Furuta Tadaomi 古田忠臣

… Alternative Names

FURUTA Tadaomi 古田忠臣

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Researcher Number	10431834
Other IDs
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 助教
Affiliation (based on the past Project Information) *help	2016 – 2023: 東京工業大学, 生命理工学院, 助教 2012 – 2015: 東京工業大学, 生命理工学研究科, 助教 2014: 東京工業大学, 大学院生命理工学研究科, 助教 2013: 東京工業大学, 准教授, 助教 2011: 東京工業大学, 大学院生命理工学研究科, 助教
Review Section/Research Field	Principal Investigator Life / Health / Medical informatics / Biophysics Except Principal Investigator Biophysics / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 37010:Bio-related chemistry / Basic Section 48020:Physiology-related / Bio-related chemistry
Keywords	Principal Investigator 構造機能相関 / 分子シミュレーション / 輸送 / 基質 / ATP / ABCトランスポーター / 構造ダイナミクス / ホモ・ヘテロ / CFTR / 疎水性クラスター … More / 変異 / 生物物理 / 構造変化 / カップリングヘリックス … More Except Principal Investigator 多角体 / 細胞内結晶化 / タンパク質工学 / タンパク質結晶 / 創薬 / フェブキソスタット / 阻害剤 / 痛風治療薬 / キサンチン / 分子動力学 / 構造・機能予測 / 酸化還元酵素 / 発光センサ / 細胞機能 / 代謝 / 発光分子センサ / 自由行動動物 / 近赤外生物発光 / クリスタルエンジニアリング / 構造解析 / 結晶構造解析 / タンパク質集合体 / 嚢胞線維症 / CFTR / 高速原子間力顕微鏡 / １分子直接観察 / 分子間相互作用 / 抗原ー抗体反応 / 膜蛋白複合体 / ウイルス / 昆虫細胞 / 分子機械 / 自己集合 / 超分子化学 / BOF / ｷｻﾝﾁﾝ Less

自由行動動物の深部臓器における細胞応答の光イメージング
- Principal Investigator
  
  口丸高弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Jichi Medical University
Study for the mechanism of functional expression and dysfunction of membrane proteins through direct observations of single molecular fluctuation
- Principal Investigator
  
  Sohma Yoshiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  International University of Health and Welfare
In-cell syntheisi of protein crystal materials
- Principal Investigator
  
  Ueno Takafumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
In cell synthesis of multy-layer protein crystals
- Principal Investigator
  
  Ueno Takafumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Asymmetric dynamics of hetero dimeric ABC transporters explored by molecular simulationsPrincipal Investigator
- Principal Investigator
  
  Furuta Tadaomi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Tokyo Institute of Technology
The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF
- Principal Investigator
  
  Kikuchi Hiroto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Nippon Medical School
Elucidation of "rock-paper-scissors" mechanism of ABC transporters by molecular simulationsPrincipal Investigator
- Principal Investigator
  
  FURUTA TADAOMI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo Institute of Technology
The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system
- Principal Investigator
  
  KIKUCHI Hiroto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Nippon Medical School

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery2018
- Author(s)
  Tadaomi Furuta, Minoru Sakurai
- Total Pages
  353
- Publisher
  Springer
- ISBN
  9789811084591
- Data Source
  KAKENHI-PROJECT-15K00400
[Journal Article] Protein Needles Designed to Self‐Assemble through Needle Tip Engineering2022
- Author(s)
  Kikuchi Kosuke、Fukuyama Tatsuya、Uchihashi Takayuki、Furuta Tadaomi、Maeda Yusuke T.、Ueno Takafumi
- Journal Title
  
