Yanagisawa Tatsuo 柳沢達男

… Alternative Names

YANAGISAWA Tatsuo 柳沢達男

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Researcher Number	10450420
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2025: 順天堂大学, 医学部, 非常勤助教
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2019: 順天堂大学, 医学部, 非常勤助教 2018: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2017: 理化学研究所, 横山構造生物学研究室, 研究員 2015 – 2017: 国立研究開発法人理化学研究所, 横山構造生物学研究室, 研究員 … More 2014: 理化学研究所, 横山構造生物学教室, 研究員 2013 – 2014: 独立行政法人理化学研究所, 横山構造生物学研究室, 研究員 2012: 独立行政法人理化学研究所, その他部局等, 研究員 2009 – 2011: 独立行政法人理化学研究所, システム研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Chemistry related to living body / Basic Section 43020:Structural biochemistry-related / Bio-related chemistry Except Principal Investigator Bacteriology (including mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator 翻訳後修飾 / tRNA / アミノアシルtRNA合成酵素 / 翻訳 / ケミカルバイオロジー / タンパク質 / 非天然型アミノ酸 / バイオテクノロジー / ピロリジン / クロスリンカー … More / クライオ電子顕微鏡解析 / 転写終結 / RNAポリメラーゼII / 転写 / 蛋白質 / 酵素 / 細菌 / X線結晶構造解析 / 抗生物質 / 病原性細菌 / ピロリジルtrNA合成酵素 / ピロリジルtRNA合成酵素 / ピロリジル-tRNA合成酵素 / 有用性官能基 / アミノアシル-tRNA合成酵素 … More Except Principal Investigator 感染 / 髄膜炎菌 / 脳血管内皮細胞 / 莢膜多糖体合成遺伝子 / 臨床分離株 / アミノ酸 / ヒト脳血管内皮細胞 / グルタチオン / ヒト培養細胞 / システイン / 細胞内 / ヒト / 病原性 / 侵入 / ヒト内皮細胞 / 転写後制御 / 宿主細胞侵入 / 細胞侵入 / トランスポーター / グルタミン酸 / Neisseria meningitidis Less

Structural basis of RNA processing coupled to transcription terminationPrincipal Investigator
- Principal Investigator
  
  柳沢達男
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Structural biochemistry of translation-related proteins from pathogenic bacteriaPrincipal Investigator
- Principal Investigator
  
  Yanagisawa Tatsuo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Juntendo University
  Institute of Physical and Chemical Research
Identification of meningococcal virulence factors and the expression profile by using clinical isolates
- Principal Investigator
  
  Takahashi Hideyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institute of Infectious Diseases
Chemical biology using the protein-introduced unnatural lysine derivatives as probesPrincipal Investigator
- Principal Investigator
  
  Yanagisawa Tatsuo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Institute of Physical and Chemical Research
Systematic analyses of signal transduction systems on GltT-GltM glutamate transporter mediated invasion into the host cell in Neisseria meningitidis
- Principal Investigator
  
  TAKAHASHI Hideyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  National Institute of Infectious Diseases
Site-specific incorporation of non-natural amino acids into proteins by using pyrrolysyl-tRNA synthetasePrincipal Investigator
- Principal Investigator
  
  YANAGISAWA Tatsuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The Institute of Physical and Chemical Research

