaptan in patients with liver cirrhosis.2018
    • Author(s)
      3.Nakai M, Ogawa K, Takeda R, Ohara M, Kawagishi N, Izumi T, Umemura M, Ito J, Sho T, Suda G, Morikawa K, Sakamoto N
    • Journal Title

      Hepatology Research

      Volume: in press

    • NAID

      120006551584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08980

  • [Journal Article] Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells.2018
    • Author(s)
      Fu Q, Ohnishi S, Sakamoto N
    • Journal Title

      Stem Cells Int

      Volume: 20 Pages: 4898152-4898152

    • DOI

      10.1155/2018/4898152

    • NAID

      120006541895

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05282

  • [Journal Article] Safety and efficacy of sofosbuvir and ribavirin for genotype 2 hepatitis C Japanese patients with renal dysfunction2018
    • Author(s)
      Sho T, Suda G,, Nagasaka A, Yamamoto Y, Furuya K, Kumagai K, Uebayashi M, Terashita K, Kobayashi T, Tsunematsu I, Onodera M, Meguro T, Kimura M, Ito J, Umemura M, Izumi T, Kawagishi N, Ohara M, Ono Y, Nakai M, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N
    • Journal Title

      Hepatology Research

      Volume: in press

    • DOI

      10.1111/hepr.13056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-16K15420

  • [Journal Article] Evaluation of amnion-derived mesenchymal stem cells for treatment-resistant moderate Crohn's disease: study protocol for a phase I/II, dual-centre, open-label, uncontrolled, dose-response trial.2018
    • Author(s)
      Otagiri S, Ohnishi S, Miura A, Hayashi H, Kumagai I, Ito YM, Katsurada T, Nakamura S, Okamoto R, Yamahara K, Cho KY, Isoe T, Sato N, Sakamoto N
    • Journal Title

      BMJ Open Gastroenterol

      Volume: 5

    • DOI

      10.1136/bmjgast-2018-000206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05282

  • [Journal Article] Liver steatosis and dyslipidemia after HCV eradication by direct acting antiviral agents are synergistic risks of atherosclerosis.2018
    • Author(s)
      Kawagishi Naoki、Suda Goki、Nakamura Akinobu、Kimura Megumi、Maehara Osamu、Suzuki Kazuharu、Nakamura Akihisa、Ohara Masatsugu、Izumi Takaaki、Umemura Machiko、Nakai Masato、Sho Takuya、Natsuizaka Mitsuteru、Morikawa Kenichi、Ogawa Koji、Kudo Yusuke、Nishida Mutsumi、Miyoshi Hideaki、Sakamoto Naoya
    • Journal Title

      PLoS One

      Volume: 13 Pages: 615-620

    • DOI

      10.1371/journal.pone.0209615

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K19324, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-16K09334

  • [Journal Article] Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit2017
    • Author(s)
      Arima, Y., T. Ohki, N. Nishikawa, K. Higuchi, M. Ota, Y. Tanaka, J. Nio-Kobayashi, M. Elfeky, R. Sakai, Y. Mori, T. Kawamoto, A. Stofkova, Y. Sakashita, Y. Morimoto, M. Kuwatani, T. Iwanaga, Y. Yoshioka, N. Sakamoto, A. Yoshimura, M. Takiguchi, S. Sakoda, M. Prinz, D. Kamimura, M. Murakami.
    • Journal Title

      Elife

      Volume: 6:e25517 Pages: 1-27

    • DOI

      10.7554/elife.25517

    • NAID

      120006360081

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19537, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-15H04741, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15K08518, KAKENHI-PROJECT-17K15712

  • [Journal Article] Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression2017
    • Author(s)
      Ngoc NB, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M
    • Journal Title

      Journal of Medical Virology

      Volume: Epub ahead of print Pages: 1224-1234

    • DOI

      10.1002/jmv.24739

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16K15420

  • [Journal Article] Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: a case report2017
    • Author(s)
      Yoshikawa Ayumu、Terashita Katsumi、Morikawa Kenichi、Matsuda Soichiro、Yamamura Takahiro、Sarashina Koichiro、Nakano Shintaro、Kobayashi Yoshimitsu、Sogabe Susumu、Takahashi Kazuhiro、Haba Shin、Oda Hisashi、Takahashi Tatsuro、Miyagishima Takuto、Sakamoto Naoya
    • Journal Title

      Clin J Gastroenterol.

      Volume: 10 Pages: 270-273

    • DOI

      10.1007/s12328-017-0742-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Journal Article] Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors2017
    • Author(s)
      Hontani K, Tsuchikawa T, Hiwasa T, Nakamura T, Ueno T, Kushibiki T, Takahashi M, Inoko K, Takano H, Takeuchi S, Dosaka-Akita H, Kuwatani M, Sakamoto N, Hatanaka Y, Mitsuhashi T, Shimada H, Shichinohe T, Hirano S.
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 106206-106221

    • DOI

      10.18632/oncotarget.22175

    • NAID

      120006416017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08684, KAKENHI-PROJECT-16K10520, KAKENHI-PROJECT-16H05282

  • [Journal Article] Add-on effects of fluvastatin in simeprevir/pegylated-interferon/ribavirin combination therapy for patients with genotype 1 hepatitis C virus infection: A randomized controlled study2017
    • Author(s)
      Suda Goki、Morikawa Kenichi、et al.
    • Journal Title

      Hepatol Res

      Volume: 48

    • DOI

      10.1111/hepr.12938

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K15420

  • [Journal Article] Fibroblast growth factor-2 mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma2017
    • Author(s)
      Osamu Maehara, Goki Suda et al.
    • Journal Title

      carcinogenesis

      Volume: 38 Pages: 1073-1083

    • DOI

      10.1093/carcin/bgx095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-15K08943

  • [Journal Article] A Phase I Study of Combination Therapy with Sorafenib and 5-Fluorouracil in Patients with Advanced Hepatocellular Carcinoma2017
    • Author(s)
      Sho Takuya、Nakanishi Mitsuru、Morikawa Kenichi、Ohara Masatsugu、Kawagishi Naoki、Izumi Takaaki、Umemura Machiko、Ito Jun、Nakai Masato、Suda Goki、Ogawa Koji、Chuma Makoto、Meguro Takashi、Nakamura Michio、Nagasaka Atsushi、Horimoto Hiromasa、Yamamoto Yoshiya、Sakamoto Naoya
    • Journal Title

      Drugs R D.

      Volume: 17 Pages: 381-388

    • DOI

      10.1007/s40268-017-0187-7

    • NAID

      120006369333

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Journal Article] Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells2017
    • Author(s)
      Sakurai Fuminori、Kunito Takemaru、Takayama Kazuo、Hashimoto Rina、Tachibana Masashi、Sakamoto Naoya、Wakita Takaji、Mizuguchi Hiroyuki
    • Journal Title

      Hepatol Res

      Volume: 242 Pages: 7-15

    • DOI

      10.1016/j.virusres.2017.09.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-16K15420

  • [Journal Article] The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities2017
    • Author(s)
      Wang Shu-Chi、Lai Kuan-Ru、Li Chia-Yang、Chiang Chi-Shiun、Yu Guann-Yi、Sakamoto Naoya、Tu Wen-Yu、Hsieh Meng-Hsuan、Huang Jee-Fu、Chuang Wan-Long、Dai Chia-Yen、Yu Ming-Lung
    • Journal Title

      PLoS One

      Volume: 12

    • DOI

      10.1371/journal.pone.0164281

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-16K15420

  • [Journal Article] Anti-adipogenic and antiviral effects ofl-carnitine on hepatitis C virus infection2017
    • Author(s)
      Tsukuda Y, Suda G, Tsunematsu S, Ito J, Sato F, Terashita K, Nakai M, Sho T, Maehara O, Shimazaki T, Kimura M, Morikawa K, Natsuizaka M, Ogawa K, Ohnishi S, Chuma M, Sakamoto N
    • Journal Title

      Med Virol

      Volume: 89 Pages: 857866-857866

    • DOI

      10.1002/jmv.24692

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-26460982, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16K15420

  • [Journal Article] Daclatasvir and asunaprevir in hemodialysis patients with hepatitis C virus infection: a nationwide retrospective study in Japan2017
    • Author(s)
      Suda Goki、Morikawa Kenichi、et al.
    • Journal Title

      J Gastroenterol

      Volume: 53 Pages: 119-128

    • DOI

      10.1007/s00535-017-1353-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-16K15420

  • [Journal Article] Add-on effects of fluvastatin in simeprevir/pegylated-interferon/ribavirin combination therapy for patients with genotype 1 hepatitis C virus infection: A randomized controlled study2017
    • Author(s)
      5.Suda G, Ito J, Nagasaka A, Yamamoto Y, Furuya K, Okamoto M, Terashita K, Kobayashi T, Tsunematsu I, Yoshida J, Meguro T, Ohara M, Kawagishi N, Kimura M, Umemura M, Izumi T, Tsukuda Y, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N
    • Journal Title

      Hepatology Research

      Volume: 48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08980

  • [Journal Article] Safety and efficacy of daclatasvir and asunaprevir in hepatitis C virus-infected patients with renal impairment2017
    • Author(s)
      Suda G, Nagasaka A, Yamamoto Y, Furuya K, Kumagai K, Kudo M, Terashita K, Kobayashi T, Tsunematsu I, Yoshida J, Meguro T, Kimura M, Ito J, Umemura M, Izumi T, Tsunematsu S, Sato F, Tsukuda Y, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Pages: 1127-1136

    • DOI

      10.1111/hepr.12851

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16K15420

  • [Journal Article] Hepatitis B virus reactivation during hepatitis C direct-acting antiviral therapy in patients with previous HBV infection2017
    • Author(s)
      Kawagishi N, Suda G, Onozawa M, Kimura M, Maehara O, Ito J, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N
    • Journal Title

      J Hepatol

      Volume: 67 Pages: 1098-1106

    • DOI

      10.1016/j.jhep.2017.04.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-17J00434

  • [Journal Article] Retreatment with sofosbuvir, ledipasvir, and add-on ribavirin for patients who failed daclatasvir and asunaprevir combination therapy.2017
    • Author(s)
      Suda G, Ogawa K, Yamamoto Y, Katagiri M, Furuya K, Kumagai K, Konno J, Kimura M, Kawagishi N, Ohara M, Umemura M, Ito J, Izumi T, Nakai M, Sho T, Natsuizaka M, Morikawa K, Tsubota A, Shimada N, Iio E, Tanaka Y, Sakamoto N; NORTE Study Group.
    • Journal Title

      Journal of Gastroenterol

      Volume: 印刷中 Pages: 1122-1129

    • DOI

      10.1007/s00535-017-1328-z

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-15K06810, KAKENHI-PROJECT-16K15420

  • [Journal Article] Comparing the risk of hepatitis B virus reactivation between direct-acting antiviral therapies and interferon-based therapies for hepatitis C2017
    • Author(s)
      Kawagishi N.、Suda G.、Onozawa M.、Kimura M.、Maehara O.、Ohara M.、Izumi T.、Umemura M.、Ito J.、Nakai M.、Sho T.、Natsuizaka M.、Morikawa K.、Ogawa K.、Sakamoto N.
    • Journal Title

      J Viral Hepat

      Volume: 24 Pages: 1098-1106

    • DOI

      10.1111/jvh.12737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16K19324, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-16K15420

  • [Journal Article] Hepatitis B virus X protein impairs α-interferon signaling via upregulation of suppressor of cytokine signaling 3 and protein phosphatase 2A2017
    • Author(s)
      Tsunematsu S, Suda G, Yamasaki K, Kimura M, Izumi T, Umemura M, Ito J, Sato F, Nakai M, Sho T, Morikawa K, Ogawa K, Tanaka Y, Watashi K, Wakita T, Sakamoto N
    • Journal Title

      J Med Virol

      Volume: 89 Pages: 267-275

    • DOI

      10.1002/jmv.24643

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16K15420, KAKENHI-PROJECT-26460565

  • [Journal Article] Genome-wide association study identifies TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus infection.2017
    • Author(s)
      Matsuura K, Honda M, et al.
    • Journal Title

      Gastroenterology

      Volume: - Pages: 1383-1394

    • DOI

      10.1053/j.gastro.2017.01.041

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H05285, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-15K09006, KAKENHI-PROJECT-15K09019, KAKENHI-PROJECT-15K08986, KAKENHI-PROJECT-16K09335, KAKENHI-PROJECT-17K09457, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15K08077, KAKENHI-PROJECT-15K08314

  • [Journal Article] Viral life cycle of hepatitis B virus: Host factors and druggable targets.2016
    • Author(s)
      Morikawa K, Suda G, Sakamoto N
    • Journal Title

      Hepatol Res

      Volume: EPub Pages: 871-877

    • DOI

      10.1111/hepr.12650

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-16K15420

  • [Journal Article] ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma.2016
    • Author(s)
      Terashita K, Chuma M, Hatanaka Y, Hatanaka K, Mitsuhashi T, Yokoo H, Ohmura T, Ishizu H, Muraoka S, Nagasaka A, Tsuji T, Yamamoto Y, Kurauchi N, Shimoyama N, Toyoda H, Kumada T, Kaneoka Y, Maeda A, Ogawa K, Natsuizaka M, Kamachi H, Kakisaka T, Kamiyama T, Taketomi A, Matsuno Y, Sakamoto N
    • Journal Title

      J Clin Pathol.

      Volume: in press Pages: 593599-593599

    • DOI

      10.1136/jclinpath-2015-203115

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-25460449, KAKENHI-PROJECT-24590674, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26460982, KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-16K08684

  • [Journal Article] A pivotal role of Kruppel-like factor 5 in regulation of cancer stem-like cells in hepatocellular carcinoma.2016
    • Author(s)
      Maehara O, Sato F, Natsuizaka M, Asano A, Kubota Y, Itoh J, Tsunematsu S, Terashita K, Tsukuda Y, Nakai M, Sho T, Suda G, Morikawa K, Ogawa K, Chuma M, Nakagawa K, Ohnishi S, Komatsu Y, Whelan KA, Nakagawa H, Takeda H, Sakamoto N.
    • Journal Title

      Cancer Biology & Therapy

      Volume: 16 Pages: 14531461-14531461

    • DOI

      10.1080/15384047.2015.1070992

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-26460933, KAKENHI-PROJECT-26461021

  • [Journal Article] Resistance Analyses of Japanese Hepatitis C-Infected Patients Receiving Sofosbuvir or Ledipasvir/Sofosbuvir Containing Regimens in Phase 3 Studies.2016
    • Author(s)
      Mizokami M, Dvory-Sobol H, Izumi N, Nishiguchi S, Doehle B, Svarovskaia ES, De-Oertel S, Knox S, Brainard DM, Miller MD, Mo H, Sakamoto N, Takehara T, Omata M
    • Journal Title

      J Viral Hepat

      Volume: 23 Pages: 780-788

    • DOI

      10.1111/jvh.12549

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15420

  • [Journal Article] Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection.2016
    • Author(s)
      Ito J, Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kumagai K, Kikuchi H, Miyagishima T, Kobayashi T, Kimura M, Yamasaki K, Umemura M, Izumi T, Tsunematsu S, Sato F, Tsukuda Y, Terashita K, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto
    • Journal Title

      Hepatol Res

      Volume: in press Pages: 1294-1303

    • DOI

      10.1111/hepr.12685

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-16K15420

  • [Journal Article] Efficacy and safety of daclatasvir and asunaprevir combination therapy in chronic hemodialysis patients with chronic hepatitis C.2016
    • Author(s)
      Suda G, Kudo M, Nagasaka A, Furuya K, Yamamoto Y, Kobayashi T, Shinada K, Tateyama M, Konno J, Tsukuda Y, Yamasaki K, Kimura M, Umemura M, Izumi T, Tsunematsu S, Sato F, Terashita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N
    • Journal Title

      J Gastroenterol

      Volume: in press

    • NAID

      120006313426

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08980

  • [Journal Article] Efficacy and safety of daclatasvir and asnaprevir combination therapy in chronic hemodialysis patients with chronic hepatitis C2016
    • Author(s)
      Suda G, Kudo M, Nagasaka A, Furuya K, Yamamoto Y, Kobayashi T, Shinada K, Tateyama M, Konno J, Tsukuda Y, Yamasaki K, Kimura M, Umemura M, Izumi T, Tsunematsu S, Sato F, Terashita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N
    • Journal Title

      J Gastroenterol

      Volume: EPub Pages: 733740-733740

    • DOI

      10.1007/s00535-016-1162-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-15K08943

  • [Journal Article] Intratumoral artery on contrast-enhanced computed tomography imaging: differentiating intrahepatic cholangiocarcinoma from poorly differentiated hepatocellular carcinoma2015
    • Author(s)
      ３．Tsunematsu S1, Chuma M, Kamiyama T, Miyamoto N, Yabusaki S, Hatanaka K, Mitsuhashi T, Kamachi H, Yokoo H, Kakisaka T, Tsuruga Y, Orimo T, Wakayama K, Ito J, Sato F, Terashita K, Nakai M, Tsukuda Y, Sho T, Suda G, Morikawa K, Natsuizaka M, Nakanishi M, Ogawa K, Taketomi A, Matsuno Y, Sakamoto N
    • Journal Title

      Abdom Imaging.

