sugihara kazushi 杉原一司

… Alternative Names

杉原一司スギハラカズシ

SUGIHARA Kazushi 杉原一司

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Researcher Number	10377418
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 技術職員
Affiliation (based on the past Project Information) *help	2020 – 2023: 京都大学, 医学研究科, 技術職員 2018: 京都大学, 医学研究科, 技術専門職員 2017: 京都大学, 大学院医学研究科, 技術職員 2016 – 2017: 京都大学, 医学研究科, 技術職員 2015: 京都大学, 大学院医学研究科, 技術職員 … More 2011 – 2013: 金沢大学, 医学系, 技術専門職員 2009: 金沢大学, 医学系, 技術専門職員 2005 – 2007: 金沢大学, 医学系研究科, 技術職員 Less
Review Section/Research Field	Principal Investigator Laboratory animal science / Laboratory animal science Except Principal Investigator Laboratory animal science / Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Biological Sciences
Keywords	Principal Investigator 動物 / 発生・分化 / 初期胚 / 発生 / デグロンシステム / マウス初期胚発生 / ゲノム編集 / マウス / デグロン / 糖鎖生物学 / 遺伝子改変動物 / 発生工学 … More Except Principal Investigator … More マウス / 糖鎖 / IgA腎症 / エピジェネティクス / 行動解析 / ガラクトース転移酵素 / 脳機能 / 精神疾患モデル / ガングリオシド / PD-1 / プロテインノックダウン / デグロン / 腸内細菌 / 腸内細菌叢 / 遺伝子組換えマウス / 脳・神経 / 遺伝子改変マウス / 行動学 / 脳神経疾患 / Hox遺伝子 / 神経 / 発生 / 神経幹細胞 / HP1 / ヒストン脱メチル化 / ホメオティック変異 / 脱メチル化酵素 / 記憶・学習 / ミオパチー / 骨随移植 / シアル酸生合成 / ネフローゼ / 遺伝子ノックアウトマウス / 高IgA血症 Less

脆弱な大脳皮質ニューロンによる生命維持機構の障害
- Principal Investigator
  
  吉原亨
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kyoto University
Development of degron system for cancer therapy
- Principal Investigator
  
  Naruse Chie
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kyoto University
Attempt to establish totipotent stem cells using degron systemPrincipal Investigator
- Principal Investigator
  
  Sugihara Kazushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
Analysis of gut microbiota and gut immunity in the development of IgA nephropathy using its mouse model
- Principal Investigator
  
  ASANO MASAHIDE
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
The roles of histone modifications in the perinatal period.
- Principal Investigator
  
  Naruse Chie
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
  Kanazawa University
Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal models
- Principal Investigator
  
  Asano Masahide
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
  Kanazawa University
The development and demonstration of methodology to elucidate the sugar chain function and glycosyltransferase knockout mouse phenotype.Principal Investigator
- Principal Investigator
  
  SUGIHARA Kazushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kanazawa University
Development of mouse models for human diseases caused by impaired glycosylation and analysis of their mechanisms
- Principal Investigator
  
  ASANO Masahide
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kanazawa University
β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析
- Principal Investigator
  
  ASANO Masahide
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2017 2015 2013 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.2022
- Author(s)
  Naruse C, Sugihara K, Miyazaki T, Pan X, Sugiyama F, Asano M.
- Journal Title
  
  NAR Cancer
  
  Volume: 4 Issue: 2 Pages: 019-019
- DOI
  10.1093/narcan/zcac019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19188, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H03171
[Journal Article] New insights on the role of Jmjd3 and Utx in axial skeletal formation in mice.2017
- Author(s)
  Naruse C., Shibata S., Tamura M., Kawaguchi T., Abe K., Sugihara K., Kato T., Nishiuchi T., Wakana S., Ikawa M. and Asano M.
- Journal Title
  
  FASEB Journal
  
  Volume: in press Issue: 6 Pages: 2252-2266
- DOI
  10.1096/fj.201600642r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06815, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-15K14360
[Journal Article] EXTL2, a member of EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner2013
- Author(s)
  Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M.and Kitagawa, H.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Issue: 13 Pages: 9321-9333
- DOI
  10.1074/jbc.m112.416909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300142, KAKENHI-PROJECT-23500493, KAKENHI-PROJECT-24659039, KAKENHI-PLANNED-23110003
[Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I deficient mice.2010
- Author(s)
  Izumikawa, T., Kanagawa, N., Watamoto, Y., Okada, M., Saeki, M., Sakano, M., Sugahara, K., Sugihara, K., Asano, M., Kitagawa, H.
- Journal Title
  
