Otsuka Mitsuo 大塚満雄

… Alternative Names

大塚満雄オオツカミツオ

OTSUKA Mitsuo 大塚満雄

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Researcher Number	10398323
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2019: 札幌医科大学, 医学部, 研究員 2017 – 2018: 札幌医科大学, 医学部, 准教授 2016: 札幌医科大学, 医学部, 講師 2009 – 2010: Sapporo Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator 内科 / サーファクタント蛋白質 / ピルフェニドン / ニンテダニブ / サーファクタント蛋白質A / 抗線維化薬 / SP-A / 特発性肺線維症 / siRNA / HSP47 / 肺線維症 … More Except Principal Investigator … More 肺傷害 / 肺サーファクタント / 免疫学 / 内科 / 間質性肺炎 / 抗線維化 / 抗炎症 / アレルギー性気道炎症 / トル様受容体 / 肺サーファクタントタンパク質A / 肺コレクチン / ブレオマイシン / 急性肺傷害 Less

the efficacy of nintedanib for expression of surfactant proteinPrincipal Investigator
- Principal Investigator
  
  Otsuka Mitsuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Pulmonary fibrosis treatment with pulmonary surfactant as a TLR regulatory molecule and HSP47 inhibition
- Principal Investigator
  
  Takahashi Hiroki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein
- Principal Investigator
  
  TAKAHASHI HIROKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Effect of HSP47siRNA targeting to the lung myofibroblast on bleomycin-induced pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  OTSUKA Mitsuo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University

All 2020 2019 2018 2017 2015 2014 2010 Other

All Journal Article Presentation Book

[Book] インフォームドコンセントのための図解シリーズ　びまん性肺疾患と特発性肺炎．2014
- Author(s)
  高橋弘毅、千葉弘文、大塚満雄
- Total Pages
  136
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis2020
- Author(s)
  Yoshikawa Takumi、Otsuka Mitsuo、Chiba Hirofumi、Ikeda Kimiyuki、Mori Yuki、Umeda Yasuaki、Nishikiori Hirotaka、Kuronuma Koji、Takahashi Hiroki
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 20 Issue: 1 Pages: 2727-2727
- DOI
  10.1186/s12890-020-1060-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K08150
[Journal Article] Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment2018
- Author(s)
  Kuronuma Koji、Honda Hiroyuki、Mikami Tessei、Saito Atsushi、Ikeda Kimiyuki、Otsuka Mitsuo、Chiba Hirofumi、Yamada Gen、Sato Toyotaka、Yokota Shin-ichi、Takahashi Hiroki
- Journal Title
  
  Vaccine
  
  Volume: 36 Issue: 33 Pages: 4968-4972
- DOI
  10.1016/j.vaccine.2018.06.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K15956
[Journal Article] Significance of molecular biomarkers in idiopathic pulmonary fibrosis: A mini review2018
- Author(s)
  Chiba Hirofumi、Otsuka Mitsuo、Takahashi Hiroki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 56 Issue: 5 Pages: 384-391
- DOI
  10.1016/j.resinv.2018.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
[Journal Article] Poorer Prognosis of Idiopathic Pleuroparenchymal Fibroelastosis Compared with Idiopathic Pulmonary Fibrosis in Advanced Stage2018
- Author(s)
  Shioya Makoto、Otsuka Mitsuo、Yamada Gen、Umeda Yasuaki、Ikeda Kimiyuki、Nishikiori Hirotaka、Kuronuma Koji、Chiba Hirofumi、Takahashi Hiroki
- Journal Title
  
  Canadian Respiratory Journal
  
  Volume: 2018 Pages: 1-7
- DOI
  10.1155/2018/6043053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
[Journal Article] Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.2017
- Author(s)
  Otsuka M, Shiratori M, Chiba H, Kuronuma K, Sato Y, Niitsu Y, Takahashi H.
- Journal Title
  
  Experimental Lung Research
  
  Volume: 43 Pages: 271-282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone.2017
- Author(s)
  Ikeda K, Shiratori M, Chiba H, Nishikiori H, Yokoo K, Saito A, Hasegawa Y, Kuronuma K, Otsuka M, Yamada G, Takahashi H.
- Journal Title
  
  Respiratoru Medicine
  
  Volume: 131 Pages: 184-191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis.2014
- Author(s)
  Nishikiori H, Chiba H, Ariki S, Kuronuma K, Otsuka M, Shiratori M, Ikeda K, Watanabe A, Kuroki Y, Takahashi H.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 14 Pages: 196-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences.2014
- Author(s)
  Natsuizaka M, Chiba H, Kuronuma K, Otsuka M, Kudo K, Mori M, Bando M, Sugiyama Y, Takahashi H.
- Journal Title
  
  Am J Respir Crit Care Med.
  
