Oishi Naoki 大石直樹

… Alternative Names

OISHI Naoki 大石直樹

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Researcher Number	10348740
Other IDs	https://orcid.org/0000-0001-8204-9518
External Links
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 慶應義塾大学, 医学部(信濃町), 准教授 2018: 慶應義塾大学, 医学部(信濃町), 講師 2017: 慶應義塾大学, 医学部, 講師 2016: 慶應義塾大学, 医学部(信濃町), 講師 2013 – 2015: 慶應義塾大学, 医学部, 講師 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Keywords	Principal Investigator 小胞体ストレス / 加齢性難聴 / 蝸牛神経 / 顔面神経 / 中耳側頭骨 / 術中神経モニタリング / 機械学習 / 電極 / 耳音響放射 / データベース … More / 純音聴力閾値 / 術中聴覚モニタリング / 後迷路性難聴 / 蝸牛内刺激電極 / 蝸牛神経背側核活動電位 / 術中聴覚持続モニタリング / 純音聴力検査 / 蝸電図 / 聴性脳幹反応 / 聴神経腫瘍 / 蛋白質 / シグナル伝達 / ラセン神経節細胞 / コルチ器 / 有毛細胞 / 難聴 / 蝸牛 / 驚愕反射 / 加齢 / 耳鳴 / 内耳生化学 … More Except Principal Investigator 聴神経腫瘍 / 網羅的遺伝子解析 / NF2遺伝子 / 一側性聴神経腫瘍 / 個別化医療 / 臨床表現型 / 両耳聴 / 利得 / 骨伝導 / 軟骨伝導 / Cochlear Synaptopathy / 加齢性難聴 / 新規検査法 / 新規治療法 / MMP14 / ドライバー遺伝子 / ゲノム解析 / qPCR / 孤発性聴神経腫瘍 / 臨床応用 / MLPA法 / メチル化解析 / 全エクソーム解析 / 網羅的ゲノム解析 / 雑音下語音検査 / 一側性難聴 / ヒトiPS細胞 / 橋渡し研究 / コモンマーモセット / 遺伝性難聴 / Wolfram症候群 / WFS1 / 疾患iPS創薬 Less

Clinical Manifestations and Therapeutic Strategies of Sporadic Vestibular Schwannoma Based on Genetic Alterations
- Principal Investigator
  
  若林毅
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
The role of MMP14 in Vestibular Schwannoma and the development of novel treatments and diagnostic methods
- Principal Investigator
  
  百束紘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yokohama City University
Aging change and Cochlear Synaptopathy in spiral ganglion neurons of the common marmoset, a primate model animal
- Principal Investigator
  
  上野真史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
中耳側頭骨手術における術中神経モニタリング新技術の開発Principal Investigator
- Principal Investigator
  
  大石直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
一側性および非対称性難聴に対する雑音下語音聴取評価検査に係る至適条件の探索
- Principal Investigator
  
  山田悠祐
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  International University of Health and Welfare
一側伝音・混合難聴に対し軟骨伝導と骨伝導が与える聴覚利得の差とその起源の研究
- Principal Investigator
  
  西山崇経
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
一側性聴神経腫瘍の遺伝子プロファイルに基づいた臨床的特徴に関する検討
- Principal Investigator
  
  若林毅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Development of a Novel Auditory Evoked Potential Measurement Method and Algorithm for Improving Hearing Prognosis in Vestibular SchwannomasPrincipal Investigator
- Principal Investigator
  
  Oishi Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Endoplasmic stress response in cochlear culturePrincipal Investigator
- Principal Investigator
  
  Oishi Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Keio University
In vitro "virtual biopsy" of cochlear cells by using Wolfram syndrome patients derived hiPSCs
- Principal Investigator
  
  Fujioka Masato
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Keio University
tinnitus in aging model micePrincipal Investigator
- Principal Investigator
  
  Oishi Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Keio University
ER stress and presbycusisPrincipal Investigator
- Principal Investigator
  