  J. Biol. Chem. 285
  
  Pages: 12190-12196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300144
[Journal Article] Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in β4-galactosyltransferase-II-deficient mice.2009
- Author(s)
  Yoshihara, T., Sugihara, K., et al
- Journal Title
  
  J. Biol. Chem. (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300144
[Journal Article] Important role of heparan sulfate in postnatal islet growth and insulin secretion.2009
- Author(s)
  Takahashi, I., Noguchi, N., Nata, K., Yamada, S., Kaneiwa, T., Mizumoto, S., Ikeda, T., Sugihara, K., Asano, M., Yoshikawa, T., Yamauchi, A., Shervani, N.J., Uruno, A., Kato, I., Unno, M., Sugahara, K., Takasawa, S., Okamoto, H., Sugawara, A.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 383
  
  Pages: 113-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300144
[Journal Article] Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in β4-galactosyltransferase-II-deficient mice.2009
- Author(s)
  Yoshihara, T., Sugihara, K., Kizuka, Y., Oka, S., Asano, M.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 12550-12561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300144
[Patent] GNE遺伝子に変異を有するトランスジェニック非ヒト哺乳動物2007
- Inventor(s)
  浅野雅秀, 浅賀知也, 杉原一司, 吉原亨
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2007-280909
- Filing Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] The SMASh degron system targeting endogenous PD-1 inhibits the growth of MC-38 tumor cells in mice.2023
- Author(s)
  Chie Naruse, Kazushi Sugihara, Xuchi Pan, Tatsuhiko Miyazaki, Fumihiro Sugiyama, Masahide Asano
- Organizer
  IMGC2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03171
[Presentation] The SMASh degron system targeting endogenous PD-1 inhibits the growth of MC-38 tumor cells in mice.2022
- Author(s)
  成瀬智恵，杉原一司，パンシュチ，宮崎龍彦，杉山文博，浅野雅秀
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03171
[Presentation] 内在性PD-1へのデグロンタグ組込みによるマウス生体におけるがん細胞増殖の抑制2022
- Author(s)
  成瀬智恵，杉原一司，パンシュチ，宮崎龍彦，杉山文博，浅野雅秀
- Organizer
  第69回実験動物学会総会
- Data Source
  KAKENHI-PROJECT-20H03171
[Presentation] プロテインデグロンシステムによるがん免疫療法を用いたがん細胞増殖の抑制2021
- Author(s)
  成瀬智恵、杉原一司、杉山文博、浅野雅秀
- Organizer
  第68回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-20H03171
[Presentation] プロテインデグロンシステムによるがん免疫療法を用いたがん細胞増殖の抑制2021
- Author(s)
  成瀬智恵，杉原一司，杉山文博，浅野雅秀
- Organizer
  第68回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-20H03171
[Presentation] Suppression of cancer cell growth in mice with a degron system.2020
- Author(s)
  Chie Naruse, Kazushi Sugihara, Fumihiro Sugiyama, Masahide Asano
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03171
[Presentation] マウス体軸形成に対するKdm6ファミリーの関与2015
- Author(s)
  成瀬智恵，柴田進和，阿部可奈恵，川口隆之，杉原一司，伊川正人，浅野雅秀
- Organizer
  第62回日本実験動物学会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25290031
[Presentation] マウス体軸形成に対するKdm6ファミリーの関与2015
- Author(s)
  成瀬智恵，柴田進和，阿部可奈恵，川口隆之，杉原一司，伊川正人，浅野雅秀
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ，京都市
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-25430085
[Presentation] マウス体軸形成に対するKdm6ファミリーの機能2015
- Author(s)
  成瀬智恵，柴田進和，阿部可奈恵，川口隆之，杉原一司，伊川正人，浅野雅秀
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25290031
[Presentation] マウス体軸形成に対するKdm6ファミリーの関与2015
- Author(s)
  成瀬智恵，柴田進和，阿部可奈恵，川口隆之，杉原一司，伊川正人，浅野雅秀
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都府京都市京都テルサ
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-25430085
[Presentation] マウス体軸形成におけるKdm6ファミリーの機能2015
- Author(s)
  成瀬智恵，柴田進和，阿部可奈恵，川口隆之，杉原一司，伊川正人，浅野雅秀
- Organizer
  BMB2015第38回日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市神戸国際展示場，神戸ポートピアホテル
