Suzuki Hiroaki 鈴木宏昌

… Alternative Names

鈴木宏昌スズキヒロアキ

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Researcher Number	10424178
Other IDs
Affiliation (Current)	2026: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 東京医科大学, 医学部, 准教授 2018 – 2023: 東京医科大学, 医学部, 講師 2013 – 2015: 東京医科大学, 医学部, 助教 2012: 東京医科大学, 医学部, その他 2011: 東京医科大学, 医学部, 兼任助手 … More 2010: 東京医科大学, 医学部, ポスドク 2007: 慶應大, 医学部 2006: 慶應義塾大学, 医学部, 嘱託(非常勤) Less
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / General pharmacology / Neurology
Keywords	Principal Investigator 神経変性疾患 / 筋萎縮性側索硬化症 / TDP-43 / 神経細胞死 / C9ORF72 / 前頭側頭型認知症 / 前頭側頭葉変性症 / 神経科学 / Paraspeckle / 凝集体 … More / 相分離異常 / RNA結合タンパク質 / リボソーム / RNAヘリカーゼ / リボソーム生合成 / NEAT1 / パラスペックル / C9ORF72遺伝子変異 / ADAR / RNA編集 / C9orf72遺伝子変異 / hnRNPA1 / hnRNP / FUS / Caspase / 小胞体ストレス / 脳・神経 / 薬理学 / シグナル伝達 Less

Research Projects
(6 results)
Research Products
(29 results)

Paraspeckle形成異常に着目した新規ALS治療戦略の確立Principal Investigator
- Principal Investigator
  
  鈴木宏昌
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
Development of a new therapeutic strategy targeting increased expression of TDP-43 in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  Suzuki Hiroaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
Elucidation of the ALS/FTLD pathomechanism mediated by the dysfunction of ribosome biogenesisPrincipal Investigator
- Principal Investigator
  
  Suzuki Hiroaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
Elucidation of molecular pathomechanism of TDP-43 and FUS-linked ALSPrincipal Investigator
- Principal Investigator
  
  Suzuki Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tokyo Medical University
小胞体ストレスを介した運動神経細胞変性機構の解析Principal Investigator
- Principal Investigator
  
  鈴木宏昌
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tokyo Medical University
神経細胞死抑制因子ADNFの受容体の同定Principal Investigator
- Principal Investigator
  
  鈴木宏昌
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Keio University

All 2024 2022 2021 2020 2019 2018 2016 2015 2014 2012 2011 2010

All Journal Article Presentation Book

[Book] 神経変性疾患と細胞死, 実験医学別冊もっとよくわかる！シリーズもっとよくわかる！細胞死2024
- Author(s)
  鈴木宏昌, 金蔵孝介
- Total Pages
  10
- Publisher
  羊土社
- ISBN
  9784758122146
- Data Source
  KAKENHI-PROJECT-24K09851
[Book] 医学のあゆみ2022
- Author(s)
  長谷川成人、岩崎憲治、樽谷愛理、Cesar Aguirre、富田泰輔、鈴木宏昌、佐原成彦、Ruben Fernandez-Busnadiego、服部憲幸、坂口一樹、高澤知規、章　白浩、瀬口典子、清川慎介、大川純代、横山優二、他
- Total Pages
  70
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-21K06583
[Journal Article] Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA2021
- Author(s)
  Hiroaki Suzuki, Masaaki Matsuoka
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 158 Issue: 3 Pages: 753-765
- DOI
  10.1111/jnc.15445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06583
[Journal Article] C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation2019
- Author(s)
  Suzuki Hiroaki、Shibagaki Yoshio、Hattori Seisuke、Matsuoka Masaaki
- Journal Title
  
  Cell Death & Disease
  
  Volume: 10 Issue: 10 Pages: 746-746
- DOI
  10.1038/s41419-019-1983-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06705
[Journal Article] The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis2018
- Author(s)
  Hiroaki Suzuki, Yoshio Shibagaki, Seisuke Hattori, Masaaki Matsuoka
- Journal Title
  
  Cell Death & Disease
  
  Volume: 9 Issue: 10 Pages: 975-975
- DOI
  10.1038/s41419-018-1028-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06705
[Journal Article] Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs2015
- Author(s)
  Hiroaki Suzuki, Yoshio Shibagaki, Seisuke Hattori, and Masaaki Matsuoka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 24 Issue: 6 Pages: 1513-1527
- DOI
  10.1093/hmg/ddu563
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460342
[Journal Article] The effect of self-training in advance using an e-learning system on pharmacological practice2015
- Author(s)
  Ichie Hara, Hiroaki Suzuki, Shinya Kusakari, and Masaaki Matsuoka
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 145 Issue: 2 Pages: 80-84
- DOI
  10.1254/fpj.145.80
- NAID
  130004827723
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460342
[Journal Article] Overexpression of nuclear FUS induces neuronal cell death2015
- Author(s)
  Hiroaki Suzuki and Masaaki Matsuoka
- Journal Title
  
  Neuroscience
  
  Volume: 287 Pages: 113-124
- DOI
  10.1016/j.neuroscience.2014.12.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460342
[Journal Article] TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression2012
- Author(s)
  Hiroaki Suzuki
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: VOL.90 Issue: 3 Pages: 641-647
- DOI
  10.1002/jnr.22777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790261
[Journal Article] Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells2012
- Author(s)
  Lee Kikyo, Hiroaki Suzuki (Co-first author)
- Journal Title
  
