Okuhara Shigeru 奥原滋

… Alternative Names

OKUHARA Shigeru 奥原滋

Less

Researcher Number	10451973
Other IDs
Affiliation (Current)	2025: 日本女子大学, 食科学部, 研究員
Affiliation (based on the past Project Information) *help	2025: 日本女子大学, 家政学部, 研究員 2021 – 2023: 日本女子大学, 家政学部, 研究員 2016 – 2020: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2012 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 2010 – 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 2007 – 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Morphological basic dentistry
Keywords	Principal Investigator 舌 / Sonic hedgehog / 口蓋裂 / 軟骨 / Shh / 咽頭 / 甲状軟骨 / 喉頭 / 喉頭蓋 / 腱 … More / エンハンサー / sonic hedgehog / Foxc1 / SHH / 骨 / 口腔 / 弾性軟骨 / 嚥下 / ＳＨＨ / Ｓｈｈ / 内舌筋 / 鼻咽腔閉鎖機能 / ソニックヘッジホック / ソニック:ヘッジホッグ / 口蓋 / 病態検査学 / 口蓋突起 / 歯胚 / 舌筋 / in situ hybridization / 器官培養 / MFCS4 / マウス Less

咽頭発生におけるSHHシグナリングとそのエンハンサーの役割Principal Investigator
- Principal Investigator
  
  奥原滋
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Japan Women's University
咽頭諸器官の発生におけるＳＨＨシグナリングの役割Principal Investigator
- Principal Investigator
  
  奥原滋
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Japan Women's University
Shh signalling in the development of oral and pharyngeal organsPrincipal Investigator
- Principal Investigator
  
  OKUHARA Shigeru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Japan Women's University
  Tokyo Medical and Dental University
The role of Shh in tongue developmentPrincipal Investigator
- Principal Investigator
  
  OKUHARA Shigeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
Shh signaling in pharyngeal developmentPrincipal Investigator
- Principal Investigator
  
  OKUHARA Shigeru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
MFCS4 in palate developmentPrincipal Investigator
- Principal Investigator
  
  OKUHARA Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
口蓋発生におけるShhの役割Principal Investigator
- Principal Investigator
  
  OKUHARA Shigeru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019 2018 2016 2015 2013 2012 2011 2010 2008 Other

All Journal Article Presentation

[Journal Article] Overexpression of PD‐L1 in gingival basal keratinocytes reduces periodontal inflammation in a ligature‐induced periodontitis model2021
- Author(s)
  Wongtim Keeratika、Ikeda Eri、Ohno Tatsukuni、Nagai Shigenori、Okuhara Shigeru、Kure Keitetsu、Azuma Miyuki
- Journal Title
  
  Journal of Periodontology
  
  Volume: 93 Issue: 1 Pages: 146-155
- DOI
  10.1002/jper.21-0017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22702, KAKENHI-PROJECT-19K21376, KAKENHI-PROJECT-19K10260, KAKENHI-PROJECT-20K18500
[Journal Article] Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development2020
- Author(s)
  Shirabe Ohki, Kyoko Oka, Kayoko Ogata, Shigeru Okuhara, Mihoko Rikitake, Masako Toda-Nakamura, Shougo Tamura, Masao Ozaki, Sachiko Iseki, Takayoshi Sakai
- Journal Title
  
  Frontiers in physiology
  
  Volume: 11 Pages: 532-532
- DOI
  10.3389/fphys.2020.00532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10260, KAKENHI-PROJECT-19K19305, KAKENHI-PROJECT-19KK0230, KAKENHI-PROJECT-19H03852, KAKENHI-PROJECT-18K09849
[Journal Article] Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature2019
- Author(s)
  Okuhara Shigeru、Birjandi Anahid A.、Adel Al-Lami Hadeel、Sagai Tomoko、Amano Takanori、Shiroishi Toshihiko、Xavier Guilherme M.、Liu Karen J.、Cobourne Martyn T.、Iseki Sachiko
- Journal Title
  
  Development
  
  Volume: 146 Issue: 21 Pages: 180075-180075
- DOI
  10.1242/dev.180075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10260, KAKENHI-PROJECT-17H04357
[Journal Article] Transcription factor Foxc1 is involved in anterior part of cranial base formation.2018
- Author(s)
  Mya N, Furutera T, Okuhara S, Kume T, Takechi M, Iseki S.
- Journal Title
  
  Conget. Anom.
  
