Ochiai Kyoko 落合恭子

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OCHIAI Kyoko 落合恭子

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Researcher Number	10455785
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 医学系研究科, 助教 2017: 東北大学, 医学(系)研究科(研究院), 助教 2016 – 2017: 東北大学, 医学系研究科, 助教 2012 – 2014: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / Basic Section 48040:Medical biochemistry-related / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator 転写因子 / 遺伝子 / 遺伝子発現制御 / 抗体産生 / タンパク質蓄積制御 / 遺伝子発現ネットワーク / 形質細胞分化 / 新規化合物開発 / クロマチン制御因子 / IKAROS … More / 転写因子IRF4 / クロマチン制御因子PC4 / 転写因子IKAROS / 多発性骨髄腫 / 細胞分化制御 / 細胞分化 / エピゲノム / ゲノム / 核内ポジショニング / CSR / エピゲノム制御 … More Except Principal Investigator エピジェネティクス / 転写因子 / 頭頸部癌 / 乳癌 / 膵癌 Less

BACH2遺伝子発現プログラムによるIRF4蓄積制御と抗体産生制御機構の解明Principal Investigator
- Principal Investigator
  
  落合恭子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Development of an agent promoting IKAROS protein destabilization in Multiple myeloma cellsPrincipal Investigator
- Principal Investigator
  
  Ochiai Kyoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
Development of anti-cancer strategy by exploiting BACH1 addiction
- Principal Investigator
  
  五十嵐和彦
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Tohoku University
選択的遺伝子領域の動的ヘテロクロマチン化誘導機構Principal Investigator
- Principal Investigator
  
  落合恭子
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Orchestration of memory B cell differentiation controlled by the regulation of IRF4 protein degradationPrincipal Investigator
- Principal Investigator
  
  Ochiai Kyoko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
エピゲノム制御によるDNA損傷修復機構と細胞分化Principal Investigator
- Principal Investigator
  
  落合恭子
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Dynamic regulation of cell differentiation via gene regulatory networks organized by multiple transcription factorsPrincipal Investigator
- Principal Investigator
  
  OCHIAI Kyoko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2018 2017 2016 2014 2013 2012

All Journal Article Presentation

[Journal Article] Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions2024
- Author(s)
  Ochiai Kyoko、Shima Hiroki、Tamahara Toru、Sugie Nao、Funayama Ryo、Nakayama Keiko、Kurosaki Tomohiro、Igarashi Kazuhiko
- Journal Title
  
  The EMBO Journal
  
  Volume: 印刷中 Issue: 10 Pages: 1947-1964
- DOI
  10.1038/s44318-024-00077-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-23K27362
[Journal Article] TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO222024
- Author(s)
  Liu Liang、Matsumoto Mitsuyo、Watanabe-Matsui Miki、Nakagawa Tadashi、Nagasawa Yuko、Pang Jingyao、Callens Bert K. K.、Muto Akihiko、Ochiai Kyoko、Takekawa Hirotaka、Alam Mahabub、Nishizawa Hironari、Shirouzu Mikako、Shima Hiroki、Nakayama Keiko、Igarashi Kazuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 8 Pages: 4141-4141
- DOI
  10.3390/ijms25084141
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0176, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-23K24156
[Journal Article] Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies2022
- Author(s)
  Kyoko Ochiai , Kazuhiko Igarashi
- Journal Title
  
  International immunology
  
  Volume: Dec 27 Issue: 6 Pages: 257-265
- DOI
  10.1093/intimm/dxac065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07351, KAKENHI-PROJECT-22H00443
[Journal Article] BACH1 Expression Is Promoted by Tank Binding Kinase 1 (TBK1) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin.2022
- Author(s)
  Liu, L., Matsumoto M., Matsui-Watanabe, M., Ochiai, K., Callens, B.K.K., Nguyen,. L.C., Kozuki, Y., Tanaka, M., Nishizawa, H. and Igarashi, K.
- Journal Title
  
  Antioxidants (Basel)
  