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] 翻訳因子EF-Pのアミノアシル化とラムノシル化2019
- Author(s)
  柳沢達男
- Total Pages
  6
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-16K05859
[Book] 糖転移酵素EarPによる翻訳因子EF-PのArgのラムノシル化の構造的な基盤2018
- Author(s)
  仙石徹、横山茂之、柳沢達男
- Publisher
  新着論文レビュー
- Data Source
  KAKENHI-PROJECT-16K05859
[Book] Photon Factory Activity Report Research Highlights 20102011
- Author(s)
  T. Yanagisawa, T. Sumida, S. Yokoyama
- Total Pages
  1
- Publisher
  The Crystal Structure of Translation Elongation Factor P (EF-P) Complexed with An Aminoacyl-tRNA Synthetase Paralog, GenX, Reveals that EF-P Functionally Mimics Transfer RNA
- Data Source
  KAKENHI-PROJECT-21550167
[Book] SPring-8 Research Frontiers 20102011
- Author(s)
  T. Yanagisawa, T. Sumida, S. Yokoyama
- Total Pages
  1
- Publisher
  Structure and function of a protein mimicking transfer RNA revealed from the structure of translation elongation factor P complexed with an aminoacyl-tRNA synthetase paralog, GenX.
- Data Source
  KAKENHI-PROJECT-21550167
[Book] 化学と生物2011
- Author(s)
  柳沢達男、澄田智美、横山茂之
- Total Pages
  4
- Publisher
  転移RNAを擬態する大腸菌翻訳因子EF-Pのアミノアシル化修飾-抗菌薬ターゲットとしての可能性に期待-
- Data Source
  KAKENHI-PROJECT-21550167
[Book] SPring-8 Research Frontiers 2010 : Structure and Function of a Protein Mimicking transfer RNA Revealed from the Structure of Translation Elongation Factor P Complexed with an Aminoacyl-tRNA Synthetase Paralog, GenX2011
- Author(s)
  柳沢達男、澄田智美、横山茂之
- Total Pages
  2
- Publisher
  SPring-8
- Data Source
  KAKENHI-PROJECT-21550167
[Book] RIKEN Research : Copycat protein finds a perfect match核酸と瓜二つのタンパク質2010
- Author(s)
  柳沢達男、澄田智美、横山茂之
- Total Pages
  1
- Publisher
  理化学研究所
- Data Source
  KAKENHI-PROJECT-21550167
[Book] ライフサイエンス新着論文レビュー:リジル-tRNA合成酵素パラログGenX-YjeKシステムによる翻訳因子EF-Pのリジル化修飾2010
- Author(s)
  柳沢達男、横山茂之
- Total Pages
  3
- Publisher
  ライフサイエンス統合データベースセンター
- Data Source
  KAKENHI-PROJECT-21550167
[Journal Article] Fully productive cell-free genetic code expansion with structure-based engineering of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus2020
- Author(s)
  Eiko Seki, Tatsuo Yanagisawa, Mitsuo Kuratani, Kensaku Sakamoto, and Shigeyuki Yokoyama
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 9 Issue: 4 Pages: 718-732
- DOI
  10.1021/acssynbio.9b00288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05859
[Journal Article] 翻訳因子EF-Pのアミノアシル化とラムノシル化2019
- Author(s)
  柳沢達男
- Journal Title
  
  生化学総説（みにれびゅー）
  
  Volume: 91 Pages: 91-95
- NAID
  40021833039
- Data Source
  KAKENHI-PROJECT-16K05859
[Journal Article] Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase2019
- Author(s)
  Yanagisawa Tatsuo、Kuratani Mitsuo、Seki Eiko、Hino Nobumasa、Sakamoto Kensaku、Yokoyama Shigeyuki
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 26 Issue: 7 Pages: 1-14
- DOI
  10.1016/j.chembiol.2019.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-16K05859
[Journal Article] Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP2018
- Author(s)
  Sengoku Toru、Suzuki Takehiro、Dohmae Naoshi、Watanabe Chiduru、Honma Teruki、Hikida Yasushi、Yamaguchi Yoshiki、Takahashi Hideyuki、Yokoyama Shigeyuki、Yanagisawa Tatsuo
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 14 Issue: 4 Pages: 368-374
- DOI
  10.1038/s41589-018-0002-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21626, KAKENHI-PROJECT-15K08485, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-16H03293, KAKENHI-PROJECT-16K05859, KAKENHI-PROJECT-16H04758
[Journal Article] Cell-Free Protein Synthesis for Multiple Site-Specific Incorporation of Noncanonical Amino Acids Using Cell Extracts from RF-1 Deletion E. coli Strains.2018
- Author(s)
  Seki E, Yanagisawa T, Yokoyama S.
- Journal Title
  
  Methods. Mol. Biol.
  
