Sakuma Yuji 佐久間裕司

… Alternative Names

SAKUMA Yuji 佐久間裕司

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Researcher Number	10364514
Other IDs	https://orcid.org/0000-0003-2298-1359
Affiliation (Current)	2025: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 札幌医科大学, 医学部, 准教授 2013: 自治医科大学, 医学部, 講師 2012: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態学部, 副技幹 2011: 地方独立行政法人神奈川県立病院機構, 神奈川県立がんセンター(臨床研究所)・がん分子病態学部, 副技幹 2011: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究部), がん分子病態学部, 副技幹 … More 2010: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態研究部門, 主査 2009: Kanagawa Cancer Center Research Institute, がん分子病態研究部門, 主査 2009: Kanagawa Cancer Center Research Institute, 神奈川県立がんセンター(臨床研究所)・がん分子病態研究部門, 主査 2006 – 2009: 神奈川県立がんセンター, 臨床研究所, 研究員 2008: Kanagawa Cancer Center Research Institute, がん分子病態研究部門, 主査 Less
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 49020:Human pathology-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Biological Sciences / Basic Section 49020:Human pathology-related / Respiratory organ internal medicine / Tumor therapeutics / Human pathology
Keywords	Principal Investigator EGFR遺伝子変異 / 肺腺癌 / EGFR / アポトーシス / MET阻害薬 / MET exon14 skipping / 非小細胞肺癌 / ANTXR2 / JAM3 / BCL2 family分子 … More / MET依存性肺腺癌 / TGF-beta / 線維芽細胞巣 / TGF- β / 筋線維芽細胞 / 周皮細胞 / 特発性肺線維症 / 分子標的治療 / 幹細胞 / TTF-1 / 肺胞上皮 / 薬剤耐性 / 上皮間葉移行 / 細胞外基質 / autophagy / アポトーシス抵抗性 / 上皮間葉転換 / 薬剤抵抗性 / EGFR 遺伝子変異 / がん遺伝子 Src / がん遺伝子Src / Src / 転移 / 脈管浸潤 / 予後予測式 / 術後再発 / 小型肺腺癌 … More Except Principal Investigator モノクローナル抗体 / 抗体 / イミュノトキシン / DT3C / ADC型抗体薬 / 上皮間葉転換 / 肺腺癌 / メチル化 / EGFR / c-kit / GIST / ADC / SCLC / 小細胞肺がん / L1CAM / 治療薬開発 / 抗体薬物複合体 / 小細胞肺癌 / 病理組織 / 細胞分化 / 分子標的 / 特発性肺線維症の治療 / 選択的な培養 / 選択的培養法 / 肺上皮幹細胞 / 選択的培養 / 慢性閉塞性肺疾患の治療 / 選択な培養 / 肺上皮前駆/幹細胞 / 高性能イミュノトキシン / SP-D / 肺コレクチン / 肺サーファクタント / 肺サーファクタント蛋白質 / EGFR遺伝子変異 / 肺サーファクタントタンパク質 / レクチン / 糖鎖 / 肺がん / 変異型EGFR / 肺サーファクタント蛋白質D / 抗体結合型トキシンタンパク質 / EGFR阻害薬耐性 / 内在化 / 抗体スクリーニング / EGFR阻害薬耐性細胞株 / エピジェネティクス / 肺癌 / 分化形質 / エピジェネティックス / 分子標的治療 / マイクロアレイ / RTKs inhibitor / Met / PDGFRB / KIT陰性化 / imatinib治療 / 病理解剖 / 発生頻度 / 顕微鏡的 / LOH / microarray / CGH / microscopic Less

Integrative study of MET-dependent non-small cell lung carcinomaPrincipal Investigator
- Principal Investigator
  
  佐久間裕司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
高性能イミュノトキシンを用いた小細胞肺がんの標的化治療法の開発
- Principal Investigator
  
  山口美樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Pericytes play a critical role in the development of idiopathic pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  Sakuma Yuji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Sapporo Medical University
Development of a selective culture method for pulmonary epithelial stem cells using high-performance immunotoxin
- Principal Investigator
  