  Volume: 11 Issue: 8 Pages: 1460-1460
- DOI
  10.3390/antiox11081460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0176, KAKENHI-PROJECT-22H00443, KAKENHI-PROJECT-23K24156
[Journal Article] Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins2021
- Author(s)
  Ochiai Kyoko、Shima Hiroki、Ikura Tsuyoshi、Franke Marissa C.、Sievert Evelyn P.、Sciammas Roger、Igarashi Kazuhiko
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 3 Pages: 100633-100633
- DOI
  10.1016/j.xpro.2021.100633
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04336, KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-20K07351
[Journal Article] Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF42020
- Author(s)
  Ochiai Kyoko、Yamaoka Mari、Swaminathan Amrutha、Shima Hiroki、Hiura Hitoshi、Matsumoto Mitsuyo、Kurotaki Daisuke、Nakabayashi Jun、Funayama Ryo、Nakayama Keiko、Arima Takahiro、Ikawa Tomokatsu、Tamura Tomohiko、Sciammas Roger、Bouvet Philippe、Kundu Tapas K.、Igarashi Kazuhiko
- Journal Title
  
  Cell Reports
  
  Volume: 33 Issue: 12 Pages: 108517-108517
- DOI
  10.1016/j.celrep.2020.108517
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07321, KAKENHI-PROJECT-20K07351, KAKENHI-PROJECT-19KK0222, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-18H02355, KAKENHI-PROJECT-18K09215
[Journal Article] Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell2018
- Author(s)
  Kyoko Ochiai, Haruka Kondo, Yasunobu Okamura, Hiroki Shima, Yuko Kurokochi, Kazumi Kimura, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Katsuyuki Yui, Kengo Kinoshita and Kazuhiko Igarashi
- Journal Title
  
  Blood advances
  
  Volume: Apr 24;2(8) Issue: 8 Pages: 883-894
- DOI
  10.1182/bloodadvances.2017010413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01295, KAKENHI-PROJECT-16K19026, KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-18H04021
[Journal Article] mTOR-Bach2 cascade controls cell cycle and class switch recombination2017
- Author(s)
  Toru Tamahara, Kyoko Ochiai, Akihiko Muto, Yukinari Kato, Nicolas Sax, Mitsuyo Matsumoto, Takeyoshi Koseki and Kazuhiko Igarashi
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: Nov 28;37(24)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19026
[Journal Article] The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation.2017
- Author(s)
  Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, Koseki T, Igarashi K.
- Journal Title
  
  Molecular and cellular biology
  
  Volume: 37 Issue: 24
- DOI
  10.1128/mcb.00418-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07108, KAKENHI-PUBLICLY-16H01295, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-15K15771
[Journal Article] Orchestrating B lymphopoiesis through interplay of IL-7R and pre-BCR signaling2014
- Author(s)
  Marcus R. Clark, Malay Mandal, Kyoko Ochiai, Harinder Singh
- Journal Title
  
  Nature Reviews Immunology
  
  Volume: 14(2) Pages: 69-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790271
[Journal Article] Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF42013
- Author(s)
  Kyoko Ochiai, Mark Maienschein-Cline, Jianjun Chen, Anita S. Chong, Aaron R. Dinner, Harinder Singh, Roger Sciammas
- Journal Title
  
  Immunity
  
  Volume: 38(5) Pages: 918-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790271
[Journal Article] A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation2012
- Author(s)
  Kyoko Ochiai, Maienschein-Cline, Malay Mandal, Joseph R Triggs, Eric Bertolino, Roger Sciammas, Aaron R Dinner, Marcus R Clark, Harinder Singh
- Journal Title
  