  Small
  
  Volume: 18 Issue: 10 Pages: 2106401-2106401
- DOI
  10.1002/smll.202106401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21244, KAKENHI-PLANNED-18H05421, KAKENHI-PLANNED-18H05427, KAKENHI-PUBLICLY-20H04669, KAKENHI-PUBLICLY-21H00393, KAKENHI-PROJECT-19H02830, KAKENHI-PROJECT-20H01872, KAKENHI-PROJECT-21H01772
[Journal Article] Single-molecule level dynamic observation of disassembly of the apo-ferritin cage in solution2020
- Author(s)
  Maity Basudev、Li Zhipeng、Niwase Kento、Ganser Christian、Furuta Tadaomi、Uchihashi Takayuki、Lu Diannan、Ueno Takafumi
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 22 Issue: 33 Pages: 18562-18572
- DOI
  10.1039/d0cp02069a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05421, KAKENHI-PUBLICLY-19H05389, KAKENHI-PUBLICLY-20H04669, KAKENHI-PROJECT-18H01837, KAKENHI-PROJECT-19H02830, KAKENHI-PROJECT-20K21244
[Journal Article] Dynamic behavior of an artificial protein needle contacting a membrane observed by high-speed atomic force microscopy2020
- Author(s)
  Ueno Takafumi、Niwase Kento、Tsubokawa Daisho、Kikuchi Kosuke、Takai Natsumi、Furuta Tadaomi、Kawano Ryuji、Uchihashi Takayuki
- Journal Title
  
  Nanoscale
  
  Volume: in press Issue: 15 Pages: 8166-8173
- DOI
  10.1039/d0nr01121e
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05421, KAKENHI-PROJECT-18K19143, KAKENHI-PROJECT-19H02830, KAKENHI-PUBLICLY-19H05382, KAKENHI-PUBLICLY-19H05389, KAKENHI-PUBLICLY-20H04669, KAKENHI-PROJECT-18H01837
[Journal Article] Development of an ATP force field for coarse‐grained simulation of ATPases and its application to the maltose transporter2019
- Author(s)
  Ryosuke Hirano, Tsubasa Yabuchi, Minoru Sakurai, Tadaomi Furuta
- Journal Title
  
  J. Comput. Chem.
  
  Volume: - Issue: 24 Pages: 2096-2102
- DOI
  10.1002/jcc.25861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K00400
[Journal Article] The mechanism of nucleotide‐binding domain dimerization in the intact maltose transporter as studied by all‐atom molecular dynamics simulations2018
- Author(s)
  Wei‐Lin Hsu Tadaomi Furuta Minoru Sakurai
- Journal Title
  
  Proteins
  
  Volume: 86 Issue: 2 Pages: 237-247
- DOI
  10.1002/prot.25433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PROJECT-16K12520, KAKENHI-PUBLICLY-16H00825
[Journal Article] Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR2018
- Author(s)
  Mitsuhiko Odera, Tadaomi Furuta, Yoshiro Sohma, Minoru Sakurai
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 15 Issue: 0 Pages: 33-44
- DOI
  10.2142/biophysico.15.0_33
- NAID
  130006337976
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PUBLICLY-16H00825, KAKENHI-PROJECT-16H05122
[Journal Article] Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA2017
- Author(s)
  Daiki Tatsumi, Kei Nanatani, Yuto Koike, Kiyoto Kamagata, Satoshi Takahashi, Ayumu Konno, Tadaomi Furuta, Minoru Sakurai, Nobuyuki Uozumi
- Journal Title
  
  Biochem. J.
  
  Volume: 474 Issue: 12 Pages: 1993-2007
- DOI
  10.1042/bcj20161051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PROJECT-16K07313, KAKENHI-PUBLICLY-16H00825, KAKENHI-PLANNED-25104007, KAKENHI-PLANNED-16H06558, KAKENHI-PROJECT-16H04906
[Journal Article] Analysis of an ATP-induced conformational transition of ABC transporter MsbA using a coarse-grained model2017
- Author(s)
  Naoki Arai, Tadaomi Furuta, Minoru Sakurai
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 14 Issue: 0 Pages: 161-171
- DOI
  10.2142/biophysico.14.0_161
- NAID
  130006243558
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PUBLICLY-16H00825
[Journal Article] Mechanism for the Transport of ABC Transporters by Experimental and Simulation Studies2016
- Author(s)
  古田忠臣、山口知宏、加藤博章、櫻井実
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 56 Issue: 1 Pages: 005-008
- DOI
  10.2142/biophys.56.005
- NAID
  130005121652
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PUBLICLY-26104511
[Journal Article] Thermal fluctuations enable rapid protein-protein associations inaqueous solution by lowering the reaction barrier2016
- Author(s)
  Honami Sakaizawa, Hiroshi C. Watanabe, Tadaomi Furuta, Minoru Sakurai
- Journal Title
  
  Chem. Phys. Lett.
  