  Yamaguchi Miki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Integrated regulatory mechanism that govern differentiation and survival of driver-mutation-independent lung adenocarcinoma
- Principal Investigator
  
  niki toshiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Jichi Medical University
Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR
- Principal Investigator
  
  Hasegawa Yoshihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Generation of immunotoxins with super-targeting mAb in the EGFR-mutant lung adenocarcinoma
- Principal Investigator
  
  YAMAGUCHI MIKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Sapporo Medical University
Integrative analyses of lung adenocarcinomas that have undergone epithelial to mesenchymal transition (EMT) and those that retain an epithelial phenotypePrincipal Investigator
- Principal Investigator
  
  Sakuma Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Epigenetic abnormalities and reprogramming in epithelial-mesenchymal transition of lung adenocarcinoma
- Principal Investigator
  
  Niki Toshiro
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
Identification of molecular mechanisms other than genetic abnormalities in EGFR-TKI resistance of lung adenocarcinomasPrincipal Investigator
- Principal Investigator
  
  SAKUMA Yuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
  Jichi Medical University
  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所)
肺腺癌の転移成立を防ぐための研究Principal Investigator
- Principal Investigator
  
  SAKUMA Yuji
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  地方独立行政法人神奈川県立病院機構
   Kanagawa Cancer Center Research Institute
GISTの発生、顕性化、悪性化に関与する遺伝子異常の解明
- Principal Investigator
  
  櫻井信司
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Development of a logistic regression predictive model for the outcome of patients with resected lung adenocarcinoma of 2cm or less in sizePrincipal Investigator
- Principal Investigator
  
  SAKUMA Yuji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Kanagawa Cancer Center Research Institute
真のGISTの発生頻度と、その顕性化、悪性化に関与する遺伝子異常
- Principal Investigator
  
  櫻井信司
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University

[Journal Article] Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma2023
- Author(s)
  Yamaguchi Miki、Hirai Sachie、Idogawa Masashi、Sumi Toshiyuki、Uchida Hiroaki、Fujitani Naoki、Takahashi Motoko、Sakuma Yuji
- Journal Title
  
  Experimental Cell Research
  
  Volume: 426 Issue: 2 Pages: 113570-113570
- DOI
  10.1016/j.yexcr.2023.113570
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08161, KAKENHI-PROJECT-22K06962, KAKENHI-PROJECT-21K06083
[Journal Article] Dual inhibition of KIF11 and BCL2L1 induces apoptosis in lung adenocarcinoma cells2023
- Author(s)
  Sakuma Yuji、Hirai Sachie、Sumi Toshiyuki、Niki Toshiro、Yamaguchi Miki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 678 Pages: 84-89
- DOI
  10.1016/j.bbrc.2023.08.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08161, KAKENHI-PROJECT-22K06945, KAKENHI-PROJECT-22K06962
[Journal Article] Anthrax toxin receptor 2 is a potential therapeutic target for non-small cell lung carcinoma with MET exon 14 skipping mutations2022
- Author(s)
  Yamaguchi M, Hirai S, Idogawa M, Uchida H, Sakuma Y
- Journal Title
  
  Exp Cell Res
  
  Volume: 413 Issue: 2 Pages: 113078-113078
- DOI
  10.1016/j.yexcr.2022.113078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06962, KAKENHI-PROJECT-19K08372
[Journal Article] Dual inhibition of BCL2L1 and MCL1 is highly effective against RET fusion-positive or MET exon 14 skipping mutation-positive lung adenocarcinoma cells.2022
- Author(s)
  Hirai S, Idogawa M, Sumi T, Yamaguchi M, Niki T, Sakuma Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 630 Pages: 24-29
- DOI
  10.1016/j.bbrc.2022.09.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06945, KAKENHI-PROJECT-22K06962, KAKENHI-PROJECT-19K08372
[Journal Article] MCL1 inhibition enhances the efficacy of docetaxel against airway-derived squamous cell carcinoma cells.2021
- Author(s)
  Sakuma Y, Hirai S, Sumi T, Tada M, Kojima T, Niki T, Yamaguchi M
- Journal Title
  
