Okubo Tadashi 大久保直

… Alternative Names

OHKUBO Tadashi 大久保直

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Researcher Number	10450719
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2024: 北里大学, 医学部, 准教授 2011 – 2012: 北里大学, 医学部, 講師 2010: 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 2009: National Institutes of Natural Sciences Okazaki Research Facilities, 岡崎統合バイオサイエンスセンター, 助教 2008: National Institutes of Natural Sciences Okazaki Research Facilities, 岡崎統合バイオサイエンスセンター, 助教
Review Section/Research Field	Principal Investigator Developmental biology / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / Biological Sciences Except Principal Investigator Basic Section 56020:Orthopedics-related / Laboratory animal science / Biological Sciences / Neurochemistry/Neuropharmacology / Developmental biology
Keywords	Principal Investigator Ripply3 / 咽頭弓 / 咽頭弓分節 / Tbx1 / 心臓形成 / ゲノム編集 / 分節 / 咽頭嚢 / 舌咽神経 / 転写制御 … More / 転写調節 / 咽頭弓形成 / ゲノム編集マウス / Glyr1 / FPVQモチーフ / アミノ酸モチーフ / RIpply3 / 胸腺の移動 / 心臓流出路 / WRPWモチーフ / 内胚葉 / 胸腺形成 / 神経分化 / epibranchial placode / 転写抑制因子 / レチノイン酸 / 舌咽神経節 / プロモーター制御 / レチノイン酸シグナル / 味蕾形成 / 発現制御 / GFP / ネガティブフィードバック機構 / ネガティブフィードバック / 転写活性化 / 鰓弓動脈 / 鰓上板 / 細胞系譜解析 / 味覚受容器官 / 心臓血管系 / T-box / マウス / 心血管系 / 先天性心疾患 / 副甲状腺 / 胸腺 … More Except Principal Investigator 変形性関節症 / 疼痛 / 非炎症性 / 変形性膝関節症 / TGF-β / 神経ペプチド / 運動制御 / 学習記憶 / 運動調節 / パーキンソン病 / 遺伝子操作マウス / ドーパミン受容体 / 発生 / 咽頭弓 / シグナル伝達 / 遺伝子 / 細胞・組織 / 発生・分化 / 性差 / MAIT / Peptide Lv / peptide Lv / 椎間板 / 非炎症下 / M2極性化 / 線維輪 / M2 マクロファージ / M2 polarization / 腰痛 / マクロファージ / 膝蓋下脂肪体 / ゲノム編集 / 非古典経路 / 古典経路 / 血管内皮成長因子 / Apelin / 血管内皮増殖因子 / 運動機能調節 / ニホンザル / 生殖工学的技術 / 時期特異的ノックダウン / 遺伝子改変マウス / パーキンソン病モデル動物 / 発達期 / 電気生理学的性質 / 時期特異的発現抑制 / 運動学習 / 電気生理学的解析 / 可逆的発現制御マウス / 神経活動 / テトラサイクリン制御システム / 大脳基底核回路 / D2ドーパミン受容体 / D1ドーパミン受容体 / 免疫 / 免疫学 / 細胞 / 胸腺 / 細胞分化 / ドキシサイクリン / 発生工学 / マウス / 遺伝子操作動物 / 大脳基底核 / 遺伝子工学 / 協調運動 / ノックアウト / 変異体 / 転写制御 / 脊椎動物 / 形態形成 / 転写調節 / 体節 / 発現制御 Less

MAIT細胞に着眼した変形性関節症病態の性差の解明
- Principal Investigator
  
  高相晶士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
心臓形成におけるGlyr1を介した転写制御機構とRipply3の作用機序解明Principal Investigator
- Principal Investigator
  
  大久保直
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kitasato University
Peptide LvによるOA疼痛制御機構の解明と疼痛治療シーズの創出
- Principal Investigator
  
  相川淳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
Role of M2 macrophages-produced neuropeptides in inflammatory-independent low back pain
- Principal Investigator
  
  Miyagi Masayuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
Functional analysis of Ripply3 in the migration of thymus from pharyngeal pouchPrincipal Investigator
- Principal Investigator
  
  Okubo Tadashi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Kitasato University
Relationship between infrapatellar fat pad derived neuropeptides and osoteoarthritic pain
- Principal Investigator
  
  Aikawa Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
Inflammatory-independent pain mechanism via to VEGF/neuropeptide axis
- Principal Investigator
  