  Volume: - Issue: 5 Pages: 158-166
- DOI
  10.1111/cga.12268
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04357, KAKENHI-PROJECT-16K11744
[Journal Article] Foxc1 is required for early stage telencephalic vascular development.2015
- Author(s)
  Prasitsak T, Nandar M, Okuhara S, Ichinose S, Ota MS, Iseki S.
- Journal Title
  
  Dev Dyn.
  
  Volume: 244 Issue: 5 Pages: 703-711
- DOI
  10.1002/dvdy.24269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670831, KAKENHI-PROJECT-25463130
[Journal Article] Epithelial integrity in palatal shelf elevation2012
- Author(s)
  Shigeru Okuhara
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 48 Issue: 1 Pages: 18-22
- DOI
  10.1016/j.jdsr.2011.07.001
- NAID
  10030281764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592254
[Journal Article] Effects of embryonic hypoxia on lip formation.2012
- Author(s)
  Nagaoka R, Okuhara S, Sato Y, Amagasa T, Iseki S.
- Journal Title
  
  Birth Defects Res A Clin Mol Teratol.
  
  Volume: 94(4) Issue: 4 Pages: 215-22
- DOI
  10.1002/bdra.23000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592254
[Journal Article] Pocket epithelium in the pathological setting for HMGB1 release.2011
- Author(s)
  Ebe N, Hara-Yokoyama M, Iwasaki K, Iseki S, Okuhara S, Podyma-Inoue KA, Terasawa K, Watanabe A, Akizuki T, Watanabe H, Yanagishita M,Izumi Y.
- Journal Title
  
  J Dent Res.
  