  Volume: 643 Pages: 114-118
- DOI
  10.1016/j.cplett.2015.11.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PUBLICLY-26104511, KAKENHI-PROJECT-14J03041
[Journal Article] Kirkwood-Buff integrals for aqueous urea solutions based upon the quantum chemical electrostatic potential and interaction energies2016
- Author(s)
  S Chiba, T Furuta, S Shimizu
- Journal Title
  
  J. of Phys. Chem. B
  
  Volume: 120 Issue: 31 Pages: 7714-7723
- DOI
  10.1021/acs.jpcb.6b05611
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440081
[Journal Article] Structural Dynamics of the Heterodimeric ABC Transporter TM287/ 288 Induced by ATP and Substrate Binding2016
- Author(s)
  T. Furuta, Y. Sato, M. Sakurai
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 48 Pages: 6730-6738
- DOI
  10.1021/acs.biochem.6b00947
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00825, KAKENHI-PROJECT-15K00400
[Journal Article] ATP Hydrolysis Mechanism in a Maltose Transporter Explored by QM/MM Metadynamics Simulation2016
- Author(s)
  W.-L. Hsu, T. Furuta, and M. Sakurai
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 120 Issue: 43 Pages: 11102-11112
- DOI
  10.1021/acs.jpcb.6b07332
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00825, KAKENHI-PROJECT-15K00400
[Journal Article] Analysis of the free energy landscapes for the opening-closing dynamics of the maltose transporter ATPase MalK2 using enhanced-sampling molecular dynamics simulation2015
- Author(s)
  Wei-Lin Hsu, Tadaomi Furuta, Minoru Sakurai
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 119 Issue: 30 Pages: 9717-9725
- DOI
  10.1021/acs.jpcb.5b05432
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PUBLICLY-26104511
[Journal Article] Analysis of the structural and functional roles of coupling helices in the ATP-binding cassette transporter MsbA through enzyme assays and molecular dynamics simulations2014
- Author(s)
  Furuta, T., Yamaguchi, T., Kato, H., Sakurai, M.
- Journal Title
  
  Biochemistry
  
  Volume: 53 Issue: 26 Pages: 4261-4272
- DOI
  10.1021/bi500255j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25251006, KAKENHI-PROJECT-25870220, KAKENHI-PUBLICLY-26102724, KAKENHI-PROJECT-26670014, KAKENHI-PROJECT-26840048
[Journal Article] The Tryptophan Residue at the Active Site Tunnel Entrance of Trichoderma reesei Cellobiohydrolase Ce17A Is Important for Initiation of Degradation of Crystalline Cellulose2013
- Author(s)
  Akihiko Nakamura, Tsukada, T., Auer, S., Furuta, T., Wada, M., Koivula, A., Igarashi, K. and Samejima M.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 19 Pages: 13503-13510
- DOI
  10.1074/jbc.m113.452623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J07574, KAKENHI-PROJECT-23570198, KAKENHI-PLANNED-24114008, KAKENHI-PROJECT-24380089
[Journal Article] Dynamics and structural changes induced by ATP and/or substrate binding in the inward-facing conformation state of P-glycoprotein2013
- Author(s)
  Y. Watanabe
- Journal Title
  
  Chem. Phys. Left
  
  Volume: 557 Pages: 145-149
- DOI
  10.1016/j.cplett.2012.12.040
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-23570198
[Journal Article] The Power Stroke Driven by ATP Binding in CFTR As Studied by by ATP Binding in CFTR As Studied by Molecular Dynamics Simulations2013
- Author(s)
  T. Furukawa-Hagiya
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 117 Issue: 1 Pages: 83-93
- DOI
  10.1021/jp308315w
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-22590212, KAKENHI-PUBLICLY-23118714, KAKENHI-PROJECT-23570198
[Journal Article] The tryptophan redidue at the active site tunnel entrance of Trichoderma reesei cellobiohydrolase Cel7A is important for initiation of degradation of crystalline cellulose2013
- Author(s)
  A. Nakamura, T. Tsukada, S. Auer, T. Furuta, M. Wada, A. Koivula, K. Igarashi, M. Samejima.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 13403-13510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] Minimum Free Energy Path of Ligand-Induced Transition in Adenylate Kinase2012
- Author(s)
  Y. Matsunaga, H. Fujisaki, T. Terada, T. Furuta, K. Moritsugu, and A. Kidera
- Journal Title
  
