Hasegawa Makoto 長谷川慎

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HASEGAWA Makoto 長谷川慎

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Researcher Number	10367899
Affiliation (Current)	2025: 長浜バイオ大学, バイオサイエンス学部, 教授
Affiliation (based on the past Project Information) *help	2025: 長浜バイオ大学, バイオサイエンス学部, 教授 2014 – 2021: 長浜バイオ大学, バイオサイエンス学部, 教授 2010 – 2013: 長浜バイオ大学, バイオサイエンス学部, 准教授 2006 – 2008: 長浜バイオ大学, バイオサイエンス学部, 講師
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 38010:Plant nutrition and soil science-related / Basic Section 37030:Chemical biology-related / Chemical biology Except Principal Investigator Tumor therapeutics / Hygiene and public health / Drug development chemistry / Clinical oncology
Keywords	Principal Investigator 中分子医薬 / 分子進化工学 / プロテアソーム阻害剤 / 薬剤反応性 / 蛋白質 / 翻訳後修飾 / 進化分子工学 / ケミカルバイオロジー / 膜透過性ペプチド / 薬剤耐性骨髄腫 … More / 膜透過ペプチド / 機能性ペプチド / バイオプローブ / 翻訳語修飾 / 抗癌剤 / スプライシング / 癌 / プロテアソーム / 医薬分子機能学 … More Except Principal Investigator 分子標的治療 / 抗がん剤耐性 / ウイルス粒子検出 / ノロウイルス / ウイルス検出システム / ケニア / 感染モード / ワクチン効果 / ジェノタイピング / ロタウイルス / molecular target / telomere / drug reactivity / protein / cancer / 蛋白質 / 分子標的 / テロメア / 薬剤反応性 / タンパク質 / 癌 Less

植物根圏の細菌叢における植物成長促進物質の探索Principal Investigator
- Principal Investigator
  
  長谷川慎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38010:Plant nutrition and soil science-related
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Development of novel middle-molecule proteasome inhibitors and their drug delivery methodsPrincipal Investigator
- Principal Investigator
  
  Hasegawa Makoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Development of novel middle molecular weight anticancer agents based on proteasome inhibitionPrincipal Investigator
- Principal Investigator
  
  Hasegawa Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Epidemiological study on rotavirus diarrhea and a study on the mode of trasmisson
- Principal Investigator
  
  ICHINOSE Yoshio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  Nagasaki University
Functional analysis of novel oncogene dynAP and the identification of its inhibitors
- Principal Investigator
  
  Mizukami Tamio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Development of drug-resistance-overcoming agents targeting histone demethylase JARID1A
- Principal Investigator
  
  Tamio Mizukami
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Oncogenic properties of human dynactin-associated protein (dynAP)
- Principal Investigator
  
  MIZUKAMI Tamio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Development of cell membrane penetrating peptidesPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Makoto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Splicing Inhibition Mechanism of GEX1A, An Antitumor Natural ProductPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Makoto
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology
A study on a novel anticancer drug candidate regulating proteasome activityPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Makoto
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Chemical genomics screening of drugs modulating functions of telomere/telomerase
- Principal Investigator
  
  MIZUKAMI Tamio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology

[Book] がんの分子標的治療(35章プロテアソーム阻害剤)2008
- Author(s)
  長谷川慎、水上民夫
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-18790092
[Journal Article] Structure and Function of Potential Glycosylation Sites of Dynactin-Associated Protein dynAP2022
- Author(s)
  Yin Xiaobo、Konishi Takayuki、Horikawa Kazuo、Tanaka Ryota、Togo Yuki、Noda Takanori、Hosoi Miho、Tsuchida Mie、Kunoh Tatsuki、Wada Shuichi、Nakamura Toshinobu、Tsuda Eisuke、Sasaki Ryuzo、Mizukami Tamio、Hasegawa Makoto
- Journal Title
  
