KIMURA Yasuhisa 木村泰久

Researcher Number	10415143
Other IDs
Affiliation *help	2016 – 2018 : 京都大学, 農学研究科, 助教 2012 – 2015 : 京都大学, (連合)農学研究科(研究院), 助教 2014 : 京都大学, 大学院農学研究科, 助教 2007 – 2009 : Kyoto University, 農学研究科, 助教 2008 : Kyoto University, 大学院・農学研究科, 助教 2007 : 京大, 薬学研究科(研究院), 研究員 2006 : 京都大学, 農学研究科, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Applied biochemistry / Complex systems / Biological Sciences / Medium-sized Section 38:Agricultural chemistry and related fields Except Principal Investigator Broad Section F / Applied molecular and cellular biology / Structural biochemistry
Keywords	Principal Investigator ABCタンパク質 / ATP感受性カリウムチャネル / HDL / 高密度リポタンパク質 / 膜輸送体 / 能動輸送 / ABCG1 / 単粒子解析 / 基質取り込みゲート / 高速AFM … More Except Principal Investigator 結晶化 / 細胞外マトリックス / 反応中間体アナログ / 変異体 / コラーゲン / 接着斑 / 発光反応 / ルシフェラーゼ / X線結晶構造解析 / 遷移状態アナログ / ルシフェリン / 細胞・組織 / ABC蛋白質 / トランスポーター / コレステロール / 動脈硬化 / メカノバイオロジー / 癌 / シグナル伝達 / 構造生物学 / 細胞分化 / オキシルシフェリン / 生体分子 / 細胞接着 / ルシフェリン再生酵素 / 量子収率 / 構造解析 / がん Less

Uncovering the secrets of lipid-transporting ABC proteinsOngoing
- Principal Investigator
  
  植田和光
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Kyoto University
Evolutionary possibility of drug transporters from lipid transportersPrincipal InvestigatorOngoing
- Principal Investigator
  
  木村泰久
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Kyoto University
Biochemical analysis of the generation of high density lipoprotein(HDL) by ABC proteinsPrincipal Investigator
- Principal Investigator
  
  木村泰久
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto University
分子内運動に着目したヒト多剤排出トランスポーターの輸送機構解明Principal Investigator
- Principal Investigator
  
  木村泰久
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
複合体解析によるKATPチャネル制御機構解明Principal Investigator
- Principal Investigator
  
  木村泰久
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of molecular mechanim for sensing stiffness of extracellular matrix
- Principal Investigator
  
  KIOKA Noriyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Kyoto University
Functional analysis of human ABC transporters involved in HDL generation.Principal Investigator
- Principal Investigator
  
  KIMURA Yasuhisa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto University
How does firefly luciferase control the bioluminescence reaction?
- Principal Investigator
  
  NAKATSU Toru
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
The structural analysis of the sulfonylurea receptor by single particle analysisPrincipal Investigator
- Principal Investigator
  
  KIMURA Yasuhisa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
スルフォニル尿素剤受容体の構造生物学的解析Principal Investigator
- Principal Investigator
  
  木村泰久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University

All 2018 2017 2016 2014 2013 2012 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation2018
- Author(s)
  Masato Ishigami, Fumihiko Ogasawara, Kohjiro Nagao, Hidehiko Hashimoto, Yasuhisa Kimura, Noriyuki Kioka and Kazumitsu Ueda
- Journal Title
  
  Scientific Reports
  
  Volume : 8 Pages : 6170-6170
- DOI
  10.1038/s41598-018-24428-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-17J08206, KAKENHI-PROJECT-15K07390
[Journal Article] Vinculin Association with Actin Cytoskeleton is Necessary for Stiffness-dependent Regulation of Vinculin Behavior.2017
- Author(s)
  Tomohiro Omachi, Takafumi Ichikawa, Yasuhisa Kimura, Kazumitsu Ueda, and Noriyuki Kioka.
- Journal Title
  
  PLos One
  
  Volume : 12 Issue : 4
- Publisher
  Public Library of Science
- DOI
  10.1371/journal.pone.0175324
- ISSN
  1932-6203
- Year and Date
  2017-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07390, KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-16K15090
[Journal Article] Vinculin Promotes Nuclear Localization of TAZ to Inhibit ECM Stiffness-Dependent Differentiation into Adipocytes2017
- Author(s)
  Mito Kuroda, Hiroki Wada, Yasuhisa Kimura, Kazumitsu Ueda and Noriyuki Kioka
- Journal Title
  