  Volume: 90(2) Issue: 2 Pages: 235-40
- DOI
  10.1177/0022034510385688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] 新規免疫チェクポイント分子ILDR2 の発現2022
- Author(s)
  張晨陽、奥原滋、永井重徳、東みゆき
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10134
[Presentation] A novel immune checkpoint molecule, ILDR2 is upregulated in the inflammatory by brain2022
- Author(s)
  Farzana Sultana, Chenyang Zhang, Shigeru Okuhara, Sigenori Nagai, Miyuki Azuma
- Organizer
  第87回口腔病学会
- Data Source
  KAKENHI-PROJECT-22K10134
[Presentation] A novel immune checkpoint molecule, ILDR2 is upregulated in the inflammatory by brain.2022
- Author(s)
  Farzana Sultana, Chenyang Zhang, Shigeru Okuhara, Sigenori Nagai, Miyuki Azuma
- Organizer
  第87回口腔病学会
- Data Source
  KAKENHI-PROJECT-19K10260
[Presentation] 新規免疫チェクポイント分子ILDR2の発現2022
- Author(s)
  張晨陽、奥原滋、永井重徳、東みゆき
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10260
[Presentation] 口蓋上皮 TGF-β および Shh は，口蓋間葉の Tenascin C 発現を誘導する2018
- Author(s)
  大木調，岡暁子，緒方佳代子，中村雅子，奥原滋，尾崎正雄，井関祥子，阪井丘芳
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16K11744
[Presentation] Sonic hedgehog is required for neural crest-dependent patterning of the intrinsic tongue musculature2018
- Author(s)
  Shigeru Okuhara Anahid A. Birjandi, Hadeel Adel Al-Lami, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi, Karen J. Liu, Martyn T. Cobourne
- Organizer
  Gordon Research Conference Craniofacial Morphogenesis and Tissue Regeneration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11744
[Presentation] Shh signaling during patterning of the murine tongue2016
- Author(s)
  Shigeru OKUHARA, Tomoko Sagai, Anahid A. Birjandi2Hadeel Al-Lami, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi, Karen Liu, Martyn T. Cobourne, Sachiko Iseki
- Organizer
  JSDB Special Symposium: Frontier of Developmental Biology
- Place of Presentation
  東京大学小柴ホール（東京都・文京区）
- Data Source
  KAKENHI-PROJECT-16K11744
[Presentation] MFCS4はShhとSox9を介して咽頭諸器官の発生を制御する2015
- Author(s)
  奥原滋、濱崎七海、嵯峨井知子、天野孝紀、大内淑代、城石俊彦、井関祥子
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25463130
[Presentation] 舌の形態形成異常に起因する口蓋裂モデルマウスの解析2013
- Author(s)
  奥原滋、町田章彦、天野孝紀、嵯峨井知子、城石俊彦、井関祥子
- Organizer
  第53回日本先天異常学会学術集会
- Place of Presentation
  吹田　大阪千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25463130
[Presentation] Tongue development in Shh-/+MFCS4+/-.2012
- Author(s)
  Shigeru OKUHARA, Ryosuke NAGAOKA,Takanori AMANO, Tomoko SAGAI, ToshihikoSHIROISHI, Sachiko ISEKI
- Organizer
  Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2012-03-18
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Tongue and palate development in Shh-/+MFCS4+/-.2012
- Author(s)
  Shigeru OKUHARA
- Organizer
  Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Shh in development of pharyngeal region2012
- Author(s)
  Shigeru Okuhara
- Organizer
  Gordon Research Conference Craniofacial Mophogenesis and Tissue Regeneration
- Place of Presentation
  Ventura, CA.,米国
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Tongue and palate development in Shh-/+MFCS4+/-2012
- Author(s)
  Shigeru OKUHARA, Ryosuke NAGAOKA, Takanori AMANO, Tomoko SAGAI, Toshihiko SHIROISHI, Sachiko ISEKI
- Organizer
  Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  神戸
- Year and Date
  2012-05-28
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Cleft palate in compound heterozygote of sonic hedgehog and MFCS42010
- Author(s)
  Okuhara S, Sagai T, Nagaoka R, Amano T, Shiroishi T, Iseki S
- Organizer
  The 16th International Society of Differntiation Conference
- Place of Presentation
  Nara, Japan
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] 胎児期低酸素状態が顔面形成に与える影響2010
- Author(s)
  長岡亮介、奥原滋、天笠光雄、井関祥子
- Organizer
  第50回日本先天異常学会学術集会
- Place of Presentation
  淡路市
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Cleft palate in mice of sonic hedgehog and its cis-regulatory region MFCS4 compound heterozygote2010
- Author(s)
  Okuhara S, Sagai T, Nagaoka R, Amano T, Shiroishi T, Iseki S
- Organizer
  43^<rd> Annual Meeting for Japanese Society of Developmental Scientists
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Effects of embryonic hypoxia on maxillofacial development2010
- Author(s)
  Nagaoka R, Okuhara S, Amagasa T, Iseki S
- Organizer
  The 16th International Society of Differntiation Conference
- Place of Presentation
  Nara, Japan
- Data Source
  KAKENHI-PROJECT-22592254
[Presentation] Sonic hedgehog and Sall3 in tooth and palate development2008
- Author(s)
  Shigeru OKUHARA and Sachiko ISEKI
- Organizer
  Gordon Research Conference, Craniofacial Morphogenesis & Tissue Regeneration
- Place of Presentation
  Barga(イタリア)
- Data Source
  KAKENHI-PROJECT-19890071
[Presentation] Sonic hedgehog and Sall3 in tooth and palate Development2008
- Author(s)
  Shigeru OKUHARA and Sachiko ISEKI
- Organizer
  Gordon Research Conferences CRANIOFACIAL MORPHOGENESIS & TISSUE REGENERATION
- Place of Presentation
  Lucca, Italy
- Data Source
  KAKENHI-PROJECT-19890071
[Presentation] Shh in tongue development
- Author(s)
  Shigeru OKUHARA, Sachiko ISEKI
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25463130

1. ISEKI Sachiko (80251544)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. 森田圭一 (10396971)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SATO Yutaka (90361716)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. HARADA Kiyoshi (30228639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 長岡亮介 (30760805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKECHI Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 太田正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 東みゆき

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuhara Shigeru 奥原 滋

OKUHARA Shigeru 奥原 滋

Research Projects

Research Products

Co-Researchers

咽頭発生におけるSHHシグナリングとそのエンハンサーの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

咽頭諸器官の発生におけるＳＨＨシグナリングの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Shh signalling in the development of oral and pharyngeal organsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Shh in tongue developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Shh signaling in pharyngeal developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MFCS4 in palate developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口蓋発生におけるShhの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Overexpression of PD‐L1 in gingival basal keratinocytes reduces periodontal inflammation in a ligature‐induced periodontitis model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor Foxc1 is involved in anterior part of cranial base formation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foxc1 is required for early stage telencephalic vascular development.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial integrity in palatal shelf elevation2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Effects of embryonic hypoxia on lip formation.2012

Author(s)

Okuhara Shigeru 奥原滋

OKUHARA Shigeru 奥原滋