      Volume: Epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] The JAK2 inhibitor AZD1480 inhibits hepatitis A virus replication in Huh7 cells2015
    • Author(s)
      Jiang X, Kanda T, Nakamoto S, Saito K, Nakamura M, Wu S, Haga Y, Sasaki R, Sakamoto N, Shirasawa H, Okamoto H, Yokosuka O
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 印刷中 Pages: 908-912

    • DOI

      10.1016/j.bbrc.2015.02.058

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590955, KAKENHI-PROJECT-26430155

  • [Journal Article] Human amnion-derived mesenchymeal stem cell transplantation ameliorates dextran sulfate sodium-induced severe colitis in rats.2015
    • Author(s)
      ２．Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, Sakamoto N
    • Journal Title

      Cell Transplantation

      Volume: Epub ahead of print

    • NAID

      120005690898

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression.2015
    • Author(s)
      Tasaka-Fujita M, Sugiyama N, Kang W, Masaki T, Murayama A, Yamada N, Sugiyama R, Tsukuda S, Watashi K, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 13994-13994

    • DOI

      10.1038/srep13994

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-15K15285, KAKENHI-PROJECT-26860309, KAKENHI-PLANNED-24115003, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-25293169

  • [Journal Article] Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.2015
    • Author(s)
      Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 印刷中 Pages: 1075-84

    • DOI

      10.1111/jgh.12902

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-26460986, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-26460988, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-15K19316, KAKENHI-PROJECT-15K08989

  • [Journal Article] Human Amnion-derived Mesenchymal Stem Cell Transplantation Ameliorates Liver Fibrosis in Rats2015
    • Author(s)
      Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, Sakamoto N
    • Journal Title

      Transplant Direct

      Volume: 印刷中

    • NAID

      120005773991

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Journal Article] Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.2015
    • Author(s)
      Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590959

  • [Journal Article] Intratumoral artery on contrast-enhanced computed tomography imaging: differentiating intrahepatic cholangiocarcinoma from poorly differentiated hepatocellular carcinoma.2015
    • Author(s)
      Tsunematsu S, Chuma M, Kamiyama T, Miyamoto N, Yabusaki S, Hatanaka K, Mitsuhashi T, Kamachi H, Yokoo H, Kakisaka T, Tsuruga Y, Orimo T, Wakayama K, Ito J, Sato F, Terashita K, Nakai M, Tsukuda Y, Sho T, Suda G, Morikawa K, Natsuizaka M, Nakanishi M, Ogawa K, Taketomi A, Matsuno Y, Sakamoto N
    • Journal Title

      Abdominal Imaging

      Volume: 40 Pages: 1492-1499

    • DOI

      10.1007/s00261-015-0352-9

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-26460982, KAKENHI-PROJECT-26461021

  • [Journal Article] Serum granulysin levels as a predictor of serious telaprever-induced dermatological reactions2015
    • Author(s)
      Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kudo M, Chuganji Y, Tsukuda Y, Tsunematsu S, Sato F, Terasita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Ogawa K, Ohnishi S, Chuma M, Fujita Y, Abe R, Taniguchi M, Nakagawa M, Asahina Y, Sakamoto N
    • Journal Title

      Hepatology Res

      Volume: 印刷中 Pages: 837-45

    • DOI

      10.1111/hepr.12421

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860513, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-15K08980

  • [Journal Article] New molecularly targeted therapies against advanced hepatocellular carcinoma: From molecular pathogenesis to clinical trials and future directions.2015
    • Author(s)
      Chuma M, Terashita K, Sakamoto N
    • Journal Title

      Hepatology Research

      Volume: 印刷中

    • DOI

      10.1111/hepr.12459

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26460982

  • [Journal Article] Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial.2015
    • Author(s)
      Mizokami M, Yokosuka O, Takehara T, Sakamoto N, Korenaga M, Mochizuki H, Nakane K, Enomoto H, Ikeda F, Yanase M, Toyoda H, Genda T, Umemura T, Yatsuhashi H, Ide T et al.
    • Journal Title

      Lancet Infect Dis

      Volume: 印刷中

    • DOI

      10.1016/s1473-3099(15)70099-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-26670375

  • [Journal Article] EGFR inhibitors eliminate cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition2015
    • Author(s)
      １．Fumiyuki Sato, Yoshimasa Kubota, Mitsuteru Natsuizaka, Osamu Maehara, Yutaka Hatanaka, Katsuji Marukawa, Katsumi Terashita, Goki Suda, Shunsuke Ohnishi, Yuichi Shimizu, Yoshito Komatsu, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Kelly Whelan, Anil Rustgi, Hiroshi Nakagawa, and Naoya Sakamoto
    • Journal Title

      Cancer Biology & Therapy

      Volume: Epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C2015
    • Author(s)
      Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H et al.
    • Journal Title

      Human Genetics

      Volume: 134 Pages: 279-289

    • DOI

      10.1007/s00439-014-1520-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378, KAKENHI-PROJECT-26293179

  • [Journal Article] Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese2015
    • Author(s)
      N. Nishida, J. Ohashi, M. Sugiyama, T. Tsuchiura, K. Yamamoto, K. Hino, M. Honda, S. Kaneko, H. Yatsuhashi, K. Koike, O. Yokosuka, E. Tanaka, A. Taketomi, M. Kurosaki, N. Izumi, N. Sakamoto, Y. Eguchi, T. Sasazuki, K. Tokunaga, and M. Mizokami
    • Journal Title

      Tissue Antigens

      Volume: 5 Pages: 406-12

    • DOI

      10.1111/tan.12684

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K05577, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-25291103

  • [Journal Article] Hepatocellular carcinoma risk assessment using gadoxetic acid-enhanced hepatocyte phase magnetic resonance imaging2015
    • Author(s)
      Komatsu N, Motosugi U, Maekawa S, Shindo K, Sakamoto M, Sato M, Tatsumi A, Miura M, Amemiya F, Nakayama Y, Inoue T, Fukasawa M, Uetake T, Ohtaka M, Sato T, Asahina Y, Kurosaki M, Izumi N, Ichikawa T, Araki T, Enomoto N.
    • Journal Title

      Hepatol Res.

      Volume: -

    • DOI

      10.1111/hepr.12309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366

  • [Journal Article] ITPA genetic variants influence efficacy of PEG-IFN/RBV therapy in older patients infected with HCV genotype 1 and favourable IL28B type.2014
    • Author(s)
      Matsuura K, Tanaka Y, Watanabe T, Fujiwara K, Orito E, Kurosaki M, Izumi N, Sakamoto N, Enomoto N, Yatsuhashi H, Kusakabe A, Shinkai N, Nojiri S, Joh T, Mizokami M.
    • Journal Title

      J Viral Hepat

      Volume: 21 Pages: 466-474

    • DOI

      10.1111/jvh.12171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461004, KAKENHI-PROJECT-26670375

  • [Journal Article] Hepatosplenic Gamma-delta T-cell Lymphoma Associated with Epstein-Barr Virus2014
    • Author(s)
      ６．Seiji Tsunematsu, Mitsuteru Natsuizaka, Hiromi Fujita, Noriyuki Otsuka, Katsumi Terashita, Fumiyuki Sato, Tomoe Kobayashi, Masato Nakai, Yoko Tsukuda, Hiromasa Horimoto, Takuya Sho, Goki Suda, Mitsuru Nakanishi, Satoshi Hashino, Makoto Chuma, Naoya Sakamoto
    • Journal Title

      Intern Med

      Volume: 53(18) Pages: 2079-2082

    • NAID

      130004687645

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] Sofosbuvir plus ribavirin in Japanese patients with chronic genotype 2 HCV infection: an open-label, phase 3 trial.2014
    • Author(s)
      Omata M, Nishiguchi S, Ueno Y, Mochizuki H, Izumi N, Ikeda F, Toyoda H, Yokosuka O, Nirei K, Genda T, Umemura T, Takehara T, Sakamoto N, Nishigaki Y, Nakane K, Toda N, Ide T, Yanase M, Hino K et al.
    • Journal Title

      J Viral Hepat

      Volume: 21 Pages: 762-768

    • DOI

      10.1111/jvh.12312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670375

  • [Journal Article] The J6JFH1 strain of hepatitis C virus infects human B-cells with low replication efficacy.2014
    • Author(s)
      Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH.
    • Journal Title

      Viral Immunol

      Volume: 27 Pages: 285-294

    • DOI

      10.1089/vim.2013.0140

    • NAID

      120005468145

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-26670375

  • [Journal Article] インターフェロン少量長期療法の実際と新薬時代における役割2014
    • Author(s)
      須田剛生、坂本直哉
    • Journal Title

      内科

      Volume: 113 Pages: 681-685

    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] The J6JFH1 strain of hepatitis C virus infects human B cells with low replication efficacy.2014
    • Author(s)
      Masato Nakai, Tsukasa Seya, Misako Matsumoto, Kunitada Shimotohno, Naoya Sakamoto, and Hussein H Aly
    • Journal Title

      Viral Immunology

      Volume: in press

    • NAID

      120005468145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus2014
    • Author(s)
      Maekawa S, Enomoto N
    • Journal Title

      PLoS ONE

      Volume: 49(1) Pages: 163-164

    • DOI

      10.1371/journal.pone.0082299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590965, KAKENHI-PROJECT-24659204, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25460985, KAKENHI-PROJECT-25293110

  • [Journal Article] The J6JFH1 strain of hepatitis C virus infects human B cells with low replication efficacy2014
    • Author(s)
      Masato Nakai, Tsukasa Seya, Misako Matsumoto, Kunitada Shimotohno, Naoya Sakamoto, and Hussein H Aly
    • Journal Title

      Viral Immunology

      Volume: (in press)

    • NAID

      120005468145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Telaprevir:副作用とその対策2014
    • Author(s)
      須田剛生、坂本直哉
    • Journal Title

      Internal Medicine

      Volume: ６７ Pages: 855-860

    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase.2014
    • Author(s)
      Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, Suda G, Sho T, Hatakaka K, Matsuno Y, Yokoo H, Kamiyama T, Taketomi A, Fujii G, Tashiro K, Hikiba Y, Fujimoto M, Asaka M, Maeda S.
    • Journal Title

      Carcinogenesis

      Volume: 35(2) Pages: 272-281

    • DOI

      10.1093/carcin/bgt343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25440010, KAKENHI-PROJECT-25860512, KAKENHI-PROJECT-25860513, KAKENHI-PROJECT-26460982

  • [Journal Article] Association of ITPA gene variation and serum ribavirinconcentration with a decline in blood cell concentrations during pegylated interferon-alpha plus ribavirin therapy for chronic hepatitis C2013
    • Author(s)
      Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K,Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M,Watanabe M, Ochanomizu Liver Conference Study Group
    • Journal Title

      Hepatol Int.

      Volume: 7(1) Pages: 153-161

    • DOI

      10.1007/s12072-012-9363-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958

  • [Journal Article] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Haliclona (Reniera) sp.2013
    • Author(s)
      Fujimoto Y, Salam KA, Sakamoto N, et al.
    • Journal Title

      Plos One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Journal Article] The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.2013
    • Author(s)
      Kakinuma S, Kiyohashi K, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, YoshinoK, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, and *WatanabeM
    • Journal Title

      Development

      Volume: (in press) Pages: 2502-13

    • DOI

      10.1002/hep.26293

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23689040, KAKENHI-PROJECT-23790777, KAKENHI-PUBLICLY-24112505, KAKENHI-PUBLICLY-24112519, KAKENHI-PROJECT-24390304, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-25460271, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522, KAKENHI-PLANNED-23102003, KAKENHI-PLANNED-23106004

  • [Journal Article] NX-PVKA assay, a conventional but refined prognostic biomarker for Hepatocellular carcinoma2013
    • Author(s)
      Sakamoto N
    • Journal Title

      Journal of Gastroenterol and Hepatol

      Volume: 28 Pages: 755-756

    • DOI

      10.1111/jgh.12138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] IL6を介したC型慢性肝炎のインターフェロン治療抵抗性機構2013
    • Author(s)
      須田剛生、坂本直哉
    • Journal Title

      消化器内科

      Volume: 56 Pages: 421-426

    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C2013
    • Author(s)
      Kohjima M, Enjoji M, Sakamoto N, et al.
    • Journal Title

      J Med Virol

      Volume: 85 Pages: 250-260

    • DOI

      10.1002/jmv.23464

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C2013
    • Author(s)
      Kurosaki M, Sakamoto N, Asahina Y, Izumi N et al
    • Journal Title

      J Med Virol.

      Volume: 85 Pages: 2449-2458

    • DOI

      10.1002/jmv.23497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24790728, KAKENHI-PROJECT-24890058, KAKENHI-PROJECT-24590964

  • [Journal Article] A multi-center survey of re-treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan2013
    • Author(s)
      Oze T, Hiramatsu N, Mita E, Akuta N, Sakamoto N, et al.
    • Journal Title

      Hepatol Res

      Volume: 43 Pages: 35-43

    • DOI

      10.1111/j.1872-034x.2012.01056.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis C.2013
    • Author(s)
      Kurosaki M, Sakamoto N, Nakagawa M, et al.
    • Journal Title

      Journal of Hepatology

      Volume: 56(3) Pages: 602-608

    • DOI

      10.1016/j.jhep.2011.09.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590836, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790632, KAKENHI-PROJECT-23590982, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24659359

  • [Journal Article] Cyclophilin A and nuclear factor of activated T cells are essential in cyclosporin A-mediated suppression of polyomavirus BK replication.2013
    • Author(s)
      Li YJ, Wu HH, Sakamoto N, et al.
    • Journal Title

      Am J Transplantation

      Volume: 12 Pages: 2348-2362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Journal Article] 肝炎ウイルス学近年の進歩2013
    • Author(s)
      坂本直哉
    • Journal Title

      診断と治療

      Volume: 101(9) Pages: 1283-1286

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis.2013
    • Author(s)
      Masayuki Kurosaki
    • Journal Title

      Antivir Ther

      Volume: 17(1) Pages: 35-43

    • DOI

      10.3851/imp1923

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590982, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24590964

  • [Journal Article] Hypoxia-inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors.2013
    • Author(s)
      Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, Kobayashi M, Takeda H
    • Journal Title

      PLoS ONE

      Volume: 8

    • DOI

      10.1371/journal.pone.0066255

    • NAID

      120005326763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590074, KAKENHI-PROJECT-24659359

  • [Journal Article] C型肝炎ウイルス蛋白によるシグナル伝達制御2013
    • Author(s)
      須田剛生、坂本直哉
    • Journal Title

      分子消化器病

      Volume: 10 Pages: 68-72

    • Data Source
      KAKENHI-PROJECT-25860513

  • [Journal Article] Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase2013
    • Author(s)
      Huang JT, Tseng CP, Liao MH, Lu SC, Sakamoto N, et al.
    • Journal Title

      Journal of Virology

      Volume: (Epub) Pages: 4994-5004

    • DOI

      10.1128/jvi.02526-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity.2013
    • Author(s)
      Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, asahina Y, Yoneyama M, Fujita T, Watanabe M
    • Journal Title

      Hepatology

      Volume: 57 Pages: 46-58

    • DOI

      10.1002/hep.26017

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24890058, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522

  • [Journal Article] Let-7b is a novel regulator of hepatitis C virus replication2013
    • Author(s)
      Cheng J-C, Yeh YJ, Tseng CP, Hsu SD, Chang YL, Sakamoto N, Huang HD
    • Journal Title

      Cell Mol Life Sci

      Volume: 69 Pages: 2621-2633

    • DOI

      10.1007/s00018-012-0940-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Pages: 1315-23

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.2012
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M.
    • Journal Title

      Antimicrob Agents Chemother.