  PLoS Comput. Biol
  
  Volume: 8 Issue: 6 Pages: 12-12
- DOI
  10.1371/journal.pcbi.1002555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22540421, KAKENHI-PROJECT-23247027, KAKENHI-PROJECT-23540454, KAKENHI-PROJECT-23570198, KAKENHI-PROJECT-24770159
[Journal Article] Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics2012
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K.Okamoto, S. Leimkuhler, and T. Nishino
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 331-331
- DOI
  10.1038/srep00331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22540421, KAKENHI-PROJECT-23570198
[Journal Article] 理論生物物理と生化学を組み合わせた薬物研究―キサンチン酸化還元酵素と阻害剤フェブキソスタットの結合機序―2012
- Author(s)
  藤崎弘士, 古田忠臣, 岡本研, 菊地浩人
- Journal Title
  
  日本医科大学医学会誌
  
  Volume: 8 Pages: 222-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] 理論生物物理と生化学を組み合わせた薬効研究―キサンチン酸化還元酵素と阻害剤フェブキソスタットの結合機序―2012
- Author(s)
  藤崎弘士, 古田忠臣, 岡本研, 菊地浩人
- Journal Title
  
  日本医科大学医学会誌
  
  Volume: 8 Pages: 222-227
- NAID
  130004471511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Therapeutic drugs developed for CFTR mutants found in Caucasian Cystic Fibrosis patients also succeeded to rescue CFTR mutants found in Japanese patients.2022
- Author(s)
  君島莉央、相馬光流、中川大、古田忠臣、石黒洋、中尾香菜子、相馬義郎
- Organizer
  日本生理学会第100回記念大会　国立京都国際会館
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] Dynamics structural analysis of miniprotein by in-cell crystal engineering2022
- Author(s)
  Mariko Kojima, Yuki Hishikawa, Satoshi Abe, Tadaomi Furuta, Duy Phuoc Tran, Akio Kitao, Takafumi Ueno
- Organizer
  102nd CSJ Annual Meeting
- Data Source
  KAKENHI-PROJECT-19H02830
[Presentation] AbbVie 第Ⅱ相治験薬 Galicaftor の日本人型病因性CFTR変異体への効果2022
- Author(s)
  小川亜美、小川未裕、石塚柊太、大塚悠花、黒澤歩実、小林可奈、齋藤佑香、髙橋柚妃、植松咲貴、中島乃愛、君島莉央、相馬光流、中尾香菜子、中川大、古田忠臣、相馬義郎
- Organizer
  第8回嚢胞性線維症情報交換会　名古屋大学鶴友会館
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] タンパク質分子針の末端設計による二次元集合パターン制御2021
- Author(s)
  菊池幸祐, 福山達也, 古田忠臣, 前多裕介, 内橋貴之, 上野隆史
- Organizer
  The 70th SPSJ Annual Meeting
- Data Source
  KAKENHI-PROJECT-19H02830
[Presentation] βヘリックスタンパク質分子針の末端設計による二次元集合制御2021
- Author(s)
  菊池幸祐, 福山達也, 古田忠臣, 内橋貴之, 前多裕介, 上野隆史
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H02830
[Presentation] Energy Analysis of Miniprotein by in Vivo Protein Crystallization2021
- Author(s)
  小島摩利子, 菱川湧輝, 安部聡, 古田忠臣, Tran Phuoc Duy, 北尾彰朗, 上野隆史
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19H02830
[Presentation] β-ヘリックス人工分子針の動的集合設計2021
- Author(s)
  菊池幸祐, 福山達也, Maity Basudev, 古田忠臣, 前多裕介, 内橋貴之, 上野隆史
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19H02830
[Presentation] タンパク質分子針の末端構造設計による二次元集合パターン制御2021
- Author(s)
  菊池幸祐, 福山達也, 古田忠臣, 前多裕介, 内橋貴之, 上野隆史
- Organizer
  第１回発動分子科学研究会
- Data Source
  KAKENHI-PROJECT-19H02830
[Presentation] Development of an ATP force field for coarse-grained simulation of ATPases and its application to the maltose transporter2019
- Author(s)
  Ryosuke Hirano, Tsubasa Yabuchi, Minoru Sakurai, Tadaomi Furuta
- Organizer
  The 63rd Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] MDシミュレーションを用いたグルコーストランスポーター8(GLUT8)の膜貫通ヘリックス7(TM7)に関する解析2018
- Author(s)
  中田康太, 古田忠臣, 櫻井実
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] ABCトランスポーターにおけるヌクレオチドドメイン2量体化の駆動力に関する計算化学的解析2018
- Author(s)
  境澤穂波, 許維麟, 古田忠臣, 櫻井実
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] ABCトランスポーターCFTRの構造変化及び基質輸送機構の計算化学的解析2018
- Author(s)
  千葉一輝, 古田忠臣, 櫻井実
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 転写制御因子LmrRおよびQacRにおける多剤認識メカニズムに関する分子シミュレーション研究2018
- Author(s)
  クライヤー篠塚一穂, 古田忠臣, 櫻井実
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 粗視化MDシミュレーションを用いたATP結合により誘起されるマルトーストランスポーターの構造変化の解析2018
- Author(s)
  平野諒輔, 古田忠臣, 櫻井実
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] Structural and Functional dynamics of ABC transporters explored by molecular simulations2018
- Author(s)
  Tadaomi Furuta
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 親水性タンパク質ータンパク質間会合の駆動力に関するMD及び3D-RISM計算2017
- Author(s)
  境澤穂波, 古田忠臣, 櫻井実
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] Martini 力場を用いた粗視化シミュレーションによるCl-チャネルCFTRのダイナミクスの解析2017
- Author(s)
  矢渕翼, 南條舜, 古田忠臣, 櫻井実
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 多剤認識転写因子LmrRにおける薬剤分子認識機構の計算化学的解析2016
- Author(s)
  クライヤー篠塚一帆、古田忠臣、櫻井実
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 分子シミュレーションで探るABCトランスポーターの機能的ダイナミクス2016
- Author(s)
  古田忠臣
- Organizer
  大阪大学蛋白質研究所セミナー「膜タンパク質の構造ダイナミクス」
- Place of Presentation
  大阪大学蛋白質研究所（大阪府吹田市）
- Year and Date