  Molecular Biotechnology
  
  Volume: 64 Issue: 6 Pages: 611-620
- DOI
  10.1007/s12033-021-00435-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05739, KAKENHI-PUBLICLY-20H05374, KAKENHI-PUBLICLY-22H04680
[Journal Article] Development of microparticle counting sensor based on structural and spectroscopic properties of metal mesh device.2021
- Author(s)
  Hirokazu Seto, Atsushi Saiki, Ryosuke Matsushita, Wataru Mitsukami, Seiji Kamba, Makoto Hasegawa, Yoshiko Miura, Yumiko Hirohashi, Hiroyuki Shinto
- Journal Title
  
  Advanced Powder Technology
  
  Volume: - Issue: 6 Pages: 1920-1926
- DOI
  10.1016/j.apt.2021.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05042, KAKENHI-PROJECT-19K05739
[Journal Article] Expression and cell transformation activity of dynactin‐associated protein isoforms2021
- Author(s)
  Yin Xiaobo、Yamada Shota、Kobayashi Hiroaki、Tanaka Ryota、Togo Yuki、Hosoi Miho、Tsuchida Mie、Kunoh Tatsuki、Wada Shuichi、Nakamura Toshinobu、Sasaki Ryuzo、Mizukami Tamio、Hasegawa Makoto
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 8 Pages: 2110-2117
- DOI
  10.1002/2211-5463.13202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05739, KAKENHI-PUBLICLY-20H05374
[Journal Article] Enrichment of Uncommon Bacteria in Soil by Fractionation Using a Metal Mesh Device2021
- Author(s)
  KAMBA Seiji、OGURA Atsushi、MIURA Yoshiko、HASEGAWA Makoto
- Journal Title
  
  Anal. Sci.
  
  Volume: 37 Issue: 9 Pages: 1295-1300
- DOI
  10.2116/analsci.21P042
- NAID
  130008087322
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2021-09-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05739, KAKENHI-PROJECT-20K21452
[Journal Article] Amplification of Sensor Signals from Metal Mesh Device with Fine Periodic Structure2019
- Author(s)
  Seto, H., Saiki, A., Kamba, S., Kondo, T., Hasegawa, M., Miura, Y., Hirohashi, Y. and Shinto, H.
- Journal Title
  
  Anal. Sci.
  
  Volume: 35 Issue: 6 Pages: 619-623
- DOI
  10.2116/analsci.18P498
- NAID
  130007661685
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2019-06-10
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08329
[Journal Article] Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation.2019
- Author(s)
  Yamashita, S., Tanaka, M., Nodono, H., Hamada, A., Hamada, T., Hasegawa, M., Nishi, Y., Moss, J., Miwa, M.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 印刷中 Pages: 27-32
- DOI
  10.1016/j.bcp.2019.03.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08329
[Journal Article] Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death.2018
- Author(s)
  Tanaka, M., Zhu, Y., Shionyu, M., Ota, N., Shibata, N., Watanabe, C., Mizusawa, A., Sasaki, R., Mizukami, T., Shiina, I., Hasegawa, M.
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 146 Pages: 636-650
- DOI
  10.1016/j.ejmech.2018.01.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08329, KAKENHI-PROJECT-15K00411, KAKENHI-PROJECT-17H03024
[Journal Article] Detection of rotavirus in clinical specimens using an immunosensor prototype based on the photon burst counting technique2017
- Author(s)
  Makoto Hasegawa, Ernest Apondi Wandera, Yuka Inoue, Nanami Kimura, Ryuzo Sasaki, Tamio Mizukami, Mohammad Monir Shah, Nobuaki Shirai, Osamu Takei, Hironori Shindo, and Yoshio Ichinose
- Journal Title
  
  Biomed. Opt. Express
  
  Volume: 8(7) Pages: 3383-3394
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05286
[Journal Article] Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.2015
- Author(s)
  Itoh Y, Sawada H, Suzuki M, Tojo T, Sasaki R, Hasegawa M, Mizukami T, Suzuki T
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 6 Issue: 6 Pages: 665-670
- DOI
  10.1021/acsmedchemlett.5b00083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640093
[Journal Article] Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction.2015
- Author(s)
  Kunoh T, Wang W, Kobayashi H, Matsuzaki D, Togo Y, Tokuyama M, Hosoi M, Koseki K, Wada S, Nagai N, Nakamura T, Nomura S, Hasegawa M, Sasaki R, Mizukami T.
- Journal Title
  
  PLoS One.
  