      Volume: 56(3) Issue: 3 Pages: 1315-1323

    • DOI

      10.1128/aac.05764-11

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-21249013

  • [Journal Article] Anemia and thrombocytosis induced by ribavirin monotherapy in patients with chronic hepatitis C2012
    • Author(s)
      Kobayashi T, Hige s, Sakamoto N, et al.
    • Journal Title

      J Gastroenterol

      Volume: 47 Pages: 1228-1237

    • DOI

      10.1007/s00535-012-0579-y

    • NAID

      10031126955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-22a.2012
    • Author(s)
      Sakurai F, Furukawa N, Higuchi M, Okamoto S, Ono K, Yoshida T, Kondoh M, Yagi K, Sakamoto N, Katayama K, Mizuguchi H
    • Journal Title

      Virus Research

      Volume: 165 Pages: 214-218

    • DOI

      10.1016/j.virusres.2012.02.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Pages: 1315-1323

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Cyclophilin A and nuclear factor of activated T cells are essential in cyclosporin A-mediated suppression of polyomavirus BK replication2012
    • Author(s)
      Li YJ, Wu HH, Weng CH, Chen YC, Hung CC, Yang CW, Wang YL, Sakamoto N, Tian YC.
    • Journal Title

      Am J Transplantation

      Volume: 12(9) Pages: 2348-2362

    • DOI

      10.1111/j.1600-6143.2012.04116.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis2012
    • Author(s)
      Kurosaki M, Sakamoto N, et al
    • Journal Title

      Antivir Ther

      Volume: 17(1) Pages: 35-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Journal Article] Ochanomizu Liver Conference Study Group : Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C2012
    • Author(s)
      Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M
    • Journal Title

      Hepatol Int

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] HBV無症候性キャリアの自然経過と診療2012
    • Author(s)
      中西満、坂本直哉
    • Journal Title

      医学のあゆみ

      Volume: 242 (5) Pages: 401-406

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Haliclona (Reniera) sp2012
    • Author(s)
      Fujimoto Y
    • Journal Title

      Plos One

      Volume: 7 Pages: 744-761

    • DOI

      10.1371/journal.pone.0048685

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-22603007, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-23590544, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659204, KAKENHI-PROJECT-24659359

  • [Journal Article] Ochanomizu Liver Conference Study Group : Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C.2012
    • Author(s)
      Nakagawa M, Sakamoto N, Watanabe T, et al.
    • Journal Title

      Hepatol Int

      Volume: (Epub)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Journal Article] Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis2012
    • Author(s)
      Kurosaki M, Sakamoto N, et al
    • Journal Title

      Antivir Ther

      Volume: 17(1) Pages: 35-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012
    • Author(s)
      Kusano-Kitazume A, Sakamoto N(equalcontribution), Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Pages: 1315-1323

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] C型肝炎の近未来治療2012
    • Author(s)
      坂本直哉
    • Journal Title

      化学療法の領域

      Volume: 28(S-1) Pages: 1134-1140

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Factors responsible for the discrepancy between IL28B polymorphism prediction and the viral response to peginterferon plus ribavirin therapy in Japanese chronic hepatitis C patients.2012
    • Author(s)
      Saito H, Ito K, Sugiyama M, Matsui T, Aoki Y, Imamura M, Murata K, Masaki N, Nomura H, Adachi H, Hige S, Enomoto N, Sakamoto N, Kurosaki M, Mizokami M, Watanabe S
    • Journal Title

      Hepatol Res.

      Volume: 42(10) Pages: 958-65

    • DOI

      10.1111/j.1872-034x.2012.01013.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390117, KAKENHI-PROJECT-23591005, KAKENHI-PROJECT-23890255, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] Data Mining Analysis of Hepatocellular Carcinoma Risk Predictors in Chronic Hepatitis C2012
    • Author(s)
      Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Izumi NHiramatsu N, Sakamoto M, Suzuki Y, iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N
    • Journal Title

      C.J Hepatol

      Volume: 56(3) Pages: 602-8

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis2012
    • Author(s)
      Kurosaki M, Kakinuma S, Sakamoto N, Nakagawa M, et al.
    • Journal Title

      Antivir Ther

      Volume: 17(1) Pages: 35-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.2012
    • Author(s)
      Kaushik-Basu N, Sakamoto N
    • Journal Title

      Eur J Med Chem

      Volume: 49 Pages: 191-199

    • DOI

      10.1016/j.ejmech.2012.01.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24659359

  • [Journal Article] 座談会-B型肝炎 : 克服へのロードマップ2012
    • Author(s)
      坂本直哉
    • Journal Title

      肝胆膵

      Volume: 65(4) Pages: 763-778

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] HBV無症候性キャリアの自然経過と診療2012
    • Author(s)
      中西満、坂本直哉
    • Journal Title

      肝胆膵

      Volume: 65 (4) Pages: 627-634

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] C型肝炎治療のEBM : テラプレビル2012
    • Author(s)
      坂本直哉
    • Journal Title

      肝胆膵

      Volume: 64(3) Pages: 319-325

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response2012
    • Author(s)
      Asahina Y, Sakamoto N, Izumi N et al
    • Journal Title

      Hepatology

      Volume: 55 Pages: 20-29

    • DOI

      10.1002/hep.24623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21659186, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24890058

  • [Journal Article] Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives2012
    • Author(s)
      Nichols DB, Fournet G, Gurukumar KR, Basu A, Lee JC, Sakamoto N, Kozielski F, Musmuca I, Joseph B, Ragno R, Kaushik-Basu N
    • Journal Title

      Eur J MedChem

      Volume: 49 Pages: 191-199

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia2012
    • Author(s)
      Yamashita A, Maekawa S, et al
    • Journal Title

      Marine Drugs

      Volume: 10 Pages: 744-761

    • DOI

      10.3390/md10040744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-22603007, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24659359

  • [Journal Article] C型肝炎治療薬テラプレビル2012
    • Author(s)
      坂本直哉
    • Journal Title

      薬局

      Volume: 63 (1) Pages: 123-128

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis2012
    • Author(s)
      Kurosaki M, Sakamoto N, Nakagawa M, et al.
    • Journal Title

      Antivir Ther

      Volume: 17(1) Pages: 35-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Suppression ofhath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2012
    • Author(s)
      Zheng X, Nakamura T, et al
    • Journal Title

      Inflamm Bowel Di

      Volume: 17 Pages: 2251-2260

    • DOI

      10.1002/ibd.21611

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24659359

  • [Journal Article] Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis2012
    • Author(s)
      Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sakaguchi F, Sakamoto N, Nakagawa M, Izumi N
    • Journal Title

      C.J Hepatol

      Volume: 56(3) Pages: 602-8

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Ochanomizu Liver Conference Study Group : Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C2012
    • Author(s)
      Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M.
    • Journal Title

      Hepatol Int

      Volume: (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Association between hpid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes.2011
    • Author(s)
      Tbyoda M, Kitaoka A, Machida K, Nishinakagawa T, Yada R, Kohjima M, Kato M, Kotoh K, Sakamoto N, et al.
    • Journal Title

      Int J Mol Med

      Volume: (EPub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferonalpha 2b plus ribavirin.2011
    • Author(s)
      Ueyama M, Nakagawa M, Sakamoto N,Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M and the Ochanomizu-Liver Conference Study Group
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • DOI

      10.3851/imp1864

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23790778

  • [Journal Article] Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes2011
    • Author(s)
      Toyoda M, Kitaoka A, Machida K, Nishinakagawa T, Yada R, Kohjima M, Kato M, Kotoh K, Sakamoto N, Shiota G, Nakamuta M, Nakashima M, Enjoji M
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 619-624

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes2011
    • Author(s)
      Toyoda M, Sakamoto N, et al
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 619-624

    • DOI

      10.3892/ijmm.2011.622

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832

  • [Journal Article] A new method for induced fit docking (GENIUS)and its application to virtual screening of novel HCV NS3-4A protease inhibitors2011
    • Author(s)
      Takaya D, Sakamoto N, et al.
    • Journal Title

      Bioorg Med Chem

      Volume: 19(22) Pages: 6892-6905

    • DOI

      10.1016/j.bmc.2011.09.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-21659186, KAKENHI-PROJECT-22590724, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-24659359

  • [Journal Article] Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response2011
    • Author(s)
      Asahina Y, Tsuchiya K, Muraoka M, TanakaK, Suzuki Y, Tamaki N, Hoshioka Y, Yasui Y, Katoh T, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nitta S, Sakamoto N, Izumi N
    • Journal Title

      Hepatology

      Volume: 55(1) Pages: 20-29

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Pretreatment Prediction of response to peginterferon plus ribavirin in chronic hepatitis C using data mining analysis.2011
    • Author(s)
      Masayuki Kurosaki, Naoya Sakamoto, et al.
    • Journal Title

      J Gastroenterol

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes..2011
    • Author(s)
      Toyoda M, Kitaoka A, Machida K, Nishinakagawa T, Yada R, Kohjima M, Kato M, Kotoh K, Sakamoto N, et al.
    • Journal Title

      Int J Mol Med

      Volume: (EPub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Pretreatment prediction of anemia progression by pegylated interferon a2b plus ribavirin combination therapy in chronic hepatitis C infection : Decision-tree analysis2011
    • Author(s)
      Hiramatsu N, Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Sakaguchi F, Tamori A, Kakinuma S, Matsuura K, Izumi N
    • Journal Title

      JGastroenterol

      Volume: 46 Pages: 1111-19

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response2011
    • Author(s)
      Asahina Y, Sakamoto N, et al.
    • Journal Title

      Hepatology

      Volume: 55(1) Pages: 20-29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Adenovirus vector-mediated assay system for hepatitis C virus replication2011
    • Author(s)
      Yoshida T, Sakamoto N, et al.
    • Journal Title

      Nucleic Acids Res

      Volume: 39(10)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011
    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 55(6) Pages: 2537-2545

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin.2011
    • Author(s)
      Mayumi Ueyama, Mina Nakagawa, Naova Sakamoto, Seishin Azuma, Mamoru Watanabe, et al.
    • Journal Title

      Antivral Therapy

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Funaoka Y, Sakamoto N, Nakagawa M, Kakinuma S, Suda S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, and Watanabe M
    • Journal Title

      J Virol

      Volume: 85(12) Pages: 5986-5994

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection2011
    • Author(s)
      Yoshida T, Takayama K, Kondoh M, Sakurai F, Tani H, Sakamoto N, Matsuura Y, Mizuguchi H, Yagi K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 416(1-2) Pages: 119-124

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis Cvirus cell culture.2011
    • Author(s)
      Machi Yamamoto, Naoya Sakamoto, et al.
    • Journal Title

      Hepatology Research

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-alpha2b plus ribavirin2011
    • Author(s)
      Ueyama M, Nakagawa M, Sakamoto N, et al.
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylatedinterferon and ribavirin therapy for chronic hepatitis C2011
    • Author(s)
      Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura K, Sakamoto N, Enomoto N, Yatsuhashi H, Nishiguchi S, Hino K, Hige S, Itoh Y, Tanaka E, Mochida S, Honda M, Hiasa Y, Koike A, Sugauchi F, Kaneko S, Izumi N, Tokunaga K, Mizokami M
    • Journal Title

      Human Molecular Genetics

      Volume: 20(17) Pages: 3507-3516

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] シクロフィリン阻害剤2011
    • Author(s)
      中川美奈、坂本直哉、渡辺守
    • Journal Title

      肝胆膵

      Volume: 62 Pages: 403-412

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection2011
    • Author(s)
      Yoshida T, Takayama K, Kondoh M, Sakurai F, Tani H, Sakamoto N, Matsuura Y, Mizuguchi H, Yagi K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 416(1-2) Pages: 119-124

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] The inhibitory effect on hepatitis C virus infection of a triterpenoid compound, with or without interferon-alpha2011
    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 55(6) Pages: 2537-2545

    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Inhibitory effect of a triterpenoid compound, with or without interferon-alpha, on hepatitis C virus infection2011
    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 55(6) Pages: 2537-2545

    • DOI

      10.1128/aac.01780-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790778

  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Funaoka Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al
    • Journal Title

      Journal of Virology

      Volume: 85 Pages: 5986-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Pretreatment Prediction of Response to Pegylated-Interferon Plus Ribavirin for Chronic Hepatitis C using Genetic Polymorphism in IL28B and Viral Factors2011
    • Author(s)
      Kurosaki M, Sakamoto N, Nakagawa M, Watanabe M, et al.
    • Journal Title

      J Hepatol.

      Volume: 54 Pages: 439-448

    • DOI

      10.1016/j.jhep.2010.07.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21390227, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590836, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23390117

  • [Journal Article] Studies on virus kinetics using injbctious fluorescence-tagged hepatitis C ViruS Cell Culture.2011
    • Author(s)
      Machi Yamamoto, Naoya Sakamoto, et al.
    • Journal Title

      Hepatology Research

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C.2011
    • Author(s)
      Tanaka Y, Sakamoto N, et al.
    • Journal Title

      Hum Mol Genet

      Volume: 20(17) Pages: 3507-16

    • DOI

      10.1093/hmg/ddr249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21390227, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21659186, KAKENHI-PROJECT-22390151, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-23390201

  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Funaoka Y, Sakamoto N(equal contribution), Nakagawa M, Kakinuma S, Suda S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, and Watanabe M
    • Journal Title

      J Virol

      Volume: 85(12) Pages: 5986-5994

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Pre-treatment prediction of response topegylated-interferon plus ribavirin forchronic hepatitis C using genetic polymorphism in IL28B and viral factors2011
    • Author(s)
      Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, SugiyamaM, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M
    • Journal Title

      JHepatol

      Volume: 54 Pages: 439-448

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy2011
    • Author(s)
      Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
    • Journal Title

      PLoS One

      Volume: 6(9)

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] NCV-NS4B蛋白とIFN発現計シグナル分子との分子間相互作用の解析2011
    • Author(s)
      新田沙由梨,坂本直哉
    • Journal Title

      消化器と免疫

      Volume: 48 Pages: 174-177

    • Data Source
      KAKENHI-PROJECT-24659359

  • [Journal Article] Association of IL28B variants with response to pegylated-interferon alphaplus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.2011
    • Author(s)
      Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
    • Journal Title

      J Medical Viro

      Volume: 83 Pages: 871-8

    • DOI

      10.1002/jmv.22038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590833, KAKENHI-PROJECT-22390151, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22710191, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23390117, KAKENHI-PROJECT-23790778

  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M
    • Journal Title

      J Virol

      Volume: 85 Pages: 5986-94

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Association of IL28B polymorphism with response to pegylated-interferonalpha plus ribavirin combination therapy in patients with chronic genotype 2 hepatitis C.2011
    • Author(s)
      Naoya Sakamoto, et al.
    • Journal Title

      J Medical Virol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture2011
    • Author(s)
      Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 258-269

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Association of IL28B polymorphism withresponse to pegylated-interferon alpha plusribavirin combination therapy in patientswith chronic genotype 2 hepatitis C2011
    • Author(s)
      Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M
    • Journal Title

      JMedical Virol

      Volume: 83 Pages: 871-878

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Adenovirus vector-mediated assay system for hepatitis C virus replication2011
    • Author(s)
      Yoshida T, Kondoh M, Ojima M, Mizuguchi H, Yamagishi Y, Sakamoto N, Yagi K.
    • Journal Title

      Nucleic Acids Res

      Volume: 39(10)

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy2011
    • Author(s)
      Kadokura M, Nakagawa M, Sakamoto N, Watanabe M, et al.
    • Journal Title

      PLoS One.