  2016-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] ヒトには効くがバクテリアには効かない痛風薬　ー酵素と阻害剤BOFとの相互作用ダイナミクスー2016
- Author(s)
  菊地浩人、藤崎弘士、古田忠臣、岡本研、西野武士
- Organizer
  日本物理学会2016年秋季大会
- Place of Presentation
  金沢大学角間キャンパス
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] MDシミュレーションによるCFTRチャネルの基質輸送機構及び変異による影響の解析2016
- Author(s)
  古田忠臣、南條舜、相馬義朗、櫻井実
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 多剤認識転写因子LmrRにおける薬剤分子認識機構の計算化学的解析2016
- Author(s)
  クライヤー篠塚一帆、古田忠臣、櫻井実
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] QM/MM Metadynamicsで探るマルトーストランスポーターのATP加水分解メカニズム2016
- Author(s)
  許維麟、古田忠臣、櫻井実
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] キサンチン酸化還元酵素基質結合ポケットの動的解析2016
- Author(s)
  岡本研、菊地浩人、藤崎弘士、古田忠臣、西野武士
- Organizer
  第49回日本痛風・核酸代謝学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-02-18
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] Molecular dynamics investigation of the full maltose transporter with and without the maltose binding protein MalE2016
- Author(s)
  許維麟、古田忠臣、櫻井実
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 熱ゆらぎと水和効果に着目したABCトランスポーターのNBD二量体化過程の統計熱力学的解析2015
- Author(s)
  境澤穂波、渡邉宙志、古田忠臣、櫻井実
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館(金沢市)
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 熱ゆらぎと水和効果に着目したABCトランスポーターのNBD二量体化過程の統計熱力学的解析2015
- Author(s)
  境澤穂波, 渡邉宙志, 古田忠臣, 櫻井実
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール(徳島市)
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] 3D-RISM study of water-meditated forces between the nucleotide binding domains responsible for the power stroke in an ABC transporter2015
- Author(s)
  Tomoka Furukawa-Hagiya, Norio Yoshida, Shuntaro Chiba, Tomohiko Hayashi, Tadaomi Furuta, Minoru Sakurai
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
- Place of Presentation
  Hawaii Convention Center, Honolulu, Hawaii, U.S.A.(ホノルル)
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] キサンチン酸化還元酵素の基質ガイド機構の解析2015
- Author(s)
  岡本研、菊地浩人、藤崎弘士、古田忠臣、西野武士
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] On the motion of a loop located in the entrance to the ligand-binding pocket of bacterial XOR with the inhibitor BOF2015
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, T. Nishino.
- Organizer
  53rd Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Kanazawa
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] Free energy calculation for the ATP-induced dimerization of the nucleotide-binding domains in a maltose transporter: Importance of the water-mediated entropic force2015
- Author(s)
  Tomohiko Hayashi, Shuntaro Chiba, Tadaomi Furuta, Minoru Sakurai
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
- Place of Presentation
  Hawaii Convention Center, Honolulu, Hawaii, U.S.A.(ホノルル)
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] Analysis of the free energy landscape for the open-close dynamics of maltose transporter ATPase, MalK, using enhanced sampling MD simulation2015
- Author(s)
  Wei-Lin Hsu, Tadaomi Furuta, Minoru Sakurai
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
- Place of Presentation
  Hawaii Convention Center, Honolulu, Hawaii, U.S.A.(ホノルル)
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] Analysis of the Free Energy Landscapes for the Open-Closing Dynamics of MalK2 Using Enhanced Sampling MD Simulation2015
- Author(s)
  許維麟, 古田忠臣, 櫻井実
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス自然科学本館(金沢市)
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] Structural and functional roles of coupling helices in ABC transporter MsbA: Experimental and computational studies2015
- Author(s)
  Tadaomi Furuta, Tomohiro Yamaguchi, Hiroaki Kato, Minoru Sakurai
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
- Place of Presentation
  Hawaii Convention Center, Honolulu, Hawaii, U.S.A.(ホノルル)
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00400
[Presentation] Elastic Network Modelを用いたABCトランスポーターのglobal motionの解析2014
- Author(s)
  荒井直樹, 古田忠臣, 櫻井実
- Organizer
  第52回日本生物物理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] MDシミュレーションを用いたマウスと線虫のABCB1トランスポーターの動的性質の解析2014
- Author(s)
  西本達志、古田忠臣、櫻井実
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜産貿ホールマリネリア
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] MDシミュレーションで探るマルトーストランスポーターATPアーゼ（MalK）のダイナミクスと構造変化2014
- Author(s)
  許維麟、古田忠臣、櫻井実
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜産貿ホールマリネリア
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] MDシミュレーションで探るマルトーストランスポーターATPアーゼ（MalK）のダイナミクスと構造変化2014
- Author(s)
  許維麟, 古田忠臣, 櫻井実
- Organizer