  Volume: 10(8) Issue: 8 Pages: e0135836-e0135836
- DOI
  10.1371/journal.pone.0135836
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112006, KAKENHI-PROJECT-15H04314, KAKENHI-PROJECT-26640063, KAKENHI-PROJECT-25291053
[Journal Article] A Novel Tamoxifen Derivative, Ridaifen-F, Is a Nonpeptidic Small-molecule Proteasome Inhibitor2014
- Author(s)
  Makoto Hasegawa, Yukari Yasuda, Makoto Tanaka, Kenya Nakata, Eri Umeda, Yanwen Wang, Chihiro Watanabe, Shoko Uetake,Tatsuki Kunoh, Masafumi Shionyu, Ryuzo Sasaki, Isamu Shiina, Tamio Mizukami
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 71 Pages: 290-305
- DOI
  10.1016/j.ejmech.2013.11.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22350044, KAKENHI-PROJECT-24510317
[Journal Article] Metal mesh device sensor immobilized with a trimethoxysilane-containing glycopolymer for label-free detection of proteins and bacteria2014
- Author(s)
  Hirokazu Seto, Seiji Kamba, Takashi Kondo, Makoto Hasegawa, Shigeki Nashima, Yoshinobu Ehara, Yuichi Ogawa, Yu Hoshino, Yoshiko Miura
- Journal Title
  
  ACS Applied Materials & Interfaces
  
  Volume: 6 Issue: 15 Pages: 13234-13241
- DOI
  10.1021/am503003v
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J05206, KAKENHI-PROJECT-23685027, KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-26620106
[Journal Article] Regulation of TFPI-2 (Tissue Factor Pathway Inhibitor 2) expression by Lysine-Specific Demethylase 1 and 2 (LSD1 and LSD2).2014
- Author(s)
  2.Mino, K., Nishimura, S., Ninomiya, S., Tujii, H., Matsumori, Y., Tsuchida, M., Hosoi, M., Koseki, K., Wada, S., Hasegawa, M., Sasaki, R., Murakami-Yamaguchi, Y., Narita, H., Suzuki, T., Miyata, N., Mizukami, T.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 78 Issue: 6 Pages: 1010-1017
- DOI
  10.1080/09168451.2014.910104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-221S0001
[Journal Article] Biotinyiation of silicon and nickel surfaces and detection of streptavidin as biasensor.2013
- Author(s)
  Hirokazu Seto, Chie Yamashita, Seiji Karnba, Takashi Kondo, Makoto Hasegawa, Mitsuhiro Matsuno, Yuichii Ogawa, Yu Hoshino, Yoshiko Miura
- Journal Title
  
  Langmuir
  
  Volume: 29 Issue: 30 Pages: 9457-9463
- DOI
  10.1021/la401068n
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J05206, KAKENHI-PROJECT-23685027, KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24655157
[Journal Article] Alarin but not its alternative-splicing form, GALP (Galanin- like peptide) has antimicrobial activity.2013
- Author(s)
  A. Wada, Y. Kuboら
- Journal Title
  
  Biochemical and Biophysical Research Communication
  
  Volume: 434 Issue: 2 Pages: 223-227
- DOI
  10.1016/j.bbrc.2013.03.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24592432, KAKENHI-PROJECT-24651263
[Journal Article] Lysine-Specific Demethylase 1-Selective Inactivators Based on Protein-Targeted Drug Delivery Mechanism2013
- Author(s)
  Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N, Suzuki T
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 52 Issue: 33 Pages: 8620-8624
- DOI
  10.1002/anie.201303999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24790117, KAKENHI-PROJECT-24890193, KAKENHI-PROJECT-221S0001
[Journal Article] Identification of a Selective Inhibitor of KDM2/7 Histone Lysine Demethylases and its Antiproliferative Activity.2013
- Author(s)
  Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 56 Issue: 18 Pages: 7222-7231
- DOI
  10.1021/jm400624b
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24770165, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112008, KAKENHI-PROJECT-221S0001
[Journal Article] Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor.2011
- Author(s)
  Ogasawara, D., Suzuki, T., Mino, K., Ueda, R., Khan, M.N., Matsubara, T., Koseki, K., Hasegawa, M., Sasaki, R., Nakagawa, H.Mizukami, T., Miyata, N.
- Journal Title
  