  Journal of cell science
  
  Volume : 130 Pages : 989-1002
- DOI
  10.1242/jcs.194779
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-15J02241, KAKENHI-PROJECT-15K07390, KAKENHI-PROJECT-16K15090
[Journal Article] Non-specific protein modifications by a phytochemical induce heat shock response for self-defense2014
- Author(s)
  Chiba, T., T. Sakurada, R. Watanabe, K. Yamaguchi, Y. Kimura, N. Kioka, H. Kawagishi, M. Matsuo, K. Ueda
- Journal Title
  
  PLoS One
  
  Volume : 9 Pages : 1-15
- DOI
  10.1371/journal.pone.0058641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24380185, KAKENHI-PROJECT-10J03355, KAKENHI-PROJECT-23580164, KAKENHI-PROJECT-23658118, KAKENHI-PROJECT-24650507, KAKENHI-PROJECT-24658094
[Journal Article] 脂質輸送型ABCタンパク質の基質認識2014
- Author(s)
  木村泰久
- Journal Title
  
  輸送機構
  
  Volume : 39(2) Pages : 68-73
- Data Source
  KAKENHI-PROJECT-24780101
[Journal Article] Interaction of the vinculin proline-rich linker region with vinexin alpha in sensing extracellular matrix stiffness.2014
- Author(s)
  Hiroshi Yamashita, Takafumi Ichikawa, Daisuke Matsuyama, Yasuhisa Kimura, Kazumitsu Ueda, Susan W. Craig, Ichiro Harada, and Noriyuki Kioka
- Journal Title
  
  Journal of cell science
  
  Volume : 127 Pages : 1875-86
- DOI
  10.1242/jcs.133645
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J03633, KAKENHI-PROJECT-24380185, KAKENHI-PROJECT-24604001, KAKENHI-PROJECT-24658094, KAKENHI-PUBLICLY-26112707, KAKENHI-PROJECT-26660291
[Journal Article] ATPaseactivity of human ABCG1 is stimulated by cholesterol and sphingomyelin2013
- Author(s)
  Hirayama, H., Kimura, Y., Kioka, N., Matsuo,M. and Ueda, K.
- Journal Title
  
  J. Lipid Res
  
  Volume : 54 Pages : 496-502
- DOI
  10.1194/jlr.m033209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228001, KAKENHI-PROJECT-21688007, KAKENHI-PROJECT-24580139, KAKENHI-PROJECT-24780101
[Journal Article] ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin2013
- Author(s)
  Hirayama H, Kimura Y, Kioka N, Matsuo M, Ueda K
- Journal Title
  
  J. Lipid Res.
  
  Volume : 54 Pages : 496-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780101
[Journal Article] ATP hydrolysis・dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding2012
- Author(s)
  Nagao, K., Takahashi, K., Azuma, Y., Takada, M., Kimura, Y., Matsuo, M., Kioka, N. and Ueda, K.
- Journal Title
  
  J.Lipid Res.
  
  Volume : 53 Pages : 126-136
- DOI
  10.1194/jlr.m019976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20228001, KAKENHI-PROJECT-20380186, KAKENHI-PROJECT-21688007, KAKENHI-PROJECT-22880016, KAKENHI-PROJECT-24380185, KAKENHI-PROJECT-24580139, KAKENHI-PROJECT-24658094
[Journal Article] Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP2010
- Author(s)
  Terakado K, Kodan A, Nakano H, Kimura Y, Ueda K, Nakatsu T, Kato H.
- Journal Title
  
  Acta Crystallogr D Vol.66
  
  Pages : 319-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370039
[Journal Article] Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP2010
- Author(s)
  Terakado K, Kodan A, Nakano H, Kimura Y, Ueda K, Nakatsu T, Kato H.
- Journal Title
  
  Acta Crystallogr D 66
  
  Pages : 319-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370039
[Journal Article] Functional role of the linker region in purified human P-glycoprotein.2009
- Author(s)
  Sato T, Kodan A, Kimura Y, Ueda K, Nakatsu T, Kato H.
- Journal Title
  
  FEBS J. Vol.276
  
  Pages : 3504-3516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370039
[Journal Article] Functional role of the linker region in purified human P-glycoprotein2009
- Author(s)
  Sato T, Kodan A, Kimura Y, Ueda K, Nakatsu T, Kato H.
- Journal Title
  