  Volume: 1728 Pages: 49-65
- DOI
  10.1007/978-1-4939-7574-7_3
- ISBN
  9781493975730, 9781493975747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05859
[Journal Article] Meningococcal cysteine transport system plays a crucial role for Neisseria meningitidis sustaining in the human brain microvascular endothelial cells2018
- Author(s)
  Hideyuki Takahashi, Haruo Watanabe, Kwang Sik Kim, Shigeyuki Yokoyama, Tatsuo Yanagisawa
- Journal Title
  
  MBio
  
  Volume: 9 Issue: 6
- DOI
  10.1128/mbio.02332-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05859
[Journal Article] Extensive Survey of Antibody Invariant Positions for Efficient Chemical Conjugation Using Expanded Genetic Codes2017
- Author(s)
  Kato Akifumi、Kuratani Mitsuo、Yanagisawa Tatsuo、Ohtake Kazumasa、Hayashi Akiko、Amano Yoshimi、Kimura Kaname、Yokoyama Shigeyuki、Sakamoto Kensaku、Shiraishi Yasuhisa
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 28 Issue: 8 Pages: 2099-2108
- DOI
  10.1021/acs.bioconjchem.7b00265
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21631, KAKENHI-PROJECT-16K05859
[Journal Article] Neisseria meningitidis Translation Elongation Factor P and Its Active-Site Arginine Residue Are Essential for Cell Viability2016
- Author(s)
  Yanagisawa T, Takahashi H, Suzuki T, Masuda A, Dohmae N, Yokoyama S.
- Journal Title
  
  PLoS ONE
  
  Volume: 11(2) Issue: 2 Pages: e0147907-e0147907
- DOI
  10.1371/journal.pone.0147907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26410190, KAKENHI-PROJECT-15K08485
[Journal Article] Multiple Functions of Glutamate Uptake via Meningococcal GltT-GltM　L-Glutamate ABC Transporter in Neisseria meningitidis　Internalization into Human Brain Microvascular Endothelial Cells.2015
- Author(s)
  Takahashi H, Yanagisawa T, Kim KS, Yokoyama S, Ohnishi M.
- Journal Title
  
  Infection and Immunity
  
  Volume: 83 Issue: 9 Pages: 35553567-35553567
- DOI
  10.1128/iai.00654-15
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08485
[Journal Article] A SelB/EF-Tu/aIF2γ-like protein from Methanosarcina mazei in the GTP-bound form binds cysteinyl-tRNA(Cys).2015
- Author(s)
  Yanagisawa, T., Ishii, R., Hikida, Y., Fukunaga, R., Sengoku, T., S. Sekine, Yokoyama,S.
- Journal Title
  
  J. Struct. Funct. Genomics
  
  Volume: 16 Issue: 1 Pages: 25-41
- DOI
  10.1007/s10969-015-9193-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550203
[Journal Article] Multiple site-specific installations of N(ε)-monomethyl-L-lysine into histone proteins by cell-based and cell-free protein synthesis2014
- Author(s)
  Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., and Umehara, T. and Yokoyama, S.
- Journal Title
  
  ChemBioChem
  
  Volume: 15 Issue: 12 Pages: 1830-1838
- DOI
  10.1002/cbic.201402291
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24550203, KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-26291035
[Journal Article] Expanded genetic code technologies for modified lysine installation at multiple sites2014
- Author(s)
  Yanagisawa, T., Umehara, T., Sakamoto, K., and Yokoyama, S.
- Journal Title
  
  ChemBioChem
  
  Volume: 15 Issue: 15 Pages: 2181-2187
- DOI
  10.1002/cbic.201402266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550203, KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-26291035
[Journal Article] Meningococcal PilV potentiates Neisseria meningitidis type IV pilus-mediated internalization into human endothelial and epithelial cells.2012
- Author(s)
  Hideyuki Takahashi, Tatsuo Yanagisawa, Kwang Sik Kim, Shigeyuki Yokoyama and Makoto Ohnishi
- Journal Title
  
  Infection and Immunity
  
  Volume: 80 Issue: 12 Pages: 4154-4166
- DOI
  10.1128/iai.00423-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590545
[Journal Article] Wade-range protein photo-crosslinking achieved by a genetically encoded N^ε-(benzyloxycarbonyl) lysine derivative with a diazirinyl moiety2012
- Author(s)
  T. Yanagisawa, N. Hino, F. Iraha, T. Mukai, K. Sakamoto, S. Yokoyama
- Journal Title
  
  Mol. Bio Syst.
  