  Takaso Masashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kitasato University
Elucidation of motor control mechanism by D1 / D2 dopamine receptor conditionally expressing mice
- Principal Investigator
  
  SASAOKA Toshikuni
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Niigata University
Molecular basis of glossopharyngeal nerve formation during pahryngeal arch developmentPrincipal Investigator
- Principal Investigator
  
  Okubo Tadashi
- Project Period (FY)
  2014 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Kitasato University
Moleculara mechanism and regulation of the lymphoid organ
- Principal Investigator
  
  TAKADA Shinji
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Okazaki Research Facilities, National Institutes of Natural Sciences
咽頭弓分節による頭部神経軸索と鰓弓動脈の束化・配線分け機構Principal Investigator
- Principal Investigator
  
  大久保直
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
Regulatory mechanism of the periodic expression of Ripply3 during pharyngeal arch segmentationPrincipal Investigator
- Principal Investigator
  
  OKUBO Tadashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kitasato University
Understanding of regulatory mechanism of motor activity using D1 and D2 dopamine receptor gene-modified mice
- Principal Investigator
  
  SASAOKA Toshikuni
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kitasato University
Functional analysis of a novel transcriptional co-repressor in the development of pharyngeal arch derived organsPrincipal Investigator
- Principal Investigator
  
  OKUBO Tadashi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  National Institutes of Natural Sciences Okazaki Research Facilities
Molecular mechanism underlying metameric morphogenesis
- Principal Investigator
  
  TAKADA Shinji
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Developmental biology
- Research Institution
  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設)
  National Institutes of Natural Sciences Okazaki Research Facilities

[Book] New Principles in Developmental Processes2014
- Author(s)
  Hisato Kondoh, Atsushi Kuroiwa (Editors), Tadashi Okubo, et al.
- Total Pages
  321
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23770268
[Book] Tbx1/Ripply3/Retinoic acid signal network that regulates pharyngeal arch development. Chapter 8.2014
- Author(s)
  Okubo T.
- Publisher
  New Principles in Developmental Processes (Springer)
- Data Source
  KAKENHI-PROJECT-23770268
[Book] Tbx1/Ripply3/Retinoic Acid Network that Regulates Pharyngeal Arch Development in "New Principles in Developmental Processes. eds by Hisato Kondoh and Atsushi Kuroiwa"2014
- Author(s)
  Tadashi Ohkubo
- Total Pages
  321
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-24111002
[Book] 咽頭弓からの胸腺形成と先天性異常の発症機構2012
- Author(s)
  大久保直、高田慎治
- Data Source
  KAKENHI-PROJECT-18107006
[Journal Article] Effect of retinoic acid signaling on Ripply3 expression and pharyngeal arch morphogenesis in mouse embryos2021
- Author(s)
  Tadashi Okubo, Keiko Hara, Sadahiro Azuma, Shinji Takada
- Journal Title
  
  Developmental Dynamics
  
  Volume: 250 Issue: 7 Pages: 1036-1050
- DOI
  10.1002/dvdy.301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07274, KAKENHI-PUBLICLY-19H04797, KAKENHI-PROJECT-18H02454
[Journal Article] Regulation of tumor necrosis factor-alpha by peptide Lv in bone marrow macrophage and synovium2021
- Author(s)
  3.Mukai M, Uchida K. Okubo T, Takano S, Matsumoto T, Satoh M, Inoue G, Takaso M
- Journal Title
  
  Frontiers in Medicine Rheumatology
  
  Volume: 8 Pages: 701216-701216
- DOI
  10.3389/fmed.2021.702126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07274, KAKENHI-PROJECT-19K09011, KAKENHI-PROJECT-20K07397
[Journal Article] TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model2021
- Author(s)
  Yokozeki Y, Uchida K, Kawakubo A, Nakawaki M, Okubo T, Miaygi M, Inoue G, Itakura M, Sekiguchi H, Takaso M
- Journal Title
  
  BMC Musculoskelet Disord
  
  Volume: 22 Issue: 1 Pages: 634-634
- DOI
  10.1186/s12891-021-04509-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22984, KAKENHI-PROJECT-19K07274, KAKENHI-PROJECT-20K09510
[Journal Article] Differential behavioral phenotypes of Dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages2018
- Author(s)
  Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T.
- Journal Title
  
  International Journal of Developmental Neuroscience
  
  Volume: 66 Issue: 1 Pages: 1-8
- DOI
  10.1016/j.ijdevneu.2017.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460257, KAKENHI-PUBLICLY-16H01606, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-18H04937, KAKENHI-PROJECT-18H02540
[Journal Article] Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches2018
- Author(s)
  Tsuchiya, Y., Mii, Y., Okada, K., Furuse, M., Okubo, T., Takada, S.
- Journal Title
  
  Dev. Growth Diff.
  