  Exp Cell Res
  
  Volume: 406 Issue: 2 Pages: 112763-112763
- DOI
  10.1016/j.yexcr.2021.112763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07418, KAKENHI-PROJECT-19K07464
[Journal Article] Reciprocal expression of trefoil factor‐1 and thyroid transcription factor‐1 in lung adenocarcinomas2020
- Author(s)
  Matsubara Daisuke、Yoshimoto Taichiro、Soda Manabu、Amano Yusuke、Kihara Atsushi、Funaki Toko、Ito Takeshi、Sakuma Yuji、Shibano Tomoki、Endo Shunsuke、Hagiwara Koichi、Ishikawa Shumpei、Fukayama Masashi、Murakami Yoshinori、Mano Hiroyuki、Niki Toshiro
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 6 Pages: 1-13
- DOI
  10.1111/cas.14403
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-19K07441, KAKENHI-PROJECT-19K10094, KAKENHI-PROJECT-19K16565, KAKENHI-PROJECT-18H02634
[Journal Article] EGFR-independent EGFR-mutant lung adenocarcinoma cells depend on Bcl-xL and MCL1 for survival.2020
- Author(s)
  Hirai S, Tada M, Yamaguchi M, Niki T, Sakuma Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 526 Pages: 417-423
- DOI
  10.1016/j.lungcan.2019.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02634
[Journal Article] Pericyte-myofibroblast transition in the human lung2020
- Author(s)
  Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Tada M, Takahashi H, Watanabe A, Sakuma Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 528 Issue: 2 Pages: 269-275
- DOI
  10.1016/j.bbrc.2020.05.091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07418, KAKENHI-PROJECT-18K08151
[Journal Article] 肺組織に存在する線維芽細胞巣の由来と病的意義2019
- Author(s)
  佐久間　裕司
- Journal Title
  
  BIO Clinica
  
  Volume: 34 Pages: 1230-1233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07418
[Journal Article] Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung.2018
- Author(s)
  Tanaka Y, Yamaguchi M, Hirai S, Sumi T, Tada M, Saito A, Chiba H, Kojima T, Watanabe A, Takahashi H, Sakuma Y.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 372(2) Issue: 2 Pages: 141-149
- DOI
  10.1016/j.yexcr.2018.09.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08151, KAKENHI-PROJECT-18K15956, KAKENHI-PROJECT-17K16053
[Journal Article] Trametinib downregulates survivin expression in RB1-positive KRAS-mutant lung adenocarcinoma cells.2018
- Author(s)
  Sumi T, Hirai S, Yamaguchi M, Tanaka Y, Tada M, Niki T, Takahashi H, Sakuma Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 1 Pages: 253-258
- DOI
  10.1016/j.bbrc.2018.04.230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02634, KAKENHI-PROJECT-26293080
[Journal Article] Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas.2018
- Author(s)
  Sumi T, Hirai S, Yamaguchi M, Tanaka Y, Tada M, Yamada G, Hasegawa T, Miyagi Y, Niki T, Watanabe A, Takahashi H, Sakuma Y.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 52 Pages: 33-46
- DOI
  10.3892/ijo.2018.4365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-16K19459, KAKENHI-PROJECT-18H02634
[Journal Article] Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis.2017
- Author(s)
  Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Miyajima M, Mishina T, Yamada G, Otsuka M, Hasegawa T, Kojima T, Niki T, Watanabe A, Takahashi H, Sakuma Y.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 97 Pages: 232-242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293080
[Journal Article] Surfactant protein A down-regulates epidermal growth factor receptor by mechanisms different from those of surfactant protein D2017
- Author(s)
  Yoshihiro Hasegawa, Motoko Takahashi, Shigeru Ariki, Atsushi Saito, Yasuaki Uehara, Rina Takamiya, Koji Kuronuma, Hirofumi Chiba, Yuji Sakuma, Hiroki Takahashi, Yoshio Kuroki
- Journal Title
  