  Volume: 8 Issue: 4 Pages: 1131-1135
- DOI
  10.1039/c2mb05321g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167, KAKENHI-PROJECT-22570175
[Journal Article]2012
- Author(s)
  Yanagisawa, T., Hino, N., Iraha, F., Mukai, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Mol. BioSyst
  
  Volume: 8 Pages: 1131-1135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167
[Journal Article] Genetic-code evolution for protein synthesis with non-natural amino acids2011
- Author(s)
  T. Mukai, T. Yanagisawa, K. Ohtake, M. Wakamori, J. Adachi, N. Hino, A. Sato, T. Kobayashi, A. Hayashi, M. Shirouzu, T. Umehara, S. Yokoyama, K. Sakamoto
- Journal Title
  
  Biochem. Biophys. Res. Comm.
  
  Volume: 411 Pages: 757-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167
[Journal Article]2011
- Author(s)
  Mukai, T., Yanagisawa, T., Ohtake, K., Wakamori, M., Adachi, J., Hino, N., Sato, A., Kobayashi, T., Hayashi, A., Shirouzu, M., Umehara, T., Yokoyama, S., Sakamoto, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 411 Pages: 757-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167
[Journal Article] A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P2010
- Author(s)
  T. Yanagisawa. T. Sumida, R. Ishii, C. Takemoto, S. Yokoyama
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 17 Pages: 1136-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167
[Journal Article] Crystallizaton and preliminary X-ray crystallographic study of GenX, a lysyl-tRNA synthetase paralogue from Escherichia coli, in complex with translation elongation factor P2010
- Author(s)
  T. Sumida, T. Yanagisawa, R. Ishii, S. Yokoyama
- Journal Title
  
  Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commn.
  
