Tokunaga Takahiro 徳永貴広

Researcher Number	10464075
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2019: 福井大学, 学術研究院医学系部門, 特別研究員 2016 – 2017: 福井大学, 医学部附属病院, その他 2016 – 2017: 福井大学, 学術研究院医学系部門(附属病院部), 特命助教 2015 – 2016: 福井大学, 医学部附属病院, 特命助教 2014: 福井大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Otorhinolaryngology Except Principal Investigator Laboratory medicine / Otorhinolaryngology
Keywords	Principal Investigator TRPV3 / アレルギー・ぜんそく / TRPV1 / 好酸球性炎症 / トランスクリプトーム / 次世代シーケンサー / 鼻茸 / 好酸球性副鼻腔炎 Except Principal Investigator アレルギー / 炎症 … More / 細胞死 / ETosis / galectin-10 / シャルコー・ライデン結晶 / 好酸球 / ヒスタミン遊離 / Dectin 1 / アレルギー性鼻炎 / IL-17A / IgE / 免疫学 / 発現制御 / 細胞・組織 / 遺伝子 / Hexaponda / CpG-DNA / ヒスタミン / Apolipoprotein　A-IV / HLA-DPB / C5a / C3a / IL-33 / TSLP / Dectin-1 / Apolipoprotein A4 / HLA-DR / スギ花粉症 Less

Functional analysis of TRP receptor family on eosinophilic inflammation in mucous membranePrincipal Investigator
- Principal Investigator
  
  Tokunaga Takahiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  University of Fukui
Significance of Charcot-Leiden crystals (galectin-10) in the pathogenesis of eosinophilic inflammation
- Principal Investigator
  
  Ueki Shigeharu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Akita University
Degranulation from mast cell in the onset of allergic rhinitis
- Principal Investigator
  
  Fujieda Shigeharu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  University of Fukui
Analysis of gene expression and function of TRP receptor in nasal polyps of eosinophilic chronic rhinosinusitisPrincipal Investigator
- Principal Investigator
  
  Tokunaga Takahiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  University of Fukui

All 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis2019
- Author(s)
  Yamada Takechiyo、Miyabe Yui、Ueki Shigeharu、Fujieda Shigeharu、Tokunaga Takahiro、Sakashita Masafumi、Kato Yukinori、Ninomiya Takahiro、Kawasaki Yohei、Suzuki Shinsuke、Saito Hidekazu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 74-74
- DOI
  10.3389/fimmu.2019.00074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08926, KAKENHI-PROJECT-17K11356, KAKENHI-PROJECT-18K09311, KAKENHI-PROJECT-18K16879, KAKENHI-PROJECT-17H04344, KAKENHI-PROJECT-15KK0329
[Journal Article] Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death2018
- Author(s)
  Ueki Shigeharu、Tokunaga Takahiro、Melo Rossana C. N.、Saito Hidekazu、Honda Kohei、Fukuchi Mineyo、Konno Yasunori、Takeda Masahide、Yamamoto Yohei、Hirokawa Makoto、Fujieda Shigeharu、Spencer Lisa A.、Weller Peter F.
- Journal Title
  
  Blood
  
  Volume: 132 Issue: 20 Pages: 2183-2187
- DOI
  10.1182/blood-2018-04-842260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08926, KAKENHI-PROJECT-17K11356, KAKENHI-PROJECT-18K16827, KAKENHI-PROJECT-15KK0329, KAKENHI-PROJECT-17K17611
[Journal Article] The significant expression of TRPV3 in nasal polyps of eosinophilic chronic rhinosinusitis2017
- Author(s)
  Tokunaga T, Ninomiya T, Kato Y, Imoto Y, Sakashita M, Takabayashi T, Noguchi E, Fujieda S
- Journal Title
  
  Allergol. Int.
  