  Volume: 60 Issue: 2 Pages: 87-96
- DOI
  10.1111/dgd.12425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19418, KAKENHI-PLANNED-24111002, KAKENHI-PUBLICLY-17H05782, KAKENHI-PROJECT-15K14532
[Journal Article] Pharyngeal Arch Deficiencies Affect Taste Bud Development in the Circumvallate Papilla With Aberrant Glossopharyngeal Nerve Formation2015
- Author(s)
  Tadashi Okubo, Shinji Takada
- Journal Title
  
  Developmental Dynamics
  
  Volume: 244 Issue: 7 Pages: 874-887
- DOI
  10.1002/dvdy.24289
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460257, KAKENHI-PLANNED-24111002
[Journal Article] Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation2015
- Author(s)
  Okubo T, Takada S
- Journal Title
  
  Dev Dyn
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24111002
[Journal Article] 統合失調症モデルマウスの行動解析方法の試み2015
- Author(s)
  笹岡俊邦,佐藤朝子,中村徹,大久保直,佐藤俊哉,藤澤信義,前田宜俊,小田佳奈子,酒井清子,神保幸弘,馬川恵梨子,木津川尚史,籾山俊彦,山森哲雄
- Journal Title
  
  日本生物学的精神医学会誌
  
  Volume: 26 Pages: 87-94
- NAID
  130005395590
- Open Access
- Data Source
  KAKENHI-PROJECT-26290029
[Journal Article] Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.2014
- Author(s)
  Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA
- Journal Title
  
  Development
  
  Volume: 141 Issue: 15 Pages: 2939-2949
- DOI
  10.1242/dev.104810
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24111002, KAKENHI-PROJECT-26460257
[Journal Article] 咽頭弓からの胸腺形成と先天性異常の発症機構2012
- Author(s)
  大久保直、高田慎治
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 168-176
- NAID
  10030564140
- Data Source
  KAKENHI-PROJECT-23770268
[Journal Article] 咽頭弓からの胸腺の形成と先天性異常の発症機構2012
- Author(s)
  大久保直、高田慎治
- Journal Title
  
  生化学
  
  Volume: 84巻 Pages: 168-176
- Data Source
  KAKENHI-PROJECT-23770268
[Journal Article] 咽頭弓からの胸腺形成と先天性異常の発症機構2012
- Author(s)
  大久保直、高田慎治
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 168-176
- NAID
  10030564140
- Data Source
  KAKENHI-PUBLICLY-23122523
[Journal Article] Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice2011
- Author(s)
  Okubo, T., Kawamura, A., Takahashi, J., Yagi, H., Morishima, M., Matsuoka, R., & Takada, S.
- Journal Title
  
  Development
  
  Volume: 138 Pages: 339-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18107006
[Journal Article] 細胞系譜解析からみた舌・軟口蓋上皮の幹細胞システム2011
- Author(s)
  大久保直
- Journal Title
  
  日本味と匂学会誌
  
  Volume: 18 Pages: 29-35
- Data Source
  KAKENHI-PUBLICLY-23122523
[Journal Article] 細胞系譜解析からみた舌・軟口蓋上皮の幹細胞システム2011
- Author(s)
  大久保直
- Journal Title
  
  日本味と匂学会誌
  
  Volume: 18 Pages: 29-35
- Data Source
  KAKENHI-PROJECT-23770268
[Journal Article] 細胞系譜解析からみた舌・軟口蓋上皮の幹細胞システム2011
- Author(s)
  大久保直
- Journal Title
  
  日本味と匂い学会誌
  
  Volume: 18巻 Pages: 29-35
- Data Source
  KAKENHI-PROJECT-23770268
[Journal Article] Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression2008
- Author(s)
  Alvarez-Medina, R., Cayuso, J., Okubo, T., Takada, S., & Marti, E.
- Journal Title
  