  Volume: 66 Pages: 1115-1119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21550167
[Patent] 新規な非天然型アミノ酸、及びその利用(N^ε-(p-trifluoromethyldia zirinylbenzyloxycarbonyl)-lysine)2011
- Inventor(s)
  横山茂之、坂本健作、柳沢達男、樋野展正、伊良波史枝
- Industrial Property Rights Holder
  横山茂之、坂本健作、柳沢達男、樋野展正、伊良波史枝
- Industrial Property Rights Type
  特許
- Filing Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21550167
[Patent] 新規非天然型アミノ酸とその応用に関する研究: N(epsilin)-(p-trifluoromethyldiazirinylbenzylo xycarbonyl) lysine
- Inventor(s)
  Yokoyama, S., Sakamoto, K., Yanagisawa, T., Hino, N., F. Iraha
- Industrial Property Rights Holder
  Yokoyama, S., Sakamoto, K., Yanagisawa, T., Hino, N., F. Iraha
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] Expanding the genetic code of Neisseria meningitidis with unnatural amino acids.2019
- Author(s)
  高橋英之、大西真、横山茂之、柳沢達男
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] Analyses of meningococcal cysteine transport system as a nutrient virulence factor for the infection2019
- Author(s)
  高橋英之、横山茂之、柳沢達男
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 複合体構造より明らかになったEF-P(Arg32)ラムノシル化の反応メカニズム2018
- Author(s)
  仙石徹・鈴木健裕・堂前直・渡邉千鶴・本間光貴・疋田泰士・山口芳樹・高橋英之・横山茂之・柳沢達男○
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] ピロリシルtRNA合成酵素の構造生物学：様々な非天然型アミノ酸を割り当てる遺伝暗号拡張の構造基盤2018
- Author(s)
  ○柳沢達男、倉谷光央、関英子、樋野展正、坂本健作、横山茂之
- Organizer
  第41回分子生物学会ワークショップ：アミノアシルtRNA合成酵素とtRNA研究の新展開－「遺伝暗号の起源」50周年
- Invited
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] Mechanism of EF-P(Arg32) rhamnosylation revealed by the crystal structure of glycosyltransferase EarP/translation factor EF-P complex2018
- Author(s)
  Toru Sengoku, Takehiro Suzuki, Naoshi Dohmae, Chiduru Watanabe, Teruki Honma, Yasushi Hikida, Yoshiki Yamaguchi, Hideyuki Takahashi, Shigeyuki Yokoyama, ○Tatsuo Yanagisawa
- Organizer
  tRNA Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 臨床分離株の宿主細胞への侵襲能と細胞外因子の発現量の相互比較による髄膜炎菌の病原性因子の探索及び解析2018
- Author(s)
  高橋英之、柳沢達男、横山茂之
- Organizer
  第90回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K08485
[Presentation] 髄膜炎菌由来EF-Pとラムノシル化修飾部位Arg32は生存に不可欠である2017
- Author(s)
  柳沢達男、高橋英之、鈴木健裕、益田晶子、堂前直、横山茂之
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  宮城県仙台市　仙台国際センター
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] ピロリシルtRNA合成酵素による寛容な非天然型アミノ酸認識の構造基盤2017
- Author(s)
  ○柳沢達男、倉谷光央、関英子、樋野展正、坂本健作、横山茂之
- Organizer
  ConBio2017（2017年12月10日、神戸）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 髄膜炎菌由来の翻訳因子EF-Pのラムノース修飾による活性化の構造的基盤2017
- Author(s)
  〇仙石徹、鈴木健裕、堂前直、渡邉千鶴、本間光貴、疋田泰士、山口芳樹、高橋英之、横山茂之、柳沢達男
- Organizer
  ConBio2017（2017年12月11日、神戸）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 反転型糖鎖転移酵素によるタンパク質アルギニン・ラムノシル化の構造基盤2017
- Author(s)
  仙石徹、鈴木健裕、堂前直、渡邉千鶴、本間光貴、疋田泰士、山口芳樹、高橋英之、柳沢達男、横山茂之
- Organizer
  ComBio2017
- Data Source
  KAKENHI-PROJECT-15K08485
[Presentation] 無細胞タンパク質合成法を用いて導入したセレノシステインによるタンパク質の機能改変2017
- Author(s)
  ○関英子、柳沢達男、横山茂之
- Organizer
  第17回日本蛋白質科学会年会（2017年6月21日、仙台）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 髄膜炎菌由来の翻訳因子EF-Pのラムノース修飾による活性化の構造的基盤2017
- Author(s)
  仙石徹、鈴木健裕、堂前直、渡邉千鶴、本間光貴、疋田泰士、山口芳樹、高橋英之、横山茂之、柳沢達男
- Organizer
  ComBio2017
- Data Source
  KAKENHI-PROJECT-15K08485
[Presentation] ピロリジルtRNA合成酵素による寛容な非天然型アミノ酸認識の構造的基盤2017
- Author(s)
  倉谷光央、○柳沢達男、関英子、樋野展正、坂本健作、横山茂之
- Organizer
  第12回ケミカルバイオロジー学会年会（2017年6月8日、札幌）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 無細胞タンパク質合成法を用いたセレノシステイン導入によるタンパク質の機能改変2017
- Author(s)
  〇関英子、柳沢達男、横山茂之
- Organizer
  ConBio2017（2017年12月10日、神戸）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 臨床分離株の宿主細胞への侵襲能と細胞外因子の発現量の相互比較による髄膜炎菌の病原性因子の探索及び解析2017
- Author(s)
  ○高橋英之、横山茂之、柳沢達男
- Organizer
  第91回日本細菌学会総会 (2018年3月28日、福岡)
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 反転型糖転移酵素によるタンパク質アルギニン・ラムノシル化の構造基盤2017
- Author(s)
  仙石徹、鈴木健裕、堂前直、渡邉千鶴、本間光貴、疋田泰士、山口芳樹、高橋英之、柳沢達男、〇横山茂之
- Organizer
  ConBio2017（2017年12月10日、神戸）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] ピロリジルtRNA合成酵素による寛容な非天然型アミノ酸認識の構造基盤2017
- Author(s)
  倉谷光央、○柳沢達男、関英子、樋野展正、坂本健作、横山茂之
- Organizer
  第19回日本RNA学会年会（2017年7月19日、富山）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] アジド基含有非天然型アミノ酸を導入したトラスツズマブFabのX線結晶構造2017
- Author(s)
  〇倉谷光央、柳沢達男、加藤明文、大竹和正、林明子、天野芳美、木村要、白石泰久、坂本健作、横山茂之
- Organizer
  ConBio2017（2017年12月11日、神戸）