  第52回日本生物物理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] Elastic Network Modelを用いたABCトランスポーターのglobal motionの解析2014
- Author(s)
  荒井直樹、古田忠臣、櫻井実
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜産貿ホールマリネリア
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] MDシミュレーションを用いたマウス・線虫ABCB1トランスポーターの構造・ダイナミクスの解析2014
- Author(s)
  西本達志, 古田忠臣, 櫻井実
- Organizer
  第52回日本生物物理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] Molecular Dynamics and Free Energy Analysis of Xanthine Oxidoreductase-Ligand Interactions2013
- Author(s)
  K. Okamoto, H. Kikuchi, H. Fujisaki, T. Furuta, S. Leimkuhler, and T. Nishino.
- Organizer
  2013 Molybdenum & Tungsten Enzymes Conference
- Place of Presentation
  Sintra (Portugal)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Mutation studies on the mammalian and the bacterial XORs with inhibitors2013
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, T. Nishino
- Organizer
  The 51st Annual meeting of the Biophysics Society of Japan
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Mutation studies on the mammalian and the bacterial XORs with inhibitors2013
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, and T. Nishino.
- Organizer
  The 51^<st> Annual Meeting of the Biophysics society of japan
- Place of Presentation
  Kyoto (Jpn)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Molecular dynamics simulations and binding free energy analysis of xanthine oxidoreductase-ligand complexes2012
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, and T. Nishino.
- Organizer
  The 50^<st> Annual Meeting of the Biophysics society of Japan
- Place of Presentation
  Nagoya (Japan)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Molecular dynamics and free energy analysis of xanthine oxidoreductase-ligand interactions2012
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, and T. Nishino.
- Organizer
  TACC 2012 Theory and Applications of Computational Chemistry
- Place of Presentation
  Pavia (Italy)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] 抗痛風薬フェブキソスタットとキサンチン酸化還元酵素との相互作用の解析2012
- Author(s)
  岡本研, 菊地浩人, 藤崎弘士, 古田忠臣, 西野武士
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] キサンチン酸化還元酵素に対するファブキソスタットの阻害作用2011
- Author(s)
  菊地浩人, 藤崎弘士, 古田忠臣, 岡本研, 西野武士
- Organizer
  日本物理学会2011年秋季大会
- Place of Presentation
  富山大学
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] キサンチン酸化還元酵素に対するフェブキソスタットの阻害作用2011
- Author(s)
  菊地浩人、藤崎弘士、古田忠臣、岡本研、西野武士
- Organizer
  日本物理学会2011年秋季大会
- Place of Presentation
  富山大学
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Structure-based inhibitor mechanism of febuxostat for xanthine oxidoreductase : molecular dynamics study2011
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, S. Leimkuhler, and T. Nishino.
- Organizer
  Ninth Triennial Congress of the World Association of Theoretical and Computational Chemists
- Place of Presentation
  Santiago de Compostela (Spain)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Structure-based inhibitor mechanism of febuxostat for xanthine oxidoreductase: molecular dynamics study2011
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, S. Leimkuhler, and T. Nishino
- Organizer
  Ninth Triennial Congress of the World Association of Theoretical and Computational Chemists
- Place of Presentation
  Santiago de Compostela, Spain
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] ABCトランスポーターのヌクレオチド結合ドメイン二量体化の理論的解析―ATPと水の役割
- Author(s)
  林智彦、萩谷朋佳、千葉峻太朗、古田忠臣、吉田紀生、櫻井実
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] 分子動力学シミュレーションで探るCFTRにおける変異の影響
- Author(s)
  小寺充彦、萩谷朋佳、古田忠臣、相馬義郎、櫻井実
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] 分子動力学シミュレーションを用いたABCトランスポーターTM287/288におけるATP・基質結合による構造変化
- Author(s)
  佐藤雪子、古田忠臣、櫻井実
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25870220
[Presentation] The loop opening motion of the bacterial XOR with the inhibitor BOF: molecular dynamics study
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, T. Nishino
- Organizer
  10th Congress of the World Association of Theoretical and Computational Chemists
- Place of Presentation
  Santiago, Chile
- Year and Date
  2014-10-05 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] The gate opening motion of xanthine binding pocket of XOR
- Author(s)
  K. Okamoto, H. Kikuchi, H. Fujisaki, T. Furuta, S. Leimkühler, T. Nishino
- Organizer
  International simposium of Flavins and Flavoproteins
- Place of Presentation
  Phechaburi, Thailand
- Year and Date
  2014-07-27 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26440081