  Volume: 66 Issue: 4 Pages: 610-616
- DOI
  10.1016/j.alit.2017.04.002
- NAID
  130006179515
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11207, KAKENHI-PROJECT-16K11208
[Journal Article] 好酸球性副鼻腔炎の診断と治療2016
- Author(s)
  徳永貴広, 藤枝重治
- Journal Title
  
  週刊日本医事新報
  
  Volume: 4800 Pages: 36-41
- NAID
  130003395285
- Data Source
  KAKENHI-PROJECT-26861360
[Journal Article] Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation.2016
- Author(s)
  Ueki, S., Tokunaga, T., Fujieda, S., Honda, K., Hirokawa, M., Spencer, LA., Weller, PF.
- Journal Title
  
  Curr Allergy Asthma Rep.
  
  Volume: 36 Pages: 1349-1352
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08926
[Journal Article] Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts.2016
- Author(s)
  Yamada T, Ogi K, Sakashita M, Kanno M, Kubo S, Ito Y, Imoto Y, Tokunaga T, Okamoto M, Narita N, Fujieda S.
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 44（4） Issue: 4 Pages: 398-403
- DOI
  10.1016/j.anl.2016.10.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293368, KAKENHI-PROJECT-17H04344, KAKENHI-PROJECT-17K11356
[Journal Article] Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen2015
- Author(s)
  Imoto Y, Takabayashi T, Sakashita M, Tokunaga T, Ninomiya T, Ito Y, Narita N, Yamada T, Fujieda S
- Journal Title
  
  Immun Inflamm Dis
  
  Volume: 3 Issue: 3 Pages: 300-308
- DOI
  10.1002/iid3.69
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462660, KAKENHI-PROJECT-25293348, KAKENHI-PROJECT-26293368
[Journal Article] 好酸球性副鼻腔炎の診断基準2015
- Author(s)
  徳永貴広、坂下雅文、二之宮貴裕、意元義政、冨田かおり、森川太洋、藤枝重治
- Journal Title
  
  アレルギー・免疫
  
  Volume: 22 Pages: 22-28
- Data Source
  KAKENHI-PROJECT-26861360
[Journal Article] Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.2015
- Author(s)
  Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, Tahara-Hanaoka S, Shibuya A.
- Journal Title
  
  PLoS One, 10(12), 2015
  
  Volume: 10 Issue: 12 Pages: 1-16
- DOI
  10.1371/journal.pone.0144436
- NAID
  120007130029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15319, KAKENHI-PUBLICLY-15H01365, KAKENHI-PROJECT-15H04862, KAKENHI-PROJECT-26893027, KAKENHI-PROJECT-13J00798, KAKENHI-PROJECT-15K15659, KAKENHI-PROJECT-26861360
[Journal Article] Factors associated with the development and remission of allergic diseases in an epidemiological survey of high school students in Japan.2015
- Author(s)
  Tokunaga T, Ninomiya T, Osawa Y, Imoto Y, Ito Y, Takabayashi T, Narita N, Kijima A, Murota H, Katayama I, Fujieda S.
- Journal Title
  
  Am J Rhinol Allergy.
  
  Volume: 29 Issue: 2 Pages: 94-9
- DOI
  10.2500/ajra.2015.29.4135
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293348, KAKENHI-PROJECT-26293368, KAKENHI-PROJECT-15K15418, KAKENHI-PROJECT-25462660
[Journal Article] 好酸球性副鼻腔炎　診断ガイドライン (JESREC Study)2015
- Author(s)
  藤枝重治, 坂下雅文, 徳永貴広, 岡野光博, 春名威範, 他
- Journal Title
  
  日本耳鼻咽喉科学会会報
  
  Volume: 118 Pages: 728-735
- NAID
  130005088297
- Data Source
  KAKENHI-PROJECT-26861360
[Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study.2015
- Author(s)
  Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
- Journal Title
  