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] Neisseria meningitidis translation elongation factor P and its active-site arginine residue are essential for cell viability2016
- Author(s)
  Tatsuo Yanagisawa, Hideyuki Takahashi, Takehiro Suzuki, Akiko Masuda, Naoshi Dohmae, Shigeyuki Yokoyama
- Organizer
  RNA2016
- Place of Presentation
  京都府京都市　京都国際会館
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 髄膜炎菌由来EF-Pとラムノシル化修飾部位Arg32は生存に不可欠である2016
- Author(s)
  柳沢達男、高橋英之、鈴木健裕、益田晶子、堂前直、横山茂之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県仙台市　仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] Multiple functions of glutamate uptake via meningococcal GltT-GltM L-glutamate ABC transporter for Neisseria meningitidis internalization into human brain microvascular endothelial cells.2016
- Author(s)
  Hideyuki Takahashi, Tatsuo Yanagisawa, Kwang Sik Kim, Shigeyuki Yokoyama　and Makoto Ohnishi.
- Organizer
  International Pathogenic Neisseria Conference
- Place of Presentation
  Manchester UK
- Year and Date
  2016-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08485
[Presentation] 構造ゲノム科学でタンパク質の未知機能を探る2016
- Author(s)
  柳沢達男、横山茂之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] 髄膜炎菌由来EF-Pとラムノシル化修飾部位Arg32は生存に不可欠2016
- Author(s)
  柳沢達男、高橋英之、鈴木健裕、益田晶子、堂前直、横山茂之
- Organizer
  第16回蛋白質科学会年会
- Place of Presentation
  福岡県福岡市　福岡国際会議場
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] Neisseria meningitidis translation elongation factor P and its active-site arginine residue are essential for cell viability2016
- Author(s)
  Tatsuo Yanagisawa, Hideyuki Takahashi, Takehiro Suzuki, Akiko Masuda, Naoshi Dohmae, Shigeyuki Yokoyama
- Organizer
  2016 tRNA Conference
- Place of Presentation
  大韓民国済州市　ロッテホテル済州
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05859
[Presentation] RF1ノックアウト大腸菌のタンパク質発現系および無細胞タンパク質合成系を利用したモノメチルリジンのヒストンへの部位特異的複数導入2015
- Author(s)
  高橋美穂子、柳沢達男、向井崇人、佐藤心、若森昌聡、白水美香子、坂本健作、梅原崇史、横山茂之
- Organizer
  第10回無細胞生命科学研究会
- Place of Presentation
  横浜　理研横浜キャンパス
- Year and Date
  2015-10-13
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] 非天然型アミノ酸の部位特異的導入技術とタンパク質科学研究への展開2015
- Author(s)
  柳沢達男、梅原崇史、坂本健作、横山茂之
- Organizer
  第15回日本蛋白質科学会大会
- Place of Presentation
  徳島　あわぎんホール
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] In vivo and in vitro site-specific incorporation/installation of non-canonical lysine derivatives into proteins by using pyrrolysyl-tRNA synthetase-tRNAPyl pair and its application for epigenetic studies2014
- Author(s)
  ○Tatsuo Yanagisawa, Mihoko Takahashi, Shin Sato, Takahito Mukai, Masatoshi Wakamori, Mikako Shirouzu, Takashi Umehara, Kensaku Sakamoto, and Shigeyuki Yokoyama
- Organizer
  RIKEN EPIGENETICS in Yokohama
- Place of Presentation
  横浜、理研横浜キャンパス
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] Expanded Genetic Code Technologies for Incorporating Modified Lysine at Multiple Sites: Multiple Site-Specific Installations of N(ε)-Monomethyl-L-Lysine into Histone Proteins by Cell-Based and Cell-Free Protein Synthesis.2014
- Author(s)
  ○Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., Umehara, T., Yokoyama, S.
- Organizer
  The 12th Interdisciplinary Exchange Evening
- Place of Presentation
  理研和光キャンパス、和光市
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] Crystallographic studies on specific aminoacylation of tRNA and genetic code expansion2013
- Author(s)
  Naganuma M, Sasaki HM, Mukai T, Yanagisawa T, Ohtake K, Wakamori M, Hikida Y, Higashijima K, Shibata R, Nishimoto M, Bessho Y, Chong YE, Guo M, Yang XL, Shimmel P, Fukunaga R, Harada Y, Kimoto M, Adachi J, Hino N, Sato A, Hayashi A, Terada T, Umehara T, Ito T, Sekine S, Hirao I, Shirouzu M, Sakamoto K, ○Yokoyama S.
- Organizer
  7th International Conference on Structural Genomics 2013
- Place of Presentation
  札幌、京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] Synthesis of histone with multiple site-specific monomethylation for reconstitution of epigenetic nucleosome2013
- Author(s)
  ○Mihoko Takahashi, Tatsuo Yanagisawa, Shin Sato, Masatoshi Wakamori, Takahito Mukai, Mikako Shirouzu, Kensaku Sakamoto1, Shigeyuki Yokoyama, Takashi Umehara
- Organizer
  The 65th Fujihara Seminar; International Symposium on Synthetic Biology of Unnatural Base Pairs and Amino Acids
- Place of Presentation
  苫小牧、グランドホテルニュー王子