  OISHI Naoki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Keio University

All 2024 2023 2022 2021 2016 2015 2012 Other

All Journal Article Presentation

[Journal Article] Natural history of hearing and tumor growth in vestibular schwannoma in neurofibromatosis type 2-related schwannomatosis2024
- Author(s)
  Wakabayashi Takeshi、Tamura Ryota、Karatsu Kosuke、Hosoya Makoto、Nishiyama Takanori、Inoue Yasuhiro、Ogawa Kaoru、Kanzaki Jin、Toda Masahiro、Ozawa Hiroyuki、Oishi Naoki
- Journal Title
  
  European Archives of Oto-Rhino-Laryngology
  
  Volume: - Issue: 8 Pages: 4175-4182
- DOI
  10.1007/s00405-024-08601-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09750
[Journal Article] Characteristics of pure tone audiogram in patients with untreated sporadic vestibular schwannoma: Analysis of audiometric shape and interaural differences stratified by age and mode of onset2024
- Author(s)
  Tsuzuki Nobuyoshi、Kitama Tsubasa、Wasano Koichiro、Wakabayashi Takeshi、Hosoya Makoto、Nishiyama Takanori、Ozawa Hiroyuki、Oishi Naoki
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 51 Issue: 2 Pages: 347-355
- DOI
  10.1016/j.anl.2023.09.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09574, KAKENHI-PROJECT-21K09565
[Journal Article] A novel intraoperative continuous monitoring method combining dorsal cochlear nucleus action potentials monitoring with auditory nerve test system2023
- Author(s)
  Hosoya Makoto、Nagaoka Yuriko、Wakabayashi Takeshi、Shimanuki Marie N.、Nishiyama Takanori、Ueno Masafumi、Ozawa Hiroyuki、Oishi Naoki
- Journal Title
  
  Journal of Otolaryngology - Head & Neck Surgery
  
  Volume: 52 Issue: 1 Pages: 67-67
- DOI
  10.1186/s40463-023-00671-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09565
[Journal Article] Vestibular Schwannoma Surgery with Endoscope-Assisted Retrolabyrinthine Approach under Modified Reinforced Continuous Intraoperative Monitoring for Hearing Preservation: Experience of 33 Cases in a Single Center2023
- Author(s)
  Makoto Hosoya , Takanori Nishiyama, Takeshi Wakabayashi, Marie N Shimanuki , Hidemi Miyazaki, Hiroyuki Ozawa, Naoki Oishi
- Journal Title
  
  Diagnostics
  
  Volume: 13 Issue: 2 Pages: 275-275
- DOI
  10.3390/diagnostics13020275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09565
[Journal Article] Understanding the Molecular Mechanism of Vestibular Schwannoma for Hearing Preservation Surgery: Otologists’ Perspective from Bedside to Bench2022
- Author(s)
  Makoto Hosoya, Takeshi Wakabayashi, Koichiro Wasano,Takanori Nishiyama,Nobuyoshi Tsuzuki,Naoki Oishi
- Journal Title
  
  Diagnostics
  
  Volume: 12 Issue: 5 Pages: 1044-1044
- DOI
  10.3390/diagnostics12051044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09565, KAKENHI-PROJECT-22K09750
[Journal Article] Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea.2016
- Author(s)
  Suzuki N, Hosoya M, Oishi N, Okano H, Fujioka M, Ogawa K.
- Journal Title
  
  Neuroreport.
  
  Volume: 3;27(11) Issue: 11 Pages: 833-6
- DOI
  10.1097/wnr.0000000000000624
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15624, KAKENHI-PROJECT-16K20277, KAKENHI-PROJECT-15H04991
[Journal Article] Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.2016
- Author(s)
  Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K.
- Journal Title
  
