Fujiwara Hironori 藤原博典

… Alternative Names

藤原博典フジワラヒロノリ

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Researcher Number	10396442
Affiliation (Current)	2025: 医療創生大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2017: 富山大学, 和漢医薬学総合研究所, 助教 2007: Tohoku University, 大学院・医学系研究科, 助教 2006: 東北大学, 大学院医学系研究科, 助手 2005 – 2006: 東北大学, 大学院・医学系研究科, 助手
Review Section/Research Field	Principal Investigator Natural medicines / Experimental pathology Except Principal Investigator General internal medicine(including psychosomatic medicine) / Biological Sciences
Keywords	Principal Investigator アルツハイマー病 / 漢方 / 老化促進マウス / 嗅球摘出（OBX）マウス / GSK-3β阻害作用 / タウ蛋白リン酸化抑制作用 / 黄ごん / タウ蛋白リン酸化 / タウタンパクリン酸化 / 三黄瀉心湯 … More / 黄連解毒湯 / CRMP2 / タウ蛋白 / GSK-3β / 認知症 / ペンタガロイルグルコース / トランスジェニックマウス / 桂皮 / 牡丹皮 / 釣藤鈎 / β-アミロイド蛋白 … More Except Principal Investigator 漢方薬 / 社会性行動 / 行動異常 / ADHD / 発達障害モデル / エピジェネティックス / 社会的隔離ストレス / attention-like behavior / Social isolation / repeated behavior / sociability / Kampo medicine / epigenetics / developmental disorders / ADHD model / social isolation / 神経ステロイド / 発達障害 / 自閉症スペクトラム障害 / 注意欠陥多動性障害 / エピジェネティックモデル / 隔離飼育 / アミロイド(Aβ)蛋白 / 発症予防 / 生薬 / 牡丹皮 / 予防 / 漢方生薬 / アミロイドβ蛋白 / アルツハイマー病 Less

Investigation of pathogenic mechanisms and Kampo medicine-based preventive and therapeutic strategy for ADHD using an epigenetic animal model.
- Principal Investigator
  
  MATSUMOTO KINZO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  University of Toyama
Exploration and identification of kampo medicines as therapeutic agent for Alzheimer's disease targeting tau proteinPrincipal Investigator
- Principal Investigator
  
  Fujiwara Hironori
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Natural medicines
- Research Institution
  University of Toyama
アミロイドβ蛋白凝集抑制作用を有するアルツハイマー病予防薬の開発
- Principal Investigator
  
  荒井啓行
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
アミロイド蛋白を標的としたアルツハイマー病治療に有効な漢方の探索及び作用機序解明Principal Investigator
- Principal Investigator
  
  藤原博典
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University

All 2018 2017 2016 2015 2008 2007 2006

All Journal Article Presentation Patent

[Journal Article] Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice2017
- Author(s)
  Fujiwara H., Yaoyu, H., Ebihara K., Awale S., Araki R., Yabe T., Matsumoto K.
- Journal Title
  
  BMC Complement Altern Med
  
  Volume: 17 Issue: 1 Pages: 195-195
- DOI
  10.1186/s12906-017-1710-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15269
[Journal Article] Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: A novel animal model of ASD2017
- Author(s)
  Ken Ebihara, Hironori Fujiwara, Suresh Awale, Dya Fita Dibwe, Ryota Arakai, Takeshi Yabe, Kinzo Matsumoto
- Journal Title
  
  Behav. Brain Res.
  
  Volume: 334 Pages: 6-15
- DOI
  10.1016/j.bbr.2017.07.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15269
[Journal Article] Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress2017
- Author(s)
  Fujiwara H., Tsushima R., Okada R., Awale S., Araki R., Yabe T., Matsumoto K.
- Journal Title
  
  J Traditional and Complementary Medicine
  
  Volume: 印刷中 Issue: 1 Pages: 81-88
- DOI
  10.1016/j.jtcme.2017.03.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15269
[Journal Article] 漢方薬2008
- Author(s)
  藤原博典, 他
- Journal Title
  
  日本臨床 66
  
  Pages: 533-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790253
[Journal Article] 【認知症ケアと医療の地域連携】認知症でも穏やかに暮す漢方治療の新展開2007
- Author(s)
  藤原博典, 他
- Journal Title
  
  Geriatric Medicine 45
  
  Pages: 1135-1138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790253
[Journal Article] アルツハイマー病の薬物治療2007
- Author(s)
  藤原博典、古川勝敏、荒井啓行
- Journal Title
  
