SAKURAI Daiju 櫻井大樹

Researcher Number	10375636
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 山梨大学, 大学院総合研究部, 教授 2016 – 2018: 千葉大学, 大学院医学研究院, 講師 2012 – 2016: 千葉大学, 医学(系)研究科(研究院), 講師 2011: 千葉大学, 大学院・医学研究院, 講師 2010: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Otorhinolaryngology / Basic Section 90130:Medical systems-related / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 免疫抑制 / 頭頸部癌 / 花粉症 / アレルギー性鼻炎 / 遺伝子 / 腫瘍免疫 / リスク因子 / 発症機序 / 発症因子 / 小児 … More / T細胞 / エピゲノム / 骨髄性免疫抑制細胞 / 頭頸部扁平上皮癌 / 免疫治療 / 免疫抑制細胞 / 制御性T細胞 / 癌免疫 / 骨髄性抑制細胞 / 免疫学 / 癌 / 核酸 / 医療・福祉 … More Except Principal Investigator 頭頸部癌 / ディープラーニング / 診断支援装置 / 機械学習 / 生体音 / 嚥下音 / 筋電図 / 超音波動画像 / 嚥下 / 遠隔転移 / 骨髄系免疫抑制細胞 / 代謝解析 / MDSC / 一次代謝産物 / 免疫修飾 / 酸化的リン酸化 / パクリタキセル / ATP / 免疫原性細胞死 / MDSCs / 光線力学治療 / アレルギー性鼻炎 / アミノレブリン酸 / 光線力学的治療 / アジュバンド療法 / 先進医療 / アジュバント療法 / 細胞障害性T細胞 / 悪性黒色腫 / 扁平上皮癌 / 癌免疫療法 / NKT細胞 Less

小児スギ花粉症の発症リスク因子の解明と予防治療の確立に向けた多角的縦断的研究Principal Investigator
- Principal Investigator
  
  櫻井大樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  University of Yamanashi
急増する小児アレルギー性鼻炎の発症リスク因子と発症機序の解明に向けた研究Principal Investigator
- Principal Investigator
  
  櫻井大樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  University of Yamanashi
超音波動画像と筋電図と嚥下音を用いた非侵襲計測による嚥下評価のための装置開発研究
- Principal Investigator
  
  鈴木裕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Toyo University
Immunometabolism-targeted cancer therapy in HNSCC
- Principal Investigator
  
  Ishii Hiroki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  University of Yamanashi
The study of epigenetic regulation in peripheral immune cells associated with onset and remission of allergic rhinitis.Principal Investigator
- Principal Investigator
  
  SAKURAI DAIJU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  University of Yamanashi
  Chiba University
唾液腺癌に対する抗LAG-3/PD-1抗体併用によるNKT細胞療法の開発
- Principal Investigator
  
  蒔田勇治
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of novel immunotherapy for head and neck cancer patients; combination of reversal of immune suppression and activation of NKT cellsPrincipal Investigator
- Principal Investigator
  
  Daiju Sakurai
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of photodynamic therapy for the allergic rhinitis
- Principal Investigator
  
  SUZUKI TAKESHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosa
- Principal Investigator
  
  Okamoto Yoshitaka
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Study of immunosuppressive mechanism in head and neck cancer and development of novel treatmentPrincipal Investigator
- Principal Investigator
  
  SAKURAI Daiju
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of new therapy to activate anti-tumor immunity against head and neck squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  SAKURAI Daiju
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University

All 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] スギ・ヒノキ花粉観測25年間の報告　山梨県における地域差と年次推移の検討2023
- Author(s)
  島村歩美, 代永孝明, 渡邉大輔, 五十嵐賢, 石井裕貴, 松岡伴和, 増山敬祐, 櫻井大樹
- Journal Title
  
  日本耳鼻咽喉科免疫アレルギー感染症学会誌
  
  Volume: 3 Pages: 2435-7952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09740
[Journal Article] Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma2022
- Author(s)
  Ishii Hiroki、Tsujikawa Takahiro、Oishi Naoki、Kinouchi Arisa、Sakamoto Kaname、Mitsuda Junichi、Ogi Hiroshi、Itoh Kyoko、Kondo Tetsuo、Hirano Shigeru、Sakurai Daiju
- Journal Title
  
