UWAI Yuichi 上井優一

… Alternative Names

上井優一ウワイユウイチ

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Researcher Number	10378664
Other IDs
Affiliation (Current)	2026: 愛知学院大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 愛知学院大学, 薬学部, 准教授 2012 – 2018: 愛知学院大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator GSK3β / 薬物相互作用 / 腎皮質 / 尿細管再吸収 / ホスカルネット / リチウム / 有機アニオントランスポータ / データベース / 心膜炎 / 心筋炎 … More / 非定型抗精神病薬 / 非血液学的悪性腫瘍 / クロザピン / FAERS / 先天性斜視 / バルプロ酸 / FAERSデータベース / 糖尿病 / 炭酸リチウム / クエチアピン / オランザピン / 調剤レセプトデータ / アポトーシス / 腎挙動 / 立体選択性 / フルルビプロフェン / 非線形 / ラット / ナトリウム-リン酸共輸送体 / インスリン / Akt / リン酸化 / シスプラチン / 急性腎障害 / 腎虚血再灌流 / アセタゾラミド / 非線形体内動態 / リン酸トランスポータ / α-ケトグルタル酸 / OAT3 / OAT1 / 駆動力 / α－ケトグルタル酸 / 副甲状腺ホルモン / SLC34A1 / 尿毒症物質 / xanthurenic acid / kynurenic acid / プロベネシド / Xanthurenic acid / Kynurenic acid / ナトリウム利尿 / 輸送 / キサンツレン酸 / キヌレン酸 Less

Research Projects
(4 results)
Research Products
(23 results)

データベース解析とGSK3β阻害に基づく抗精神病薬治療における炭酸リチウム利活用Principal Investigator
- Principal Investigator
  
  上井優一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Aichi Gakuin University
Protection for acute kidney injury by lithium using GSK3beta inhibition and membrane transportPrincipal Investigator
- Principal Investigator
  
  Uwai Yuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Aichi Gakuin University
Drug interaction via expression change of renal drug transportersPrincipal Investigator
- Principal Investigator
  
  Uwai Yuichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Aichi Gakuin University
Regulation of tryptophan metabolism by organic anion transportersPrincipal Investigator
- Principal Investigator
  
  UWAI Yuichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Aichi Gakuin University

All 2024 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] A safety signal for congenital strabismus associated with valproic acid: A pharmacovigilance analysis utilizing the FDA Adverse Event Reporting System database2024
- Author(s)
  Yuichi Uwai, Tomohiro Nabekura
- Journal Title
  
  Congenital Anomalies
  
  Volume: 64 Issue: 5 Pages: 207-214
- DOI
  10.1111/cga.12579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06266
[Journal Article] Relationship between clozapine and non-hematological malignant tumors: A pharmacovigilance analysis using the FDA Adverse Event Reporting System database2024
- Author(s)
  Yuichi Uwai, Tomohiro Nabekura
- Journal Title
  
  Drugs-Real World Outcomes
  
  Volume: 11 Issue: 2 Pages: 185-193
- DOI
  10.1007/s40801-024-00417-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06266
[Journal Article] Effect of renal ischemia on urinary excretion of lithium in rats2018
- Author(s)
  Uwai Y, Suzuki T, Kondo R, Kawasaki T, Nabekura T
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 39 Issue: 9 Pages: 448-451
- DOI
  10.1002/bdd.2163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08419
[Journal Article] Enantioselective drug recognition by drug transporters2018
- Author(s)
  Uwai Y
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 12 Pages: 3062-3062
- DOI
  10.3390/molecules23123062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08419
[Journal Article] Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium-phosphate cotransporter as a cause2018
- Author(s)
  Uwai Y, Kawasaki T, Nabekura T
- Journal Title
  
  Biopharmaceutics and drug disposition
  
  Volume: 39 Issue: 2 Pages: 83-87
- DOI
  10.1002/bdd.2116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08419
[Journal Article] Enantioselective effect of flurbiprofen on lithium disposition in rats2017
- Author(s)
  Uwai, Y., Matsumoto, M., Kawasaki, T., Nabekura, T.
- Journal Title
  
  Pharmacology
  
  Volume: 99 Issue: 5-6 Pages: 236-239
- DOI
  10.1159/000455917
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08419
[Journal Article] Foscarnet, inhibitor of sodium-phosphate cotransporter NaPi-IIa, inhibits phosphorylation of glycogen synthase kinase-3β by lithium in rat kidney cortex2016
- Author(s)
  Uwai, Y., Kawasaki, T., Nabekura, T.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 31 Issue: 3 Pages: 256-259
- DOI
  10.1016/j.dmpk.2016.02.003
- NAID
  50014431270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08419
[Journal Article] Lithium interferes with the urinary excretion of phenolsulfonphthalein in rats: involvement of a reduced content of α-ketoglutarate, the driving force for organic anion transporters OAT1 and OAT3, in the kidney cortex2015
- Author(s)
  Uwai, Y., Tsuge, M., Tokai, Y., Kawasaki, T., Nabekura, T.
- Journal Title
  
  Pharmacology
  
  Volume: 96 Issue: 5-6 Pages: 278-283
- DOI
  10.1159/000441253
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860117
[Journal Article] Minor contribution of biliary excretion in lithium elimination in rats2015
- Author(s)
  Uwai, Y., Kawasaki, T, Nabekura, T.
- Journal Title
  
  Drug Metabolism and Personalized Therapy
  
  Volume: 30 Issue: 1 Pages: 65-67
- DOI
  10.1515/dmdi-2014-0033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860117
[Journal Article] Diuresis by intravenous administration of xanthurenic acid in rats, and inhibition by probenecid2014
- Author(s)
  Uwai, Y., Nakashima, Y., Honjo, E., Kawasaki, T., Nabekura, T
- Journal Title
  
  Biomed. Res.
  