  PLoS One in press
  
  Volume: 11 Issue: 4 Pages: e0153957-e0153957
- DOI
  10.1371/journal.pone.0153957
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10762, KAKENHI-PROJECT-15K15624, KAKENHI-PROJECT-15H04991, KAKENHI-PROJECT-26462714
[Presentation] 聴力温存聴神経腫瘍手術2024
- Author(s)
  大石直樹
- Organizer
  日本頭頸部外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] メチル化解析を用いた孤発性聴神経腫瘍のNF2遺伝子プロモーター領域におけるエピゲノム変化の網羅的検討2023
- Author(s)
  若林毅、和佐野浩一郎、大石直樹、細谷誠、島貫茉莉江、西山崇経、小澤宏之
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K09750
[Presentation] 当科における聴神経腫瘍に対する後迷路法での聴力温存手術の術後成績の検討2023
- Author(s)
  細谷誠, 西山崇経, 若林毅, 島貫茉莉江, 小澤宏之, 大石直樹
- Organizer
  日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 聴神経腫瘍摘出と同時同側人工内耳植え込み術のための蝸牛内電気刺激による新規術中持続聴覚モニタリング法2023
- Author(s)
  細谷誠, 若林毅, 島貫茉莉江, 上野真史, 西山崇経, 小澤宏之, 大石直樹
- Organizer
  日本耳科学会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 聴神経腫瘍による突発難聴と突発性難聴の純音聴力像　聴力型の比較解析2023
- Author(s)
  都築伸佳, 大石直樹, 和佐野浩一郎, 辺土名貢, 島貫茉莉江, 西山崇経, 平賀良彦, 北間翼, 新田清一, 小川郁, 小澤宏之
- Organizer
  日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 当科におけるTM電極を用いた蝸電図測定の実際2023
- Author(s)
  上野真史, 細谷誠, 堀明美, 島貫茉莉江, 西山崇経, 小澤宏之, 大石直樹
- Organizer
  日本聴覚医学会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 聴神経腫瘍と人工内耳　聴神経腫瘍手術における蝸牛神経温存と人工内耳埋め込み術2023
- Author(s)
  大石直樹
- Organizer
  日本耳科学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 未治療聴神経腫瘍症例における語音聴力・耳音響放射の特徴2022
- Author(s)
  北間翼, 大石直樹, 都築伸佳, 南隆二, 若林毅, 細谷誠, 西山崇経, 和佐野浩一郎, 小澤宏之
- Organizer
  第125回日本耳鼻咽喉科頭頸部外科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 後迷路法による聴神経腫瘍手術における聴力温存率向上に寄与する当科の取り組み2022
- Author(s)
  細谷誠, 西山崇経, 若林毅, 島貫茉莉江, 小澤宏之, 大石直樹
- Organizer
  第32回日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 孤発性前庭神経鞘腫におけるNF2遺伝子変化についての検討－PCRを用いた定量評価－2022
- Author(s)
  若林毅、和佐野浩一郎、大石直樹、細谷誠、都築伸佳、秋山武紀、戸田正博
- Organizer
  第31回日本聴神経腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K09750
[Presentation] HEARING-FOCUSED STRATEGY IN THE MANAGEMENT OF VESTIBULAR SCHWANNOMA2022
- Author(s)
  Naoki Oishi
- Organizer
  ICORL 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 未治療聴神経腫瘍症例における聴力型の特徴2022
- Author(s)
  都築伸佳, 大石直樹, 北間翼, 南隆二, 若林毅, 細谷誠, 西山崇経, 和佐野浩一郎, 小澤宏之
- Organizer
  第125回日本耳鼻咽喉科頭頸部外科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 孤発性聴神経腫瘍の包括的ゲノム解析による病因解明について2022
- Author(s)
  若林毅、和佐野浩一郎、大石直樹、細谷誠、都築伸佳、西山崇経、小澤宏之
- Organizer
  第123回日本耳鼻咽喉科頭頸部外科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K09750
[Presentation] 当科における蝸電図検査の工夫2021
- Author(s)
  堀明美, 細谷誠, 大石直樹, 山野邉義晴, 藤岡正人, 忰田かおり, 西山崇経, 都築伸佳, 若林毅, 南隆二
- Organizer
  第66回日本聴覚医学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 術前スケールアウトから著明に術後聴力回復を認めた聴神経腫瘍手術例2021
- Author(s)
  榊悠佑, 細谷誠, 大石直樹, 西山崇経, 都築伸佳, 若林毅, 南隆二, 藤岡正人, 神崎晶, 小澤宏之
- Organizer
  第31回日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09565
[Presentation] 母親にのみ新規<I>EYA4</I>遺伝子変異を認めた家族性難聴の1例2016
- Author(s)
  藤岡正人・松永達雄・長谷部夏希・神崎晶・大石直樹・平賀良彦・鈴木法臣・松崎佐栄子・川浦光弘・小川郁
- Organizer
  第78回耳鼻咽喉科臨床学会総会・学術講演会
- Place of Presentation
  城山観光ホテル(鹿児島県鹿児島市)
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-15K15624
[Presentation] 両側進行性内耳性難聴の病態生理研究～疾患iPS創薬の立場から～2016
- Author(s)
  藤岡正人・細谷誠・鈴木法臣・大石直樹・松崎佐栄子・小川郁
- Organizer
  第26回日本耳科学会総会・学術講演会
- Place of Presentation
  ホテル国際21（長野県長野市）
- Year and Date
  2016-10-05
- Data Source
  KAKENHI-PROJECT-15K15624
[Presentation] 9.4T MRIを用いたヒト固定側頭骨の高解像度描出のこころみ（第２報）2015
- Author(s)
  藤岡正人　大石　直樹・栗原　渉・神崎　晶・小島　博己・小川　郁
- Organizer
  第60回日本聴覚医学会総会・学術講演会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-10-21
- Data Source
  KAKENHI-PROJECT-15K15624
[Presentation] Endoplasmic reticulum stress in aminoglycoside ototoxicity2012
- Author(s)
  大石直樹
- Organizer
  日本耳科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24890231
[Presentation] 小胞体ストレスと内耳性難聴
- Author(s)
  大石直樹
- Organizer
  東大慶應ジョイントカンファレンス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24890231