  Clinical Case Reports
  
  Volume: 10 Issue: 7
- DOI
  10.1002/ccr3.6050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06883, KAKENHI-PROJECT-22K09688, KAKENHI-PROJECT-20K09706
[Journal Article] Sublingual Immunotherapy for Japanese Cedar Pollinosis: Current Clinical and Research Status2022
- Author(s)
  Sakurai Daiju、Ishii Hiroki、Shimamura Ayumi、Watanabe Daisuke、Yonaga Takaaki、Matsuoka Tomokazu
- Journal Title
  
  Pathogens
  
  Volume: 11 Issue: 11 Pages: 1313-1313
- DOI
  10.3390/pathogens11111313
- Data Source
  KAKENHI-PROJECT-20K09706
[Journal Article] 頭頸部癌に対するNKT免疫細胞治療と今後の展開2017
- Author(s)
  櫻井大樹
- Journal Title
  
  耳鼻咽喉科免疫アレルギー
  
  Volume: 35 Pages: 291-295
- NAID
  130006287911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10799
[Journal Article] Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer.2016
- Author(s)
  Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Issue: 3 Pages: 207-16
- DOI
  10.1111/cas.12866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181
[Presentation] ダニ舌下免疫療法の基礎から最近の話題まで2023
- Author(s)
  櫻井大樹
- Organizer
  日本鼻科学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09740
[Presentation] 舌下免疫療法の効果と最近の話題2023
- Author(s)
  櫻井大樹
- Organizer
  日本職業・環境アレルギー学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09740
[Presentation] 重症アレルギー性鼻炎診療のポイント2022
- Author(s)
  櫻井大樹
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09740
[Presentation] Unique feature of Japanese cedar pollinosis2020
- Author(s)
  櫻井大樹
- Organizer
  日本アレルギー学会・世界アレルギー機構合同学会2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] ダニ舌下免疫療法の長期寛解への期待・寛解機序と最新の知見2020
- Author(s)
  櫻井大樹
- Organizer
  第121回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] アレルギー性鼻炎に対するアレルゲン免疫療法・舌下免疫療法の現状と課題2020
- Author(s)
  櫻井大樹
- Organizer
  第4回日本アレルギー学会関東地方会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] スギ舌下免疫療法におけるスギ反応性Th2細胞の解析2019
- Author(s)
  櫻井大樹
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] スギ舌下免疫療法におけるスギ反応性Th2細胞の解析2019
- Author(s)
  櫻井大樹
- Organizer
  第37回　日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] 臨床効果、奏効機序とバイオマーカーUp-to-date2019
- Author(s)
  櫻井大樹
- Organizer
  第1回　日本アレルギー学会関東地方会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] アレルギー性鼻炎に対する免疫療法と感作の関係　作用機序とマーカー2019
- Author(s)
  櫻井大樹
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] 舌下免疫療法のメカニズムと最新知見2019
- Author(s)
  櫻井大樹
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] スギ花粉症の特徴をふまえた今後の治療戦略2018
- Author(s)
  櫻井大樹
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] Immunological parameters observed in sublingual immunotherapy2018
- Author(s)
  櫻井大樹
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] アレルギー性鼻炎の症状と病態から考える治療戦略2018
- Author(s)
  櫻井大樹
- Organizer
  第49回日本職業・環境アレルギー学会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] 千葉大学の取り組み　臨床と基礎のteam-up2018
- Author(s)
  櫻井大樹
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09314
[Presentation] 頭頸部癌に対するNKT免疫細胞治療と今後の展開2017
- Author(s)
  櫻井大樹
- Organizer
  第35回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-15K10799
[Presentation] The functional subsets of regulatory T cells correlate with clinical outcome .2016
- Author(s)
  Ihara F, Sakurai D, Motohashi S, Kunii N, Okamoto Y.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] The functional subsets of regulatory T cells correlate with clinical outcome and invariant NKT cells suppression in head and neck cancer patients.2016
- Author(s)
  Ihara F, Sakurai D, Kunii N, Motohashi S, Okamoto Y.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] A Randomized Double-blind Phase II Trial Evaluating Adjuvant Therapy for Advanced Oro- and Hypo-pharyngeal Cancer using the Injection of aGalCer-loaded DCs into the Nasal Submucosa.2016
- Author(s)
  Naoki Kunii, Yuji Makita, Fumie Ihara, Daiju Sakurai, Shinichiro Motohashi, Toshinori Nakayama, Yoshitaka Okamoto.
