NOJIMA HIROYUKI 野島広之

Researcher Number	10507320
Affiliation (based on the past Project Information) *help	2024: 帝京大学, 医学部, 講師 2019 – 2021: 帝京大学, 医学部, 講師 2019: 帝京大学, 医学部, 助教 2016 – 2019: 千葉大学, 医学部附属病院, 助教 2017: 千葉大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords	Principal Investigator 上皮間葉転換 / S1P受容体 / スフィンゴシン1－リン酸（S1P） / S1Pレセプター / スフィンゴシン1-リン酸（S1P） / cancer stemness / EMT / スフィンゴシン1リン酸 / 進行肝細胞癌 / miRNA / 膵癌 / エクソソーム … More Except Principal Investigator … More サルコペニア / 胃癌 / 間葉上皮転移 / 上皮間葉転移 / 転移性肝癌 / メタドへリン / 上皮間葉転換 / Snail1 / メタドヘリン / 肝転移 / 大腸癌 / Gankyrin / IL-32 / 肝内胆管癌 / 外科 / 膵癌 / バイオマーカー / 胆道癌 / 加齢 / 肝切除 / 微小循環障害 / NF-kappaB-p65 / 高齢肝 / STAT3 / NF-kappaB / Pin1 / 肝再生 / 拡大肝切除 / 高齢者 Less

Lin28/let-7シグナル制御による胃癌及び腫瘍関連サルコペニアの治療戦略
- Principal Investigator
  
  首藤潔彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Teikyo University
Mechanism of cancer progression mediated by IL-32-Gankyrin axis in intrahepatic cholangiocarcinoma
- Principal Investigator
  
  Mishima Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
Biological role of metadherin in liver metastases of colon cancer and development of novel molecular target therapy
- Principal Investigator
  
  Shimizu Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Teikyo University
Sphingosine-1-phosphate receptor-1 promotes vascular invasion and EMT in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  NOJIMA HIROYUKI
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Teikyo University
  Chiba University
A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.
- Principal Investigator
  
  Kuboki Satoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Identification of biomarkers for biliary tract cancer by proteomic approaches
- Principal Investigator
  
  Miyazaki Masaru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  International University of Health and Welfare
Exosomal microRNA transfer regulates cell proliferation and tumor progression in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  NOJIMA HIROYUKI
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Sphingosine-1-phosphate Receptor-1 Promotes Vascular Invasion and EMT in Hepatocellular2021
- Author(s)
  Yokota T, Nojima H, Kuboki S, Yoshitomi H, Furukawa K, Takayashiki T, Takano S, Ohtsuka M.
- Journal Title
  
  J Surg Res
  
  Volume: 259 Pages: 200-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09134
[Journal Article] OLFM4 Enhances STAT3 Activation and Promotes Tumor Progression by Inhibiting GRIM19 Expression in Human Hepatocellular Carcinoma2019
- Author(s)
  Ashizawa Y, Kuboki S, Nojima H, Takano S, Ohtsuka M, et al
- Journal Title
  