  Development
  
  Volume: 135 Pages: 237-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18107006
[Presentation] Phenotypic analysis of mouse embryos with mutations in two evolutionarily conserved amino acid motifs in Ripply32023
- Author(s)
  Daisuke Narita, Ryusuke Ishizuka, Yosuke Kajiyama, Yudai Yabe, Shinji Takada, Tadashi Okubo
- Organizer
  The 56th Annual Meeting of the Japanese Society of Developmental Biologists
- Data Source
  KAKENHI-PROJECT-23K07274
[Presentation] Phenotypic analysis of mouse embryos with mutations in two evolutionarily conserved amino acid motifs in Ripply32023
- Author(s)
  Daisuke Narita, Ryusuke Ishizuka, Yosuke Kajiyama, Yudai Yabe, Shinji Takada, Tadashi Okubo
- Organizer
  The 56th Annual Meeting of the Japanese Society of Developmental Biologists. Sendai, Japan
- Data Source
  KAKENHI-PROJECT-19K07274
[Presentation] Phenotypic analysis of mouse embryos with mutations in two evolutionarily conserved amino acid motifs in Ripply32022
- Author(s)
  Ryusuke Ishizuka, Yosuke Kajiyama, Yudai Yabe, Daisuke Narita, Shinji Takada, Tadashi Okubo
- Organizer
  第45回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07274
[Presentation] Peptide Lvは椎間板傷害後のMacrophage polarizationを制御する2020
- Author(s)
  内田健太郎　川久保　歩　大久保直　宮城正行　井上　玄　横関雄司　迎　学　関口裕之　高相晶士
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09510
[Presentation] The effect of retinoic acid signaling on the expression of Ripply3 gene in pharyngeal arch development2019
- Author(s)
  Tadashi Okubo, Keiko Hara, Sadahiro Azuma, Shinji Takada
- Organizer
  第52回　日本発生生物学会
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] The effect of retinoic acid signaling on the expression of Ripply3 gene in pharyngeal arch development2019
- Author(s)
  Tadashi Okubo, Keiko Hara, Sadahiro Azuma, Shinji Takada
- Organizer
  第52回日本発生生物学会
- Data Source
  KAKENHI-PROJECT-19K07274
[Presentation] WRPW motif of Ripply3 is essential for the outflow tract formation2018
- Author(s)
  Okubo T, Hara K, Kajiyama Y. Takada S
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] WRPW motif of Ripply3 is essential for the outflow tract formation2018
- Author(s)
  Okubo T, Hara K, Kajiyama Y. Takada S
- Organizer
  Weinstein 2018 Cardiovascular development and regeneration conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] Adapter protein Ripply3 is required for epithelial morphogenesis in the mouse pharyngeal pouch.2017
- Author(s)
  Yoshihiro TSUCHIYA, Tadashi OKUBO, Yusuke MII, & Shinji TAKADA
- Organizer
  18th International Congress of Developmental Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111002
[Presentation] Adapter protein Ripply3 is required for epithelial morphogenesis in the mouse pharyngeal pouch. 18th International Congress of Developmental Biology2017
- Author(s)
  Tsuchiya Y, Okubo T, Mii Y, Takada S
- Organizer
  The 18th congress of the International Society of Developmental Biologist
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] Dopamine D1 receptor-mediated transmission maintains information flow through the cortico-striato-entopeduncular direct pathway to release movements2017
- Author(s)
  笹岡俊邦，佐藤朝子，知見聡美，大久保直，前島純，新井慧，砂山智子，小田佳奈子，酒井清子，前田宜俊，神保幸弘，中尾聡宏，佐藤俊哉，藤澤信義，南部篤
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県浜松市浜松アクトシティコングレスセンター
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] Ripply3 expressing cells give rise to epibranchial placode derived ganglia and vestibulocochlear ganglia2017
- Author(s)
  Okubo T, Hara K, Kano M, and Takada S
- Organizer
  日本発生生物学会
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] Ｄ１/Ｄ２ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明2017
- Author(s)
  笹岡俊邦, 佐藤朝子, 知見聡美, 大久保直, 阿部学, 川村名子, 中尾聡宏, 小田佳奈子, 酒井清子, 前田宜俊, 神保幸弘, 佐藤俊哉, 藤澤信義, 崎村建司, 南部篤
- Organizer
  平成28年度先端モデル動物支援プラットフォーム成果発表会
- Place of Presentation
  滋賀県大津市琵琶湖ホテル
- Year and Date
  2017-02-06
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] Adaptor protein Ripply3 is required for epithelial morphogenesis in the mouse pharyngeal pouch2016
- Author(s)
  土屋凱寛、大久保直、三井優輔、高田慎治
- Organizer
  日本発生生物学会秋期シンポジウム
- Place of Presentation
  三島市民文化会館（静岡県三島市）
- Year and Date
  2016-10-19