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] A randomized double-blind phase II trial evaluating adjuvant therapy for advanced oro- and hypo-pharyngeal cancer using the injection of alpha-GalCer-loaded DCs into the nasal submucosa.2016
- Author(s)
  Kunii N, Makita Y, Ihara F, Sakurai D, Motohashi S, Nakayama T, Okamoto Y.
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Analysis of regulatory T cells in peripheral blood of the patients with Head and Neck cancer and their inhibitory role on NKT cells2015
- Author(s)
  Ihara, F., Sakurai, D., Motohashi, S., and Okamoto, Y.
- Organizer
  International Conference of Cancer Immunotherapy and Macrophages 2015
- Place of Presentation
  Ito Hall, Ito International Research Center, The University of Tokyo
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 標準治療後の進行期中・下咽頭癌症例に対するαGalCerパルス樹状細胞療法の有効性に関するランダム二重盲検試験2015
- Author(s)
  國井直樹、蒔田勇治、伊原史英、内田亮介、佐々原剛、藤川陽、櫻井大樹、岡本美孝
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東武レバントホテル（東京都墨田区）
- Year and Date
  2015-02-27
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T Cells Targeted to Salivary Gland Tumor2014
- Author(s)
  Kunii, N., Makita, Y., Ihara, F., Uchida, R., Fujikawa, A., Sakurai, D., Motohashi, S., Nakayama, T. and Okamoto, Y.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] MYELOID-DERIVED SUPPRESSOR CELLS ATTENUATE ANTI-TUMOR IMMUNITY IN PATIENTS WITH HEAD AND NECK CANCER2013
- Author(s)
  櫻井大樹
- Organizer
  20ｔｈ international Federation of Oto-Rhino-Laryngological Societies (IFOS 2013)
- Place of Presentation
  COEX　Convention and Exhibition Center (ソウル・韓国)
- Data Source
  KAKENHI-PROJECT-24592589
[Presentation] 頭頸部癌における骨髄系免疫抑制細胞MDSCの検討2013
- Author(s)
  櫻井大樹
- Organizer
  第114回　日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  ロイトン札幌（札幌）
- Data Source
  KAKENHI-PROJECT-24592589
[Presentation] Myeloid-derived suppressor cells attenuate anti-tumor immunity in patients with head and neck cancer2013
- Author(s)
  櫻井大樹
- Organizer
  第20回国際耳鼻咽喉科学会議
- Place of Presentation
  韓国ソウル
- Data Source
  KAKENHI-PROJECT-24592589
[Presentation] 炭素イオン線治療後の頭頸部粘膜悪性黒色腫患者に対するaガラクトシルセラミドパルス抗原提示細胞を用いたアジュバント免疫治療に関する第I/II相臨床研究2013
- Author(s)
  藤川陽,國井直樹,櫻井大樹,長谷川安都佐,鎌田正,溝江純悦,岡本美孝,本橋新一郎,中山俊憲
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  ANAクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-24249081
[Presentation] 頭頸部癌における腫瘍免疫抑制機構の検討2012
- Author(s)
  櫻井大樹
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  滋賀県
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22791569
[Presentation] 頭頸部癌における腫瘍免疫抑制機構の検討2012
- Author(s)
  櫻井大樹
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  琵琶湖ホテル(滋賀県)
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22791569
[Presentation] 頭頸部癌に対するNKT細胞免疫系を標的とした免疫療法の開発2012
- Author(s)
  櫻井大樹
- Organizer
  第74回　耳鼻咽喉科臨床学会
- Place of Presentation
  東京ドームホテル（東京）
- Data Source
  KAKENHI-PROJECT-24592589
[Presentation] 頭頸部癌患者における骨髄由来抑制細胞の検討2011
- Author(s)
  櫻井大樹
- Organizer
  第29回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大分県
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-22791569
[Presentation] 頭頸部扁平上皮癌で増加する骨髄由来抑制細胞による腫瘍免疫抑制機構の解析2011
- Author(s)
  櫻井大樹
- Organizer
  第112回日本耳鼻咽喉科学会総会学術講演会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22791569
[Presentation] 頭頸部扁平上皮癌で増加する骨髄由来抑制細胞による腫瘍免疫抑制機構の解析2011
- Author(s)
  櫻井大樹
- Organizer
  第112回日本耳鼻咽喉科学会総会学術講演会
- Place of Presentation
  京都府
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22791569
[Presentation] 頭頸部癌患者における骨髄由来抑制細胞の検討2011
- Author(s)
  櫻井大樹
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  全日空ホテル(大分県)
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-22791569
[Presentation] 頭頸部癌患者で誘導されるMDSCによる免疫系への影響
- Author(s)
  櫻井大樹
- Organizer
  第38回日本頭頸部癌学会
- Place of Presentation
  東京ファッションタウンビル　東京都江東区
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24592589
[Presentation] ユビキチン化抵抗性LATによるT細胞のエフェクター機能の強化
- Author(s)
  國井直樹、櫻井大樹、岡本美孝
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷市芸文館（岡山県）
- Data Source
  KAKENHI-PROJECT-24249081

