FUJIMOTO Takahiro 藤本崇宏

… Alternative Names

TAKAHIRO Fujimoto 藤本崇宏

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Researcher Number	10446114
Other IDs	https://orcid.org/0000-0002-9975-7008
Affiliation (Current)	2024: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2016 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2013 – 2015: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2012: 福岡大学, 医学部, 講師 2009 – 2010: Fukuoka University, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Chemical biology / Pathological medical chemistry Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator Dp71 / ジストロフィン / リン酸化 / 分子間相互作用 / ジストログリカン / 会合蛋白 / 癌 / てんかん / 分子複合体 / シナプス … More / タグ挿入マウス / アストロサイト / BBB / 血液脳関門 / 神経筋疾患 / カリウムチャネル / 水チャネル / グリア / 小脳 / DMD / 分子ネットワーク / 中枢神経症状 / BioID / 動物モデル / 蛋白安定化 / 蛋白相互作用 / 分子病態 / 膜局在化 / 点変異 / モデル細胞 / 分子機序 / 知的障害 / 脳神経細胞 / プロテアソーム / 蛋白分解 / バイオプローブ / 化合物 / 翻訳後修飾 / リンパ球 / カルシウムイオンシグナル / 分子標的 / 結合蛋白質 / トランスジェニックマウス / 細胞生物学 / 分子生物学 / 結合蛋白 / KRAP … More Except Principal Investigator 脳オルガノイド / 神経幹・前駆細胞 / 脳形成異常 / 胎児医学 / 子宮内電気穿孔法 / 体細胞モザイク / 治療標的分子 / タナトフォリック骨異形成症 / 白血病阻害因子 / ヒト神経幹・前駆細胞 / 脳形成異常脳形成異常 / 繊毛病 / 一次繊毛 Less

Molecular pathogenesis of brain malformations in de novo postzygotic mutations in the brain
- Principal Investigator
  
  伊東恭子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Functional analysis of dystrophin in blood-brain barrier and its relevance to epilepsyPrincipal Investigator
- Principal Investigator
  
  藤本崇宏
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidation of molecular pathomechanisms and the search for therapeutic targets of brain malformations, by employing cerebral organoids generated from patients-derived neural stem/progenitor cells
- Principal Investigator
  
  Itoh Kyoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular analysis of brain-type dystrophin to understand dystrophinopahy-related neurological disorderPrincipal Investigator
- Principal Investigator
  
  Fujimoto Takahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Degradation mechanism of dystrophin short isoform, Dp71Principal Investigator
- Principal Investigator
  
  Fujimoto Takahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of the molecular interaction between KRAP and IP3R and its application for drug discoveryPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Takahiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto Prefectural University of Medicine
  Fukuoka University
Establishment of KRAP-transgenic mice and elucidation of KRAP function in cancerPrincipal Investigator
- Principal Investigator
  
  TAKAHIRO Fujimoto
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fukuoka University

All 2023 2022 2020 2018 2017 2016 2013 2012 2010 2009

All Journal Article Presentation Patent

[Journal Article] Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons2023
- Author(s)
  Fujimoto T, Stam K, Yaoi T, Nakano K, Arai T, Okamura T, Itoh K.
- Journal Title
  
  Molecular Neurobiology
  
  Volume: - Issue: 7 Pages: 3664-3677
- DOI
  10.1007/s12035-023-03296-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07279
[Journal Article] Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans2022
- Author(s)
  Fujimoto Takahiro、Yaoi Takeshi、Nakano Kenta、Arai Tetsuya、Okamura Tadashi、Itoh Kyoko
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 79 Issue: 2 Pages: 109-109
- DOI
  10.1007/s00018-022-04151-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07279
[Journal Article] Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.2020
- Author(s)
  Fujimoto T, Yaoi T, Tanaka H, Itoh K.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 29(19) Issue: 19 Pages: 3312-3326
- DOI
  10.1093/hmg/ddaa217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07883
[Journal Article] Serotonin induces Arcadlin in hippocampal neurons2020
- Author(s)
  Tanaka Hidekazu、Sawano Toshinori、Konishi Naoko、Harada Risako、Takeuchi Chiaki、Shin Yuki、Sugiura Hiroko、Nakatani Jin、Fujimoto Takahiro、Yamagata Kanato
- Journal Title
  
  Neuroscience Letters
  
  Volume: 721 Pages: 134783-134783
- DOI
  10.1016/j.neulet.2020.134783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02536, KAKENHI-PROJECT-18K07883
[Journal Article] Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.2017
- Author(s)
  Fujimoto T, Yaoi T, Fushiki S, Itoh K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 492(3) Issue: 3 Pages: 349-355
- DOI
  10.1016/j.bbrc.2017.08.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09629
[Journal Article] HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab.2016
- Author(s)
  Nishida A, Yasuno S, Takeuchi A, Awano H, Lee T, Niba ET, Fujimoto T, Itoh K, Takeshima Y, Nishio H, Matsuo M.
- Journal Title
  
  Histochem Cell Biol.
  