  Hepatology Communications
  
  Volume: 3 Issue: 7 Pages: 954-970
- DOI
  10.1002/hep4.1361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19H03725, KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-18K15040
[Journal Article] Roles of Pin1 as a Key Molecule for EMT Induction by Activation of STAT3 and NF-κB in Human Gallbladder Cancer.2019
- Author(s)
  Nakada S, Kuboki S, Nojima H, Yoshitomi H, Furukawa K, Takayashiki T, Takano S, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 26 Issue: 3 Pages: 907-917
- DOI
  10.1245/s10434-018-07132-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-16K10564, KAKENHI-PROJECT-16K10589, KAKENHI-PROJECT-16K15607, KAKENHI-PROJECT-18K15040
[Journal Article] Successful treatment of a locally advanced unresectable pancreatic cancer patient with interstitial pneumonitis by conversion surgery following gemcitabine plus nab-paclitaxel chemotherapy: A case report.2019
- Author(s)
  Yokota T, Takano S, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Nojima H, Mishima T, Nakadai E, Ohtsuka M.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 10 Pages: 419-424
- DOI
  10.3892/mco.2019.1807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-19H03725, KAKENHI-PROJECT-18K15040
[Journal Article] Conversion surgery with gemcitabine plus nab-paclitaxel for locally advanced unresectable pancreatic cancer: A case report.2018
- Author(s)
  Okura R, Takano S, Yokota T, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Nojima H, Mishima T, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 9 Pages: 389-393
- DOI
  10.3892/mco.2018.1688
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-16K15607
[Journal Article] Glucagonoma with necrolytic migratory erythema: metabolic profile and detection of biallelic inactivation of DAXX gene.2018
- Author(s)
  ①Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 23 Issue: 7 Pages: 1-4
- DOI
  10.1210/jc.2017-02646
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09875, KAKENHI-PROJECT-16KK0197, KAKENHI-PROJECT-18K07439, KAKENHI-PROJECT-18K08464, KAKENHI-PROJECT-18K15040, KAKENHI-PROJECT-17K16160, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] Novel treatment strategy with radiofrequency ablation and surgery for pregnant patients with hepatocellular carcinoma: a case report.2018
- Author(s)
  Matsuo M, Furukawa K, Shimizu H, Yoshitomi H, Takayashiki T, Kuboki S, Takano S, Suzuki D, Sakai N, Kagawa S, Nojima H, Ohsuka M.
- Journal Title
  
  Surg Case Rep.
  
  Volume: 4 Issue: 1 Pages: 43-43
- DOI
  10.1186/s40792-018-0434-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-18K15040
[Journal Article] Duffy antigen receptor for chemokines (DARC) expressing in cancer cells inhibits tumor progression by suppressing CXCR2 signaling in human pancreatic ductal adenocarcinoma.2017
- Author(s)
  32.Maeda S, Kuboki S, Nojima H, Shimizu H, Yoshitomi H, Furukawa K, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Cytokine
  