  Volume: 35 Pages: 223-226
- NAID
  130004470871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790176
[Journal Article] Sodium-phosphate cotransporter mediates reabsorption of lithium in rat kidney2014
- Author(s)
  Uwai, Y., Arima, R., Takatsu, C., Furuta, R., Kawasaki, T., Nabekura, T.
- Journal Title
  
  Pharmacological Research
  
  Volume: 87 Pages: 94-98
- DOI
  10.1016/j.phrs.2014.06.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860117
[Journal Article] Transport of kynurenic acid by rat organic anion transporters rOAT1 and rOAT3: species difference between human and rat in OAT1.2013
- Author(s)
  Uwai Y, Hara H, Iwamoto K.
- Journal Title
  
  International Journal of Tryptophan Research
  
  Volume: 6 Pages: 1-6
- DOI
  10.4137/ijtr.s11206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790176
[Journal Article] Transport of Xanthurenic Acid by Rat/Human Organic Anion Transporters OAT1 and OAT32013
- Author(s)
  Uwai Y., Honjo E.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 7 Pages: 1517-1521
- DOI
  10.1271/bbb.130178
- NAID
  10031190462
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790176
[Journal Article] Transport of kynurenic acid by rat organic anion transporters rOAT1 and rOAT3 : species difference between human and rat in OAT12013
- Author(s)
  Uwai, Y., Hara, H., Iwamoto, K
- Journal Title
  
  Int. J. Tryptophan Res.
  
  Volume: 6 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790176
[Journal Article] Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT32013
- Author(s)
  Uwai, Y., Honjo, E
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 77 Pages: 1517-1521
- NAID
  10031190462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790176
[Presentation] 医薬品有害事象データベースFAERSを用いたクロザピンと非血液学的悪性腫瘍の関連についてのシグナル検出2024
- Author(s)
  上井優一、鍋倉智裕
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06266
[Presentation] ラットにおけるリチウムの非線形体内動態：リン酸トランスポータによる尿細管再吸収の飽和が原因か？2018
- Author(s)
  上井優一、川嵜達也、鍋倉智裕
- Organizer
  第28回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-16K08419
[Presentation] ラットを用いたリチウムの尿細管再吸収機構に関する研究2016
- Author(s)
  上井優一、川嵜達也、鍋倉智裕
- Organizer
  医療薬学フォーラム2016
- Place of Presentation
  滋賀県立芸術劇場びわ湖ホール（滋賀県・大津市）
- Year and Date
  2016-06-25
- Data Source
  KAKENHI-PROJECT-16K08419
[Presentation] 腎有機アニオン輸送系に及ぼすリチウムの影響2015
- Author(s)
  上井優一、柘植みさと、東海雄太、川嵜達也、鍋倉智裕
- Organizer
  第25回日本医療薬学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26860117
[Presentation] ラット有機アニオントランスポータrOAT1とrOAT3によるkynurenic acidの輸送特性 : ヒト型ホモログとの比較2013
- Author(s)
  上井優一、原浩晃、岩本喜久生
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24790176
[Presentation] Xanthurenic acidの有機アニオントランスポータによる輸送特性と利尿作用2013
- Author(s)
  本庄絵美、中島悠太、上井優一、鍋倉智裕
- Organizer
  第59回日本薬学会東海支部大会
- Place of Presentation
  名古屋市
- Year and Date
  2013-07-06
- Data Source
  KAKENHI-PROJECT-24790176
[Presentation] ラット有機アニオントランスポータrOAT1とrOAT3によるkynurenic acidの輸送特性：ヒト型ホモログとの比較2013
- Author(s)
  上井優一、原　浩晃、岩本喜久生
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790176
[Presentation] ラットにおけるリチウムの体内動態に及ぼすホスカルネットの影響
- Author(s)
  上井優一、有馬亮輔、高津千裕、古田　涼、川嵜達也、鍋倉智裕
- Organizer
  第24回日本医療薬学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-26860117

UWAI Yuichi 上井 優一

上井 優一 ウワイ ユウイチ

Research Projects

Research Products

データベース解析とGSK3β阻害に基づく抗精神病薬治療における炭酸リチウム利活用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Protection for acute kidney injury by lithium using GSK3beta inhibition and membrane transportPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug interaction via expression change of renal drug transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of tryptophan metabolism by organic anion transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A safety signal for congenital strabismus associated with valproic acid: A pharmacovigilance analysis utilizing the FDA Adverse Event Reporting System database2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between clozapine and non-hematological malignant tumors: A pharmacovigilance analysis using the FDA Adverse Event Reporting System database2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of renal ischemia on urinary excretion of lithium in rats2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enantioselective drug recognition by drug transporters2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium-phosphate cotransporter as a cause2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enantioselective effect of flurbiprofen on lithium disposition in rats2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foscarnet, inhibitor of sodium-phosphate cotransporter NaPi-IIa, inhibits phosphorylation of glycogen synthase kinase-3β by lithium in rat kidney cortex2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Lithium interferes with the urinary excretion of phenolsulfonphthalein in rats: involvement of a reduced content of α-ketoglutarate, the driving force for organic anion transporters OAT1 and OAT3, in the kidney cortex2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Minor contribution of biliary excretion in lithium elimination in rats2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diuresis by intravenous administration of xanthurenic acid in rats, and inhibition by probenecid2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Sodium-phosphate cotransporter mediates reabsorption of lithium in rat kidney2014

UWAI Yuichi 上井優一

上井優一ウワイユウイチ