1. 細谷誠 (30645445)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. 和佐野浩一郎 (40528866)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. Fujioka Masato (70398626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 高橋英俊 (90625485)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 藤田岳 (90533711)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 若林毅 (40868600)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 中村康平 (10775802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 小川郁 (00169179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 山田悠祐 (30839303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松田悠佑 (00774340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 東野哲也 (80145424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高橋優宏 (50315800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岩崎聡 (00232653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 鬼頭良輔 (80419358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中西啓 (20444359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 柿木章伸 (60243820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 石野岳志 (80363068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉田忠雄 (90567017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 菅原一真 (20346555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 實川純人 (80706549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 百束紘 (80712794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 都築伸佳 (60836633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 荒井康裕 (90614818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 上野真史 (10973844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 文入悠 (60991180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 西山崇経 (90627168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 神崎晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oishi Naoki 大石 直樹

OISHI Naoki 大石 直樹

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Clinical Manifestations and Therapeutic Strategies of Sporadic Vestibular Schwannoma Based on Genetic Alterations

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The role of MMP14 in Vestibular Schwannoma and the development of novel treatments and diagnostic methods

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Aging change and Cochlear Synaptopathy in spiral ganglion neurons of the common marmoset, a primate model animal

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中耳側頭骨手術における術中神経モニタリング新技術の開発Principal Investigator

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一側性および非対称性難聴に対する雑音下語音聴取評価検査に係る至適条件の探索

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一側伝音・混合難聴に対し軟骨伝導と骨伝導が与える聴覚利得の差とその起源の研究

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一側性聴神経腫瘍の遺伝子プロファイルに基づいた臨床的特徴に関する検討

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Development of a Novel Auditory Evoked Potential Measurement Method and Algorithm for Improving Hearing Prognosis in Vestibular SchwannomasPrincipal Investigator

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Endoplasmic stress response in cochlear culturePrincipal Investigator

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In vitro "virtual biopsy" of cochlear cells by using Wolfram syndrome patients derived hiPSCs

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tinnitus in aging model micePrincipal Investigator

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ER stress and presbycusisPrincipal Investigator

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[Journal Article] Natural history of hearing and tumor growth in vestibular schwannoma in neurofibromatosis type 2-related schwannomatosis2024

Author(s)

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Oishi Naoki 大石直樹

OISHI Naoki 大石直樹

[Presentation] 聴神経腫瘍による突発難聴と突発性難聴の純音聴力像　聴力型の比較解析2023

[Presentation] 聴神経腫瘍と人工内耳　聴神経腫瘍手術における蝸牛神経温存と人工内耳埋め込み術2023

[Presentation] 孤発性前庭神経鞘腫におけるNF2遺伝子変化についての検討－PCRを用いた定量評価－2022