  Volume: 95 Pages: 15-21
- DOI
  10.1016/j.cyto.2017.02.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462036, KAKENHI-PROJECT-16K19915
[Journal Article] Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes2016
- Author(s)
  Nojima H, Konishi T, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E1, Lentsch AB
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 8 Pages: e0161443-e0161443
- DOI
  10.1371/journal.pone.0161443
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19915
[Presentation] 大腸癌同時性肝転移切除例の原発巣と転移巣におけるMTDHおよびSnail1の発現からみたEMT関連マーカーの意義2021
- Author(s)
  村上　崇、清水　宏明、野島　広之、芦澤　陽介、碓井　彰大、小杉　千弘、首藤　潔彦、山崎　将人、幸田　圭史
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-19K09134
[Presentation] 胆嚢癌におけるSTAT3およびNF-kB活性亢進を介したEMT誘導に関するPin1の意義2021
- Author(s)
  仲田真一郎, 久保木知, 野島広之, 吉富秀幸, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 賀川真吾, 細川勇, 三島敬, 小西孝宣, 宮崎勝, 大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] Safety and efficacy of down staging of neoadjuvant chemotherapy with modified FOLFOX6 (combination chemotherapy of infusional 5-FU/l-Leucovorin and intermittent oxaliplatin) with bevacizumab in patients with advanced lower rectal cancer .2020
- Author(s)
  Kosugi C, Koda K, Shimizu H, Yamazaki M, Shuto K, Nojima H, Murakami T, Ashizawa Y.
- Organizer
  The 30th Biennial Congress of ISUCRS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09134
[Presentation] 脾動脈背側アプローチによる腹腔鏡下尾側膵切除術の有用性2019
- Author(s)
  野島広之　清水宏明　幸田圭史　吉富秀幸　古川勝規　高屋敷吏　久保木知　高野重紹　大塚将之
- Organizer
  第11回膵臓内視鏡外科研究会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 当科における3D腹腔鏡を使用した腹腔鏡下脾動静脈温存尾側膵切除術2019
- Author(s)
  野島広之　吉富秀幸　古川勝規　高屋敷吏　久保木知　高野重紹　鈴木大亮　酒井望　賀川真吾　三島敬　宮崎勝　大塚将之
- Organizer
  第119回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 肝門部領域胆管癌での胆道再建を伴う肝葉切除におけるSSIリスク因子の検討2019
- Author(s)
  野島広之　久保木知　吉富秀幸　古川勝規　高屋敷吏　高野重紹　鈴木大亮　酒井望　賀川真吾　大塚将之
- Organizer
  第74回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] Initial results and the effectiveness of laparoscopic hepatectomy2019
- Author(s)
  H Nojima, , M Ohtsuka
- Organizer
  2nd World Congress of the International Laparoscopic Liver Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] Evaluation of neoadjuvant chemotherapy with modified FOLFOX6 (Combination chemotherapy of infusional 5-FU/I-Leucovorin and intermittent Oxaliplatin) with Bevacizumab/ Cetuximab in patients with advanced lower rectal cancer2019
- Author(s)
  Kosugi C, Koda K, Shimizu H, Yamazaki M, Shuto K, Nojima H, Hosokawa I, Murakami T, Takhashi M, Miyazawa Y
- Organizer
  IASGO 2019
- Data Source
  KAKENHI-PROJECT-19K09134
[Presentation] Risk factors for postoperative complications after hepatectomy in super-elderly patients2018
- Author(s)
  H Nojima, H Yoshitomi, K Furukawa, T Takayashiki, S Kuboki, S Takano, D Suzuki, N Sakai, S Kagawa T Mishima, M Miyazaki, M Ohtsuka
- Organizer
  第30回日本肝胆膵外科学会・学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 80歳以上の超高齢者に対する肝切除術での術後合併症とリスク因子の検討2018
- Author(s)
  野島広之　吉富秀幸　古川勝規　高屋敷吏　久保木知　高野重紹　鈴木大亮　酒井望　宮崎勝　大塚将之
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 局所進行膵癌に対する門脈合併切除再建の意義2018
- Author(s)
  野島広之，高野重紹，吉富秀幸，古川勝規，高屋敷吏，久保木知，鈴木大亮，酒井望，賀川真吾，三島敬，中台英里，大塚将之
- Organizer
  第80回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 肝細胞癌におけるスフィンゴシン1リン酸レセプターの発現についての検討2018
- Author(s)
  横田哲生　野島広之　久保木知　吉富秀幸　古川勝規　高屋敷吏　高野重紹　鈴木大亮　酒井望　賀川真吾　佐藤豊　宮崎勝　大塚将之
- Organizer
  第16回　日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 胃癌肝転移に対する適切な手術適応、予後予測因子としてのmodified Glasgow prognostic score (mGPS)の有用性の検討2018
- Author(s)
  野島広之　久保木知　吉富秀幸　古川勝規　高屋敷吏　高野重紹　鈴木大亮　酒井望　賀川真吾　佐藤豊　宮崎勝　大塚将之
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K15040
[Presentation] 80歳以上の高齢者に対する膵頭十二指腸切除術における手術リスクの検討2017
- Author(s)
  野島広之、久保木知、高屋敷吏、吉富秀幸、古川勝規、高屋敷吏、高野重紹、鈴木大亮、酒井　望、賀川真吾、宮崎　勝、大塚将之
- Organizer
  第117回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K19915
[Presentation] 膵癌における術前FDG-PET検査による細胞増殖能評価，予後予測での有用性2017
- Author(s)
  高橋誠野島広之久保木知鈴木崇之鈴木謙介西野仁惠米浦直子清水宏明吉富秀幸　古川勝規　高屋敷吏　高野重紹　鈴木大亮　酒井望　賀川真吾　宮崎勝　大塚将之
- Organizer
  第117回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K19915
[Presentation] 高齢胆道癌患者に対する拡大肝切除術を安全に施行するための至適残肝率の再考2017
- Author(s)
  久保木　知、渡邉　善寛、野島　広之、吉富　秀幸、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、賀川　真吾、三島　敬、宮崎　勝、大塚　将之
- Organizer
  第79回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] Management and risk factors for postoperative pancreatic fistula grade C in pancreaticoduodenectomy2017
- Author(s)
  Hiroyuki Nojima, Satoshi Kuboki, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki, Masayuki Ohtsuka
- Organizer
  Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association & The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
- Data Source
  KAKENHI-PROJECT-16K19915
[Presentation] 膵癌早期診断マーカーとしての血清C4BPA値の意義2017
- Author(s)
  高野重紹、曽川一幸、吉富秀幸、清水宏明、古川勝規、高屋敷　吏、久保木　知、鈴木大亮、酒井　望、賀川真吾、野島広之、野村文夫、宮崎　勝、大塚将之
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17H04287
[Presentation] 残肝容量不足時のshare stress増強に伴う類洞内皮障害軽減に対する脾摘の意義に関する基礎的研究2017
- Author(s)
  久保木　知、清水　宏明、吉富　秀幸、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、賀川　真吾、野島　広之、宮崎　勝、大塚　将之
- Organizer
  第35回日本肝移植研究会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] Chemokine receptors, CXCR1 and CXCR2, differentially regulate exosome release in hepatocytes2016
- Author(s)
  HIROYUKI NOJIMA
- Organizer
  AASLD
- Place of Presentation
  Boston, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19915