  Bioorganic & medicinal chemistry
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790117
[Journal Article] Identification of SAP155 as the Target of GEX1A (Herboxidiene), An Antitumor Natural Product.2011
- Author(s)
  Hasegawa, M., Miura, T., Kuzuya, K., Inoue, A., Se Won Ki, Horinouchi, S., Yoshida, T., Kunoh, T., Koseki, K., Mino, K., Sasaki, R., Yoshida, M., Mizukami, T.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 18 Pages: 229-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790117
[Journal Article] Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product2011
- Author(s)
  Hasegawa, M., Miura, T., Kuzuya, K., Inoue, A., Ki, S. W., Horinouchi, S., Yoshida, T., Kunoh, T., Koseki, K., Mino, K., Sasaki, R., Yoshida, M., and Mizukami, T
- Journal Title
  
  ACS Chem. Biol
  
  Volume: 6 Issue: 3 Pages: 229-233
- DOI
  10.1021/cb100248e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21228003, KAKENHI-PROJECT-22790117
[Journal Article] Characteristic increase in nucleocytoplasmic protein glycosylation by O-GlcNAc in 3T3-L1 adipocyte differentiation.2010
- Author(s)
  Ishihara K, Takahashi I, Tsuchiya Y, Hasegawa M, Kamemura K.
- Journal Title
  
  Biochemical and Biophysical Research Communication
  
  Volume: 398 Pages: 489-494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790117
[Journal Article] Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors.2010
- Author(s)
  Hamada, S., Suzuki, T., Mino, K., Koseki, K., Oehme, F., Flamme, I., Ozasa, H., Itoh, Y., Ogasawara, D., Komaarashi, H., Katoh, A., Tsumoto, H., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T., Miyata, N.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 53 Pages: 5629-5638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790117
[Journal Article] Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity.2010
- Author(s)
  Wada, A., Hasegawa, M., Wong, P-F., Shirai, E., Shirai, N., Tan, L-J., Llanes, R., Hojo, H., Yamasaki, E., Ichinose, A., Ichinose, Y., Senba, M.
- Journal Title
  
  Glycobiology
  
  Volume: 20 Pages: 668-678
- NAID
  120006984983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790117
[Journal Article] Affinity labeling of the proteasome by a belactosin A derived inhibitor2008
- Author(s)
  Hasegawa, M., Kinoshita, K., Nishimura, C., Matsumur a, U., Shionyu, M., Ikeda, S., and Mizukami, T.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 18
  
  Pages: 5668-5671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790092
[Journal Article] Affinity labeling of the proteasome by a belactosin A derived inhibitor2008
- Author(s)
  Hasegawa, M., Kinoshita, K., Nishimura, C., Matsumura, U., Shionyu, M., Ikeda, S., and Mizukami, T.
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 18
  