      Volume: 6(9)

    • DOI

      10.1371/journal.pone.0024514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-21659186, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-23390195

  • [Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacer bated in matrix metalloproteinase-2 deficient mice2011
    • Author(s)
      Onozuka I, Sakamoto N, Nakagawa M, Watanabe M, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 406 Pages: 134-140

    • DOI

      10.1016/j.bbrc.2011.02.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22591762, KAKENHI-PROJECT-22659145, KAKENHI-PUBLICLY-23117507, KAKENHI-PROJECT-23689040

  • [Journal Article] Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-alpha2b plus ribavirin2011
    • Author(s)
      Ueyama M, Sakamoto N, et al
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K,Watanabe M
    • Journal Title

      J Virol

      Volume: 85 Pages: 5986-5994

    • DOI

      10.1128/jvi.02583-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PUBLICLY-23130506

  • [Journal Article] A new method for induced fit docking(GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors2011
    • Author(s)
      Takaya D, Yamashita A, Kamijo K, Gomi J, Ito M, Maekawa S, Enomoto N, SakamotoN, Watanabe Y, Arai R, Umeyama H, Honma T, Matsumoto T, Yokoyama S
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 19(22) Pages: 6892-6905

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Inhibitory effect of triterpenoid compound, with or without interferon-alpha, on hepatitis C virus infection2011
    • Author(s)
      Watanabe T, Sakamoto N, Nakagawa M, Kakinuma S, Itsui Y, Nishimura-Sakurai Y, Ueyama M, Funaoka Y, Kitazume A, Nitta S, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Oooka S, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 55 Pages: 2537-45

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis2011
    • Author(s)
      Kurosaki M, Sakamoto N, et al.
    • Journal Title

      J Gastroenterol

      Volume: 46(3) Pages: 401-409

    • DOI

      10.1007/s00535-010-0322-5

    • NAID

      10029028096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145

  • [Journal Article] Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-alpha2b plus ribavirin2011
    • Author(s)
      Ueyama M, Nakagawa M, Sakamoto N, et al.
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Adenovirus vector-mediated assay system for hepatitis C virus replication2011
    • Author(s)
      Yoshida T, Sakamoto N, et al
    • Journal Title

      Nucleic Acids Res

      Volume: 39(10)

    • DOI

      10.1093/nar/gkr047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145

  • [Journal Article] Adenovirus vector-mediated assay system for hepatitis C virus replication2011
    • Author(s)
      Yoshida T, Kondoh M, Ojima M, Mizuguchi H, Yamagishi Y, Sakamoto N, Yagi K
    • Journal Title

      Nucleic Acids Res

      Volume: 39(10)

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture2011
    • Author(s)
      Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 258-269

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Studies on virus kineticsusing infectious fluorescence-taggedhepatitis C virus cell culture.2011
    • Author(s)
      Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M
    • Journal Title

      Hepatology Research

      Volume: 41 Pages: 258-269

    • DOI

      10.1111/j.1872-034x.2010.00771.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22790633, KAKENHI-PROJECT-23790778

  • [Journal Article] Adenovirus vector-mediated assay system for Hepatitis C virus replication.2011
    • Author(s)
      Takeshi Yoshida, Masuo Kondoh, Manabu Ojima, Hiroyuki Mizuguchi, Naoya Sakamoto
    • Journal Title

      Nucl Acid Res

      Volume: (EPub ahead ofprint)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Association of IL28B polymorphism with response to pegylated-interferon alpha plus ribavirin combination therapy in patients with chronic genotype 2 hepatitis C.2011
    • Author(s)
      Naova Sakamoto, et al.
    • Journal Title

      JMedical Virol

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection2011
    • Author(s)
      Yoshida T, Sakamoto N, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 416(1-2) Pages: 119-124

    • DOI

      10.1016/j.bbrc.2011.11.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-24659359

  • [Journal Article] Pretreatment prediction of anemia progression by pegylated interferon α2b plus ribavirin combination therapy in chronic hepatitis C infection : Decision-tree analysis2011
    • Author(s)
      Hiramatsu N, Sakamoto N, et al.
    • Journal Title

      J Gastroenterol

      Volume: 46(9) Pages: 1111-1119

    • DOI

      10.1007/s00535-011-0412-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590836, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790632

  • [Journal Article] Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice2011
    • Author(s)
      Kakinuma S, Onozuka I, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, NakagawaM, Koshikawa N, Seiki M, Nakauchi H, and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 134-140

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Sequences in the Interferon Sensitivity Determining Region and Core Region of Hepatitis C Virus Impact Pretreatment Prediction of Response to Peg-interferon Plus Ribavirin : Data Mining Analysis.2011
    • Author(s)
      Masayuki Kurosaki, Naoya Sakamoto, Manabu Iwasaki, Minoru Sakamoto, et al.
    • Journal Title

      J Medical Virol

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-alpha2b plus ribavirin2011
    • Author(s)
      Ueyama M, Sakamoto N, et al
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Journal Article] Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes2011
    • Author(s)
      Toyoda M, Kitaoka A, Machida K, Nishinakagawa T, Yada R, Kohjima M, Kato M, Kotoh K, Sakamoto N, Shiota G, Nakamuta M, Nakashima M, Enjoji M
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 619-624

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Pretreatment Prediction of response to peginterferon plus ribavirin inchronic hepatitis C using data mining analysis.2011
    • Author(s)
      Masayuki Kurosaki, Naoya Sakamoto, et al.
    • Journal Title

      J Gastroenterol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus inassociation with the response to peginterferon and ribavirin therapy2011
    • Author(s)
      Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
    • Journal Title

      PLoSOne

      Volume: 6(9)

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon plus ribavirin : data mining analysis. J Med Virol2011
    • Author(s)
      Kurosaki M, Sakamoto N, Nakagawa M, et al.
    • Journal Title

      J Medical Virol

      Volume: 83 Pages: 445-452

    • DOI

      10.1002/jmv.22005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-22790633

  • [Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronichepatitis C infection with pegylated-interferon alpha 2b plus ribavirin.2011
    • Author(s)
      Mayumi Ueyama, Mina Nakagawa, Naova Sakamoto, Seishin Azuma, Mamoru Watanabe, et al.
    • Journal Title

      Antiviral Therapy

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin2011
    • Author(s)
      Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
    • Journal Title

      Antivir Ther

      Volume: 16 Pages: 1081-1091

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Sequences in the Interferon Sensitivity Determining Region and Core Region of Hepatitis C Virus Impact Pretreatment Prediction of Response toPeg-interferon Plus Ribavirin : Data Mining Analysis.2011
    • Author(s)
      Masayuki Kurosaki, Naoya Sakamoto, Manabu Iwasaki, Minoru Sakamoto, et al.
    • Journal Title

      J Medical Virol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy2011
    • Author(s)
      Kadokura M, Nakagawa M, Sakamoto N, Watanabe M, et al.
    • Journal Title

      Hepatol Int.

      Volume: 5(3) Pages: 789-799

    • DOI

      10.1007/s12072-011-9267-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-21590832, KAKENHI-PROJECT-21590837, KAKENHI-PROJECT-22659145, KAKENHI-PROJECT-24659359

  • [Journal Article] Cell Culture and in vivo analyses of cytopathic hepatitis C virus mutanis2010
    • Author(s)
      Mishima K, Sakamoto N, Sekine
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590720

  • [Journal Article] Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway2010
    • Author(s)
      Kim K, Kim KH, Kim HY, Cho HK, Sakamoto N, Cheong J
    • Journal Title

      FEBS Lett

      Volume: 584 Pages: 707-712

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1pathway2010
    • Author(s)
      KyeongJin Kim, Kook Hwan Kim, Hye Ybung Kim, Hyun Kook Cho, Naova Sakamoto, et al.
    • Journal Title

      FEBS Letter

      Volume: 584 Pages: 707-712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis Cvirus mutants.2010
    • Author(s)
      Kako Mishima, Naoya Sakamoto, et al
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase2010
    • Author(s)
      Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54 Pages: 3179-3186

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants2010
    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Tuchiya K, Imamura M, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis Cvirus mutants.2010
    • Author(s)
      Suda G, Sakamoto N, Azuma S
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-richprotein kinase.2010
    • Author(s)
      Yuko Karakama, Naoya Sakamoto, et al.
    • Journal Title

      Antimicrobial Agent and Chemotherapy

      Volume: 54 Pages: 3179-3186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010
    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] HCVの複製・増殖機構と遺伝子型・遺伝子変異2010
    • Author(s)
      筬島裕子、中川美奈、坂本直哉
    • Journal Title

      日本臨床

      Volume: 69 Pages: 52-58

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.2010
    • Author(s)
      Nakagawa M, Sakamoto N, Ueyama M, Mogushi K, Nagaie S, Itsui Y, Azuma S, Kakinuma S, Tanaka H, Enomoto N, Watanabe M
    • Journal Title

      J Gastroentorol (in press)

    • NAID

      10027216778

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790485

  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated in terferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C.2010
    • Author(s)
      Sakamoto N, et al.
    • Journal Title

      Hepatology Research

      Volume: 40 Pages: 1063-1071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590720

  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase2010
    • Author(s)
      Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka S, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob AgentChemother

      Volume: 54 Pages: 3179-86

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells2010
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Sekine-Osajima Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima M, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Chen CH, Kakinuma S, Tsuchiya K, Tanaka H, Enomoto N, Watanabe
    • Journal Title

      J Gastroentorol

      Volume: 45 Pages: 523-36

    • NAID

      10027216127

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.2010
    • Author(s)
      Kim K, Sakamoto N, et al
    • Journal Title

      FEBS Lett. 584

      Pages: 707-712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.2010
    • Author(s)
      Goki Suda, Naova Sakamoto, et al.
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Comparison of HCVLassociated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2010
    • Author(s)
      Yuki Nishimura-Sakurai, Naoya Sakamoto, et al.
    • Journal Title

      JGastroentorol

      Volume: 45 Pages: 523-536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronichepatitis C.2010
    • Author(s)
      Naova Sakamoto, Yasuhito Tanaka, et al.
    • Journal Title

      Hepatology Research

      Volume: 40 Pages: 1063-1071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.2010
    • Author(s)
      KyeongJin Kim, Kook Hwan Kim, Hye Young Kim, Hyun Kook Cho, Naova Sakamoto., et al.
    • Journal Title

      FEBS Letter

      Volume: 584 Pages: 707-712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010
    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronic hepatitis C2010
    • Author(s)
      Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 1063-1071

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2010
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto, N, Sekine-Osaiima Y, et al.
    • Journal Title

      J.Gastroenterol

      Volume: 45 Pages: 523-536

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590720

  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase.2010
    • Author(s)
      Yuko Karakama, Naoya Sakamoto, Shinva Oooka, et al.
    • Journal Title

      Antimicrobial Agent and Chemotherapy

      Volume: 54 Pages: 3179-31869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Mutations in the Interferon Sensitivity Determining Region and virological response to combination therapy with Pegylated-interferon alpha 2b plusribavirin in patients with chronic hepatitis C-1b infection.2010
    • Author(s)
      Mina Nakagawa, Naoya Sakamoto, et al.
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 656-665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Inhibition of hepatitis C virus replication by chloroquine targeting virus'associated autophagy.2010
    • Author(s)
      Tomokazu Mizui, Shunhei Yamashina, Isei Tanida, MotokiTakashima, Naova Sakamoto, etal.
    • Journal Title

      J Gastroenterol

      Volume: 5 Pages: 195-203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Pretreatment Prediction of Response to Pegylated-Interferon Plus Ribavirinfor Chronic Hepatitis C using Genetic Polymorphism in IL28B and ViralFactors.2010
    • Author(s)
      Masayuki Kurosaki, Yasuhito Tanaka, Nao Nishida, Masaya Sugiyama, Naoya Sakamoto, et al.
    • Journal Title

      J Hepatol

      Volume: (EPub)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alpha and ribavirin therapy for Japanese patients with chronic hepatitis C2010
    • Author(s)
      Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 1063-1071

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010
    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity inhepatitis C virus genotype 2a/2b chimeric clones.2010
    • Author(s)
      Goki Suda, Naova Sakamoto, et al.
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants2010
    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase.2010
    • Author(s)
      Yuko Karakama,Naoya Sakamoto, et al.
    • Journal Title

      Antimicrobial Agent and Chemotherapy

      Volume: 54 Pages: 3179-3186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] SR蛋白リン酸化酵素阻害剤によるHCV増殖抑制効果の解析2010
    • Author(s)
      唐鎌優子、坂本直哉、井津井康浩、中川美奈、藤田めぐみ、櫻井幸、柿沼晴、大岡真也、東正新、土屋輝一郎、小野木博、萩原正敏、渡辺守
    • Journal Title

      消化器内科

      Volume: 51(6) Pages: 632-635

    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Inhibition of HCV replication by a specific inhibitor of serin-arginine-rich protein kinase2010
    • Author(s)
      Karakama Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 54 Pages: 3179-3186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells2010
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
    • Journal Title

      Journal of Gastroenterorlogy (印刷中(Epub ahead of print))

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2010
    • Author(s)
      Yuki Nishimura-Sakurai, Naoya Sakamoto, et al.
    • Journal Title

      J Gastroentorol

      Volume: 45 Pages: 523-536

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2010
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N,Mogushi K, Nagaie S, Nakagawa M,Itsui Y, Sekine-Osajima Y,Tasaka-Fujita M, Onuki-Karakama Y,Suda G, Mishima M, Yamamoto M,Ueyama M, Funaoka Y, Watanabe T,Chen CH, Kakinuma S, Tsuchiya K,Tanaka H, Enomoto N, Watanabe M
    • Journal Title

      J Gastroentorol (in press)

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790485

  • [Journal Article] Cen culture and in-vivo analyses of plaque-derived cytopathic hepatitis C Vlrus mutants.2010
    • Author(s)
      Kako Mishima, Naova Sakamoto, et al
    • Journal Title

      Virology

      Volume: 405 Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.2010
    • Author(s)
      Suda G, Sakamoto N, Azuma S, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronichepatitis C2010
    • Author(s)
      Naova Sakamoto, Yasuhito Tanaka, et al.
    • Journal Title

      Hepatology Research

      Volume: 40 Pages: 1063-1071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.2010
    • Author(s)
      Tomokazu Mizui, Shunhei Yamashina, Isei Tanida, Motoki Takashima, Naova Sakamoto, et al.
    • Journal Title

      J Gastroenterol

      Volume: 5 Pages: 195-203

    • NAID

      10027214573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Mutations in the Interferon Sensitivity Determining Region and virological response to combination therapy with Pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.2010
    • Author(s)
      Nakagawa M, Sakamoto N(equal contribution), et al
    • Journal Title

      J Gastroenterol (in press)

    • NAID

      10027216778

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010
    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Mishima K, Onuki-Karakama Y, Yamamoto M, Funaoka Y, Watanabe T, Kiyohashi K, Nitta S, Azuma S, Kakinuma S, Tuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection2010
    • Author(s)
      Nakagawa M, Sakamoto N, Ueyama M, Mogushi K, Nagaie S, Itsui Y, Azuma S, Kakinuma S, Tanaka H, Enomoto N, Watanabe M
    • Journal Title

      J Gastroentorol

      Volume: 45 Pages: 656-665

    • NAID

      10027216778

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Mutations in the Interferon Sensitivity Determining Region and virological response to combination therapy with Pegylated-interferon alpha 2b plusribavirin in patients with chronic hepatitis C-1b infection.2010
    • Author(s)
      Mina Nakagawa, Naoya Sakamoto, et al.
    • Journal Title

      JGastroenterol

      Volume: 45 Pages: 656-665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Mutations in the Interferon Sensitivity Determining Region and virological response to combination therapy with Pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.2010
    • Author(s)
      Nakagawa M, Sakamoto N(equal contribution), et al.
    • Journal Title

      J Gastroenterol (in press)