1. Ishii Hiroki (40568250)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. Okamoto Yoshitaka (40169157)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. SUZUKI TAKESHI (20422230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YONEKURA Syuji (20400939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKUMA Yusuke (50745825)

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6. KUNII Naoki (00456047)

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7. MORIMOTO Yuki (40802575)

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8. 蒔田勇治 (90706722)

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9. 関直彦 (50345013)

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10. 本橋新一郎 (60345022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. 福本一郎 (70748764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 金田篤志 (10313024)

# of Collaborated Projects: 1 results

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13. 吉村健太郎 (70516921)

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14. 鈴木裕 (40516928)

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15. 駒形純也 (20712798)

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# of Collaborated Products: 0 results
16. 阪田治 (30391197)

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17. 笹沼里圭子 (30982582)

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18. 谷本守正 (60621323)

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19. 小谷信司 (80242618)

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20. 小佐野雅識 (20622426)

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21. 高橋真理 (30622427)

# of Collaborated Projects: 1 results

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22. 大石直輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKURAI Daiju 櫻井 大樹

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小児スギ花粉症の発症リスク因子の解明と予防治療の確立に向けた多角的縦断的研究Principal Investigator

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急増する小児アレルギー性鼻炎の発症リスク因子と発症機序の解明に向けた研究Principal Investigator

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超音波動画像と筋電図と嚥下音を用いた非侵襲計測による嚥下評価のための装置開発研究

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Immunometabolism-targeted cancer therapy in HNSCC

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The study of epigenetic regulation in peripheral immune cells associated with onset and remission of allergic rhinitis.Principal Investigator

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唾液腺癌に対する抗LAG-3/PD-1抗体併用によるNKT細胞療法の開発

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Development of novel immunotherapy for head and neck cancer patients; combination of reversal of immune suppression and activation of NKT cellsPrincipal Investigator

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Development of photodynamic therapy for the allergic rhinitis

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Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosa

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Study of immunosuppressive mechanism in head and neck cancer and development of novel treatmentPrincipal Investigator

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Development of new therapy to activate anti-tumor immunity against head and neck squamous cell carcinomaPrincipal Investigator

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[Journal Article] スギ・ヒノキ花粉観測25年間の報告 山梨県における地域差と年次推移の検討2023

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[Journal Article] Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma2022

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[Journal Article] Sublingual Immunotherapy for Japanese Cedar Pollinosis: Current Clinical and Research Status2022

SAKURAI Daiju 櫻井大樹

[Journal Article] スギ・ヒノキ花粉観測25年間の報告　山梨県における地域差と年次推移の検討2023

[Presentation] アレルギー性鼻炎に対する免疫療法と感作の関係　作用機序とマーカー2019