Tanio Michikazu 谷生道一

… Alternative Names

谷生道一タニオミチカズ

TANIO Michikazu 谷生道一

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Researcher Number	10416662
Other IDs	https://orcid.org/0000-0001-5652-4952
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所次世代生物学的製剤研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2025: 国立感染症研究所, 次世代生物学的製剤研究センター, 主任研究官 2021 – 2023: 国立感染症研究所, 次世代生物学的製剤研究センター, 主任研究官 2017 – 2021: 国立感染症研究所, 血液・安全性研究部, 主任研究官 2014: 国立感染症研究所, 血液・安全性研究部, 主任研究官 2012 – 2013: 分子科学研究所, 物質分子科学研究領域, 特任助教 2008 – 2009: Mitsubishi Kagaku Institute of Life Sciences, 研究部門・蛋白質立体構造研究グループ, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Biophysics Except Principal Investigator Tumor diagnostics / Structural biochemistry
Keywords	Principal Investigator NMR / フィコリン / 立体構造 / 複合体 / 可逆的凝集 / pH / 可逆的 / 動脈硬化 / 凝集 / M-フィコリン … More / C反応性タンパク質 / 熱安定性 / 分子内アロステリック効果 / native PAGE / PHドメイン / 分子内アロステリー / 相互作用 / タンパク質 / 分子内情報伝達 / 生物物理 / 蛋白質 / Brevibacillus choshinensis / 構造平衡 / 異物認識 / 自然免疫 … More Except Principal Investigator 腫瘍検査・診断 / 腫瘍マーカー / HTLV-1変異解析 / HTLV-1挿入部位解析 / ATLリスク評価法 / 腫瘍診断学 / RAISING / 成人T細胞白血病 / クロナリティ / HTLV-1挿入部位 / HTLV-1変異 / ATLL患者 / HAM/TSP患者 / キャリア / HTLV-1 / PLC-δ1 / 開発 / PHドメイン / PLCδ1 / 膜表在性 / バイセル / 配向試料 / 固体NMR / 膜タンパク質 / 構造生物化学 / 生物科学 Less

C反応性タンパク質と血清成分の共凝集機構の解明Principal Investigator
- Principal Investigator
  
  谷生道一
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  National Institute of Infectious Diseases
Molecular mechanism of reversible coaggregation of M-ficolin-C-reactive protein complexPrincipal Investigator
- Principal Investigator
  
  Tanio Michikazu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  National Institute of Infectious Diseases
Development of ATLL and B-cell lymphoma risk assesment method
- Principal Investigator
  
  Saito Masumichi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institute of Infectious Diseases
Intramolecular allosteric interactions in proteinsPrincipal Investigator
- Principal Investigator
  
  TANIO Michikazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  National Institute of Infectious Diseases
  Institute for Molecular Science
Investigation of membrane binding mechanism of peripheral membrane protein based on solid state NMR using magnetically aligned membrane bilayers at room temperature
- Principal Investigator
  
  NISHIMURA Katsuyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute for Molecular Science
Investigation of self and non-self discrimination mechanism by M-ficolin based on 2-state conformational equilibrium modelPrincipal Investigator
- Principal Investigator
  
  TANIO Michikazu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Mitsubishi Kagaku Institute of Life Sciences

All 2023 2022 2014 2013 2012 2009 2008

All Journal Article Presentation

[Journal Article] Calcium-dependent reversible coaggregation activity of C-reactive protein and M-ficolin2022
- Author(s)
  Michikazu Tanio
- Journal Title
  
  Molecular Immunology
  
  Volume: 149 Pages: 157-164
- DOI
  10.1016/j.molimm.2022.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05739
[Journal Article] 1H, 13C and 15N backbone resonance assignments of the monomeric human M-ficolin fibrinogen-like domain secreted by Brevibacillus choshinennsis2014
- Author(s)
  Tanio, M. Kusunoki, H. and Kohno, T
- Journal Title
  
  Biomol. NMR Assign.
  
  Volume: 8 Issue: 1 Pages: 207-211
- DOI
  10.1007/s12104-013-9484-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370056, KAKENHI-PROJECT-24570190
[Journal Article] Intramolecular allosteric interaction in the phospholipase C-δ1 pleckstrin homology domain2013
- Author(s)
  M.Tanio, K.Nishimura
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1834 Issue: 6 Pages: 1034-1043
- DOI
  10.1016/j.bbapap.2013.01.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570126, KAKENHI-PROJECT-24570190, KAKENHI-PROJECT-25410158
[Journal Article] Analysis of the phospholipase C-δ1 pleckstrin homology domain using Native polyacrylamide gel electrophoresis2012
- Author(s)
  M. Tanio, and K. Nishimura
- Journal Title
  
  Anal. Biochem
  
  Volume: 431 Issue: 2 Pages: 106-114
- DOI
  10.1016/j.ab.2012.09.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570126, KAKENHI-PROJECT-24570190
[Journal Article] Histidine -regulated activity of M-ficolin2009
- Author(s)
  Tanio, M., Kohno, T
- Journal Title
  