    • NAID

      10027216778

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010
    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Journal Title

      Virology

      Volume: 407 Pages: 80-90

    • Data Source
      KAKENHI-PROJECT-22659145

  • [Journal Article] Pretreatment Prediction of Response to Pegylated-Interferon Plus Ribavirin for Chronic Hepatitis C using Genetic Polymorphism in IL28B and Viral Factors.2010
    • Author(s)
      Masayuki Kurosaki, Yasuhito Tanaka, Nao Nishida, Masaya Sugiyama, Naoya Sakamoto, et al.
    • Journal Title

      J Hepatol

      Volume: (EPub)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein2009
    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1727-37

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by nelfinavir and interferon-a.2009
    • Author(s)
      Satoshi Toma, Tsuyoshi Yamashiro, Shingo Arakaki, Joji Shiroma, Tatsuji Maeshiro, Kenji Hibiya, Naoya Sakamoto, Fukunori Kinjo, Masao Tateyama, Jiro Fujita
    • Journal Title

      Journal of Viral Hepatitis In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Signaling pathway via TNFa/NFkB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009
    • Author(s)
      Onizawa M, Sakamoto N, et al
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatology Res 39(1)

      Pages: 60-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein2009
    • Author(s)
      Itsui Y, Sakamoto N, Megumi Tasaka- Fujita
    • Journal Title

      Hepatology 50

      Pages: 1727-1737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Journal Article] Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.2009
    • Author(s)
      Wang SY, Sakamoto N, et al
    • Journal Title

      Biochem Biophys Res Commun 385

      Pages: 230-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Prospects for future therapy of hepatitis C virus infection.2009
    • Author(s)
      Sakamoto N, Wu GY
    • Journal Title

      Future Virology 4

      Pages: 453-462

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 39 Pages: 60-69

    • NAID

      10025324061

    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Prospects for future therapy of hepatitis Cvirus infection2009
    • Author(s)
      Sakamoto N, Wu GY
    • Journal Title

      Future Virology

      Volume: 4 Pages: 453-462

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.2009
    • Author(s)
      Mizui T, Sakamoto N, et al
    • Journal Title

      J Gastroenterol 45

      Pages: 195-203

    • NAID

      10027214573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] The isomerase active site of cyclophilin A is critical for hepatitis C virus replication2009
    • Author(s)
      Chatterji U, Bobardt M, Selvarajah S, Yang F, Tang H, Sakamoto N, Vuagniaux G, Parkinson T, Gallay P
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 16998-17005

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Musashi-1 suppressesexpression of Paneth cell-specific genes inhuman intestinal epithelial cells2009
    • Author(s)
      Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T and Watanabe M
    • Journal Title

      Gasroenterology 44

      Pages: 173-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] New therapeutic approaches to HCV.J2009
    • Author(s)
      Naoya Sakamoto, Mamoru Watanabe
    • Journal Title

      Gastroenterol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Inhibition of intracellular hepatitis C virus replication by nelfinavir and synergistic effect with interferon-alpha.2009
    • Author(s)
      Toma S, Sakamoto N, et al
    • Journal Title

      Journal of Viral Hepatitis 16

      Pages: 506-512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.2009
    • Author(s)
      Tanaka Y, Sakamoto N, et al
    • Journal Title

      Nature Genetics 41

      Pages: 1105-1109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Two flavonoidsextracts from Glycyrrhizae radix inhibit in vitrohepatitis C virus replication2009
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K and Watanabe M
    • Journal Title

      Hepatol Res 39

      Pages: 60-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatoloj Res 39

      Pages: 60-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein.2009
    • Author(s)
      Itsui Y, Sakamoto N(equal contribution), et al
    • Journal Title

      Hepatology 50

      Pages: 1727-1737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Long-lived Colitogenic CD4+ Memory T Cells Residing Outside the Intestine Participate in the Perpetuation of Chronic Colitis.2009
    • Author(s)
      Nemoto Y, Sakamoto N, et al
    • Journal Title

      J Immunol 183

      Pages: 5059-5068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Signaling pathway via TNFa/NFnB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009
    • Author(s)
      Onizawa, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Nagaishi T, Sakamoto N, Watanabe M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
    • Journal Title

      Hepatol Res

      Volume: 39 Pages: 60-69

    • NAID

      10025324061

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein.2009
    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Azuma S, Watanabe M, et al.
    • Journal Title

      Hepatology 50

      Pages: 1727-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2009
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, et al
    • Journal Title

      J Gastroentorol (EPub)

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C2009
    • Author(s)
      Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M
    • Journal Title

      NatGenet

      Volume: 41 Pages: 1105-1109

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.2009
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, et al
    • Journal Title

      J Gastroentorol

    • NAID

      10027216127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.2009
    • Author(s)
      Tai AW, Sakamoto N, et al
    • Journal Title

      Cell Host Microbe. 5

      Pages: 298-307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cellsin bone marrow2009
    • Author(s)
      Fujii T, Kanai T, Tomita T, Nemoto Y,Totsuka T, Sakamoto N, Nakamura T,Tsuchiya K, Okamoto R, Watanabe M
    • Journal Title

      Eur J Immunol 38(12)

      Pages: 3290-3303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] New therapeutic approaches to hepatitis C virus.2009
    • Author(s)
      Sakamoto N, Watanabe M.
    • Journal Title

      J Gastroenterol. 44

      Pages: 643-649

    • NAID

      10025175879

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein.2009
    • Author(s)
      Itsui Y, Sakamoto N(equal contribution)
    • Journal Title

      Hepatology 50

      Pages: 1727-1737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein.2009
    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
    • Journal Title

      Hepatology 50

      Pages: 1727-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790485

  • [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice.2009
    • Author(s)
      Ohira M, Sakamoto N, et al
    • Journal Title

      J Clin Invest 119

      Pages: 3226-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] HCV-associated gene expression and cell signaling pathway in cells with or without HCV replicon and in replicon-cured cells.2009
    • Author(s)
      Nishimura-Sakurai Y, Sakamoto N, Megumi Tasaka-Fujita
    • Journal Title

      J.Gastroentelorogy

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Journal Article] A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.2009
    • Author(s)
      Andrew W. Tai, Yair Benita, Lee F. Peng, Sun-Suk Kim, Naoya Sakamoto, Ramnik J. Xavier, Raymond T. Chung
    • Journal Title

      Cell Host & Microbe In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] IL-7 is Essential for Lymphopenia-driven Turnover of Colitogenic CD4+ Memory T Cells in Chronic Colitis.2009
    • Author(s)
      Tomita T, Sakamoto N, et al
    • Journal Title

      Eur J Immuno 39

      Pages: 2737-2747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article]2009
    • Author(s)
      坂本直哉、横田隆徳
    • Journal Title

      siRNAによるC型肝炎遺伝子治療.バイオ医薬品の開発技術とシーズ(シーエムシー出版)

      Pages: 246-251

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C2009
    • Author(s)
      Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M
    • Journal Title

      NatGenet

      Volume: 41 Pages: 1105-1109

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5Bprotein2009
    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
    • Journal Title

      Hepatology

      Volume: 50(6) Pages: 1727-37

    • DOI

      10.1002/hep.23195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Journal Article] Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma.2009
    • Author(s)
      Kim K, Sakamoto N, et al
    • Journal Title

      FEBS Letter 583

      Pages: 2720-2726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein2009
    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
    • Journal Title

      Hepatology

      Volume: 50 Pages: 1727-1737

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] New therapeutic approaches to hepatitis Cvirus2009
    • Author(s)
      Sakamoto N, Watanabe M
    • Journal Title

      JGastroenterol

      Volume: 44 Pages: 643-649

    • NAID

      10025175879

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] The isomerase active site of cyclophilin A is critical for hepatitis C virus replication.2009
    • Author(s)
      Chatterji U, Sakamoto N, et al
    • Journal Title

      J Biol Chem 284

      Pages: 16998-17005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Signaling pathway via TNFa/NFkB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis2009
    • Author(s)
      Onizawa M, Nagaishi T, Kanai T, Nagano KI, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, TsuchiyaK, Aoki K, Ohya K, Yagita H and Watanabe M
    • Journal Title

      Am J Physol Gastrntest Liver Physiol (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] A functional genomic screen identifies cellular cofactors of hepatitis C virus replication2009
    • Author(s)
      Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT
    • Journal Title

      Cell Host Microbe

      Volume: 5 Pages: 298-307

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq2009
    • Author(s)
      Wang SY, Tseng CP, Tsai KC, Lin CF, Wen CY, Tsay HS, Sakamoto N, Tseng CH, Cheng JC
    • Journal Title

      Biochem BiophysRes Commun

      Volume: 385 Pages: 230-235

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.2009
    • Author(s)
      Totsuka T, Sakamoto N, et al
    • Journal Title

      J Immunol. 182

      Pages: 6079-6087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
    • Author(s)
      Aragaki M, Sakamoto N, Kanai T, et. al.
    • Journal Title

      Biochem Biophys Res Commun (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Systemic, but not intestinal,IL-7 is essential for the persistence ofchronic colitis2008
    • Author(s)
      Tomita T, Kanai T, Nemoto Y, Totsuka T,Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M
    • Journal Title

      J immunol 180(1)

      Pages: 383-390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.2008
    • Author(s)
      Fujii T, Kanai T, Tomita T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M
    • Journal Title

      Eur J Immunol 38

      Pages: 3290-3303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Continuous generation ofcolitogenic CD4(+) T cells in persistent colitis2008
    • Author(s)
      Tomita T, Kanai T, Fujii T, Nemoto Y,Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N and Watanabe M
    • Journal Title

      Eur J Immunol 38

      Pages: 1264-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008
    • Author(s)
      Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol 23

      Pages: 1437-1447

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008
    • Author(s)
      Sakamoto N, Chen CH, Watanabe M, et. al.
    • Journal Title

      Journal of Gastroenterology and Hepatology (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Systemic, but not intestinal, IL-7is essential for the persistence of chronic colitis2008
    • Author(s)
      Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N and Watanabe M
    • Journal Title

      J Immunol 180

      Pages: 383-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Potential relevance of cytoplasmic viralsensors and related regulators involving innate immunity in antiviral response2008
    • Author(s)
      Asahina Y, Izumi N, Hirayama I, Tanaka T,Sato M, Yasui Y, Komatsu N, Umeda N,Hosokawa T, Ueda K, Tsuchiya K,Nakanishi H, Itakura J, Kurosaki M,Enomoto N, Tasaka M, Sakamoto N, Miyake S
    • Journal Title

      Gastroenterology 134(5)

      Pages: 1396-1405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral response.2008
    • Author(s)
      Asahina Y, Izumi N, Hirayama I, Tanaka T, Sato M, Yasui Y, Komatsu N, Umeda N, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Kurosaki M, Enomoto N, Tasaka M, Sakamoto N, Miyake S
    • Journal Title

      Gastroenterology 134

      Pages: 1396-1405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Continuous generation of colitogenic CD4+ T cells may be one of the mechanisms to persist colitis.2008
    • Author(s)
      Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N. Watanabe M
    • Journal Title

      Eur J Immunol 38

      Pages: 1264-1274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
    • Author(s)
      Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, Kanai T, Watanabe M
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 923-929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Effects of immunosuppressants on the progression of hepatitis C in hepatitis C virus-positive renal transplantation and the usefulness of interferon therapy.2008
    • Author(s)
      Nanmoku K, Imaizumi R, Tojimbara T, Nakajima I, Fuchinoue S, Sakamoto N, Watanabe M, Teraoka S
    • Journal Title

      Transplant Proc 40

      Pages: 2382-2385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Effects of immunosuppressants on the progression ofhepatitis C in hepatitis C virus-positive renal transplantation and the usefulness of interferon therapy2008
    • Author(s)
      Nanmoku K, Imaizumi R, Tojimbara T,Nakajima I, Fuchinoue S, Sakamoto N, Watanabe M, Teraoka S
    • Journal Title

      Transplant Proc 40(7)

      Pages: 2382-2385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Negative feedback regulation of colitogenicCD4(+) T cells by increased granulopoiesis2008
    • Author(s)
      Nemoto Y, Kanai T, Tohda S, Totsuka T,Okamoto R, Tsuchiya K, Nakamura T, SakamotoN, Fukuda T, Miura O, Yagita H and Watanabe M
    • Journal Title

      In flamm Bowel Dis

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow2008
    • Author(s)
      Fujii T, Tomita T, Kanai T, Nemoto Y,Totsuka T, Sakamoto N, Nakamura T, TsuchiyaK, Okamoto R and Watanabe M
    • Journal Title

      EurJ Immunol 38

      Pages: 3290-303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Development of plaque assaysfor hepatitis C virus and isolation of mutantswith enhanced cytopathogenicity and replication capacity2008
    • Author(s)
      Sekine-Osajima Y, Sakamoto N(equal contribution), Nakagawa M, Itsui Y, TasakaM, Nishimura-Sakurai Y, Chen CH, Kanai T,Tsuchiya K, Wakita T, Enomoto N and Watanabe M
    • Journal Title

      Virology 371

      Pages: 71-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Effects of immunosuppressantson the progression of hepatitis C in hepatitis Cvirus-positive renal transplantation and theusefulness of interferon therapy2008
    • Author(s)
      Nanmoku K, Imaizumi R, Tojimbara T, Nakajima I, Fuchinoue S, Sakamoto N, Watanabe M and Teraoka S
    • Journal Title

      Transplant Proc 40

      Pages: 2382-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitrohepatitis C virus replication.2008
    • Author(s)
      Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Chen CH, Watanabe M, et. al.
    • Journal Title

      Hepatology Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Immunosenescent colitogenicCD4(+) T cells convert to regulatory cells and Dsuppress colitis2008
    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R and Watanabe M
    • Journal Title

      Eur J Immunol 38

      Pages: 1275-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Development of plaque assays forhepatitis C virus-JFH1 strain and isolation ofmutants with enhanced cytopathogenicity and replication capacity2008
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, MishimaK, Nakagawa M, Itsui Y, Tasaka M,Nishimura-Sakurai Y, Chen CH, Kanai T, Tsuchiya K, Wakita T, Enomoto N and Watanabe M
    • Journal Title

      Virology 371

      Pages: 71-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Targeting lipid metabolism in the treatment of hepatitis C.2008
    • Author(s)
      Amemiya F, Maekawa S, Itakura Y, Kanayama A, Takano S, Yamaguchi T, Itakura J, Kitamura T, Inoue T, Sakamoto M, Yamauchi K, Okada S, Sakamoto N, Enomoto N
    • Journal Title

      J Infect Dis 368

      Pages: 361-370

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Blockade of NKG2D signaling prevents the development ofmurine CD4+ T cell-mediated colitis2008
    • Author(s)
      Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, OkumuraK, Yagita H and Watanabe M
    • Journal Title

      Am J Physiol Gastro intest Liver Physiol 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Griseofulvin, an oral antifungal agent, suppresses HCV replication in vitro.2008
    • Author(s)
      Jin H, Wakita T, Sakamoto N, Enomoto N, et. al.
    • Journal Title

      Hepatology Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Colitogenic CD4(+) effector-memory T cellsactively recirculate in chronic colitic mice2008
    • Author(s)
      Tomita T, Kanai T, Nemoto Y, Fujii T,Nozaki K, Okamoto R, Tsuchiya K, Nakamura T,Sakamoto N, Totsuka T and Watanabe M
    • Journal Title

      In flamm Bowel Dis

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Griseofulvin, an oral antifungal agent, suppresses HCV replication in vitro.2008
    • Author(s)
      Jin H, Yamashita A, Maekawa S, Yang P, He L, Takayanagi S, Wakita T, Sakamoto N, Enomoto N, Ito M
    • Journal Title

      Hepatology Res 38

      Pages: 909-918

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008
    • Author(s)
      Sekine-Osajima Y, Sakamoto N, Chen CH, Watanabe M, et. al.
    • Journal Title

      Virology 371

      Pages: 71-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer2008
    • Author(s)
      Aragaki M, Tsuchiya K, Okamoto R,Yoshioka S, Nakamura T, Sakamoto N,Kanai T, Watanabe M
    • Journal Title