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] Ｄ１ドーパミン受容体を介する神経伝達は運動情報の伝達と運動の発現に不可欠である2016
- Author(s)
  笹岡俊邦, 佐藤朝子, 知見聡美, 大久保直, 前島純, 新井慧, 砂山智子, 小田佳奈子, 酒井清子, 前田宜俊, 神保幸弘, 馬川恵梨子,佐藤俊哉, 藤澤信義, 横山峯介, 南部篤
- Organizer
  第57回新潟生化学懇話会
- Place of Presentation
  新潟県新潟市新潟大学医歯学総合病院新潟医療人育成センター
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] Ｄ１ドーパミン受容体を介する神経伝達は運動情報の伝達と運動の発現に不可欠である2016
- Author(s)
  笹岡俊邦, 佐藤朝子, 知見聡美, 大久保直, 前島純, 新井慧, 砂山智子, 小田佳奈子, 酒井清子, 前田宜俊, 神保幸弘, 中尾聡宏, 佐藤俊哉, 藤澤信義, 横山峯介, 南部篤
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] Lineage analysis of Ripply3 expressing cells during the mouse development2015
- Author(s)
  Tadashi Okubo, Shinji Takada
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] D1ドーパミン受容体を介するシグナルによる運動量の維持2015
- Author(s)
  笹岡俊邦、佐藤朝子、知見聡美、大久保直、前島純、新井慧、砂山-森田智子、小田佳奈子、酒井清子、前田宜俊、神保幸弘、馬川恵梨子、佐藤俊哉、藤澤信義、横山峯介、南部篤
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] D１ドーパミン受容体の発現の減少はマウスの運動量の低下を誘導する2015
- Author(s)
  笹岡俊邦、佐藤朝子、大久保直、藤澤信義、佐藤俊哉、小田佳奈子、前田宜俊、田中稔、山本美丘、酒井清子、神保幸弘、千葉さおり、馬川恵梨子、横山峯介
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ (京都府京都市)
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] 咽頭弓分節化と胸腺形成の分子基盤の解明に向けて2015
- Author(s)
  大久保直、土屋凱寛、高田慎治
- Organizer
  第34回　日本胸腺研究会　ミニシンポジウム
- Place of Presentation
  ユニコムプラザさがみはら（神奈川県・相模原市）
- Year and Date
  2015-02-07
- Invited
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] ドーパミンD1受容体を介する神経伝達は大脳基底核の直接路の情報伝達と運動の発現に不可欠である2015
- Author(s)
  笹岡俊邦, 佐藤朝子, 知見聡美, 大久保直, 前島純, 新井慧, 砂山智子, 小田佳奈子, 酒井清子, 前田宜俊, 神保幸弘, 馬川恵梨子, 佐藤俊哉, 藤澤信義, 横山峯介, 南部篤
- Organizer
  第32回生殖工学研究会
- Place of Presentation
  実験動物中央研究所 (神奈川県川崎市)
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] D１ドーパミン受容体の発現の減少はマウスの運動量の低下を誘導する2015
- Author(s)
  笹岡俊邦, 佐藤朝子, 大久保直, 藤澤信義, 佐藤俊哉, 小田佳奈子, 前田宜俊,田中稔, 山本美丘, 酒井清子, 神保幸弘, 千葉さおり, 馬川恵梨子, 横山峯介
- Organizer
  平成27年度日本生化学会関東支部例会第56回新潟生化学懇話会
- Place of Presentation
  新潟日報メディアシップ6F (新潟県新潟市)
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] D1 dopamine receptor-mediated signal is required to maintain normal motor activity.2015
- Author(s)
  Sasaoka T, Sato A, Chiken S, Maeshima J, Arai S, Sunayama-Morita T, Oda K, Maeda Y, Sakai S, Jinbo Y, Umakawa E, Sato T, Okubo T, Fujisawa N, Yokoyama M, Nambu A.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際展示場 (兵庫県神戸市)
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-26290029
[Presentation] 咽頭弓の分節化におけるscaffoldタンパク質WTIPの解析2014
- Author(s)
  土屋凱寛、大久保直、三井優輔、高田慎治
- Organizer
  第37回　日本分子生物学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26460257
[Presentation] Negative feedback regulation of Ripply3 for own promoter during pharyngeal arch development2014
- Author(s)
  Tadashi Okubo, Shinji Takada
- Organizer
  第４７回日本発生生物学会
- Place of Presentation
  愛知県名古屋市　ウィング愛知
- Data Source
  KAKENHI-PLANNED-24111002
[Presentation] Glossopharyngeal nerve deficiency in RIpply3 mutant causes the failure of taste bud differentiation in posterior tongue2013
- Author(s)
  Okubo T, Takada S.
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸(ポスター発表)
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  International Symposium Neuro-Vascular Wiring
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  International Symposium Neuro-Vascular Wiring
- Place of Presentation
  Nara, Japan(ポスター発表)
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection for the development of taste buds in the posterior tongue2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  第45回日本発生生物学会
- Place of Presentation
  神戸(ポスター発表)
- Year and Date
  2012-05-30
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection for the development of taste buds in the posterior tongue2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  第45回　日本発生生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection for the development of taste buds in the posterior tongue2012
- Author(s)
  Okubo T, Takada S
- Organizer
  第35回　日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PUBLICLY-23122523
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡(ポスター発表)
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  International Symposium Neuro-Vascular Wiring
- Place of Presentation
  奈良
- Year and Date
  2012-11-12
- Data Source
  KAKENHI-PUBLICLY-23122523