  Volume: 190 Pages: 773-779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF2019
- Author(s)
  113.Yoshikawa T, Otsuka M, Ikeda K, Mori Y, Umeda Y, Nishikiori H, Miyajima S, Takahashi M, Kuronuma K, Chiba H, Takahashi H
- Organizer
  European Respiratory Society Annual Congress: 2019 September 28-October 2: Madrid, Spain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09619
[Presentation] 抗線維化薬の治療効果の指標としての血清SP-A、SP－D, KL－6の意義2019
- Author(s)
  吉川　匠、大塚満雄、池田貴美之、錦織博貴、千葉弘文、高橋弘毅
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09619
[Presentation] 特発性肺線維症患者におけるニンテダニブの有害事象と忍容性の後方視的検討2019
- Author(s)
  大塚満雄、吉川　匠、池田貴美之、錦織博貴、千葉弘文、高橋弘毅
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09619
[Presentation] 原発性肺腺癌におけるEGFR遺伝子変異とTTF-1、SP-A、SP-D発現の検討2015
- Author(s)
  大塚満雄、梅田泰淳、成田欣史、黒沼幸治、山田玄、高橋弘毅
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] <演題>肺筋線維芽細胞にHSP47siRNA特異的導入による肺線維化抑制効果の検討2010
- Author(s)
  大塚満雄
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-21790777
[Presentation] 肺筋線維芽細胞にHSP47siRNA特異的導入による肺線維化抑制効果の検討2010
- Author(s)
  大塚満雄
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-21790777
[Presentation] 特発性肺線維症における血清マーカーとピルフェニドンの治療効果との関連についての検討
- Author(s)
  池田貴美之, 白鳥正典, 横尾慶紀, 黒沼幸治, 大塚満雄, 千葉弘文, 高橋弘毅
- Organizer
  第111回日本内科学会講演会
- Place of Presentation
  東京国際フォーラム(東京都千代田区)
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] EGFR遺伝子変異陽性肺腺癌におけるバイオマーカーとしての血清SP-A, SP-D, KL-6の有用性.
- Author(s)
  梅田泰淳, 大塚満雄, 成田欣史, 黒沼幸治, 高橋弘毅
- Organizer
  第55回日本肺癌学会学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] 特発性肺線維症におけるピルフェニドンの治療効果予測因子としての血清SP-D
- Author(s)
  池田貴美之, 白鳥正典, 横尾慶紀, 梅田泰淳, 汐谷心, 錦織博貴, 黒沼幸治, 大塚満雄, 千葉弘文, 高橋弘毅
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] 肺腺癌EGFR-TKI治療のバイオマーカーとしての血清SP-A、SP-D
- Author(s)
  梅田泰淳, 大塚満雄, 成田欣史, 黒沼幸治, 高橋弘毅
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26461164

1. TAKAHASHI HIROKI (60231396)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. 千葉弘文 (40347175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 黒沼幸治 (40563250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. 高橋素子 (00303941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. HASEGAWA YOSHIHIRO (90643180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAITO ATSUSHI (00768939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Otsuka Mitsuo 大塚 満雄

大塚 満雄 オオツカ ミツオ

OTSUKA Mitsuo 大塚 満雄

Research Projects

Research Products

Co-Researchers

the efficacy of nintedanib for expression of surfactant proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pulmonary fibrosis treatment with pulmonary surfactant as a TLR regulatory molecule and HSP47 inhibition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of HSP47siRNA targeting to the lung myofibroblast on bleomycin-induced pulmonary fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] インフォームドコンセントのための図解シリーズ びまん性肺疾患と特発性肺炎．2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of molecular biomarkers in idiopathic pulmonary fibrosis: A mini review2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Poorer Prognosis of Idiopathic Pleuroparenchymal Fibroelastosis Compared with Idiopathic Pulmonary Fibrosis in Advanced Stage2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.2017

Author(s)

Journal Title

Data Source

[Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone.2017

Author(s)

Journal Title

Data Source

[Journal Article] Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis.2014

Author(s)

Journal Title

Data Source

[Journal Article] Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences.2014

Author(s)

Journal Title

Data Source

[Presentation] Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF2019

Author(s)

Organizer

Data Source

[Presentation] 抗線維化薬の治療効果の指標としての血清SP-A、SP－D, KL－6の意義2019

Author(s)

Organizer

Data Source

[Presentation] 特発性肺線維症患者におけるニンテダニブの有害事象と忍容性の後方視的検討2019

Otsuka Mitsuo 大塚満雄

大塚満雄オオツカミツオ

OTSUKA Mitsuo 大塚満雄

[Book] インフォームドコンセントのための図解シリーズ　びまん性肺疾患と特発性肺炎．2014