      Biochem Biophys Res Commun 368(4)

      Pages: 923-929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] MyD88-dependentpathway in T cells directly modulates theexpansion of colitogenic CD4+ T cells in chroniccolitis2008
    • Author(s)
      Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, SakamotoN, Akira S and Watanabe M
    • Journal Title

      J Immunol 180

      Pages: 5291-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] MyD88-dependent Pathway in T Cells Directly Modulates the Expansion of Colitogenic CD4+ T Cells in Chronic Colitis.2008
    • Author(s)
      Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N. Akira S, Watanabe M
    • Journal Title

      J Immunol 180

      Pages: 5291-5299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.2008
    • Author(s)
      Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M
    • Journal Title

      Eur J Immunol 38

      Pages: 1275-1286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008
    • Author(s)
      Sekine-Osajima Y, Sakamoto N (equal contribution), Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Kanai T, Tsuchiya K, Wakita T, Enomoto N, Watanabe M
    • Journal Title

      Virology 368

      Pages: 71-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008
    • Author(s)
      Sakamoto N, Tanabe Y, Yokota T, Saito K,Sekine-Osajima Y, Nakagawa M, Itsui Y,Tasaka M, Sakurai Y, Chen CH, Yano M,Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol 23(9)

      Pages: 1437-1447

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Griseofulvin, an oral antifungal agent, suppresses HCV replication in vitro2008
    • Author(s)
      Jin H, Yamashita A, Maekawa S, Yang P, HeL, Takayanagi S, Wakita T, Sakamoto N,Enomoto N, Ito M
    • Journal Title

      Hepatology Res 38(9)

      Pages: 909-918

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Targeting lipid metabolism in the treatment of hepatitis C2008
    • Author(s)
      Amemiya F, Maekawa S, Itakura Y,Kanayama A, Takano S, Yamaguchi T,Itakura J, Kitamura T, Inoue T, Sakamoto M,Yamauchi K, Okada S, Sakamoto N, Enomoto N
    • Journal Title

      J Infect Dis 197(3)

      Pages: 361-370

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Proteasomal degradation ofAtoh1 by aberrant Wnt signaling maintains theundifferentiated state of colon cancer2008
    • Author(s)
      Aragaki M, Tsuchiya K, Okamoto R,Yoshioka S, Nakamura T, Sakamoto N, Kanai T and Watanabe M
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 923-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response2007
    • Author(s)
      Tasaka M, Sakamoto N, Itakura Y,Nakagawa M, Itsui Y, Sekine-Osajima Y,Nishimura-Sakurai Y, Chen CH, Yoneyama M,Fujita T, Wakita T, Maekawa S, Enomoto N and Watanabe M
    • Journal Title

      J Gen Virol 88

      Pages: 3323-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] A cell-based, high-throughput screen for small molecule regulators of HCV replication2007
    • Author(s)
      Kim SS, Peng LF, Lin W, Choe WH,Sakamoto N, Schreiber SL, Ikeda M, Kato N, Chung RT
    • Journal Title

      Gastroenterology2007 132

      Pages: 311-320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] A cell-based, high-throughput screen for small molecule regulators of HCV replication,2007
    • Author(s)
      Kim SS, Sakamoto N, Chung RT, et al.
    • Journal Title

      Gastroenterology 132

      Pages: 311-320

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response.2007
    • Author(s)
      Tasaka M, Sakamoto N, Chen CH, Watanabe M, et. al.
    • Journal Title

      Journal of General Virology 88

      Pages: 3323-3333

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2007
    • Author(s)
      Sakamoto N, Tanabe Y, Yokota T, Satoh K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S,Aoyagi Y, Maekawa S, Enomoto N, Kohara M and Watanabe M
    • Journal Title

      J Gastroenterol Hepatol

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] Bone morphogenetic protein-7 and interferon-alpha synergistically suppresshepatitis C virus replicon2007
    • Author(s)
      Sakamoto N, Yoshimura M, Kimura T, Toyama K, Sekine-Osajima Y, Watanabe M and Muramatsu M
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 467-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590752

  • [Journal Article] A cell-based, high-throughput screen for small molecule regulators of HCV replication2007
    • Author(s)
      Kim SS, Sakamoto N, Chung RT et al.
    • Journal Title

      Gastroenterology. 132

      Pages: 311-320

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon2007
    • Author(s)
      Sakamoto N, Yoshimura M, Kimura T, Toyama K, Sekine-Osajima Y, Watanabe M, Muramatsu M
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 467-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Identification of novel epoxide inhibitors of HCV replication、. a high-throughput screen2007
    • Author(s)
      Peng LF, Kim SS, Matchacheep S, Lei X, SuS, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB,Porco JA Jr, Schreiber SL and Chung RT
    • Journal Title

      Antimicrob Agent Chemother 51(10)

      Pages: 3756-3759

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Human cord blood cells transplanted into chronic-damaged liver exhibit similar characteristics to functional hepatocytes.2007
    • Author(s)
      Kakinuma S, Sakamoto N, Watanabe M, et al.
    • Journal Title

      Transplantation Proceedings. 39・1

      Pages: 240-243

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Human Cord Blood Cells Transplanted into Chronic-Damaged Liver Exhibit Similar Characteristics to Functional Hepatocytes2007
    • Author(s)
      Kakinuma S, Asahina K, Okamura K,Teramoto K, Tateno C, Yoshizato K, TanakaY, Yasumizu T, Sakamoto N, Watanabe M,Teraoka H
    • Journal Title

      Transplantation Proceedings 39

      Pages: 240-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Human cord blood cells transplanted into chronic-damaged liver exhibit similar characteristics to functional hepatocytes.2007
    • Author(s)
      Kakinuma S, Sakamoto N, Watanabe M, et al.
    • Journal Title

      Transplantation Proceedings 39(1)

      Pages: 240-243

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] HCV nonstructural proteins responsible for suppression of RIG-I/Cardif-induced interferon response2007
    • Author(s)
      Tasaka M, Sakamoto N(equal contribution), Itakura Y, Nakagawa M, Itusi Y,Sekine-Osajima Y, Nishimura-Sakurai Y,Chen CH, Yoneyama M, Fujita T, Wakita T,Maekawa S, Enomoto N, Watanabe M
    • Journal Title

      J Gen Virol 88

      Pages: 3323-3333

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Human cord blood cells transplanted into chronic-damaged liver exhibit similar characteristics to functional hepatocytes.2007
    • Author(s)
      Kakinuma S, Sakamoto N, Watanabe M, et al.
    • Journal Title

      Transplantation Proceedings 39・1

      Pages: 240-243

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.2006
    • Author(s)
      Itsui Y, Sakamoto N, Kurosaki M, Kanazawa N, Tanabe Y, Koyama T, Takeda Y, Nakagawa M, et al.
    • Journal Title

      Journal of Viral Hepatitis 13

      Pages: 690-700

    • Data Source
      KAKENHI-PROJECT-18590721

  • [Journal Article] Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication2006
    • Author(s)
      Itsui Y, Sakamoto N, et al.
    • Journal Title

      Journal of Viral Hepatitis (In press)

    • Data Source
      KAKENHI-PROJECT-17015014

  • [Journal Article] Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication.2006
    • Author(s)
      Koyama T, Sakamoto N, Tanabe Y, Nakagawa M, Itsui Y, et al.
    • Journal Title

      Hepatology Res. 34

      Pages: 41-49

    • NAID

      10020406147

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Maekawa S, Sakamoto N, Watanabe H, Tanabe Y, et al.
    • Journal Title

      J Viral Hepatitis 13

      Pages: 582-582

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modules hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Maekawa S, Sakamoto N, Watanabe H, et al.
    • Journal Title

      J Viral Hepatitis. 13

      Pages: 582-582

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.2006
    • Author(s)
      Yamashiro T, Sakamoto N, Chen CH, Watanabe M, et al.
    • Journal Title

      Journal of Gastroenterology. 41・8

      Pages: 750-757

    • NAID

      10018255879

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.2006
    • Author(s)
      Yamashiro T, Sakamoto N, Chen CH, Watanabe M, et al.
    • Journal Title

      Journal of Gastroenterology 41・8

      Pages: 750-757

    • NAID

      10018255879

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] A cell-based, high-throughput screen for small molecule regulators of HCV replication.2006
    • Author(s)
      Kim SS, Sakamoto N, Chung RT et al.
    • Journal Title

      Gastroenterology. 132

      Pages: 311-320

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.2006
    • Author(s)
      Itsui Y, Sakamoto N, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Journal of Viral Hepatitis 13・10

      Pages: 690-700

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.2006
    • Author(s)
      Yamashito T, Sakamoto N, Chen CH, Watanabe M, et al.
    • Journal Title

      Journal of Gastroenterology 41(8)

      Pages: 750-757

    • NAID

      10018255879

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication.2006
    • Author(s)
      Koyama T, Sakamoto N, Tanabe Y, Nakagawa M, Itsui Y, et al.
    • Journal Title

      Hepatology Res 34

      Pages: 41-49

    • NAID

      10020406147

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor-3.2006
    • Author(s)
      Yamashiro T, Sakamoto N, Nakagawa M, Itsui Y, et al.
    • Journal Title

      J Gastroenterol. 41

      Pages: 750-757

    • NAID

      10018255879

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication2006
    • Author(s)
      Koyama T, Sakamoto N, et al.
    • Journal Title

      Hepatology Research 34

      Pages: 41-49

    • NAID

      10020406147

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.2006
    • Author(s)
      Itsui Y, Sakamoto N, Kanazawa N, Nakagawa M, et al.
    • Journal Title

      J Viral Hepatitis. 13

      Pages: 690-700

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Journal of Viral Hepatitis 13・9

      Pages: 582-590

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor-3.2006
    • Author(s)
      Yamashiro T, Sakamoto N, Nakagawa M, Itsui Y, et al.
    • Journal Title

      J Gastroenterol 41

      Pages: 750-757

    • NAID

      10018255879

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Maekawa S, Sakamoto N, Watanabe H, et al.
    • Journal Title

      J Viral Hepatitis. 13

      Pages: 582-582

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Journal of Viral Hepatitis 13(9)

      Pages: 582-590

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication2006
    • Author(s)
      Itsui Y, Sakamoto N, et al.
    • Journal Title

      Journal of Viral Hepatitis (in press)

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Maekawa S, Sakamoto N, Watanabe H, Tanabe Y, Chen CH, Nakagawa M, Kakinuma S, et al.
    • Journal Title

      Journal of Viral Hepatitis 13

      Pages: 582-590

    • Data Source
      KAKENHI-PROJECT-18590721

  • [Journal Article] Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.2006
    • Author(s)
      Kohashi T, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Journal of Viral Hepatitis. 13・9

      Pages: 582-590

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.2006
    • Author(s)
      Itsui Y, Sakamoto N, Kurosaki M, Kanazawa N, Nakagawa M, et al.
    • Journal Title

      J Viral Hepatitis 13

      Pages: 690-700

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Site-specific mutation of interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication2006
    • Author(s)
      Kohashi T, Sakamoto N, et al.
    • Journal Title

      Journal of Viral Hepatitis (in press)

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N, Kakinuma S, Watanabe M et al.
    • Journal Title

      Gastroenterology 129(3)

      Pages: 1031-1041

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590581

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N, Chen CH, Kakinuma S, Watanabe M et al.
    • Journal Title

      Gastroenterology 129(3)

      Pages: 1031-1041

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Enhancement of Mitochondrial Gene Expression in the Liver of Primary Biliary Cirrhosis.2005
    • Author(s)
      Chen CH, Nagayama K, Enomoto N, Miyasaka Y, Kurosaki M, Sakamoto N, Meakawa S, Kakinuma S, Ideda T, Izumi N, Sato C, Watanabe M
    • Journal Title

      Hepatology Res. 31

      Pages: 24-30

    • NAID

      10015455952

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Characteristic sequence changes of hepatitis C virus genotype 2b associated with sustained biochemical response to IFN therapy.2005
    • Author(s)
      Tanabe Y, Nagayama K, Enomoto N, Sakamoto N, Watanabe M, et al.
    • Journal Title

      J Viral Hapat. 12

      Pages: 251-261

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.2005
    • Author(s)
      Hamano K, Sakamoto N, et al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 20

      Pages: 1401-1409

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M
    • Journal Title

      Gastroenterology 129(3)

      Pages: 1031-1041

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590580

  • [Journal Article] Enhancement of mitochondrial gene expression in the liver of primary biliary cirrhosis.2005
    • Author(s)
      Chen CH, Sakamoto N, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Hepatology Research 31(1)

      Pages: 24-30

    • NAID

      10015455952

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-α plus ribavirin combination therapy.2005
    • Author(s)
      Hamano K, Sakamoto N, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 20(9)

      Pages: 1401-1409

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins2005
    • Author(s)
      Nakagawa M, Sakamoto N, et al.
    • Journal Title

      Gastroenterology 129

      Pages: 1031-1041

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Viral load change and sequential evolution of entire hepatitis C virus genome in Irish recipients of single source-contaminated anti-D immunoglobulin.2005
    • Author(s)
      Itakura J, Nagayama K, Enomoto N, Hamano K, Sakamoto N, Fanning LJ, Kenny-Walsh E, Shanahan F, Watanabe M
    • Journal Title

      J Viral Hepat. 12

      Pages: 594-603

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Suppression of hepatitis C virus replication by cycosporin A is mediated by blockade of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Gastroenterology 129(3)

      Pages: 1031-1041

    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Characteristic sequence changes of hepatitis C virus genotype 2b associated with sustained biochemical response to IFN therapy.2005
    • Author(s)
      Tanaka Y, Nagayama K, Enomoto N, Izumi N, Tazawa J, Kurosaki M, Sakamoto N, Sato C, Watanabe M
    • Journal Title

      J viral Hepat. 12

      Pages: 251-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Enhancement of Mitochondrial Gene Expression in the Liver of Primary Biliary Cirrhosis.2005
    • Author(s)
      Chen CH, Nagayama K, Sakamoto N, Watanabe M, et al.
    • Journal Title

      Hepatology Res. 31

      Pages: 24-30

    • NAID

      10015455952

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N (equal contribution), Tanabe Y, Koyama T, Itsui Y, Watanabe M, et al.
    • Journal Title

      Gastroenterology. 129

      Pages: 1031-1041

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N, Chen CH, Kakinuma S, Watanabe M, et al.
    • Journal Title

      Gastroenterology. 129・3

      Pages: 1031-1041

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590625

  • [Journal Article] Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockage of cyclophilins.2005
    • Author(s)
      Nakagawa M, Sakamoto N (equal contribution), Tanabe Y, Koyama T.Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M
    • Journal Title

      Gastroenterology. 129(3)

      Pages: 1031-1041

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Viral load change and sequential evolution of entire hepatitis C virus genome in Irish recipients of single source-contaminated anti-D immunoglobulin.2005
    • Author(s)
      Itakura J, Nagayama K, Sakamoto N, Watanabe M, et al.
    • Journal Title

      J Viral Hapat. 12

      Pages: 594-603

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Characteristic sequence changes of hepatitis C virus genotype 2b associated with sustained biochemical response to IFN therapy2005
    • Author(s)
      Tanabe Y, Sakamoto N, et al.
    • Journal Title

      Journal of Viral Hepatitis 12

      Pages: 251-261

    • Data Source
      KAKENHI-PROJECT-17590626

  • [Journal Article] Regulation of hepatitis C virus replication by interferon regulatory factor-1.2004
    • Author(s)
      Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen CH, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M.
    • Journal Title

      J Virol 78(18)

      Pages: 9713-9720

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Regulation of hepatitis C virus replication by interferon regulatory factor 1.2004
    • Author(s)
      Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen CH, Kakinuma S, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M.
    • Journal Title

      J virol. 78

      Pages: 9713-9720

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha.2004
    • Author(s)
      Tanabe Y, Sakamoto N, Enomoto N, et al.
    • Journal Title

      J Infect Dis. 189・7

      Pages: 1129-1139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Regulation of hepatitis C virus replication by interferon regulatory factor-12004
    • Author(s)
      Kanazawa N, Sakamoto N, et al.
    • Journal Title