  J Bill Chem
  
  Volume: 292 Issue: 45 Pages: 18565-18576
- DOI
  10.1074/jbc.m117.800771
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma.2017
- Author(s)
  Yamaguchi M, Hirai S, Sumi T, Tanaka Y, Tada M, Nishii Y, Hasegawa T, Uchida H, Yamada G, Watanabe A, Takahashi H, Sakuma Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487(3) Issue: 3 Pages: 613-618
- DOI
  10.1016/j.bbrc.2017.04.102
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-15K08364
[Journal Article] Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.2017
- Author(s)
  Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, Ueno T, Kojima S, Shibano T, Hosono Y, Kawazu M, Yamashita Y, Endo S, Hagiwara K, Fukayama M,Takahashi T, Mano H, Niki T.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 9 Pages: 1888-1896
- DOI
  10.1111/cas.13313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-17K07250, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H02468
[Journal Article] Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis.2017
- Author(s)
  Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Miyajima M, Mishina T, Yamada G, Otsuka M, Hasegawa T, Kojima T, Niki T, Watanabe A, Takahashi H, Sakuma Y.
- Journal Title
  
  Lab Invest.
  
  Volume: Mar;97(3) Issue: 3 Pages: 232-242
- DOI
  10.1038/labinvest.2016.135
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-15K08364
[Journal Article] Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR and affects clinical outcomes of patients2017
- Author(s)
  Umeda Y、Hasegawa Y、Otsuka M、Ariki S、Takamiya R、Saito A、Uehara Y、Saijo H、Kuronuma K、Chiba H、Ohnishi H、Sakuma Y、Takahashi H、Kuroki Y、Takahashi M
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 46 Pages: 6432-6445
- DOI
  10.1038/onc.2017.253
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype.2016
- Author(s)
  Sakuma Y, Nishikiori H, Hirai S, Yamaguchi M, Yamada G, Watanabe A, Hasegawa T, Kojima T, Niki T, Takahashi H.
- Journal Title
  
  Lab Invest.
  
  Volume: 96 Issue: 4 Pages: 391-398
- DOI
  10.1038/labinvest.2015.155
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-15K08364, KAKENHI-PROJECT-25670178, KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-15K08350
[Journal Article] Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer.2014
- Author(s)
  Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T
- Journal Title
  
  Pathology International
  
  Volume: 64 Issue: 11 Pages: 560-568
- DOI
  10.1111/pin.12214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290051, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-25670178, KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-26640121
[Journal Article] The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.2014
- Author(s)
  Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Ishikawa S, Aburatani H, Fukayama M, Niki T, Yasuda Y.
- Journal Title
  
  Oncol Rep.
  
  Volume: 31(2) Issue: 2 Pages: 619-24
- DOI
  10.3892/or.2013.2899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134003, KAKENHI-PROJECT-25670178, KAKENHI-PROJECT-26293080
[Journal Article] Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells.2013
- Author(s)
  Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, and Miyagi Y.
- Journal Title
  
  Lab Invest.
  
  Volume: 93 Issue: 10 Pages: 1137-1146
- DOI
  10.1038/labinvest.2013.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-24590440, KAKENHI-PROJECT-25670178
[Journal Article] NF-kB signaling is activated and confers resistance to apoptosis in three-dimentionally cultured EGFR-mutant lung adenocarcinoma cells.2012
- Author(s)
  Sakuma, Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 243 Issue: 4 Pages: 667-671
- DOI
  10.1016/j.bbrc.2012.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-24590440
[Journal Article] WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors2012
- Author(s)
  Sakuma Y, Yamazaki Y, Nakamura Y, Yoshihara M, Matsukuma S, Nakayama H, Yokose T, Kameda Y, Koizume S, Miyagi Y.
- Journal Title
  
  Lab Invest
  
  Volume: 92 Pages: 371-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790367
[Journal Article] WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutunt lung adenocarcinomas more efficiently than Src inhibitors2012
- Author(s)
  Sakuma Y, et al
- Journal Title
  
  Laboratory Investigation
  
  Volume: 92 Issue: 3 Pages: 371-383
- DOI
  10.1038/labinvest.2011.187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790367, KAKENHI-PROJECT-23501280
[Journal Article] ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis2011
- Author(s)
  Sakuma Y, vTsunezumi J, Nakamura Y, Yoshihara M, Matsukuma S, Koizume S, Miyagi Y.
- Journal Title
  
  Oncol Rep
  
  Volume: 25 Pages: 661-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790367
[Journal Article] ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis2011
- Author(s)
  Sakuma Y, et al
- Journal Title
  
  Oncology Report
  
  Volume: 25 Pages: 661-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790367
[Journal Article] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src2010
- Author(s)
  Sakuma Y, et al.
- Journal Title
  