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] 転移RNAを擬態する大腸菌翻訳因子EF-Pのアミノアシル化修飾2011
- Author(s)
  柳沢達男、澄田智美、石井亮平、竹本千重、横山茂之
- Organizer
  第5回細菌学若手コロッセウム
- Place of Presentation
  高知県高知市
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] 終止コドンUAGがセンス・コドンに再定義された大腸菌株を用いた非天然型アミノ酸のタンパク質への導入2011
- Author(s)
  坂本健作、安達仁朗、若森昌聡、白水美香子、梅原崇史、柳沢達男、向井崇人、横山茂之
- Organizer
  第6回無細胞生命科学研究会
- Place of Presentation
  兵庫県姫路市
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] 終止コドンUAGがセンス・コドンに再定義された大腸菌株を用いた非天然型アミノ酸のタンパク質への導入2011
- Author(s)
  坂本健作、安達仁朗、若森昌聡、白水美香子、梅原崇史、柳沢達男、向井崇人、横山茂之
- Organizer
  第6回無細胞生命科学研究会
- Place of Presentation
  兵庫
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] 大腸菌、昆虫細胞、動物細胞を用いた非天然型アミノ酸のタンパク質への部位特異的導入法の開発2010
- Author(s)
  坂本健作、向井崇人、大竹和正、伊良波史枝、林明子、佐藤文、樋野展正、柳沢達男、脇山素明、横山茂之
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] リジル-tRNA合成酵素パラログGenX/PoxA/YjeA、およびYjeKによる翻訳因子EF-Pの翻訳後修飾2010
- Author(s)
  柳沢達男、澄田智美、石井亮平、竹本千重、横山茂之
- Organizer
  日本RNA学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] Structural bases of specific generation of amino-acid ligated tRNAs and proteins2010
- Author(s)
  Shun-ichi Sekine、Takuhiro Ito、Tatsuo Yanagisawa、Shigeyuki Yokoyama
- Organizer
  国際核酸化学シンポジウム (ISNAC-2010)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] Escherichia coli translation elongation factor P (EF-P) is lysylated by GenX/PoxA/YjeA, a paralog of lysyl-tRNA synthetase, and YjeK2010
- Author(s)
  Tatsuo Yanagisawa. Tomomi Sumida, Ryohei Ishii, Chie Takemoto, Shigeyuki Yokoyama
- Organizer
  Ribosomes2010
- Place of Presentation
  イタリア/オルビエート
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] 大腸菌、昆虫細胞、動物細胞を用いた非天然型アミノ酸のタンパク質への部位特異的導入法の開発2010
- Author(s)
  坂本健作、向井崇人、大竹和正、伊良波史枝、林明子、佐藤文、樋野展正、柳沢達男、脇山素明、横山茂之
- Organizer
  日本蛋白質科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] 翻訳後修飾アミノ酸のタンパク質への部位特異的導入2009
- Author(s)
  坂本健作、小林隆嗣、柳沢達男、横山茂之
- Organizer
  第4回無細胞生命科学研究会
- Place of Presentation
  岐阜
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21550167
[Presentation] 翻訳終結因子RF1欠損大腸菌のタンパク質発現系および無細胞タンパク質合成系を利用したモノメチルリジンのヒストンタンパク質への部位特異的複数導入
- Author(s)
  ○柳沢達男、高橋美穂子、向井崇人、佐藤心、若森昌聡、白水美香子、坂本健作、梅原崇史、横山茂之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] 翻訳終結因子欠損大腸菌のタンパク質発現系および無細胞タンパク質合成系を利用したモノメチル化リジンのヒストンへの部位特異的複数導入
- Author(s)
  ○柳沢達男、高橋美穂子、向井崇人、佐藤心、若森昌聡、白水美香子、坂本健作、梅原崇史、横山茂之
- Organizer
  第9回ケミカルバイオロジー学会大会
- Place of Presentation
  大阪大学豊中キャンパス、大阪
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] Expanded Genetic Code Technologies for Incorporating Modified Lysine at Multiple Sites: Multiple Site-Specific Installations of N(ε)-Monomethyl-L-Lysine into Histone Proteins by Cell-Based and Cell-Free Protein Synthesis.
- Author(s)
  ○Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., Umehara, T., Yokoyama, S.
- Organizer
  25th tRNA Conference 2014
- Place of Presentation
  Kyllini, Greece
- Year and Date
  2014-09-21 – 2014-09-25
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] Synthesis of histone proteins with multiple and site-specific monomethyl-lysines
- Author(s)
  ○Umehara, T., Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., Yokoyama, S.
- Organizer
  FASEB meeting (2014): Biological Methylation: Regulation of Chromatin, Epigenetics, and Disease
- Place of Presentation
  Nassau, Bahamas
- Year and Date
  2014-07-06 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] Expanded genetic code technologies for incorporating lysine residues with naturally-occurring post-translational modifications at multiple sites in proteins.
- Author(s)
  Yanagisawa, T., Fujii, Y., Sakamoto, K., Umehara, T., ○Yokoyama, S.
- Organizer
  RIKEN Epigenetics in Kobe 2015
- Place of Presentation
  理研CDB、神戸
- Year and Date
  2015-02-13 – 2015-02-15
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] 翻訳終結因子RF1欠損大腸菌のタンパク質発現系および無細胞タンパク質合成系を利用したモノメチルリジンのヒストンタンパク質への部位特異的複数導入
- Author(s)
  ○高橋美穂子、柳沢達男、向井崇人、佐藤心、若森昌聡、白水美香子、坂本健作、梅原崇史、横山茂之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学津島キャンパス、岡山
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24550203
[Presentation] 翻訳終結因子RF1欠損大腸菌のタンパク質発現系および無細胞タンパク質合成系を利用したモノメチル化リジンのヒストンへの部位特異的複数導入
- Author(s)
  ○柳沢達男、高橋美穂子、向井崇人、佐藤心、若森昌聡、白水美香子、坂本健作、梅原崇史、横山茂之
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち、名古屋
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24550203