      J Virol 2004;78(18):9713-9720 78(18)

      Pages: 9713-9720

    • Data Source
      KAKENHI-PROJECT-16590580

  • [Journal Article] Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4 : Evidence for impaired Skp2-dependent degradation of, p27 in terminal differentiation.2004
    • Author(s)
      Tamamori-Adachi M, Hayashida K, Nobori K, Omizu C, Yamada K, Sakamoto N, Kamura T, Fukuda K, Ogawa S, Nakayama KI, Kitajima S
    • Journal Title

      J Biol Chem 279

      Pages: 50429-50436

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Introduction of NS5A mutations enables subgenomic HCV replicon derived from chimpanzee-infectious HC-J4 isolate to replicate efficiently in Huh-7 cells.2004
    • Author(s)
      Maekawa S, Enomoto N, Sakamoto N, Kurosaki M, Ueda E, Kohashi T, Watanabe H, Chen CH, Yamashiro T, Tanabe Y, Kanazawa N, Nakagawa M, Sato C, Watanabe M.
    • Journal Title

      J Viral Hepat. 11

      Pages: 394-403

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A.2004
    • Author(s)
      Nakagawa M, Sakamoto N, Enomoto N, et al.
    • Journal Title

      Biochem Biophys Res Commun. 313・1

      Pages: 42-47

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Introduction of NS5A Mutations Enables Subgenomic HCV-Replicon Derived from Chimpanzee-Infectious HC-J4 Isolate to Replicate Efficiently in Huh-7 Cells.2004
    • Author(s)
      Maekawa S, Enomoto N, Sakamoto N, Kurosaki M, Ueda E, Kohashi T, Watanabe H, Chen CH, Yamashiro T, Tanabe Y, Kanazawa N, Nakagawa M, Sato C, Watanabe M.
    • Journal Title

      J Viral Hepatitis 11

      Pages: 394-403

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A2004
    • Author(s)
      Sakamoto N., Oooka M, et al.
    • Journal Title

      Biochem Biophys Res Com 313

      Pages: 42-47

    • Data Source
      KAKENHI-PROJECT-16590580

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha.2004
    • Author(s)
      Tanabe Y, Sakamoto N, Enomoto N, Kurosaki M, Ueada E, Maekawa S, Yamashiro T, Nakagawa M, Chen CH, Kanazawa N, Watanabe M.
    • Journal Title

      J Infect Dis 189

      Pages: 1129-1139

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Changes of HCV quasispecies during combination therapy with interferon and ribavirin.2004
    • Author(s)
      Ueda E, Enomoto N, Sakamoto N, Hamano K, Sato C, Izumi N, Watanabe M.
    • Journal Title

      Hepatol Res. 29

      Pages: 89-96

    • NAID

      10018024225

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha.2004
    • Author(s)
      Tanabe Y, Sakamoto N, Enomoto N, Kurosaki M, Ueda E, Maekawa S, Yamashiro T, Nakagawa M, Chen CH, Kanazawa N, Kakinuma S, Watanabe M.
    • Journal Title

      J Infect Dis. 189

      Pages: 1129-1139

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A.2004
    • Author(s)
      Nakagawa M, Sakamoto N, Enomoto N, Tanabe Y, Kanazawa N, Koyama T, Kurosaki M, Maekawa S, Yamashiro T, Chen CH, Itsui Y, Kakinuma S, Watanabe M.
    • Journal Title

      Biochem Biophys Res Commun. 313

      Pages: 42-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha2004
    • Author(s)
      Sakamoto N, et al.
    • Journal Title

      J Infect Dis 189

      Pages: 1129-1139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Introduction of NS5A Mutations Enables Subgenomic HCV-Replicon Derived from Chimpanzee-Infectious HC-J4 Isolate to Replicate Efficiently in Huh-7 Cells.2004
    • Author(s)
      Maekawa S, Sakamoto N, et al.
    • Journal Title

      J Viral Hepatitis 11

      Pages: 394-403

    • Data Source
      KAKENHI-PROJECT-16590580

  • [Journal Article] Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4:Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation2004
    • Author(s)
      Tamamori-Adachi M, Sakamoto N. et al.
    • Journal Title

      J Biol Chem 279

      Pages: 50429-50436

    • Data Source
      KAKENHI-PROJECT-16590580

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha2004
    • Author(s)
      Sakamoto N, et al.
    • Journal Title

      J Infect Dis 189

      Pages: 1129-1139

    • Data Source
      KAKENHI-PROJECT-16590580

  • [Journal Article] Regulation of hepatitis C virus replication by interferon regulatory factor 1.2004
    • Author(s)
      Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, et al.
    • Journal Title

      J Virol. 78・18

      Pages: 9713-9720

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370175

  • [Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A2004
    • Author(s)
      Sakamoto N. et al.
    • Journal Title

      Biochem Biophys Res Com 313

      Pages: 42-47

    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Regulation of hepatitis C virus replication by interferon regulatory factor-I2004
    • Author(s)
      Kanazawa N, Sakamoto N, et al.
    • Journal Title

      J Virol 2004;78(18):9713-9720 78(18)

      Pages: 9713-9720

    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Introduction of NS5A Mutations Enables Subgenomic HCV-Replicon Derived from Chimpanzee-Infectious HC-J4 Isolate to Replicate Efficiently in Huh-7 Cells.2004
    • Author(s)
      Maekawa S, Sakamoto N, et al.
    • Journal Title

      J Viral Hepatitis 11

      Pages: 394-403

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Specific inhibition of hepatitis C virus replication by cyclosporin A2004
    • Author(s)
      Sakamoto N, et al.
    • Journal Title

      Biochem Biophys Res Com 313

      Pages: 42-47

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Regulation of hepatitis C virus replication by interferon regulatory factor-12004
    • Author(s)
      Kanazawa N, Sakamoto N, et al.
    • Journal Title

      J Virol 78(18)

      Pages: 9713-9720

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived siRNAs2003
    • Author(s)
      Sakamoto N, Yokota T, et al.
    • Journal Title

      EMBO Reports 4

      Pages: 602-608

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Hepatitis C virus NS5A protein inhibits TNF-alpha mediated apoptosis in HUH7 Cells.2003
    • Author(s)
      Miyasaka Y, Sakamoto N, et al.
    • Journal Title

      J Infect Dis 188

      Pages: 1537-1544

    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Hepatitis C virus NS5A protein inhibits TNF-alpha mediated apontosis in HUH7 Cells.2003
    • Author(s)
      Miyasaka Y, Sakamoto N, et al.
    • Journal Title

      J Infect Dis 188

      Pages: 1537-1544

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived siRNAs2003
    • Author(s)
      Sakamoto N, Yokota T, et al.
    • Journal Title

      EMBO Roports 4

      Pages: 602-608

    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived siRNAs.2003
    • Author(s)
      Yokota T, Sakamoto N, Enomoto N, Tanabe Y, Miyagishi M, Maekawa S, Ye L, Kurosaki M, Taira K, Watanabe M, Mizusawa H.
    • Journal Title

      EMBO Reports. 4

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Journal Article] Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia
    • Author(s)
      Yamashita A, Abdus K, Furuta A, Matsuda Y, Fujita O, Tani H, Fujita Y, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, Nakakoshi M, Tsubuki M, Sekiguchi Y, Thuneda S, Akimitsu N, Noda N, Tanaka J, Moriishi K
    • Journal Title

      Marine Drugs

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21390226

  • [Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture
    • Author(s)
      Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M
    • Journal Title

      Hepatol Res

    • Data Source
      KAKENHI-PROJECT-21590833

  • [Journal Article] A functional genomic screen identifies cellular cofactors of hepatitis C virus replication
    • Author(s)
      Andrew W. Tai, Yair Benita, Lee F. Peng, Sun-Suk Kim, Naoya Sakamoto, Ramnik J.Xavier, Raymond T. Chung
    • Journal Title

      Cell Host & Microbe (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by nelfinavir and interferon-α
    • Author(s)
      Satoshi Toma, Tsuyoshi Yamashiro, ShingoArakaki, Joji Shiroma, Tatsuji Maeshiro, Kenji Hibiya, Naoya Sakamoto, FukunoriKinjo, Masao Tateyama, Jiro Fujita
    • Journal Title

      Journal of Viral Hepatitis (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Patent] C型肝炎ウイルスの増殖を抑制する医薬組成物2011
    • Inventor(s)
      坂本直哉、渡辺守、北詰晶子、萩原正敏、奥野友紀子
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2011-194082
    • Filing Date
      2011-09-06
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Patent] C型肝炎ウイルスの増殖を抑制する医薬組成物2011
    • Inventor(s)
      坂本直哉、渡辺守、北詰晶子、萩原正敏、奥野友紀子
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2011-194082
    • Filing Date
      2011-09-06
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Patent] C型肝炎ウイルスの増殖を抑制する医薬組成物2011
    • Inventor(s)
      坂本直哉、渡辺守、北詰晶子、萩原正敏、奥野友紀子
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2011-194082
    • Filing Date
      2011-09-06
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Patent] C型肝炎ウイルスの増殖を抑制する医薬組成物2011
    • Inventor(s)
      坂本直哉、渡辺守、北詰晶子、萩原正敏、奥野友紀子
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      2011-194082
    • Filing Date
      2011-09-06
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Patent] 米国特許仮出願2005
    • Inventor(s)
      坂本直哉
    • Industrial Property Rights Holder
      坂本直哉
    • Filing Date
      2005-05-23
    • Data Source
      KAKENHI-PROJECT-17590626

  • [Patent] HCVのタンパク質合成およびHCVの複製を阻害できる2本鎖オリゴヌクレオチド2003
    • Inventor(s)
      横田 隆徳, 坂本 直哉
    • Industrial Property Rights Holder
      横田 隆徳
    • Filing Date
      2003-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Patent] HCVのタンパク質合成およびHCVの複製を阻害できる2本鎖オリゴヌクレオチド2003
    • Inventor(s)
      横田 隆徳, 坂本 直哉, 他
    • Industrial Property Rights Holder
      横田 隆徳
    • Filing Date
      2003-05-01
    • Data Source
      KAKENHI-PROJECT-15590629

  • [Patent] C型肝炎ウイルスのタンパク質合成及び/又はC型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド2003
    • Inventor(s)
      横田隆徳、榎本信幸、坂本直哉、多比良和誠、宮岸真
    • Industrial Property Rights Holder
      独立行政法人産業技術総合研究
    • Industrial Property Number
      2003-104940
    • Filing Date
      2003-05-11
    • Data Source
      KAKENHI-PROJECT-19390196

  • [Presentation] 羊膜由来間葉系幹細胞の消化器疾患への治療応用2018
    • Author(s)
      大西俊介，山本幸司，坂本直哉
    • Organizer
      第17回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-16H05282

  • [Presentation] B型肝性肝炎における核酸アナログ長期治療によるHBs抗原減少効果の検討.2018
    • Author(s)
      梅村真知子, 森川賢一,坂本直哉.
    • Organizer
      第42回日本肝臓学会東部会
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Clinical phase 1b study results for safety, pharmacokinetics and efficacy of ND-L02-s0201, a novel targeted lipid nanoparticle delivering HSP47 SIRNA for the treatment of Japanese patients with advanced liver fibrosis.2018
    • Author(s)
      Sakamoto N, Ogawa K, Morikawa K, Suda G, Sho T, Nakai M, Suzuki H, Yamagata N, Tanaka Y, Ying W, Tamura Y, Niitsu Y, Maruyama K.
    • Organizer
      he European Association for the Study of the Liver (EASL) International Liver Congress.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Risk assessment of hepatocellular carcinoma in chronic liver disease patients with a combination of liver stiffness measurement and controlled attenuation parameter by FibroScan.2018
    • Author(s)
      Morikawa K, Izumi T, Sho T, Suzuki K, Nakamura A, Ohara M, Kawagishi N, Umemura M, Nakai M, Suda G, Ogawa K, Kudo Y, Nishida M, Baba M, Furuya K, Sakamoto N.
    • Organizer
      The European Association for the Study of the Liver (EASL) International Liver Congress.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Changes in liver steatosis and lipid metabolism accompanied by successful interferon-free DAAs therapy in HCV infected patients; a comprehensive analysis.2018
    • Author(s)
      Kawagishi N, Suda G, Morikawa K, Ogawa K, Sakamoto N.
    • Organizer
      The European Association for the Study of the Liver (EASL) International Liver Congress.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] B型肝炎ウイルス発現培養細胞のプロテオメタボロミクス解析.2018
    • Author(s)
      森川賢一, 梅村真知子, 坂本直哉.
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Hepatitis B virus infected cell slows down its cell cycle and proliferation by viral protein and replication.2017
    • Author(s)
      Morikawa K, Shimazaki T, Izumi T, Umemura M, Nakai M, Suda G, Sakamoto N.
    • Organizer
      The European Association for the Study of the Liver (EASL) International Liver Congress. (Amsterdam, Netherlands)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] 培養細胞を用いたB型肝炎ウイルスによる宿主免疫機構の撹乱の解析.2017
    • Author(s)
      森川賢一, 梅村真知子, 坂本直哉.
    • Organizer
      第53回日本肝臓学会総会. (広島県広島市）
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Prevalence and risk factors of hepatitis B virus reactivation in interferon-free direct-acting antiviral therapies for hepatitis C.2017
    • Author(s)
      Kawagishi N, Suda G, Onozawa M, Kimura M, Maehara O, Ohara M, Izumi T, Umemura M, Ito J, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N.
    • Organizer
      The European Association for the Study of the Liver (EASL) International Liver Congress. (Amsterdam, Netherlands)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Hepatitis B virus X protein impairs a host restriction factor via interaction with DDB1 pangenotypically.2017
    • Author(s)
      Morikawa K, Sakamoto N.
    • Organizer
      The 2017 International HBV Meeting. (Washington DC, USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Hepatitis B virus X protein modulates host restriction factor via interaction with DDB1.2017
    • Author(s)
      Izumi T, Morikawa K, Ando S, Takeda R, Umemura M, Shimazaki T, Kawagishi N, Ohara M, Ito J, Nakai M, Sho T, Suda G, Ogawa K, Sakamoto N.
    • Organizer
      The Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference. (Nagasaki, Japan)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Influence of hepatitis B virus genotypes on innate immune response by impairing Mitochondrial Antiviral Signaling Protein.2017
    • Author(s)
      Umemura M, Morikawa K, Ando S, Takeda R, Izumi T, Shimazaki T, Kawagishi N, Ohara M, Ito J, Nakai M, Sho T, Suda G, Ogawa K, Sakamoto N.
    • Organizer
      The Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference. (Nagasaki, Japan)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09400

  • [Presentation] Molecular Pathogenesis for HCC Development: HSF1 Potential Molecular Target for HCC Therapies2016
    • Author(s)
      Chuma M, Sakamoto N, Yokoo H, Kamiyama T, Taketomi A, Maeda S.
    • Organizer
      The 25th Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-02-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460982

  • [Presentation] 肝硬変患者に対するカルニチン製剤の有用性の検討2015
    • Author(s)
      小川浩司,梅村真知子,出水孝章,伊藤淳,常松聖司,佐藤史幸,中井正人,荘拓也,須田剛生,森川賢一,坂本直哉.
    • Organizer
      第117回日本消化器病学会北海道支部例会
    • Place of Presentation
      札幌コンベンションセンター（北海道　札幌市）
    • Year and Date
      2015-08-29
    • Data Source
      KAKENHI-PROJECT-15K08980