  FEBS J. 276
  
  Pages : 3504-3516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19370039
[Journal Article] Functional role of the linker region in purified human P-glycoprotein2009
- Author(s)
  Sato, T., Kodan, A., Kimura, Y., Ueda, K., Nakatsu, T. and Kato, H
- Journal Title
  
  FEBS J. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Journal Article] Sodium taurocholate-dependent lipid efflux by ABCAl-Effects of W590S mutation on lipid translocation and apoA-I dissociation.2009
- Author(s)
  Nagao, K. Zhao, Y., Takahashi, K., Kimura, Y., and Ueda, K.
- Journal Title
  
  J. Lipid Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Journal Article] Formation of two intramolecular disulfide bonds is necessary for apoA-I-dependent cholesterol efflux mediated by ABCAl.2009
- Author(s)
  Hozoji, M., Kimura, Y., Kioka, N. and Ueda, K.
- Journal Title
  
  J. Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Journal Article] Sodium taurocholate-dependent lipid efflux by ABCA1-Effects of W590S mutation on lipid translocation and apoA-I dissociation2009
- Author(s)
  Nagao, K. Zhao, Y., Takahashi, K., Kimura, Y., Ueda, K.
- Journal Title
  
  J. Lipid Res. 50
  
  Pages : 1165-1172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Journal Article] Formation of two intramolecular disulfide bonds is necessary for apoA-I-dependent cholesterol efflux mediated by ABCA12009
- Author(s)
  Hozoji, M., Kimura, Y., Kioka, N., Ueda, K.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages : 11293-11300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Journal Article] Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol2007
- Author(s)
  Kimura, Y et al.
- Journal Title
  
  Biochemical Journal 401
  
  Pages : 597-605
- Data Source
  KAKENHI-PROJECT-18890086
[Journal Article] Mechanism of multi-drug recognition by MDR1/ABCB12007
- Author(s)
  Kimura, Y., Morita, S.-y., Matsuo, M., Ueda, K.
- Journal Title
  
  Cancer Sci.
  
  Pages : 1303-1310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Journal Article] Functional role of the linker region in purified human P-glycoprotein
- Author(s)
  Sato, T., Kodan, A., Kimura, Y., Ueda, K., Nakatsu, T., Kato, H.
- Journal Title
  