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection for the development of taste buds in the posterior tongue2012
- Author(s)
  Okubo T, Takada S.
- Organizer
  第35回　日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Role of the pharyngeal arch as an infrastructure of cranial nerve projection for the development of taste buds in the posterior tongue2012
- Author(s)
  Okubo T, Takada S
- Organizer
  第45回　日本発生生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-23122523
[Presentation] 先天性多臓器異常に関与する新規転写調節因子Ripply32011
- Author(s)
  大久保直
- Organizer
  第24回北里大学バイオサイエンスフォーラム相模原
- Place of Presentation
  北里大学(口頭発表)
- Year and Date
  2011-08-24
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] A Negative Regulator of Tbx1, is Required for the Development of Pharyngeal Apparatus and Cardiovascular System.2010
- Author(s)
  Tadashi Okubo, Akinori Kawamura, Jun Takahashi, Shinji Takada Ripply3
- Organizer
  RIKEN CDB Symposium, Frontiers in organogenesis
- Place of Presentation
  神戸(ポスター発表)
- Year and Date
  2010-03-23
- Data Source
  KAKENHI-PROJECT-20770188
[Presentation] Ripply3, A Negative Regulator of Tbxl, is Required for the Development of Pharyngeal Apparatus and Cardiovascular System2010
- Author(s)
  大久保直(筆頭), 他3名
- Organizer
  理化学研究所CDBシンポジウム(ポスター発表)
- Place of Presentation
  兵庫県、神戸(理化学研究所CDB神戸)
- Year and Date
  2010-03-23
- Data Source
  KAKENHI-PROJECT-20770188
[Presentation] Tbx1の抑制因子Ripply3はPax9の転写を抑制し咽頭弓の発生を制御する2010
- Author(s)
  大久保直, 八木寿人、川村哲規、高橋潤、森島正恵、松岡瑠美子、高田慎治
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-18107006
[Presentation] Ripply3-mediated restricted modulation of Tbxl activity in the development of pharyngeal arches, thymus, parathyroid gland, and cardiovascular system2009
- Author(s)
  大久保直(筆頭), 他11名
- Organizer
  日本分子生物学会年会ワークショップ(口頭発表)
- Place of Presentation
  神奈川県、横浜(パシフィコ横浜)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20770188
[Presentation] mediated restricted modulation of Tbx1 activity in the development of pharyngeal arches, thymus, parathyroid gland, and cardiovascular system.2009
- Author(s)
  Tadashi Okubo, Hisato Yagi, Akinori Kawamura, Jun Takahashi, Masae Morishima, Kunitaka Joo, Yoshiki Mori, Kazuo Momma, Toshio Nakanishi, Rumiko Matsuoka, Shinji Takada Ripply3
- Organizer
  第32回日本分子生物学会年会ワークショップ・心臓大血管形成における器官形成メカニズムの普遍性と独自性
- Place of Presentation
  横浜(口頭発表)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20770188
[Presentation] Tbx-associatedtranscriptional corepressor, Ripply3, playsessential roles in pharyngeal development2008
- Author(s)
  Okubo, T. Kawamura, A., Takahashi, J., Ohbayashi, A., Takada, S.
- Organizer
  inannual meeting of Society for DevelopmentalBiology, Philadelphia
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-18107006
[Presentation] Tbx-associated transcriptional corepressor Ripply3 plays essential roles in pharyngeal development2008
- Author(s)
  大久保直(筆頭), 他4名
- Organizer
  米国発生生物学会年会 (Society of Developmental Biology meeting)
- Place of Presentation
  University of Pennsilvania, Philadelphia PA, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20770188
[Presentation] Tbx-associated transcriptional corepressor Ripply3 is essential for pharyngeal arch development2008
- Author(s)
  Okubo, T. Kawamura, A., Takahashi, J., Ohbayashi, A., & Takada, S.
- Organizer
  第31回日本分子生物学会大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-18107006
[Presentation] Tbx-associated transcriptional corepressor Ripply3 is essential for pharyngeal arch development2008
- Author(s)
  大久保直(筆頭), 他4名
- Organizer
  日本分子生物学会年会 BMB2008
- Place of Presentation
  神戸国際会議場
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20770188
[Presentation] Glossopharyngeal nerve deficiency in Ripply3 mutant mouse causes the failure of taste bud differentiation in posterior tongue
- Author(s)
  Tadashi Okubo, Shinji Takada
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23770268
[Presentation] Ｄ１ドーパミン受容体の発現抑制によりマウスの自発運動量が低下する
- Author(s)
  笹岡俊邦、佐藤朝子、新井慧、前島純、大久保直、藤澤信義、佐藤俊哉、小田佳奈子、前田宜俊、田中稔、山本美丘、酒井清子、神保幸弘、千葉さおり、横山峯介
- Organizer
  第61回日本実験動物学会総会
- Place of Presentation
  北海道札幌市
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26290029