  • [Presentation] DAA併用療法におけるDAA耐性ウイルス/治療予測因子の検討2014
    • Author(s)
      須田剛生　古家乾　坂本直哉
    • Organizer
      肝臓病学会東部会
    • Place of Presentation
      京王プラザホテル　（東京　新宿）
    • Year and Date
      2014-11-29
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] プロテアーゼ阻害剤併用療法の治療予測因子・薬剤耐性ウイルスの検討2014
    • Author(s)
      須田剛生　中馬 誠 坂本直哉
    • Organizer
      消化器病学会総会
    • Place of Presentation
      東京国際フォーラム (東京都　千代田区）
    • Year and Date
      2014-04-24
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] C型慢性肝炎に対するDAA療法の治療予測因子・薬剤耐性ウイルスの検討2014
    • Author(s)
      須田剛生　中馬 誠 坂本直哉
    • Organizer
      肝臓病学会総会
    • Place of Presentation
      ホテルニューオータニ　（東京都　千代田区)
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] Analysis of First and Second Generation Protease Inhibitor Combination Therapy in Patients with Chronic Hepatitis C Virus Infection2014
    • Author(s)
      須田剛生　永坂敦 坂本直哉
    • Organizer
      日本消化器病関連学会週間
    • Place of Presentation
      神戸国際展示場　（兵庫県　神戸）
    • Year and Date
      2014-10-23
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] 肝細胞癌の早期再発予測に関する血清バイオマーカー2014
    • Author(s)
      中馬　誠、坂本　直哉、神山　俊哉
    • Organizer
      第50回肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-30
    • Data Source
      KAKENHI-PROJECT-26460982

  • [Presentation] Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reaction2014
    • Author(s)
      Goki Suda1 ,Yoko Tsukuda1, Seiji Tsunematsu1, Fumiyuki Satou1, Katsumi Terasita1, Takuya Sho 1, Masato Nakai1, Mitsuteru Natsuizka1, Makoto Chuma 1, Naoya Sakamoto
    • Organizer
      65th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] Serum granulysin level is correlated with severity of telaprevir induced dermatological adverse reactions and could be a useful predictor2014
    • Author(s)
      Goki Suda , Yoshiya Yamamoto, Astusi Nagasaka, Ken Furuya, Yoko Tsukuda, Seiji Tsunematsu, Fumiyuki Satou, Katsumi Terasita, Keita Horimoto, Takuya Sh Masato Nakai, Mitsuteru Natsuizka, Makoto Chuma , Naoya Sakamoto
    • Organizer
      Asian Pacific Association for The Study of the Liver
    • Place of Presentation
      Brisbane Convention & Exhibition Centre（Brisbene）, Australia
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] Wnt5a-CaMK2経路による肝幹/前駆細胞の分化調節機構2013
    • Author(s)
      柿沼 晴、幾世橋 佳、紙谷 聡英、新田 沙由梨、東 正新、中川 美奈、朝比奈 靖浩、坂本 直哉、中内 啓光、渡辺 守
    • Organizer
      JDDW 2013 第17回日本肝臓学会大会
    • Place of Presentation
      東京（グランドプリンスホテル新高輪）
    • Data Source
      KAKENHI-PROJECT-24590959

  • [Presentation] Telaprevir/Peg-IFN/RBV3剤併用療法の治療効果および副作用予測因子の解析2013
    • Author(s)
      須田剛生　中馬誠　坂本直哉
    • Organizer
      日本消化器病関連学会週間
    • Place of Presentation
      グランドプリンス高輪ホテル（東京）
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] Wnt5a-CaMK2経路による肝幹/前駆細胞の胆管分化の調節機構2013
    • Author(s)
      柿沼晴、幾世橋佳、山中秀人、紙谷聡英、新田沙由梨、藤木純子、吉野耕平、中川美奈、東正新、坂本直哉、朝比奈靖浩、中内啓光、渡辺守
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京（京王プラザホテル）
    • Data Source
      KAKENHI-PROJECT-24590959

  • [Presentation] Substitution of amino acid 70/91 in the hepatitis C virus core region affects infectious virus production and cell surface expression of MHC class I.2013
    • Author(s)
      Tasaka-Fujita M, Sugiyama N, Kang W, Murayama A, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T.
    • Organizer
      The 64th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2013)
    • Place of Presentation
      Washington DC(USA)
    • Data Source
      KAKENHI-PROJECT-24590960

  • [Presentation] Establishment of Interferon resistant genotype 2b/JFH-1 chimeric Hepatitis C virus cell culture system2013
    • Author(s)
      Goki Suda, Yoko Tsukuda, Mitsuteru Natsuizaka, Makoto Chuma, Naoya Sakamoto
    • Organizer
      64th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      Walter E. Washington Convention Center　（Wachington DC）, USA
    • Data Source
      KAKENHI-PROJECT-25860513

  • [Presentation] HCV-NS4B blocks the RIG-I mediated IFN pathway through targeting of STING2012
    • Author(s)
      Sayuri Nitta, Naoya Sakamoto, Mina Nakagawa, Sei Kakinuma, Kako Mishima, Akiko Kusano-Kitazume, Kei Kiyohashi, Miyako Murakawa, Kohei Yoshino, Megumi Tasaka-Fujita, Yasuhiro Asahina, Mamoru Watanabe
    • Organizer
      19^<th> International Symposium of Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Venice, Italy
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Treatment and outcomes for elderly patients with hepatocellular caricinoma2012
    • Author(s)
      Azuma S, Sakamoto N, Kakinuma S, Watanabe M, et al
    • Organizer
      The 22nd Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Taipei,台湾
    • Year and Date
      2012-02-17
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Presentation] 宿主遺伝子情報に基づいたC型慢性肝炎治療の効果・安全性の最適化(シンポジウム6)2012
    • Author(s)
      中川美奈、坂本直哉、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-04-19
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Presentation] IL-6を介したC型慢性肝炎のインターフェロン治療抵抗性機構(シンポジウム3)2012
    • Author(s)
      坂本直哉、中川美奈、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-04-19
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Presentation] IFN不応例における宿主自然免疫応答とHCV逃避機構2012
    • Author(s)
      新田沙由梨,朝比奈靖浩,坂本直哉,村川美也子,北詰晶子,幾世橋佳,東正新,柿沼晴,中川美奈,渡辺守
    • Organizer
      第77回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Treatment and outcomes for elderly patientswith hepatocellular caricinoma2012
    • Author(s)
      Azuma S, Sakamoto N, Sakurai Y, Nakagawa M, Kakinuma S, Watanabe M
    • Organizer
      22nd Conference of the Asian Pacific Association for the Study of the Liver, Feb-18-2012, Taipei, Taiwan
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2012-02-18
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Presentation] HCVNS4B蛋白はSTINGを介しRIG-I誘導性 Interferon産生応答を抑制する2012
    • Author(s)
      新田沙由梨、 坂本直哉、吉野耕平、村川美也子、北詰晶子、幾世橋佳、東正新、柿沼晴、中川美奈、 朝比奈靖浩、渡辺守
    • Organizer
      第48回肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Antiviral effects and action mechanisms of novel N-(morpholine-4-carbonyloxy) amidine compaunds against hepatitis C virus.2012
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Azuma S, Asahina Y, Watanabe M et al
    • Organizer
      AASLD The Liver Meeting 2012
    • Place of Presentation
      Boston
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] 宿主遺伝子情報に基づいたC型慢性肝炎治療の効果・安全性の最適化（シンポジウム6ゲノムワイド検索（GWAS）と消化器疾患）2012
    • Author(s)
      中川美奈、坂本直哉、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル（東京）
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Presentation] Let-7b is a novel regulator of hepatitis C virus replication.2012
    • Author(s)
      Yeh YJ, Tseng CP, Sakamoto, N, et al.
    • Organizer
      19th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Palazzio del Chinema (Venice, Italy)
    • Year and Date
      2012-10-05
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Presentation] Let-7b is a novel regulator of hepatitis C virus replication. J Hepatol 2011; in submission.. 19th. International Meeting on Hepatitis C Virus &Related Viruses.2012
    • Author(s)
      Yeh YJ, Tseng CP, Sakamoto N,et al.
    • Organizer
      19th. International Meeting on Hepatitis C Virus & Related Viruses.
    • Place of Presentation
      Palazzo del Cinema（イタリア、ベニス）
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Presentation] HCV NS4B蛋白によるRIG-I誘導性Interferon発現経路の抑制機構についての解析2012
    • Author(s)
      新田沙由梨、 坂本直哉 、吉野耕平、村川美也子、北詰晶子、幾世橋佳、東正新、柿沼晴、中川美奈、朝比奈靖浩、渡辺守
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] HCV-NS4B protein binds STINGand blocks the RIG-I mediated IFN pathway2012
    • Author(s)
      Sayuri Nitta, Naoya Sakamoto, Mina Nakagawa, Sei Kakinuma, Akiko Kusano Kitazume, Miyako Murakawa, Megumi Tasaka-Fujita, Yasuhiro Asahina, Mamoru Watanabe
    • Organizer
      10th single topic conference
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] IL-6を介したC型慢性肝炎のインターフェロン治療抵抗性機構（シンポジウム3 ）2012
    • Author(s)
      坂本直哉、中川美奈、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル（東京）
    • Data Source
      KAKENHI-PROJECT-24659359

  • [Presentation] 肝線維形成過程におけるMatrix Metalloproteinase-2の機能的意義(シンポジウム8)2012
    • Author(s)
      柿沼晴、坂本直哉、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-04-19
    • Data Source
      KAKENHI-PROJECT-24390185

  • [Presentation] Imparied IL28B gene induction and poor IL28B promoter activity influenced by the IL28B minor allele are closely associated with a null response to interferon in chronic hepatitis C patients.2012
    • Author(s)
      Asahina Y, Sakamoto N, Azuma S, Watanabe M et al
    • Organizer
      AASLD The Liver Meeting 2012
    • Place of Presentation
      Boston
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Development of an RNA polymerase I-driven adenoviral vector and its application in an HCV replication assay2011
    • Author(s)
      Yoshida T, Sakamoto N, et al
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Sakamoto N, Watanabe M, et al
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] Antiviral effect of a novel interferon-inducible protein, IFI-27, against hepatitis C virus replication2011
    • Author(s)
      Itsuil Y, Sakamoto N, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] ITPA gene variant protects against treatment-induced anemia and improves viral clearance by pegylated interferon-alfa and ribavirin therapy in chronic henatitis C patients2011
    • Author(s)
      Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] Prediction model of ribavirin-induced anemia incorporating ITPA genotype could identify chronic hepatitis C patients at high risk of relapse among virological responders to pegylated-interferon and ribavirin2011
    • Author(s)
      Kurosaki M, Sakamoto N, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] Development of RNA pol-driven adenovirus vector expressing hepatitis C virus replicon2011
    • Author(s)
      Yamagishi Y, Sakamoto N, et al
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington
    • Year and Date
      2011-04-13
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] 肝線維化プロセスにおけるMatrixMetalloproteinase-2の機能2011
    • Author(s)
      柿沼晴、紙谷聡英、小野塚泉、東正新、坂本直哉、中内啓光、渡辺守
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Presentation] Development of an RNA polymerase I-driven adenoviral vector and its application in an HCV replication assay2011
    • Author(s)
      Yoshida T, Sakamoto N, et al.
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] HCV-NS4B targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immune response2011
    • Author(s)
      Nitta S, Sakamoto N, Tasaka-Fujita M, et al
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] MMP-2 and MMP-14 derived from donor cells enhance therapeutic efficacy of liver cell transplantation in mice2011
    • Author(s)
      Kakinuma S, Sakamoto N, Watanabe M, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] Cell based high-throughput screeningによる新規抗ウイルス小分子の同定及びその作用機構の解析2011
    • Author(s)
      北詰晶子、坂本直哉、奥野友紀子、筬島裕子、中川美奈、柿沼晴、植山真由美、小野塚泉、船岡祐介、渡辺貴子、幾世橋佳、新田沙由梨、村川美也子、萩原正敏、渡辺守
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京(一般口演, O-156)
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] HCV-NS4B targets STING and abrogates RIG-I-mediated type-I interferon- dependent innate immune response2011
    • Author(s)
      Nitta S, Sakamoto N, Watanabe M, et al
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] Mutations in the interferon sensitivity determining region of HCV, age and total ribavirin dose is an independent predictor of relapse among early virological responders to peg-interferon plus ribavirin therapy2011
    • Author(s)
      Kurosaki M, Sakamoto N, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] IL28B and ITPA gene variants correlate with treatment effcacy in pegylated-interferon plus ribavirin therapy for chronic hepatitis C2011
    • Author(s)
      Matsuura K, Sakamoto N, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
    • Author(s)
      Suda G, Sakamoto N, Azuma S, Watanabe M, et al
    • Organizer
      62th. Annual Meeting of American Association for the study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] Prediction model of ribavirin-induced anemia incorporating ITPA genotype could identify chronic hepatitis C patients at high risk of relapse among virological responders to pegylated-interferon and ribavirin2011
    • Author(s)
      Kurosaki M, Sakamoto N, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Development of an RNA polymerase I-driven adenoviral vector and its application in an HCV replication assay2011
    • Author(s)
      Yoshida T, Sakamoto N, et al.
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] Prediction model of ribavirin-induced anemia incorporating ITPA genotype could identify chronic hepatitis C patients at high risk of relapse among virological responders to pegylated-interferon and ribavirin2011
    • Author(s)
      Kurosaki M, Sakamoto N, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
    • Author(s)
      Suda G, Sakamoto N, Nakagawa M, Kakinuma S, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] Mutations in the interferon sensitivity determining region of HCV, age and total ribavirin dose is an independent predictor of relapse among early virological responders to peg-interferon plus ribavirin therapy2011
    • Author(s)
      Kurosaki M, Sakamoto N, Kakinuma S, Nakagawa M, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] A high-content screening assay using infectious fluorescence-tagged hepatitis C virus reveals candidates for small molecule inhibitors of viral entry2011
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Watanabe M, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] HCV-NS4B targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immune response2011
    • Author(s)
      Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-KitazumeA, KiyohashiK, Murakawa M, Yoshino K, Tasaka-Fujita M, Watanabe M
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] ITPA gene variant protects against treatment-induced anemia and improves viral clearance by pegylated interferon-alfa and ribavirin therapy in chronic hepatitis C patients2011
    • Author(s)
      Sakamoto N, Azuma S, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Loww of Wnt5A promotes biliary differentiation of murine hepatic stem/progenitor cells2011
    • Author(s)
      Kiyohashi K, Sakamoto N, Watanabe M, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] Prediction model of ribavirin-induced anemia incorporating ITPA genotype could identify chronic hepatitis C patients at high risk of relapse among virological responders to pegylated-interferon and ribavirin2011
    • Author(s)
      Kurosaki M, Sakamoto N, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] Loww of Wnt5A promotes biliary differentiation of murine hepatic stem/progenitor cells2011
    • Author(s)
      Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nakauchi H, Watanabe M
    • Organizer
      62 nd Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco, CA. USA
    • Year and Date
      2011-11-06
    • Data Source
      KAKENHI-PROJECT-21590833

  • [Presentation] A high-content screening assay using infectious fluorescence-tagged hepatitis C virus reveals candidates fo rsmall molecule inhibitors of viral entry2011
    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Yamamoto M, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Hagiwara M, Watanabe M
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco, CA.(Poster# 383)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] MMP-2 and MMP-14 derived from donor cells enhance therapeutic efficacy of liver cell transplantation in mice2011
    • Author(s)
      Kakinuma S, Sakamoto N, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011
    • Author(s)
      Sakamoto N, et al
    • Organizer
      18th. International Meeting on Hepatitis C Virus & Related Viruses
    • Place of Presentation
      Seattle
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-21590831

  • [Presentation] IL28B and ITPA gene variants correlate with treatment efficacy in pegylated-interferon plus ribavirin therapy for chronic hepatitis C2011
    • Author(s)
      Matsuura K, Sakamoto N, et al
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21590832

  • [Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
    • Author(s)
      Suda G, Sakamoto N, Nakagawa M, Azuma S, Watanabe M, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21390226

  • [Presentation] Loww of Wnt5A promotes biliary differentiation of murine hepatic stem/progenitor cells2011
    • Author(s)
      Kiyohashi K, Kakinuma S, Sakamoto N, et al.
    • Organizer
      62th. Annual Meeting of American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22659145

  • [Presentation] Development of RNA pol-driven adenovirus vector expressing hepatitis C virus replicon2011
    • Author(s)
      Yamagishi Y, Sakamoto N, et al.
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington
    • Year and Date
      2011-04-13