  Neuroscience Letters
  
  Volume: VOL.506 Pages: 271-276
- NAID
  120005340753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790261
[Journal Article] Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity2011
- Author(s)
  Hiroaki Suzuki
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: VOL.119 Issue: 5 Pages: 1099-1107
- DOI
  10.1111/j.1471-4159.2011.07491.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790261, KAKENHI-PROJECT-23390059
[Journal Article] TDP-43-induced death is associated with altered regulation of Bim and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage2011
- Author(s)
  Hiroaki Suzuki, Kikyo Lee, Masaaki Matsuoka
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Pages: 13171-13183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790261
[Journal Article] VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin2011
- Author(s)
  Rossini L, Hashimoto Y, Suzuki H, Kurita M, et al.
- Journal Title
  
  The FASEB Journal
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790261
[Presentation] TDP-43 induces cytoplasmic distribution of ALS/FTLD-related RNA-binding proteins by enhancing mRNA nuclear export and translation2024
- Author(s)
  鈴木宏昌, 宮城碧水, 金蔵孝介
- Organizer
  NEURO2024
- Data Source
  KAKENHI-PROJECT-24K09851
[Presentation] ALS/FTD原因遺伝子CHCHD10による細胞死メカニズムの解析2022
- Author(s)
  草苅伸也、小林悠理、鈴木宏昌、松岡正明
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06583
[Presentation] C9-ALS/FTD-linked proline-arginine dipeptide repeat protein inhibits adenosine deaminase acting on RNA2021
- Author(s)
  Suzuki Hiroaki、Matsuoka Masaaki
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06705
[Presentation] Poly-dipeptide linked to C9-ALS/FTD causes neuronal cell death by inhibiting ADARs2021
- Author(s)
  鈴木宏昌、松岡正明
- Organizer
  第144回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21K06583
[Presentation] The proline-arginine repeat protein linked to C9-ALS/FTD inhibits adenosine deaminase acting on RNA2021
- Author(s)
  Hiroaki Suzuki, Masaaki Matsuoka
- Organizer
  第44回日本神経科学大会/第1回 CJK 国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06583
[Presentation] C9-ALS/FTD-linked proline-arginine dipeptide repeat protein causes neurotoxicity by disrupting paraspeckle integrity2020
- Author(s)
  Suzuki Hiroaki、Matsuoka Masaaki
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06705
[Presentation] C9-ALS/FTD-linked proline-arginine dipeptide repeat protein causes neuronal cell death by associating with paraspeckle components2020
- Author(s)
  Suzuki Hiroaki、Matsuoka Masaaki
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06705
[Presentation] C9ORF72-linked proline-arginine dipeptide repeat protein inhibits RNA helicase-mediated ribosome biogenesis and causes neurotoxicity2019
- Author(s)
  鈴木宏昌、松岡正明
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06705
[Presentation] The proline-arginine repeat protein linked to C9ORF72-ALS/FTD inhibits RNA helicase-mediated ribosome biogenesis and causes neuronal cell death2018
- Author(s)
  Hiroaki Suzuki, Masaaki Matsuoka
- Organizer
  Society for Neuroscience 2018, SfN's 48th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06705
[Presentation] hnRNPA1のALS/MSP変異体は自己発現調節機構の異常により細胞毒性を示す2016
- Author(s)
  鈴木宏昌、松岡正明
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25460342
[Presentation] Nuclear TDP-43 causes neuronal toxicity by overcoming the intrinsic cell death -preventing mechanism mediated by hnRNPs2015
- Author(s)
  Hiroaki Suzuki, Yoshio Shibagaki, Seisuke Hattori, and Masaaki Matsuoka
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-25460342
[Presentation] Nuclear TDP-43 induces neuronal cell death by associating with heterogeneous nuclear ribonucleoprotein-U2014
- Author(s)
  Hiroaki Suzuki and Masaaki Matsuoka
- Organizer
  Society for Neuroscience 2014
- Place of Presentation
  Washington, DC
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-25460342
[Presentation] ALS変異型VAPBはTDP-43の神経毒性を増強させる2012
- Author(s)
  鈴木宏昌
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-22790261
[Presentation] TDP-43の神経毒性はBimの発現上昇およびBcl-xLの発現低下を介して誘導される2011
- Author(s)
  鈴木宏昌、李嬉京、松岡正明
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜、日本
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22790261
[Presentation] ALS-linked mutant VAPB enhances TDP-43-induced motor neuron toxicity2011
- Author(s)
  Hiroaki Suzuki
- Organizer
  Society for Neuroscience, 2011
- Place of Presentation
  Washington, DC
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22790261
[Presentation] Activated caspases modify TDP-43-induced toxicity in motor neuronal cells2010
- Author(s)
  Hiroaki Suzuki, Kikyo Lee, Masaaki Matsuoka
- Organizer
  Society for Neuroscience 2010
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22790261

Suzuki Hiroaki 鈴木 宏昌

鈴木 宏昌 スズキ ヒロアキ

Research Projects

Research Products

Paraspeckle形成異常に着目した新規ALS治療戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new therapeutic strategy targeting increased expression of TDP-43 in amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the ALS/FTLD pathomechanism mediated by the dysfunction of ribosome biogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular pathomechanism of TDP-43 and FUS-linked ALSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体ストレスを介した運動神経細胞変性機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経細胞死抑制因子ADNFの受容体の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 神経変性疾患と細胞死, 実験医学別冊 もっとよくわかる！シリーズ もっとよくわかる！細胞死2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 医学のあゆみ2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of self-training in advance using an e-learning system on pharmacological practice2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Overexpression of nuclear FUS induces neuronal cell death2015

Suzuki Hiroaki 鈴木宏昌

鈴木宏昌スズキヒロアキ

[Book] 神経変性疾患と細胞死, 実験医学別冊もっとよくわかる！シリーズもっとよくわかる！細胞死2024