  Biochemical Journal 417
  
  Pages: 485-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770132
[Journal Article] Amino acid-selective isotope labeling of proteins for nuclear magnetic resonance study: Proteins secreted by Brevibacillus choshinensis2009
- Author(s)
  Tanio, M., Tanaka, R., Tanaka, T., Kohno, T
- Journal Title
  
  Analytical Biochemistry 386
  
  Pages: 156-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770132
[Journal Article] Amino acid-selective isotope labeling of proteins for nuclear magnetic resonance study: Proteins secreted by Brevibacillus choshinensis2009
- Author(s)
  Michikazu Tanio
- Journal Title
  
  Analytical Biochemistry 386
  
  Pages: 156-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770132
[Journal Article] Binding site of C-reactive protein on M-ficolin2009
- Author(s)
  Michikazu Tanio
- Journal Title
  
  Molecular Immunology 47
  
  Pages: 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770132
[Journal Article] Binding site of C-reactive protein on M-ficolin2009
- Author(s)
  Tanio, M., Wakamatsu, K., Kohno, T
- Journal Title
  
  Mol. Immunol 47
  
  Pages: 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770132
[Journal Article] Histidine-regulated activity of M-ficolin2009
- Author(s)
  Michikazu Tanio
- Journal Title
  
  Biochemical Journal 417
  
  Pages: 485-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] M-フィコリンとC反応性タンパク質の可逆的凝集活性2023
- Author(s)
  谷生　道一
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K05739
[Presentation] Intramolecular allostery in the PLC-δ1 PH domain2013
- Author(s)
  谷生道一、西村勝之
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都府　国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] NMR analysis of intramolecular allostery in the PLC-δ1 PH domain2013
- Author(s)
  谷生道一、西村勝之
- Organizer
  第52回NMR討論会年会
- Place of Presentation
  石川県　石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] Role of tryptophan residues in membrane association of the SWAP-70 PH domain2013
- Author(s)
  赤井琴乃, 谷生道一, 西村勝之, 辻暁
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都府　国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] PLC-δ1 PHドメインのタンパク質分子内情報伝達2013
- Author(s)
  谷生道一、西村勝之
- Organizer
  第40回生体分子科学討論会
- Place of Presentation
  大阪府　大阪大学銀杏会館
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] Intramolecular allosteric interaction in the phospholipase C-δ1 pleckstrin homology domain2013
- Author(s)
  谷生道一、西村勝之
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取県　とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] Preparation of secretory proteins produced by Brevibacillus choshinensis for NMR study2013
- Author(s)
  谷生道一、楠英樹、河野俊之
- Organizer
  第52回NMR討論会年会
- Place of Presentation
  石川県　石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] NMR and Native-PAGE analyses of the phospholipase C-δ1 pleckstrin homology domain2012
- Author(s)
  M. Tanio, and K. Nishimura
- Organizer
  第51回NMR討論会
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] The short alpha2-helix of the phospholipase C-delta1 pleckstrin homology domain stabilizes the protein-IP3 interaction2012
- Author(s)
  Michikazu Tanio, and Katsuyuki Nishimura
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場　(愛知県)
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] The short α2-helix of the phospholipase C-δ1 pleckstrin homology domain contributes to stable IP3 binding2012
- Author(s)
  Michikazu Tanio, Katsuyuki Nishimura
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学　(愛知県)
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] NMR and Native-PAGE analyses of the phospholipase C-δ1 pleckstrin homology domain2012
- Author(s)
  Michikazu Tanio, and Katsuyuki Nishimura
- Organizer
  第５１回NMR討論会
- Place of Presentation
  ウインクあいち　(愛知県)
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] 脂質二重膜上におけるDef6 PH ドメインの高次構造の解析2012
- Author(s)
  N. Tokuda, M. Tanio, K. Nishimura, T. Kohno, D. Yokogawa, T. Ikegami, S. Tuzi
- Organizer
  第50回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] The short α2-helix of the phospholipase C-δ1 pleckstrin homology domain contributes to stable IP3 binding2012
- Author(s)
  Michikazu Tanio, Katsuyuki Nishimura
- Organizer
  日本生物物理学会第50回年会
- Place of Presentation
  愛知県　名古屋大学
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] 脂質二重膜上におけるDef6 PH ドメインの高次構造の解析2012
- Author(s)
  Naomi Tokuda、Michikazu Tanio、 Katsuyuki Nishimura、Toshiyuki Kohno、Daisuke Yokogawa、Takahisa Ikegami、Satoru Tuzi
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学　(愛知県)
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] The short τ2-helix of the phospholipase C-χ1 pleckstrin homology domain stabilizes the protein-IP_3 interaction2012
- Author(s)
  M. Tanio, and K. Nishimura
- Organizer
  第12回日本蛋白質科学会年
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] The short α2-helix of the phospholipase C-δ1 pleckstrin homology domain contributes to stable IP_3 binding2012
- Author(s)
  M. Tanio, K. Nishimura
- Organizer
  第50回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-22570126
[Presentation] Conformational properties of the Def6 PH domain located at the lipid bilayer surface2012
- Author(s)
  Naomi Tokuda, Michikazu Tanio, Katsuyuki Nishimura, Toshiyuki Kohno, Daisuke Yokogawa, Takahisa Ikegami, Satoru Tuzi,
- Organizer
  日本生物物理学会第50回年会
- Place of Presentation
  愛知県　名古屋大学
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] The short α2-helix of the phospholipase C-δ1 pleckstrin homology domain stabilizes the protein-IP3 interaction2012
- Author(s)
  Michikazu Tanio, Katsuyuki Nishimura
- Organizer
  日本蛋白質科学会第12回年会
- Place of Presentation
  愛知県　名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] NMR and Native-PAGE analyses of the phospholipase C-δ1 pleckstrin homology domain2012
- Author(s)
  Michikazu Tanio, Katsuyuki Nishimura
- Organizer
  第51回NMR討論会
- Place of Presentation
  愛知県　ウインクあいち
- Data Source
  KAKENHI-PROJECT-24570190
[Presentation] Brevibacillus choshinensis分泌発現系を用いたアミノ酸選択的安定同位体標識試料作成2009
- Author(s)
  谷生道一、楠英樹、田中利好、田中剛史、河野俊之
- Organizer
  第48回NMR討論会
- Place of Presentation
  九州大学医学部百年講堂
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] M-フィコリンのC反応性タンパク質結合部位2009
- Author(s)
  谷生道一、河野俊之
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] Brevibacillus choshinensisを用いた組換えタンパク質の分泌生産および安定同位体標識試料調製2009
- Author(s)
  谷生道一、田中利好、田中剛史、河野俊之
- Organizer
  日本蛋白質科学会第9回年会
- Place of Presentation
  熊本全日空ホテルニュースカイ
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] M-フィコリンの3価認識単位の構造平衡2008
- Author(s)
  谷生道一、近藤伸、杉尾成俊、河野俊之
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] Brevibacillus choshinensis分泌発現系を用いた^<15>N安定同位体標識試料作成2008
- Author(s)
  谷生道一
- Organizer
  第47回NMR討論会
- Place of Presentation
  筑波大学
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] Brevibacillus choshinensis分泌発現系を用いた15N安定同位体標識試料作成2008
- Author(s)
  谷生道一、田中利好、田中剛史、河野俊之
- Organizer
  第47回NMR討論会
- Place of Presentation
  筑波大学
- Data Source
  KAKENHI-PROJECT-20770132
[Presentation] M-フィコリンの3価認識単位の構造平衡2008
- Author(s)
  谷生道一
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-20770132