  The Journal of Pathology 220
  
  Pages: 574-585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790294
[Journal Article] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated2010
- Author(s)
  Sakuma Y, Takeuchi T, Nakamura Y, Yoshihara M, Matsukuma S, Nakayama H, Ohgane N, Yokose T, Kameda Y, Tsuchiya E, Miyagi Y.
- Journal Title
  
  J Pathol 220
  
  Pages: 574-585
- Data Source
  KAKENHI-PROJECT-20790294
[Journal Article] A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2cm or less in size2009
- Author(s)
  Sakuma Y, et al.
- Journal Title
  
  Lung Cancer 65
  
  Pages: 85-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790294
[Journal Article] A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2cm or less in size.2009
- Author(s)
  Sakuma Y, Okamoto N, Saito H, Yamada K, Yokose T, Kiyoshima M, Asato Y, Amemiya R, Saitoh H, Matsukuma S, Yoshihara M, Nakamura Y, Oshita F, Ito H, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y.
- Journal Title
  
  Lung Cancer 65
  
  Pages: 85-90
- Data Source
  KAKENHI-PROJECT-20790294
[Journal Article] Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan.2008
- Author(s)
  Sakuma Y, Matsukuma S, et. al.
- Journal Title
  
  Cancer Letter 259
  
  Pages: 119-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18014006
[Journal Article] High incidence of microscopic gastrointestinal stromal tumors in the stomach.2006
- Author(s)
  Kawanowa K, Sakuma Y, Sakurai S et al.
- Journal Title
  
  Human Pathology 37・12
  
  Pages: 1527-1535
- Data Source
  KAKENHI-PROJECT-18014006
[Presentation] 肺癌細胞を効果的に細胞死させる治療法の探索2023
- Author(s)
  佐久間裕司
- Organizer
  第112回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06962
[Presentation] Junctional adhesion molecule 3(JAM3)は小細胞肺がんの治療標的2023
- Author(s)
  山口美樹、平井幸恵、井戸川雅史、内田宏昭、佐久間裕司
- Organizer
  第125回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-21K08161
[Presentation] Anthrax toxin receptor 2 is a potential therapeutic target for non-small cell lung carcinoma with MET exon 14 skipping mutations2022
- Author(s)
  Yuji Sakuma
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K06962
[Presentation] 高性能イミュノトキシンを用いた小細胞肺がんに対する標的の探索2021
- Author(s)
  山口美樹、藤谷直樹、平井幸恵、高橋素子、内田宏昭、佐久間裕司
- Organizer
  第123回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-21K08161
[Presentation] Reciprocal expressions of TFF-1 and TTF-1 in lung adenocarcinomas.2018
- Author(s)
  ３１．Matsubara D, Soda M, Yoshimoto T, Amano Y, Kihara A, Sakuma Y, Endo S, Hagiwara K, Fukayama M, Mano H, Niki T.
- Organizer
  Annual Meeting of American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02634
[Presentation] Reciprocal expressions of TFF-1 and TTF-1 in lung adenocarcinomas.2018
- Author(s)
  Matsubara D, Soda M, Yoshimoto T, Amano Y, Kihara A, Sakuma Y, Endo S, Hagiwara K, Fukayama M, Mano H, Niki T.
- Organizer
  Annual Meeting of American Association for Cancer Research
- Data Source
  KAKENHI-PROJECT-26293080
[Presentation] 肺サーファクタント蛋白質Dによる変異型EGFRの制御機構2016
- Author(s)
  長谷川喜弘, 佐久間裕司, 高橋素子
- Organizer
  第75回日本癌学会学術総会, 2016年10月6日～8日
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] Isomerase Pin1 promotes survival in EGFR mutant lung adenocarcinoma c ells with an EMT phenotype2016
- Author(s)
  佐久間裕司、長谷川　匡、仁木利郎
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K08364
[Presentation] EGFR変異陽性肺腺癌と特発性肺線維症の分子細胞病理学2016
- Author(s)
  佐久間裕司
- Organizer
  第62回日本病理学会秋期特別総会
- Place of Presentation
  金沢市文化ホール（石川県金沢市）
- Year and Date
  2016-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K08364
[Presentation] 肺腺癌におけるanoikis抵抗性の研究2011
- Author(s)
  佐久間裕司、中村圭靖、横瀬智之、亀田陽一、宮城洋平
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜・パシフィコ横浜
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-22790367
[Presentation] EGFR-mutant lung adenocarcinoma cells depend critically on EGFR activation to thrive in anchorage-independent conditions2011
- Author(s)
  Sakuma Y, Nakamura Y, Yoshihara M, Koizume S, Miyagi Y
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋・名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22790367
[Presentation] ABT-263 enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis2010
- Author(s)
  Sakuma Y, Nakamura Y, Yoshihara M, Koizume S, Miyagi Y.
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪・大阪国際会議場
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790367
[Presentation] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing Src2009
- Author(s)
  Sakuma Y, et al.
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜・パシフィコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20790294
[Presentation] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing Src.2009
- Author(s)
  Sakuma Y, Takeuchi T, Nakamura Y, Yoshihara M, Matsukuma S, Yokose T, Kameda Y, Tsuchiya E, Miyagi Y.
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20790294
[Presentation] 予後不良の小型肺腺癌の特徴を明らかにするための研究2008
- Author(s)
  佐久間裕司、中村圭靖、亀田陽一、横瀬智之、土屋永寿、宮城洋平
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢・石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-20790294
[Presentation] Mutations of c-kit gene in bilateral testicular germ cell tumors in Japan2007
- Author(s)
  佐久間裕司、松隈章一, 他
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18014006
[Presentation] The HSP90 inhibitor 17-AAG improves chemoresistance of cisplatin-resistant esophageal squamous cell　carcinoma cell lines.
- Author(s)
  ２５．Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Yasuda Y, Niki T.
- Organizer
  Annual Meeting of American Association for Cancer Research
- Place of Presentation
  San Diego
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-26293080
[Presentation] EGFR遺伝子変異陽性肺腺癌におけるautophagyの役割の解明
- Author(s)
  ２．佐久間裕司、中村圭靖、横瀬智之、亀田陽一、宮城洋平
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌・ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24590440
[Presentation] EGFR遺伝子変異陽性肺癌に内在するZEB1発現細胞の研究
- Author(s)
  佐久間裕司、仁木利郎
- Organizer
  第55回日本肺癌学会総会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-24590440
[Presentation] 細胞外基質との接着が誘導するEGFR遺伝子変異陽性肺腺癌細胞のapoptosis抵抗性の研究
- Author(s)
  佐久間裕司、中村圭靖、横瀬智之、亀田陽一、宮城洋平
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京・京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24590440