  FEBS J. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] 光反応性ホスファチジルコリンを用いた脂質抱合型apoA-Iの標識手法の確立2018
- Author(s)
  藤本和希、木村泰久、安部真人、三芳秀人、植田和光
- Organizer
  日本農芸化学会 2018年度大会
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Functional analysis of transmembrane helix 4 of human ABCB42018
- Author(s)
  〇Shun Ogawa, Kento Suenaga, Noriyuki Kioka, Yasuhisa Kimura, Kazumitsu Ueda
- Organizer
  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Substrate entry mechanism of human MDR12018
- Author(s)
  Yasuhisa Kimura, Shuichi Inoue, Noriyuki Kioka, Kazumitsu Ueda
- Organizer
  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] リン脂質輸送体ABCB4の基質取り込みゲートの解析2018
- Author(s)
  小川峻、末永健人、木岡紀幸、木村泰久、植田和光
- Organizer
  日本農芸化学会 2018年度大会
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] 定量的アプローチによるABCA1とapoA-Iによる脂質排出メカニズムの解明2017
- Author(s)
  三好里奈、小笠原史彦、石神正登、永田紅、木村泰久、木岡紀幸、植田和光
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ヒトABCB4の基質取り込み経路の検討2017
- Author(s)
  小川峻、末永健人、木岡紀幸、木村泰久、植田和光
- Organizer
  "日本農芸化学会関西・中四国・西日本支部 2017年度合同大阪大会"
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ヒトABCB6によるポルフィリン認識機構の解析2017
- Author(s)
  西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
- Organizer
  2017年　日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] コレステロール認識配列CRACは、ヒトABCG4のコレステロール輸送において重要である2017
- Author(s)
  見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  2017年　日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Analysis of thermostabilizing mechanism of multidrug transporter2017
- Author(s)
  Yilun WANG, Shuichi INOUE, Noriyuki KIOKA, Yasuhisa KIMURA, Kazumitsu UEDA,
- Organizer
  2017年日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] コレステロール認識配列CRACは、ヒトABCG4のコレステロール輸送において重要である2017
- Author(s)
  見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  2017年日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] ヒトABCB6によるポルフィリン認識機構の解析2017
- Author(s)
  西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
- Organizer
  2017年日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] ヒトABCB4の第4膜貫通ヘリックスの機能解析2017
- Author(s)
  小川峻、末永健人、木岡紀幸、木村泰久、植田和光
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Analysis of thermostabilizing mechanism of multidrug transporter2017
- Author(s)
  Yilun WANG, Shuichi INOUE, Noriyuki KIOKA, Yasuhisa KIMURA, Kazumitsu UEDA,
- Organizer
  2017年　日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ポルフィリンのカルボキシル基はヒトABCB6によるポルフィリン認識に重要である2017
- Author(s)
  西澤奈美、木村泰久、大貫元、木岡紀幸、植田和光
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ヌクレオチド依存的なKATP チャネル複合体の構造変化2016
- Author(s)
  木村泰久
- Organizer
  第1 回イオンチャネル研究会
- Place of Presentation
  福岡
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ヒト培養細胞を用いた哺乳類膜タンパク質複合体の発現・精製2016
- Author(s)
  木村泰久
- Organizer
  第16回　日本蛋白質科学会年会
- Place of Presentation
  博多
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] 原子間力顕微鏡(AFM)観察に向けたABCタンパク質サンプルの最適化2016
- Author(s)
  山原一晃、木村　泰久、柴田　幹大、内橋　貴之、安藤　敏夫、木岡　紀幸、植田和光
- Organizer
  2016年(平成28年度)日本農芸化学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] ヒトABCG4に存在するコレステロール認識配列の機能解析2016
- Author(s)
  見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  2016年(平成28年度)日本農芸化学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] ヒトABCB6に存在する機能未知膜ドメイン(TMD0)の解析2016
- Author(s)
  西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
- Organizer
  2016年(平成28年度)日本農芸化学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] ヒト培養細胞を用いた哺乳類膜タンパク質複合体の発現・精製2016
- Author(s)
  木村泰久
- Organizer
  第16回　日本蛋白質科学会年会
- Place of Presentation
  福岡
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ヌクレオチド依存的なKATP チャネル複合体の構造変化2016
- Author(s)
  木村泰久
- Organizer
  第1 回イオンチャネル研究会
- Place of Presentation
  博多
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] Nucleotide induces conformational change in the channel subunit of KATP channel2016
- Author(s)
  木村泰久、菅野亮、松尾道憲、加藤博章、光岡薫、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] Analysis of functional role of TMD0 of human ABCB62016
- Author(s)
  西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] Functional analysis of the CRAC domain in TM6 of human ABCG4.2016
- Author(s)
  見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] Reconstitution of human ABCA1 in nanodisc for the functional analysis2016
- Author(s)
  川野邊峻哲、木村泰久、木岡紀幸、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01638
[Presentation] ヒトABCG4に存在するコレステロール認識配列の機能解析2016
- Author(s)
  見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  2016年(平成28年度)日本農芸化学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] 原子間力顕微鏡(AFM)観察に向けたABCタンパク質サンプルの最適化2016
- Author(s)
  木村泰久、菅野亮、松尾道憲、加藤博章、光岡薫、植田和光
- Organizer
  ヌクレオチド依存的なATP感受性カリウムチャネルの構造変化
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Analysis of functional role of TMD0 of human ABCB62016
- Author(s)
  西澤奈美、大貫元、木村泰久、木岡紀幸、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Nucleotide induces conformational change in the channel subunit of KATP channel2016
- Author(s)
  木村泰久、菅野亮、松尾道憲、加藤博章、光岡薫、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Reconstitution of human ABCA1 in nanodisc for the functional analysis2016
- Author(s)
  川野邊峻哲、木村泰久、木岡紀幸、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] Functional analysis of the CRAC domain in TM6 of human ABCG4.2016
- Author(s)
  見月俊吾、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07390
[Presentation] ナノディスクを用いたヒトABCA1の機能解析系の構築2014
- Author(s)
  川野邊峻哲、木村泰久、木岡紀幸、植田和光
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] ヒトMDR1の基質認識に関わる疎水性アミノ酸の同定2014
- Author(s)
  津山智美、木村泰久、木岡紀幸、加藤博章、植田和光
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] Substrate recognition of human ABCG1 and ABCG42014
- Author(s)
  Yasuhisa Kimura, Hiroshi Hirayama, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda
- Organizer
  5th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
- Place of Presentation
  Innsbruck, Austria
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] 軟骨細胞分化における接着斑タンパク質ビネキシンの役割2014
- Author(s)
  椀谷友紀、木村泰久、植田和光、木岡紀幸
- Organizer