1. TAKAHASHI Hideyuki (60321866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. HINO Nobumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 仙石徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 大竹和正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 益田晶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 堂前直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yanagisawa Tatsuo 柳沢 達男

YANAGISAWA Tatsuo 柳沢 達男

Research Projects

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Co-Researchers

Structural basis of RNA processing coupled to transcription terminationPrincipal Investigator

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Structural biochemistry of translation-related proteins from pathogenic bacteriaPrincipal Investigator

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Identification of meningococcal virulence factors and the expression profile by using clinical isolates

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Chemical biology using the protein-introduced unnatural lysine derivatives as probesPrincipal Investigator

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Systematic analyses of signal transduction systems on GltT-GltM glutamate transporter mediated invasion into the host cell in Neisseria meningitidis

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Site-specific incorporation of non-natural amino acids into proteins by using pyrrolysyl-tRNA synthetasePrincipal Investigator

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[Book] 翻訳因子EF-Pのアミノアシル化とラムノシル化2019

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[Book] 糖転移酵素EarPによる翻訳因子EF-PのArgのラムノシル化の構造的な基盤2018

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[Book] Photon Factory Activity Report Research Highlights 20102011

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[Book] SPring-8 Research Frontiers 20102011

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[Book] 化学と生物2011

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[Book] SPring-8 Research Frontiers 2010 : Structure and Function of a Protein Mimicking transfer RNA Revealed from the Structure of Translation Elongation Factor P Complexed with an Aminoacyl-tRNA Synthetase Paralog, GenX2011

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[Book] RIKEN Research : Copycat protein finds a perfect match核酸と瓜二つのタンパク質2010

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[Book] ライフサイエンス新着論文レビュー:リジル-tRNA合成酵素パラログGenX-YjeKシステムによる翻訳因子EF-Pのリジル化修飾2010

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Yanagisawa Tatsuo 柳沢達男

YANAGISAWA Tatsuo 柳沢達男

[Journal Article] Multiple Functions of Glutamate Uptake via Meningococcal GltT-GltM　L-Glutamate ABC Transporter in Neisseria meningitidis　Internalization into Human Brain Microvascular Endothelial Cells.2015