  Nature Immunology
  
  Volume: 13(3) Pages: 300-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790271
[Presentation] B細胞におけるBACH転写因子の量比による転写調節機構の解明2023
- Author(s)
  倉澤岳志、武藤哲彦、松本光代、落合恭子、村山和隆、五十嵐和彦
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20KK0176
[Presentation] The regulation of B cell chromatin by a non-histone chromatin protein PC4 and its interacting transcription factors2022
- Author(s)
  Kyoko Ochiai and Kazuhiko Igarashi
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K07351
[Presentation] The nucleolar role of RNA pol II/III coactivator PC4 as a cell stress sensor2021
- Author(s)
  Stephanie Kaypee, Kyoko Ochiai, Tsuyoshi Ikura, Tapas K. Kundu, Kazuhiko Igarashi
- Organizer
  American Society for Biochemistry and Molecular Biology (ASBMB) Meeting on Emerging Roles of the Nucleolus
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0176
[Presentation] Loss of chromatin-associated protein PC4 leads to altered H3K9me3-marked chromatin complex2021
- Author(s)
  Stephanie Kaypee, Kyoko Ochiai, Hiroki Shima, Kazuhiko Igarashi
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20KK0176
[Presentation] Gene regulatory networks of B-to-plasma cell differentiation orchestrated by IRF4 and its partner transcription factors2017
- Author(s)
  Kyoko Ochiai
- Organizer
  日本免疫学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01295
[Presentation] Gene regulatory networks of B-to-plasma cell differentiation orchestrated by IRF4 and its partner transcription factors2017
- Author(s)
  Kyoko Ochiai
- Organizer
  日本免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K19026
[Presentation] Gene regulatory networks composed by transcription factors orchestrate plasma cell differentiation2017
- Author(s)
  Kyoko Ochiai
- Organizer
  The 2017 Japan-NIH joint Symposium on Advances in Biomedical Research and Disease
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01295
[Presentation] Gene regulatory networks composed by transcription factors orchestrate plasma cell differentiation2017
- Author(s)
  Kyoko Ochiai
- Organizer
  The 2017 Japan-NIH joint Symposium on Advances in Biomedical Research and Disease
- Invited
- Data Source
  KAKENHI-PROJECT-16K19026
[Presentation] Dynamics of IRF4-dependent gene activation and repression during plasma cell differentiation2016
- Author(s)
  OCHIAI, Kyoko
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19026
[Presentation] 細胞分化におけるヘテロクロマチン化誘導の意義2014
- Author(s)
  落合恭子
- Organizer
  CREST研究会
- Place of Presentation
  東北大学医学部（仙台市）
- Year and Date
  2014-12-24
- Data Source
  KAKENHI-PUBLICLY-25118701
[Presentation] Regulation of Mat2α-mediated cell differentiation via nuclear organization2013
- Author(s)
  Kyoko Ochiai, Hiroki Shima, Kazuhiko Igarashi
- Organizer
  Immunity & Tolerance, the LXXVIII Cold Spring Harbor Symposium on Quantitative Biology
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-24790271
[Presentation] Organization of Plasma Cell Differentiation via Epigenome-related Complex2013
- Author(s)
  落合恭子, 五十嵐和彦
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-24790271

1. 五十嵐和彦 (00250738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 島弘季 (00448268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 西澤弘成 (30846655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 松本光代 (80400448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 井倉毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ochiai Kyoko 落合 恭子

OCHIAI Kyoko 落合 恭子

Research Projects

Research Products

Co-Researchers

BACH2遺伝子発現プログラムによるIRF4蓄積制御と抗体産生制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an agent promoting IKAROS protein destabilization in Multiple myeloma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anti-cancer strategy by exploiting BACH1 addiction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

選択的遺伝子領域の動的ヘテロクロマチン化誘導機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Orchestration of memory B cell differentiation controlled by the regulation of IRF4 protein degradationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エピゲノム制御によるDNA損傷修復機構と細胞分化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dynamic regulation of cell differentiation via gene regulatory networks organized by multiple transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO222024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BACH1 Expression Is Promoted by Tank Binding Kinase 1 (TBK1) in Pancreatic Cancer Cells to Increase Iron and Reduce the Expression of E-Cadherin.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF42020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell2018

Author(s)

Journal Title

Ochiai Kyoko 落合恭子

OCHIAI Kyoko 落合恭子