1. KIKUCHI Hiroto (00224907)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. OKAMOTO Ken (60267143)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
3. FUJISAKI Hiroshi (60573243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. Ueno Takafumi (70332179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. Sohma Yoshiro (60268183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 森肇 (80201812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 内橋貴之 (30326300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中川大 (40397039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 岩本真幸 (40452122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大崎寿久 (50533650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山下恵太郎 (20721690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 口丸高弘 (10570591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岩野智 (10734832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 花岡健二郎 (70451854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山口知宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 加藤博章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 桜井実

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Furuta Tadaomi 古田 忠臣

FURUTA Tadaomi 古田 忠臣

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自由行動動物の深部臓器における細胞応答の光イメージング

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Study for the mechanism of functional expression and dysfunction of membrane proteins through direct observations of single molecular fluctuation

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In-cell syntheisi of protein crystal materials

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In cell synthesis of multy-layer protein crystals

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Asymmetric dynamics of hetero dimeric ABC transporters explored by molecular simulationsPrincipal Investigator

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The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF

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Elucidation of "rock-paper-scissors" mechanism of ABC transporters by molecular simulationsPrincipal Investigator

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The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system

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[Book] The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery2018

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[Journal Article] Protein Needles Designed to Self‐Assemble through Needle Tip Engineering2022

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[Journal Article] Single-molecule level dynamic observation of disassembly of the apo-ferritin cage in solution2020

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[Journal Article] Dynamic behavior of an artificial protein needle contacting a membrane observed by high-speed atomic force microscopy2020

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[Journal Article] Development of an ATP force field for coarse‐grained simulation of ATPases and its application to the maltose transporter2019

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[Journal Article] The mechanism of nucleotide‐binding domain dimerization in the intact maltose transporter as studied by all‐atom molecular dynamics simulations2018

Furuta Tadaomi 古田忠臣

FURUTA Tadaomi 古田忠臣