1. NISHIMURA Katsuyuki (00334631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Saito Masumichi (20571045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 長谷川寛雄 (00398166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 緒方正男 (10332892)

# of Collaborated Projects: 1 results

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5. 今泉芳孝 (40404305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊波英克 (50242631)

# of Collaborated Projects: 1 results

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7. 日吉真照 (40448519)

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8. 百瀬暖佳 (70415488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOHNO Toshiyuki

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# of Collaborated Products: 1 results
10. 西村勝之

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# of Collaborated Products: 10 results

Tanio Michikazu 谷生 道一

谷生 道一 タニオ ミチカズ

TANIO Michikazu 谷生 道一

Research Projects

Research Products

Co-Researchers

C反応性タンパク質と血清成分の共凝集機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of reversible coaggregation of M-ficolin-C-reactive protein complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of ATLL and B-cell lymphoma risk assesment method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Intramolecular allosteric interactions in proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of membrane binding mechanism of peripheral membrane protein based on solid state NMR using magnetically aligned membrane bilayers at room temperature

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of self and non-self discrimination mechanism by M-ficolin based on 2-state conformational equilibrium modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Calcium-dependent reversible coaggregation activity of C-reactive protein and M-ficolin2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1H, 13C and 15N backbone resonance assignments of the monomeric human M-ficolin fibrinogen-like domain secreted by Brevibacillus choshinennsis2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intramolecular allosteric interaction in the phospholipase C-δ1 pleckstrin homology domain2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the phospholipase C-δ1 pleckstrin homology domain using Native polyacrylamide gel electrophoresis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histidine -regulated activity of M-ficolin2009

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid-selective isotope labeling of proteins for nuclear magnetic resonance study: Proteins secreted by Brevibacillus choshinensis2009

Author(s)

Journal Title

Data Source

[Journal Article] Amino acid-selective isotope labeling of proteins for nuclear magnetic resonance study: Proteins secreted by Brevibacillus choshinensis2009

Author(s)

Journal Title

Data Source

[Journal Article] Binding site of C-reactive protein on M-ficolin2009

Author(s)

Journal Title

Data Source

[Journal Article] Binding site of C-reactive protein on M-ficolin2009

Author(s)

Tanio Michikazu 谷生道一

谷生道一タニオミチカズ

TANIO Michikazu 谷生道一