  Clinical Neuroscience 25
  
  Pages: 181-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023006
[Journal Article] アルツハイマー病の薬物治療2007
- Author(s)
  藤原博典他
- Journal Title
  
  Clinical Neuroscience 25 (2)
  
  Pages: 181-184
- Data Source
  KAKENHI-PROJECT-17790253
[Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid β proteins.2006
- Author(s)
  Fujiwara H et al.
- Journal Title
  
  Journal of Neuroscience Research 84 (2)
  
  Pages: 427-433
- Data Source
  KAKENHI-PROJECT-17790253
[Patent] アミロイドβ蛋白の凝集抑制剤、凝集アミロイドβ蛋白の分解剤、抗痴呆薬および抗痴呆性食品2006
- Inventor(s)
  藤原博典, 荒井啓行, 岩崎鋼, 工藤幸司
- Industrial Property Rights Holder
  藤原博典, 荒井啓行, 岩崎鋼, 工藤幸司
- Industrial Property Number
  2006-193331
- Filing Date
  2006-07-13
- Data Source
  KAKENHI-PROJECT-18023006
[Patent] アミロイドβ蛋白の凝集抑制剤、凝集アミロイドβ蛋白の分解剤、抗痴呆薬および抗痴呆性食品2006
- Inventor(s)
  藤原博典他
- Industrial Property Rights Holder
  東北大学
- Industrial Property Number
  2006-193331
- Filing Date
  2006-07-13
- Data Source
  KAKENHI-PROJECT-17790253
[Presentation] 発達障害の予防治療を志向した漢方薬のリポジショニング2018
- Author(s)
  藤原博典，荒木良太，矢部武士，松本欣三
- Organizer
  日本薬学会第138年会シンポジウム
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] Repositioning of natural medicine for the preventive therapy of mild developmental disorders2017
- Author(s)
  Fujiwara H. and Matsumoto K.
- Organizer
  第90回日本薬理学会年会（シンポジウム）
- Place of Presentation
  長崎ブッリクホール
- Year and Date
  2017-03-15
- Invited
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] SKF105111 induced autism spectrum disorder (ASD) -like behavior may offer anovel animal model to explore therapeutic drugs for ASD2017
- Author(s)
  1.Ken Ebihara, Hironori Fujiwara, Suresh Awale, Dya Fita Dibwe, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
- Organizer
  The 1st International Conference on Natural Medicines: ICNM2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 自閉症スペクトラム(ASD)様症状発現における脳内神経ステロイド・アロプレグナノロンの役割と加味逍遥散による発現抑制2017
- Author(s)
  3.松本欣三，郭青雲，海老原健，Awale Suresh，荒木良太，矢部武士，藤原博典
- Organizer
  第16回日本臨床中医薬学会大会
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 神経ステロイドallopregnanoloneの生合成阻害による社会性行動低下に対する加味逍遥散の改善効果2017
- Author(s)
  2.郭青雲，藤原博典，海老原健，Awale Suresh，荒木良太，矢部武士，松本欣三
- Organizer
  第34回和漢医薬学会大会
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] Sex difference in autism spectrum disorder (ASD)-like behaviors caused by allopregnanolone (ALLO) biosynthesis inhibition and distribution of ALLO in the brain2017
- Author(s)
  Ebihara K.，Fujiwara H.，dya Fita Dibwe, Awale S., Araki R.，Yabe T.，Matsumoto K.
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブッリクホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] Daily administration of keishito prevents social isolation-induced impairments of sociability and attention-related behaviors in mice2016
- Author(s)
  藤原博典，韓 垚羽，岡田亮，スレスアワレ，荒木良太，矢部武士，松本欣三
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜国際会議場，横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 老化促進マウスの認知機能低下に対する黄連解毒湯の改善効果2016
- Author(s)
  吉田淳、星野遥、藤原博典、荒井啓行、工藤幸司、松本欣三
- Organizer
  第33回和漢医薬学会学術大会
- Place of Presentation
  東京・星薬科大学
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-25860075
[Presentation] 隔離飼育マウスの発達障害様行動に及ぼす抑肝散及び桂枝湯の効果2016
- Author(s)
  松本欣三, 藤原博典，韓ヨウウ，Awale Suresh, 荒木良太，矢部武士
- Organizer
  第15回日本臨床中医薬学会学術大会
- Place of Presentation
  京都府立医科大学
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 神経ステロイドallopregnanoloneの生合成阻害による社会性行動の低下2016
- Author(s)
  海老原健，藤原博典，荒木良太，矢部武，Suresh Awale, 松本欣三
- Organizer
  第67回日本薬理学会北部会
- Place of Presentation
  北海道大学
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 嗅球摘出マウスの認知機能低下に対する黄連解毒湯および三黄瀉心湯の改善効果2015
- Author(s)
  吉田淳、星野遥、藤原博典、荒井啓行、工藤幸司、松本欣三
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山・富山国際会議場
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-25860075
[Presentation] AD/HD様動物モデルでの病態発症機構と漢方薬作用：隔離飼育マウスでの検討2015
- Author(s)
  松本欣三，藤原博典，韓 垚羽，Awale Suresh, 荒木良太，矢部武士
- Organizer
  第32回和漢医薬学会学術大会(シンポジウム「精神疾患の緩和・治療に向けた漢方医薬学的アプローチ」)
- Place of Presentation
  富山国際会議場，富山
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 隔離飼育マウスのAD/HD様行動障害に対する抑肝散および甘麦大棗湯の改善効果の検討2015
- Author(s)
  韓 垚羽，藤原博典，岡田亮，荒木良太，矢部武士，松本欣三
- Organizer
  第32回和漢医薬学会学術大会
- Place of Presentation
  富山国際会議場，富山
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 隔離飼育マウスにおけるADHD様行動の発現とそれに対する漢方薬・抑肝散の効果の検討2015
- Author(s)
  韓 垚羽，藤原博典，岡田亮，Awale Suresh, 荒木良太，矢部武士，松本欣三
- Organizer
  生体機能と創薬シンポジウム2015
- Place of Presentation
  日本大学薬学部, 千葉
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] Social isolation rearing of mice, a putative animal model of ADHD, and Kampo medicine2015
- Author(s)
  松本欣三, 韓 垚羽, 岡田亮, 津島遼平, 藤原博典, Awale Suresh, 荒木良太, 矢部武士
- Organizer
  第14回日本臨床中医薬学会学術大会
- Place of Presentation
  パレブラン高志会館、富山
- Year and Date
  2015-09-29
- Data Source
  KAKENHI-PROJECT-15K15269
[Presentation] 生薬および漢方を用いたアミロイドβ蛋白凝集抑制作用を有するアルツハイマー病予防薬の開発研究2007
- Author(s)
  藤原博典
- Organizer
  第24回和漢医薬学会
- Place of Presentation
  富山
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-17790253
[Presentation] Novel therapeutic strategies useful for Alzheimer's disease from medicinal herbs and traditional Chinese medical formula2007
- Author(s)
  藤原博典, 他
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-17790253