1. YAMAGUCHI MIKI (10530454)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. TAKAHASHI MOTOKO (00303941)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. 内田宏昭 (20401250)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. Niki Toshiro (90198424)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. 櫻井信司 (00285769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 吉本多一郎 (20634166)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 松原大祐 (80415554)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 藤谷直樹 (10374191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. Hasegawa Yoshihiro (90643180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. TAKAHASHI HIROKI (60231396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 西井ゆかり (10619505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 角俊行 (60772291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 田中悠祐 (70792125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 多田周 (00815441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 萩原弘一 (00240705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 遠藤俊輔 (10245037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. TAKAMIYA Rina

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. KOIZUME Shiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 村上善則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 石川俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 宮城洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakuma Yuji 佐久間 裕司

SAKUMA Yuji 佐久間 裕司

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Integrative study of MET-dependent non-small cell lung carcinomaPrincipal Investigator

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Pericytes play a critical role in the development of idiopathic pulmonary fibrosisPrincipal Investigator

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Integrative analyses of lung adenocarcinomas that have undergone epithelial to mesenchymal transition (EMT) and those that retain an epithelial phenotypePrincipal Investigator

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Identification of molecular mechanisms other than genetic abnormalities in EGFR-TKI resistance of lung adenocarcinomasPrincipal Investigator

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肺腺癌の転移成立を防ぐための研究Principal Investigator

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Development of a logistic regression predictive model for the outcome of patients with resected lung adenocarcinoma of 2cm or less in sizePrincipal Investigator

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Sakuma Yuji 佐久間裕司

SAKUMA Yuji 佐久間裕司