  Pages: 5668-5671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790092
[Patent] 被験物質に対するプローブの結合親和性を測定する方法及びその利用2007
- Inventor(s)
  長谷川慎、川畑隆司、川瀬千晶、伊藤正恵、水上民夫
- Industrial Property Rights Holder
  学校法人関西文理総合学園
- Industrial Property Number
  2007-089821
- Filing Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18790092
[Patent] 被験物質に対するプローブの結合親和性を測定する方法及びその利用2007
- Inventor(s)
  長谷川慎、川畑隆司、川瀬千晶、伊藤正恵、水上民夫
- Industrial Property Rights Holder
  学校法人関西文理総合学園
- Filing Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18790092
[Presentation] 膜結合型グアニル酸シクラーゼCに対する人工リガンドペプチドの探索2021
- Author(s)
  髙橋由貴、落合慧璃、長谷川慎
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K05739
[Presentation] プロテアソーム阻害剤リダイフェン-Fへの膜透過性ペプチド付加による多剤耐性型骨髄腫細胞株への作用増強2018
- Author(s)
  田中誠、朱耘浩、塩生真史、太田のぞみ、芝田夏実、渡邊千尋、水澤彰人、佐々木隆造、水上民夫、椎名勇、長谷川慎
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-16K08329
[Presentation] 新規ヒトがんタンパク質 dynAPの糖鎖の構造解析2017
- Author(s)
  小西貴之、尹驍博、堀川和男、田中崚太、細井美穂、久能樹、和田修一、長谷川慎、佐々木隆造、水上民夫
- Organizer
  第40回日本分子生物学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04314
[Presentation] 新規がんタンパク質dynAPによる腫瘍形成機構の解明：dynAP発現依存的なスフェロイド形成の阻害剤の探索2017
- Author(s)
  田口大貴、久能樹、長谷川慎、佐々木隆造、水上民夫
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04314
[Presentation] 細胞膜透過ペプチドコンジュゲートによるタモキシフェン誘導体RID-Fの26Sプロテアソーム阻害効果の向上2017
- Author(s)
  田中誠、朱耘浩、太田のぞみ、芝田夏実、椎名勇、佐々木隆造、水上民夫、長谷川慎
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08329
[Presentation] 新規ヒトがんタンパク質 dynAPの糖鎖の機能解析2017
- Author(s)
  尹驍博、小西貴之、堀川和男、田中崚太、細井美穂、久能樹、和田修一、長谷川慎、佐々木隆造、水上民夫
- Organizer
  第40回日本分子生物学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04314
[Presentation] 進化分子工学的手法によるプロテアソーム阻害ペプチドの探索と構造活性相関研究2017
- Author(s)
  朱耘浩，田中誠，早川結実子，小牧明日美，北村幸一郎，水上民夫，長谷川慎
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08329
[Presentation] 新規がんタンパク質dynAPによる腫瘍形成機構の解明：dynAP発現依存的なアノイキス抵抗性に関わる因子の探索2016
- Author(s)
  徳山奨浩、久能樹、長谷川慎、佐々木隆造、水上民夫
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15H04314
[Presentation] 周期構造金属薄膜を用いた細胞分離と赤外線透過性による検出2015
- Author(s)
  山本晃毅，森康介，白井恵美，井上有香，萬壽優，渡邉順子，神波誠治，近藤孝志，長谷川慎
- Organizer
  第62回日本生化学会近畿支部例会
- Place of Presentation
  滋賀県
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-24510317
[Presentation] Separation and sensing of aerosol particles in Kenya using metal mesh sensor with periodic microstructures2015
- Author(s)
  5)Yamamoto, K., E. Shirai, Y. Inoue, S. Kanba, T. Kondo, E. Wandera+, Y. Ichinose+, M. Hasegawa
- Organizer
  IEEE sensors 2015
- Place of Presentation
  Busan（South Korea）
- Year and Date
  2015-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05286
[Presentation] 新規プロテアソーム阻害剤リダイフェン-Fの構造活性相関研究2015
- Author(s)
  田中誠，杉山茂仁，早川結実子，水澤彰人, 渡邊千尋, 太田のぞみ, 椎名勇，佐々木隆造，水上民夫，長谷川慎
- Organizer
  第62回日本生化学会近畿支部例会
- Place of Presentation
  滋賀県
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-24510317
[Presentation] Separation and sensing of aerosol particles in Kenya using metal mesh sensor with periodic microstructures2015
- Author(s)
  Yamamoto, K., E. Shirai, Y. Inoue, S. Kanba, T. Kondo, E. Wandera+, Y. Ichinose+, M. Hasegawa
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H05286
[Presentation] ヘリコバクター・ピロリの産生毒素VacAに対するペプチドアプタマーの探索と評価2015
- Author(s)
  早川結実子，松野充宏，田中誠，武居修，北村幸一郎，長谷川慎
- Organizer
  第62回日本生化学会近畿支部例会
- Place of Presentation
  滋賀県
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-24510317
[Presentation] 抗腫瘍活性物質GEX1Aの標的タンパク質とそのリン酸化修飾の解析2011
- Author(s)
  棚橋一晃、葛谷晃司、三浦達拓、小坂葉子、吉田哲郎、吉田稔、佐々木隆造、水上民夫、長谷川慎
- Organizer
  日本ケミカルバイオロジー学会第6回年会
- Place of Presentation
  東京
- Year and Date
  2011-05-23
- Data Source
  KAKENHI-PROJECT-22790117
[Presentation] プロテアソーム阻害化合物ベラクトシンA誘導体による活性サブユニットの標識2007
- Author(s)
  木下和拓、松村梅千代、西村千佳、園城倫子、橋本将宏、池田俊一、水上民夫、長谷川慎
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18790092
[Presentation] BelactosinAの細胞内プロテアソームへの結合動態解析2006
- Author(s)
  木下和拓、西村千佳、池田俊一、長谷川慎、水上民夫
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18790092
[Presentation] ベラクトシンAの20Sプロテアソームへの結合特異性と酵素阻害作用の解析2005
- Author(s)
  長谷川慎、松村梅千代、西村千佳、池田俊一、水上民夫
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18790092
[Presentation] プロテアソーム阻害化合物べラクトシンA誘導体による活性サブユニットの標識2005
- Author(s)
  木下和拓、松村梅千代、西村千佳、園城倫子、橋本将宏、池田俊一、水上民夫、長谷川慎
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18790092
[Presentation] リダイフェン-Fのプロテアソーム阻害作用向上のための新しい方法
- Author(s)
  田中誠、椎名勇、佐々木隆造、水上民夫、長谷川慎
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  愛媛県
- Year and Date
  2015-06-10 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-24510317