1. MATSUMOTO KINZO (10114654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
2. 荒井啓行 (30261613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 岩崎鋼 (90396432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Suresh Awale (00377243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. 堀悦郎 (90313600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YOSHIDA Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HOSHINO Haruka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Fujiwara Hironori 藤原 博典

藤原 博典 フジワラ ヒロノリ

Research Projects

Research Products

Co-Researchers

Investigation of pathogenic mechanisms and Kampo medicine-based preventive and therapeutic strategy for ADHD using an epigenetic animal model.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration and identification of kampo medicines as therapeutic agent for Alzheimer's disease targeting tau proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アミロイドβ蛋白凝集抑制作用を有するアルツハイマー病予防薬の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミロイド蛋白を標的としたアルツハイマー病治療に有効な漢方の探索及び作用機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: A novel animal model of ASD2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 漢方薬2008

Author(s)

Journal Title

Data Source

[Journal Article] 【認知症ケアと医療の地域連携】認知症でも穏やかに暮す 漢方治療の新展開2007

Author(s)

Journal Title

Data Source

[Journal Article] アルツハイマー病の薬物治療2007

Author(s)

Journal Title

Data Source

[Journal Article] アルツハイマー病の薬物治療2007

Author(s)

Journal Title

Data Source

[Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid β proteins.2006

Author(s)

Journal Title

Data Source

[Patent] アミロイドβ蛋白の凝集抑制剤、凝集アミロイドβ蛋白の分解剤、抗痴呆薬および抗痴呆性食品2006

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Patent] アミロイドβ蛋白の凝集抑制剤、凝集アミロイドβ蛋白の分解剤、抗痴呆薬および抗痴呆性食品2006

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Presentation] 発達障害の予防治療を志向した漢方薬のリポジショニング2018

Author(s)

Organizer

Data Source

Fujiwara Hironori 藤原博典

藤原博典フジワラヒロノリ

[Journal Article] 【認知症ケアと医療の地域連携】認知症でも穏やかに暮す漢方治療の新展開2007