  Volume: 146 Issue: 3 Pages: 301-309
- DOI
  10.1007/s00418-016-1439-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09629
[Journal Article] Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux.2013
- Author(s)
  Matsuzaki H, Fujimoto T, Tanaka M, Shirasawa S.
- Journal Title
  
  Biochem Bio- phys Res Commun
  
  Volume: 433(3) Issue: 3 Pages: 322-326
- DOI
  10.1016/j.bbrc.2013.02.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24710265
[Journal Article] Tespa1 protein is phosphorylated in response to store-operated calcium entry.2013
- Author(s)
  Fujimoto T, Matsuzaki H, Tanaka M, Shirasawa S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 434 Pages: 162-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710265
[Journal Article] Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.2012
- Author(s)
  Fujimoto T.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 30(6) Issue: 6 Pages: 1287-1293
- DOI
  10.3892/ijmm.2012.1126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-24710265
[Journal Article] Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes.2012
- Author(s)
  Matsuzaki H, Fujimoto T, Ota T, Ogawa M, Tsunoda T, Doi K, Hamabashiri M, Tanaka M, Shirasawa S
- Journal Title
  
  FEBS Open Bio
  
  Volume: 2 Pages: 255-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710265
[Journal Article] Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice2009
- Author(s)
  Takahiro Fujimoto
- Journal Title
  
  PLoS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790331
[Patent] イノシトール-1, 4, 5-トリスリン酸受容体結合タンパク質およびそれを含むトランスジェニック非ヒト哺乳動物2009
- Inventor(s)
  藤本崇宏、白澤専二
- Industrial Property Rights Holder
  学校法人福岡大学
- Industrial Property Number
  2009-225596
- Filing Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-21790331
[Presentation] ジストロフィン分子機能の理解に立脚したデュシェンヌ型筋ジストロフィー機序解明を目指して2022
- Author(s)
  藤本崇宏
- Organizer
  第63回日本神経病理学会総会学術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07279
[Presentation] ジストロフィン遺伝子産物Dp71の脳における役割2022
- Author(s)
  藤本崇宏
- Organizer
  第９回筋ジストロフィーのCNS障害研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07279
[Presentation] Dystrophin short isoform, Dp71, is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells2018
- Author(s)
  T. Fujimoto, K. Itoh
- Organizer
  11th FENS Forum of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07883
[Presentation] Dystrophin short isoform, Dp71, is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells2018
- Author(s)
  T. Fujimoto, T. Yaoi, S. Fushiki, K. Itoh
- Organizer
  22nd Biennial Meeting of the International Society of Developmental Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07883
[Presentation] ジストロフィン遺伝子産物であるDp71はリン酸化とユビキチンプロテアソーム系によって発現制御される2017
- Author(s)
  藤本崇宏、矢追毅、伏木信次、伊東恭子
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K09629
[Presentation] 脳型ジストロフィンの分子病態解析に基づく知的障害治療法の探索2017
- Author(s)
  藤本　崇宏、伊東　恭子
- Organizer
  第120回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09629
[Presentation] 脳型ジストロフィンの分子病態解析に基づく知的障害治療法の探索2017
- Author(s)
  藤本崇宏、伊東恭子
- Organizer
  第120回　日本小児科学会学術集会
- Place of Presentation
  東京・品川・グランドプリンスホテル新高輪
- Year and Date
  2017-04-14
- Data Source
  KAKENHI-PROJECT-15K09629
[Presentation] 癌・代謝関連遺伝子KRAPの細胞内カルシウムイオン制御機構に関する研究2012
- Author(s)
  藤本崇宏、白澤専二
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24710265
[Presentation] 新たな肥満・糖尿病治療標的としてのKRAP遺伝子2010
- Author(s)
  藤本崇宏、白澤専二
- Organizer
  第2回福岡県医学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-01-31
- Data Source
  KAKENHI-PROJECT-21790331
[Presentation] 新たな肥満・糖尿病治療標的としてのKRAP遺伝子2010
- Author(s)
  藤本崇宏
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  大宮ソニックシティ(埼玉市)
- Year and Date
  2010-10-28
- Data Source
  KAKENHI-PROJECT-21790331
[Presentation] 新たな肥満・糖尿病治療標的としてのKRAP遺伝子2010
- Author(s)
  藤本崇宏、宮坂京子、白澤専二
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  埼玉
- Year and Date
  2010-10-28
- Data Source
  KAKENHI-PROJECT-21790331
[Presentation] Altered Energy Homeostasis and Resistance to Diet-Induced Obesity in KRAP-Deficient Mice2009
- Author(s)
  藤本崇宏、宮坂京子、笹月健彦、加藤規弘、白澤専二
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21790331

1. Itoh Kyoko (80243301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 伏木信次 (80150572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 田中秀和 (70273638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 白澤専二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山形要人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIMOTO Takahiro 藤本 崇宏

TAKAHIRO Fujimoto 藤本 崇宏

Research Projects

Research Products

Co-Researchers

Molecular pathogenesis of brain malformations in de novo postzygotic mutations in the brain

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of dystrophin in blood-brain barrier and its relevance to epilepsyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular pathomechanisms and the search for therapeutic targets of brain malformations, by employing cerebral organoids generated from patients-derived neural stem/progenitor cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular analysis of brain-type dystrophin to understand dystrophinopahy-related neurological disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Degradation mechanism of dystrophin short isoform, Dp71Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the molecular interaction between KRAP and IP3R and its application for drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of KRAP-transgenic mice and elucidation of KRAP function in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dystroglycan regulates proper expression, submembranous localization and subsequent phosphorylation of Dp71 through physical interaction.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serotonin induces Arcadlin in hippocampal neurons2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dp71 is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HEK293 cells express dystrophin Dp71 with nucleus-specific localization of Dp71ab.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux.2013

Author(s)

Journal Title

FUJIMOTO Takahiro 藤本崇宏

TAKAHIRO Fujimoto 藤本崇宏