  2014年度日本農芸化学会関西支部大会
- Place of Presentation
  奈良
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-24380185
[Presentation] ヒトMDR1の輸送基質導入ゲートの解析2014
- Author(s)
  井上修一、木村泰久、木岡紀幸、松尾道憲、加藤博章、植田和光
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] 精製タンパク質を用いたヒトABCタンパク質の機能解析2014
- Author(s)
  木村泰久
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  東京
- Year and Date
  2014-03-30
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] Substrate recognition of human ABCG1 and ABCG42014
- Author(s)
  Yasuhisa Kimura
- Organizer
  5th FEBS special meeting,ATP-Binding Cassette (ABC) Proteins : From Multidrug Resistance to Genetic Diseases
- Place of Presentation
  Innsbruck, Austria
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] ヒト培養細胞によるヒトABCタンパク質の大量生産、精製手法開発2014
- Author(s)
  木村泰久
- Organizer
  日本農芸化学会　第１７回中四国支部若手シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2014-05-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] Characterization of the substrate specificity of ABCB62013
- Author(s)
  Hajime Ohnuki, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
- Organizer
  The 14th International Membrane Research Forum
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] 細胞外マトリクスの硬さの感知におけるビンキュリン-ビネキシンα相互作用2013
- Author(s)
  市川尚文, 山下寛, 木村泰久, 植田和光, 木岡紀幸
- Organizer
  第480回農芸化学会関西支部講演会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24380185
[Presentation] 単粒子解析によるATP感受性カリウムチャネルのサブユニット構造決定2013
- Author(s)
  木村泰久、菅野亮、松尾道憲、加藤博章、光岡薫、植田和光
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] ヒトMDR1の第4、第10膜貫通へリックスの基質導入ゲートとしての機能の解析2013
- Author(s)
  井上修一、木村泰久、木岡紀幸、松尾道憲、加藤博章、植田和光
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] ATPase activity of human ABCG1 is stimulated by cholesterol and choline phospholipids2013
- Author(s)
  Yasuhisa Kimura, Hiroshi Hirayama, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda
- Organizer
  Benzon Symposium No. 59 - Membrane proteins: Structure, Function and Dynamics
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] Analysis of the substrate specificity of ABCB62013
- Author(s)
  Hajime Ohnuki, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
- Organizer
  RSC-iCeMSシンポジウム
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] Purification and functional analysis of cholesterol transporter ABCG12013
- Author(s)
  Hiroshi Hirayama, Yasuhisa Kimura, Noriyuki Kioka, Michinori Matsuo, Kazumitsu Ueda
- Organizer
  RSC-iCeMSシンポジウム
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] ATPase activity of human ABCG1 is stimulated by cholesterol and choline phospholipids2013
- Author(s)
  Yasuhisa Kimura
- Organizer
  Benzon Symposium No. 59 - Membrane proteins : Structure, Function and Dynamics
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] KATPチャネル複合体のサブユニット間相互作用部位の探索2012
- Author(s)
  井上修一、木村泰久、木岡紀幸、松尾道憲、植田和光
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] Functional analysis of purified ABCG1 expressed in human cultured cells2012
- Author(s)
  Hiroshi Hirayama, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
- Organizer
  ASBMB: Frontiers in Lipid Biology
- Place of Presentation
  Canada
- Data Source
  KAKENHI-PROJECT-24780101
[Presentation] Large scale production and purification of KATP channel in mammalian cells2009
- Author(s)
  Y. Kimura, H. Kato, K. Ueda
- Organizer
  Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Tokyo
- Year and Date
  2009-05-24
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] ヒト培養細胞を用いたATP感受性カリウムチャネル復合体の大量生産、高純度精製2009
- Author(s)
  木村泰久、平山裕士、加藤博章、植田和光
- Organizer
  農芸化学会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] ヒト培養細胞を用いたATP感受性カリウムチャネル複合体の大量生産、高純度精製2009
- Author(s)
  木村泰久, 平山裕士, 松尾道憲, 木岡紀幸, 加藤博章, 植田和光
- Organizer
  農芸化学会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] ヒトABCG1の大量培養系の構築・安定化条件の探索2009
- Author(s)
  平山裕士, 木村泰久, 松尾道憲, 木岡紀幸, 植田和光
- Organizer
  農芸化学会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] Mechanism of multidrug recognition by MDR1 - cholesterol fill-in model2008
- Author(s)
  木村泰久, 松尾道憲, 木岡紀幸, 植田和光
- Organizer
  FEBS-ABC2008
- Place of Presentation
  Innsbruck, Austria
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] ヒト培養細胞を用いたヒトABCトランスポーターの大量発現系の構築および精製条件スクリーニング手法の開発2008
- Author(s)
  木村泰久, 平山裕士, 浅見成美, 木岡紀幸, 松尾道憲, 加藤博章, 植田和光
- Organizer
  分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-15
- Data Source
  KAKENHI-PROJECT-19790034
[Presentation] ヒトMDR1の基質取り込みゲート機構の解析
- Author(s)
  末永健人、井上修一、木村泰久、木岡紀幸、加藤博章、植田和光
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] 精製タンパク質を用いたヒトABCG4の機能解析
- Author(s)
  木村泰久、平山裕士、木岡紀幸、松尾道憲、植田和光
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] ヒトMDR1の内向き構造安定化機構の検討
- Author(s)
  津山智美、木村泰久、木岡紀幸、加藤博章、植田和光
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PUBLICLY-25121716
[Presentation] Interaction of the vinculin proline-rich linker region with vinexin alpha in sensing extracellular matrix stiffness
- Author(s)
  Takafumi Ichikawa, Hiroshi Yamashita, Daisuke Matsuyama, Yasuhisa Kimura, Kazumitsu Ueda, Susan W. Craig, Ichiro Harada, and Noriyuki Kioka
- Organizer
  International symposium on Mechanobiology
- Place of Presentation
  岡山
- Year and Date
  2014-05-20 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-24380185
[Presentation] 細胞外マトリクスの硬さ感知におけるビンキュリンのアクチン繊維結合能の重要性
- Author(s)
  大町朋弘、市川尚文、木村泰久、植田和光、木岡紀幸
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380185
[Presentation] 接着斑タンパク質ビネキシンαの両親媒性へリックスはビンキュリンと相互作用する
- Author(s)
  日野直也、市川尚文、木村泰久、植田和光、木岡紀幸
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24380185
[Presentation] Comparison of the effect of the vinexin family proteins on vinculin-mediated mechanosensing
- Author(s)
  Takafumi Ichikawa, Masahiro Kita, Takuhito Sezaki, Shian-Huey Chiang, Alan R. Saltiel, Yasuhisa Kimura, Kazumitsu Ueda, Noriyuki Kioka
- Organizer
  2014 Annual Meeting of The American Society for Cell Biology
- Place of Presentation
  Philadelphia, Pennsylvania, USA
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-24380185