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25430085
[Presentation] GNE V572L点変異マウスにおける腎病変の発症機序とシアル酸糖鎖の関係2009
- Author(s)
  伊藤光俊, 浅賀知也, 杉原一司, 吉原亨, 和田隆志, 浅野雅秀
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] Learning/memory impairment and reduced expression of the HNK-1 carbohydrate inβ-1, 4-Galactosyltransferase-II-deficient mice2009
- Author(s)
  Toru Yoshihara, Kazushi Sugihara, Yasuhiko Kizuka, Shogo Oka Masahide Asano
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] テストバッテリー方式によるGNE点変異マウスの行動解析2009
- Author(s)
  吉原亨, 杉原一司, 浅賀知也, 浅野雅秀
- Organizer
  第56回日本実験動物学会
- Place of Presentation
  大宮ソニックホール(埼玉県)
- Year and Date
  2009-05-14
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] GNE点変異マウスにおける不安行動の亢進-GNE V572Lマウスの行動特性および組織学的解析-2008
- Author(s)
  吉原亨, 杉原一司, 伊藤光俊, 浅賀智也, 浅野雅秀
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  戸国際会議場(兵庫県)
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] 縁取り空胞型遠位型ミオパチーモデルマウスの開発と発症機序の解析2008
- Author(s)
  杉原一司, 浅賀知也, 伊藤光俊, 吉原亨, 山本章嗣, 浅野雅秀
- Organizer
  第55回日本実験動物学会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] GNE V572L点変異マウスにおけるDMRV様病態発症機序と糖鎖の関係2008
- Author(s)
  伊藤光俊, 浅賀知也, 杉原一司, 吉原亨, 山本章嗣, 浅野雅秀
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] 縁取り空胞型遠位型ミオパチーモデルマウスの開発と発症機序の解析2008
- Author(s)
  杉原一司ら
- Organizer
  第55回日本実験動物学会
- Place of Presentation
  仙台
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] テストバッテリー方式によるβ4-GalT-II欠損マウスの行動解析2007
- Author(s)
  吉原亨, 杉原一司, 浅野雅秀
- Organizer
  第54回日本実験動物学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] 縁取り空胞型遠位型ミオパチーモデルマウスの開発と発症機序の解析2007
- Author(s)
  浅賀知也, 杉原一司, 伊藤光俊, 吉原亨, 西江敏和, 和田隆志, 山本章嗣, 浅野雅秀
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19300144
[Presentation] β4GalT-2ノックアウトマウスの学習・記憶障害と脳におけるHNK-1糖鎖の発現低下2007
- Author(s)
  吉原亨, 杉原一司, 木塚康彦, 岡昌吾, 浅野雅秀
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19300144

1. ASANO Masahide (50251450)

# of Collaborated Projects: 9 results

# of Collaborated Products: 25 results
2. Naruse Chie (30372486)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
3. YOSHIHARA Toru (00401935)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. HASHIMOTO Noriyoshi (50242524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 田村勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sugihara kazushi 杉原 一司

杉原 一司 スギハラ カズシ

SUGIHARA Kazushi 杉原 一司

Research Projects

Research Products

Co-Researchers

脆弱な大脳皮質ニューロンによる生命維持機構の障害

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of degron system for cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Attempt to establish totipotent stem cells using degron systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of gut microbiota and gut immunity in the development of IgA nephropathy using its mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of histone modifications in the perinatal period.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development and demonstration of methodology to elucidate the sugar chain function and glycosyltransferase knockout mouse phenotype.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of mouse models for human diseases caused by impaired glycosylation and analysis of their mechanisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New insights on the role of Jmjd3 and Utx in axial skeletal formation in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EXTL2, a member of EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I deficient mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in β4-galactosyltransferase-II-deficient mice.2009

sugihara kazushi 杉原一司

杉原一司スギハラカズシ

SUGIHARA Kazushi 杉原一司