  Allergy
  
  Volume: Epub ahead of print Issue: 8 Pages: 995-1003
- DOI
  10.1111/all.12644
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592582, KAKENHI-PROJECT-25293348, KAKENHI-PROJECT-26861360, KAKENHI-PROJECT-15K10790, KAKENHI-PROJECT-25462660, KAKENHI-PROJECT-25462665, KAKENHI-PROJECT-25462694, KAKENHI-PROJECT-26293366
[Presentation] 好酸球性副鼻腔炎におけるTRPチャンネルの発現2018
- Author(s)
  加藤幸宣、高林哲司、徳永貴広、二之宮貴裕、吉田加奈子、森川太洋、意元義政、藤枝重治
- Organizer
  第57回日本鼻科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K11208
[Presentation] 好酸球性副鼻腔炎におけるTRPV3遺伝子の発現解析2016
- Author(s)
  徳永貴広, 意元義政, 坂下雅文, 高林哲司, 藤枝重治
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K11208
[Presentation] Whole transcriptome解析(RNA-Seq)により同定された好酸球性副鼻腔炎関連遺伝子2016
- Author(s)
  徳永貴広, 意元義政, 坂下雅文, 高林哲司, 藤枝重治
- Organizer
  第34回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  鳥羽国際ホテル
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26861360
[Presentation] Novel scoring system and algorithm for classifying eosinophilic chronic rhinosinusitis: The JESREC Study2015
- Author(s)
  T.Tokunaga, M.Sakashita, T.Ninomiya, Y.Imoto, T.Morikawa, K.Tomita, T.Takabayashi, S.Fujieda & JESREC group
- Organizer
  The 9th Biennal Symposium of International Eosinophil Society
- Place of Presentation
  Holiday Inn Mart Plaza
- Year and Date
  2015-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861360
[Presentation] 次世代シーケンサーを用いたWhole transcriptome解析(RNA-seq)による好酸球性副鼻腔炎関連遺伝子の同定2015
- Author(s)
  徳永貴広, 二之宮貴裕, 意元義政, 坂下雅文, 野口恵美子, 藤枝重治
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-26861360
[Presentation] 次世代シーケンサーを用いたWhole transcriptome解析(RNA-seq)による好酸球性副鼻腔炎関連遺伝子の同定
- Author(s)
  徳永貴広、意元義政、坂下雅文、藤枝重治
- Organizer
  第33回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東京都・錦糸町・東武ホテルレバント東京
- Year and Date
  2015-02-26 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-26861360
[Presentation] 次世代シーケンサーを用いたWhole transcriptome解析(RNA-seq)による好酸球性副鼻腔炎関連遺伝子の同定
- Author(s)
  徳永貴広、二之宮貴裕、意元義政、坂下雅文、野口恵美子、藤枝重治
- Organizer
  第64回日本アレルギー学会
- Place of Presentation
  東京都・品川・グランドプリンスホテル新高輪国際館パミール
- Year and Date
  2015-05-26 – 2015-05-28
- Data Source
  KAKENHI-PROJECT-26861360

1. Fujieda Shigeharu (30238539)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. NOGUCHI Emiko (40344882)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Ueki Shigeharu (60361234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 高林哲司 (70397272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 三邉武彦 (00622135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田原聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 意元義政

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 吉川衛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tokunaga Takahiro 徳永 貴広

Research Projects

Research Products

Co-Researchers

Functional analysis of TRP receptor family on eosinophilic inflammation in mucous membranePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of Charcot-Leiden crystals (galectin-10) in the pathogenesis of eosinophilic inflammation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Degranulation from mast cell in the onset of allergic rhinitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of gene expression and function of TRP receptor in nasal polyps of eosinophilic chronic rhinosinusitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The significant expression of TRPV3 in nasal polyps of eosinophilic chronic rhinosinusitis2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] 好酸球性副鼻腔炎の診断と治療2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation.2016

Author(s)

Journal Title

Data Source

[Journal Article] Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 好酸球性副鼻腔炎の診断基準2015

Author(s)

Journal Title

Data Source

[Journal Article] Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Factors associated with the development and remission of allergic diseases in an epidemiological survey of high school students in Japan.2015

Author(s)

Journal Title

DOI

Data Source

Tokunaga Takahiro 徳永貴広

[Journal Article] 好酸球性副鼻腔炎　診断ガイドライン (JESREC Study)2015