SAWABE Keiko 澤邊恵子

Researcher Number	10399008
Affiliation (based on the past Project Information) *help	2005 – 2007: 帝京科学大学, 大学院・バイオテクノロジー研究センター, 非常勤研究員
Review Section/Research Field	Except Principal Investigator Functional basic dentistry
Keywords	Except Principal Investigator RBL2H3 / Site-directed mutagenesis / Proteasomes / Ubiquitination / Enzyme regulation by phosphorylation / Serotonin biosynthesis / Tryptopha hydroxylase / 部位特異的突然変異 / トリプトファン水酸化酵素抗体 / 部位特異的点変異 … More / プロテアソーム / ユビキチン化 / リン酸化による活性調節 / セロトニン生合成 / トリプトファン水酸化酵素 Less

On the Possible Control of Allergic Inflammation based on Molecular Mechanism of Serotonin Synthesizing Enzyme
- Principal Investigator
  
  HASEGAWA Hiroyuki
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Teikyo University of Science & Technology

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] Pterines, Folates and Neurotransmitters in Molecular Medicine2003
- Author(s)
  Sawabe, K., et. al.
- Publisher
  SPS Publications,Germany
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.2006
- Author(s)
  Nakamura, K., Y. Sugawara, K. Sawabe, A. Ohashi, H. Tsurui, Y. Xiu, M. Ohtsuji, Q. S. Lin, H. Nishimura, H. Hasegawa, S. Hirose
- Journal Title
  
  J Neurosci 26(2)
  
  Pages: 530-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.2006
- Author(s)
  Nakamura, K., Y. Koyama, K. Takahashi, H. Tsurui, Y. Xiu, M. Ohtsuji, Q. S. Lin, Y. Sugawara, K. Sawabe, A. Ohashi, T. Ohnuma, H. Arai, H. Nishimura, H. Hasegawa, S. Hirose
- Journal Title
  
  J Mol Biol 363(2)
  
  Pages: 345-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Intestinal uptake of 6(R)-L-erythro-tetrahydrobioterin is distinctive from liver-type MTX-sensitive accumulation process2005
- Author(s)
  Keiko Sawabe
- Journal Title
  
  Pteridines 16
  
  Pages: 6-10
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes ; direct uptake and indirect uptake mediated by a methotrexate-sensitive process2005
- Author(s)
  Sawabe Keiko
- Journal Title
  
  Mol Genet Metab 86・S1
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Accumulated BH4 in mouse liver caused by administration of either 6R- or 6SBH4 consisted solely of the 6R-diastereomer : evidence of oxidation to BH2 and enzymic reduction2005
- Author(s)
  Sawabe Keiko
- Journal Title
  
  Mol Genet Metab 86・S1
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Increase in biopterin pool after tetrahydrobiopterin administration is due to uptake and conversion of secondarily produced dihydrobiopterin.2004
- Author(s)
  Keiko Sawabe
- Journal Title
  
  Pterins, Folates and Neurotransmitters in Molecular Medicine
- Data Source
  KAKENHI-PROJECT-16591872
[Journal Article] Tetrahydrobiopterin uptake in supplemental administration : elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process2004
- Author(s)
  Keiko Sawabe
- Journal Title
  
  J.Pharmacol.Sci. 96
  
  Pages: 124-133
- NAID
  10014166544
- Data Source
  KAKENHI-PROJECT-16591872
[Presentation] Entero-hepatic circulation of BH4, another route of exogenous-BH4 transport2008
- Author(s)
  K. Sawabe
- Organizer
  International conference Tetrahydrobiopterin, PKU, and NOS
- Place of Presentation
  St. Moritz, Switzerland
- Year and Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-16591872
[Presentation] Demonstration of transcellular transport of tetrahydrobiopterin across Caco-2 cells as a model of intestinal uptake2007
- Author(s)
  澤邊恵子
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-03-19
- Data Source
  KAKENHI-PROJECT-16591872

1. HASEGAWA Hiroyuki (10092983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. NAKANISHI Nobuo (20118574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大黒一哉 (00233081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAWABE Keiko 澤邊 恵子

Research Projects

Research Products

Co-Researchers

On the Possible Control of Allergic Inflammation based on Molecular Mechanism of Serotonin Synthesizing Enzyme

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Pterines, Folates and Neurotransmitters in Molecular Medicine2003

Author(s)

Publisher

Description

Data Source

[Journal Article] Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Intestinal uptake of 6(R)-L-erythro-tetrahydrobioterin is distinctive from liver-type MTX-sensitive accumulation process2005

Author(s)

Journal Title

Data Source

[Journal Article] Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes ; direct uptake and indirect uptake mediated by a methotrexate-sensitive process2005

Author(s)

Journal Title

Data Source

[Journal Article] Accumulated BH4 in mouse liver caused by administration of either 6R- or 6SBH4 consisted solely of the 6R-diastereomer : evidence of oxidation to BH2 and enzymic reduction2005

Author(s)

Journal Title

Data Source

[Journal Article] Increase in biopterin pool after tetrahydrobiopterin administration is due to uptake and conversion of secondarily produced dihydrobiopterin.2004

Author(s)

Journal Title

Data Source

[Journal Article] Tetrahydrobiopterin uptake in supplemental administration : elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process2004

Author(s)

Journal Title

NAID

Data Source

[Presentation] Entero-hepatic circulation of BH4, another route of exogenous-BH4 transport2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Demonstration of transcellular transport of tetrahydrobiopterin across Caco-2 cells as a model of intestinal uptake2007

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SAWABE Keiko 澤邊恵子