Kitazawa Masato 北沢将人

Researcher Number	10467152
Other IDs	https://orcid.org/0000-0001-7737-7592
Affiliation (Current)	2024: 信州大学, 学術研究院医学系(医学部附属病院), 講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 信州大学, 学術研究院医学系(医学部附属病院), 講師
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator BCL-XL阻害剤 / MEK阻害剤 / KRAS変異 / 大腸癌 / STAT3 / 抗EGFR抗体 / KRAS阻害剤 / 個別化治療 / KRAS遺伝子変異 / BCL-XL / MEK / KRAS … More Except Principal Investigator … More 腸管上皮内リンパ球 / 自己免疫性腸炎 / 免疫チェックポイント阻害薬 / インターフェロン制御因子2 / T cell / IELs / IRF-2 / 発症メカニズム / 気象データ / 気圧変化 / 癒着性腸閉塞 Less

Investigation of resistance mechanisms of KRAS mutant G12C and G12D selective inhibitorsPrincipal Investigator
- Principal Investigator
  
  北沢将人
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shinshu University
Elucidation of the mechanism of the onset of adhesive small bowel obstruction focusing on changes in barometric pressure
- Principal Investigator
  
  山本悠太
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
免疫チェックポイント阻害薬誘発自己免疫性腸炎におけるIRF-2分子機能の解明
- Principal Investigator
  
  得丸重夫
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Investigation of effective therapeutic target molecules for KRAS-mutated colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Kitazawa Masato
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Shinshu University

All 2023 2021 2020

All Journal Article Presentation

[Journal Article] Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRAS<sup>G12D</sup>Inhibitor, in Colorectal Cancer Treatment2023
- Author(s)
  KATAOKA MASAHIRO、KITAZAWA MASATO、NAKAMURA SATOSHI、KOYAMA MAKOTO、YAMAMOTO YUTA、MIYAZAKI SATORU、HONDO NAO、TANAKA HIROKAZU、SOEJIMA YUJI
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 10 Pages: 4341-4348
- DOI
  10.21873/anticanres.16629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15555
[Journal Article] MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells2023
- Author(s)
  Hondo Nao、Kitazawa Masato、Koyama Makoto、Nakamura Satoshi、Tokumaru Shigeo、Miyazaki Satoru、Kataoka Masahiro、Seharada Kai、Soejima Yuji
- Journal Title
  
  Cancer Letters
  
  Volume: 567 Pages: 216264-216264
- DOI
  10.1016/j.canlet.2023.216264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15555
[Journal Article] Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG?510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL?XL2021
- Author(s)
  Kitazawa Masato、Miyagawa Yusuke、Koyama Makoto、Nakamura Satoshi、Hondo Nao、Miyazaki Satoru、Muranaka Futoshi、Tokumaru Shigeo、Yamamoto Yuta、Ehara Takehito、Kuroiwa Masatsugu、Tanaka Hirokazu、Komatsu Daisuke、Takeoka Michiko、Soejima Yuji
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 15 Issue: 1
- DOI
  10.3892/mco.2021.2310
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15238
[Journal Article] Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells2020
- Author(s)
  Koyama Makoto、Kitazawa Masato、Nakamura Satoshi、Matsumura Tomio、Miyazaki Satoru、Miyagawa Yusuke、Muranaka Futoshi、Tokumaru Shigeo、Okumura Masahiro、Yamamoto Yuta、Ehara Takehito、Hondo Nao、Takahata Shugo、Takeoka Michiko、Miyagawa Shinichi、Soejima Yuji
- Journal Title
  
  International Journal of Oncology
  
  Volume: 57 Pages: 1179-1191
- DOI
  10.3892/ijo.2020.5117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15238
[Presentation] The effect of AMG510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL2021
- Author(s)
  北沢将人
- Organizer
  日本癌治療学会総会
- Data Source
  KAKENHI-PROJECT-18K15238
[Presentation] Drug sensitivity profile of colorectal cancer cells　with　minor KRAS mutations (G12A, G12C, G12S, A146T and Q61H):　AMG510 shows highly selective antitumor effect on colorectal cancer cells with KRAS G12C mutation2021
- Author(s)
  北沢将人
- Organizer
  日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-18K15238
[Presentation] KRAS変異型大腸癌治療におけるBCL-XLのバイオマーカーとしての有用性2020
- Author(s)
  小山誠、北沢将人
- Organizer
  日本癌治療学会
- Data Source
  KAKENHI-PROJECT-18K15238
[Presentation] AMG510は大腸癌のUndruggable KRAS変異を突破できるか?2020
- Author(s)
  北沢将人
- Organizer
  日本癌治療学会
- Data Source
  KAKENHI-PROJECT-18K15238

1. 山本悠太 (20712764)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 得丸重夫 (70624683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 小山誠 (80712778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 副島雄二 (30325526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 瀧伸介 (50262027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kitazawa Masato 北沢 将人

Research Projects

Research Products

Co-Researchers

Investigation of resistance mechanisms of KRAS mutant G12C and G12D selective inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of the onset of adhesive small bowel obstruction focusing on changes in barometric pressure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫チェックポイント阻害薬誘発自己免疫性腸炎におけるIRF-2分子機能の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of effective therapeutic target molecules for KRAS-mutated colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRAS<sup>G12D</sup>Inhibitor, in Colorectal Cancer Treatment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG?510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL?XL2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] The effect of AMG510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL-XL2021

Author(s)

Organizer

Data Source

[Presentation] Drug sensitivity profile of colorectal cancer cells with minor KRAS mutations (G12A, G12C, G12S, A146T and Q61H): AMG510 shows highly selective antitumor effect on colorectal cancer cells with KRAS G12C mutation2021

Author(s)

Organizer

Data Source

[Presentation] KRAS変異型大腸癌治療におけるBCL-XLのバイオマーカーとしての有用性2020

Author(s)

Organizer

Data Source

[Presentation] AMG510は大腸癌のUndruggable KRAS変異を突破できるか?2020

Author(s)

Organizer

Data Source

Kitazawa Masato 北沢将人

[Presentation] Drug sensitivity profile of colorectal cancer cells　with　minor KRAS mutations (G12A, G12C, G12S, A146T and Q61H):　AMG510 shows highly selective antitumor effect on colorectal cancer cells with KRAS G12C mutation2021