1. 内田健太郎 (50547578)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. TAKADA Shinji (60206753)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. YABE Taijiro (30470074)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKADA Ritsuko (40450720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. SASAOKA Toshikuni (50222005)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
6. SATO Asako (10465932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
7. Takaso Masashi (90439117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Aikawa Jun (90317008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 佐藤雅 (40611843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. CHEN Quihong

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. WANGLAR Chimwar

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. KOSHIDA Sumito (40342638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AKANUMA Takashi (50450721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAWAMURA Akinori (10466691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. MII Yusuke (70634129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. FUJIMORI Sayumi (20589717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Miyagi Masayuki (90627556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 藤澤信義 (50199311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
19. 前田宜俊 (00754524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
20. 小田佳奈子 (60708212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
21. 佐藤俊哉 (90359703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
22. 岩瀬大 (30406946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 井上玄 (80594209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 板倉誠 (30398581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 美間健彦 (80596437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 松井崇 (30463582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. UTSUMI Hideko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TAKAHASHI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
29. TSUNOKUNI Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KONDOH Hisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. TAKEMOTO Tasuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. TAIRA Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. OKADA Kazunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. SHINOZUKA Takuma

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. TSUCHIYA Akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
36. TAKASHIRO Kayoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. ITO Yukiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. UKAI Sakie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. NOBATA Ryuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. NAKAO Satohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
41. NAMBU Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
42. CHIKEN Satomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
43. 中脇充章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okubo Tadashi 大久保 直

OHKUBO Tadashi 大久保 直

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心臓形成におけるGlyr1を介した転写制御機構とRipply3の作用機序解明Principal Investigator

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Functional analysis of Ripply3 in the migration of thymus from pharyngeal pouchPrincipal Investigator

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Molecular basis of glossopharyngeal nerve formation during pahryngeal arch developmentPrincipal Investigator

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咽頭弓分節による頭部神経軸索と鰓弓動脈の束化・配線分け機構Principal Investigator

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Regulatory mechanism of the periodic expression of Ripply3 during pharyngeal arch segmentationPrincipal Investigator

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Functional analysis of a novel transcriptional co-repressor in the development of pharyngeal arch derived organsPrincipal Investigator

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Okubo Tadashi 大久保直

OHKUBO Tadashi 大久保直