1. MIZUKAMI Tamio (80367896)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. NAGAI Nobuo (90260281)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SASAKI Ryuzo (60077378)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. TAKAHASHI Rei (60144565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAMURA Toshinobu (80403202)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. TSURUYAMA Tatsuaki (00303842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ICHINOSE Yoshio (70176296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. Wada Shuichi (20378607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. SUZUKI Takayoshi (90372838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. MIYATA Naoki (50114674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Yoshida Minoru (80191617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. Itoh Akihiro (40391859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. Ernest Apondi Wandera

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Mohamed Monir Shah

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Erick Odoyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 久保嘉直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 椎名勇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 瀬戸弘一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 佐々木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasegawa Makoto 長谷川 慎

HASEGAWA Makoto 長谷川 慎

Research Projects

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植物根圏の細菌叢における植物成長促進物質の探索Principal Investigator

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Development of novel middle-molecule proteasome inhibitors and their drug delivery methodsPrincipal Investigator

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Development of novel middle molecular weight anticancer agents based on proteasome inhibitionPrincipal Investigator

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Epidemiological study on rotavirus diarrhea and a study on the mode of trasmisson

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Functional analysis of novel oncogene dynAP and the identification of its inhibitors

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Development of drug-resistance-overcoming agents targeting histone demethylase JARID1A

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Oncogenic properties of human dynactin-associated protein (dynAP)

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Development of cell membrane penetrating peptidesPrincipal Investigator

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Splicing Inhibition Mechanism of GEX1A, An Antitumor Natural ProductPrincipal Investigator

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A study on a novel anticancer drug candidate regulating proteasome activityPrincipal Investigator

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Chemical genomics screening of drugs modulating functions of telomere/telomerase

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[Book] がんの分子標的治療(35章プロテアソーム阻害剤)2008

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[Journal Article] Structure and Function of Potential Glycosylation Sites of Dynactin-Associated Protein dynAP2022

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Hasegawa Makoto 長谷川慎

HASEGAWA Makoto 長谷川慎