1. NAKATSU Toru (50293949)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
2. HIRATAKE Jun (80199075)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. KATO Taiichirou (60423901)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
4. KIOKA Noriyuki (90234179)

# of Collaborated Projects : 1results

# of Collaborated Products : 11results
5. 原田伊知郎 (00361759)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
6. 植田和光 (10151789)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
7. 笠井倫志 (20447949)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 古寺哲幸 (30584635)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 木下政人 (60263125)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. MATSUO Michinori

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
11. 村上明

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 河合慶親

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 松本晋也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 長尾耕治郎

# of Collaborated Projects : 0results

# of Collaborated Products : 2results

KIMURA Yasuhisa 木村 泰久

Research Projects

Research Products

Co-Researchers

Uncovering the secrets of lipid-transporting ABC proteinsOngoing

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Evolutionary possibility of drug transporters from lipid transportersPrincipal InvestigatorOngoing

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Biochemical analysis of the generation of high density lipoprotein(HDL) by ABC proteinsPrincipal Investigator

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分子内運動に着目したヒト多剤排出トランスポーターの輸送機構解明Principal Investigator

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複合体解析によるKATPチャネル制御機構解明Principal Investigator

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Analysis of molecular mechanim for sensing stiffness of extracellular matrix

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Functional analysis of human ABC transporters involved in HDL generation.Principal Investigator

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How does firefly luciferase control the bioluminescence reaction?

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The structural analysis of the sulfonylurea receptor by single particle analysisPrincipal Investigator

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スルフォニル尿素剤受容体の構造生物学的解析Principal Investigator

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[Journal Article] Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation2018

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[Journal Article] Vinculin Association with Actin Cytoskeleton is Necessary for Stiffness-dependent Regulation of Vinculin Behavior.2017

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[Journal Article] Vinculin Promotes Nuclear Localization of TAZ to Inhibit ECM Stiffness-Dependent Differentiation into Adipocytes2017

Author(s)

KIMURA Yasuhisa 木村泰久