1. 大塚将之 (90334185)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. Kuboki Satoshi (50571410)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. Shimizu Hiroaki (80272318)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 高野重紹 (20436380)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 山崎一人 (60302519)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 小杉千弘 (60375681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 首藤潔彦 (90372359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. Miyazaki Masaru (70166156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Mishima Takashi (70802560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 酒井望 (70436385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 吉富秀幸 (60375631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 加藤厚 (70344984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 賀川真吾 (90507302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 幸田圭史 (50260477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 細川勇 (60623676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 村上崇 (80621870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 森幹人 (90399452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Takahashi Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. Nakata Shinichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 田中知明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 鈴木佐和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOJIMA HIROYUKI 野島 広之

Research Projects

Research Products

Co-Researchers

Lin28/let-7シグナル制御による胃癌及び腫瘍関連サルコペニアの治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of cancer progression mediated by IL-32-Gankyrin axis in intrahepatic cholangiocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological role of metadherin in liver metastases of colon cancer and development of novel molecular target therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sphingosine-1-phosphate receptor-1 promotes vascular invasion and EMT in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of biomarkers for biliary tract cancer by proteomic approaches

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exosomal microRNA transfer regulates cell proliferation and tumor progression in pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sphingosine-1-phosphate Receptor-1 Promotes Vascular Invasion and EMT in Hepatocellular2021

Author(s)

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[Journal Article] OLFM4 Enhances STAT3 Activation and Promotes Tumor Progression by Inhibiting GRIM19 Expression in Human Hepatocellular Carcinoma2019

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[Journal Article] Roles of Pin1 as a Key Molecule for EMT Induction by Activation of STAT3 and NF-κB in Human Gallbladder Cancer.2019

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[Journal Article] Successful treatment of a locally advanced unresectable pancreatic cancer patient with interstitial pneumonitis by conversion surgery following gemcitabine plus nab-paclitaxel chemotherapy: A case report.2019

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[Journal Article] Conversion surgery with gemcitabine plus nab-paclitaxel for locally advanced unresectable pancreatic cancer: A case report.2018

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[Journal Article] Glucagonoma with necrolytic migratory erythema: metabolic profile and detection of biallelic inactivation of DAXX gene.2018

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[Journal Article] Novel treatment strategy with radiofrequency ablation and surgery for pregnant patients with hepatocellular carcinoma: a case report.2018

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NOJIMA HIROYUKI 野島広之