Nakamura Shingen 中村信元

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NAKAMURA Shingen 中村信元

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Researcher Number	10511321
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授
Affiliation (based on the past Project Information) *help	2024: 徳島大学, 大学院医歯薬学研究部(医学域), 特任教授 2021 – 2022: 徳島大学, 大学院医歯薬学研究部(医学域), 特任准教授 2020: 徳島大学, 大学院医歯薬学研究部(医学域), 特任講師 2019: 徳島大学, 大学院医歯薬学研究部(医学域), 助教 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(医学系), 助教 … More 2015: 徳島大学, 大学病院, 助教 2014: 徳島大学, 大学病院, 特任助教 2013: 徳島大学, 病院, 特任助教 Less
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Tumor biology / Tumor therapeutics Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator 酸性環境 / アミロイドーシス / Fusobacterium / 発熱性好中球減少症 / secretory IgA / Fusobacterium nucleatum / がん抑制性ニッチ / ミトコンドリア / 成熟骨芽細胞 / PGC-1 … More / pim-2 / mature osteoblast / AMPK / PGC-1α / Pim-2 / osteoblast / multiple myeloma / cucurbitacin / 多発性骨髄腫 / pim2 / がん酸性環境 … More Except Principal Investigator 間質細胞 / 骨芽細胞 / 骨形成 / 多発性骨髄腫 Less

ALアミロイドーシスにおける単球に着目した疾患関連遺伝子と新規治療標的の探索Principal Investigator
- Principal Investigator
  
  中村信元
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokushima
Roles of Fusobacterium nucleatum in Systemic Inflammations by Cancer ChemotherapyPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Shingen
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokushima
Molecular mechanisms of activated osteoblast-induced myeloma death through mitochondrial impairment and metabolic perturbationPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Shingen
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokushima
Exploration of mechanism of drug resisitance in cancer acidic condition and development of novel therapeutic drugPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Shingen
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokushima
骨形成誘導と骨破壊性腫瘍の進展抑制を併せ持つ新たな分子標的薬の開発
- Principal Investigator
  
  日浅雅博
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima

All 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Steroid pulse therapy in patients with encephalopathy associated with severe fever with thrombocytopenia syndrome2018
- Author(s)
  Nakamura Shingen、Azuma Momoyo、Maruhashi Tomoko、Sogabe Kimiko、Sumitani Ryohei、Uemura Munenori、Iwasa Masami、Fujii Shiro、Miki Hirokazu、Kagawa Kumiko、Hiraga Takashi、Kondo Noriyasu、Fujita Hiromi、Mahara Fumihiko、Abe Masahiro
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 24 Issue: 5 Pages: 389-392
- DOI
  10.1016/j.jiac.2017.11.004
- NAID
  120006556288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18420
[Journal Article] Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity.2018
- Author(s)
  Fujii S, Nakamura S, Oda A, Miki H, Tenshin H, Teramachi J, Hiasa M, Bat-Erdene A, Maeda Y, Oura M, Takahashi M, Iwasa M, Endo I, Yoshida S, Aihara KI, Kurahashi K, Harada T, Kagawa K, Nakao M, Sano S, Abe M.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 180(2) Issue: 2 Pages: 246-258
- DOI
  10.1111/bjh.15033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09956, KAKENHI-PROJECT-17H05104, KAKENHI-PROJECT-16K18420, KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-17KK0169
[Journal Article] Effective impairment of myeloma cells and their progenitors by hyperthermia.2018
- Author(s)
  Hirokazu Miki, Shingen Nakamura, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, M. Hiasa, A. Bat-Erdene, Y. Maeda, M. Oura, M. Takahashi, M. Iwasa, T. Harada, S. Fujii, K. Kurahashi, S. Yoshida, K. Kagawa, I. Endo, K. Aihara, M. Ikuo, K. Itoh, Koichiro Hayashi, Michihiro Nakamura, Masahiro Abe
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 12 Pages: 10307-10316
- DOI
  10.18632/oncotarget.23121
- NAID
  120006576960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01358, KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-17K09956, KAKENHI-PROJECT-17H03403, KAKENHI-PROJECT-17H05104, KAKENHI-PROJECT-15K14146, KAKENHI-PROJECT-16K18420
[Journal Article] Multiple myeloma with high adenosine deaminase expression2017
- Author(s)
  Shingen NAKAMURA, Hirokazu MIKI, Masami IWASA, Akishige IKEGAME,Tomoko MARUHASHI, Ryohei SUMITANI, Munenori UEMURA, Mamiko TAKAHASHI,Asuka ODA, Shiro FUJII, Kumiko KAGAWA and Masahiro ABE
- Journal Title
  
  International Journal of Myeloma
  
  Volume: 7 Pages: 1-5
- NAID
  120006842039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18420
[Journal Article] Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.2017
- Author(s)
  Teramachi J, Hiasa M, Oda A, Harada T, Nakamura S, Amachi R, Tenshin H, Iwasa M, Fujii S, Kagawa K, Miki H, Kurahashi K, Yoshida S, Endo I, Haneji T, Matsumoto T, Abe M.
- Journal Title
  
  Br J Haematol.
  
  Volume: 印刷中
- NAID
  120006549655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18420
[Journal Article] TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects2017
- Author(s)
  Tenshin Hirofumi、Teramachi Jumpei、Tanaka Eiji、Matsumoto Toshio、Abe Masahiro (他16人中2番目）
- Journal Title
  
  Blood Advances
  
  Volume: 1 Issue: 24 Pages: 2124-2137
- DOI
  10.1182/bloodadvances.2017008813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11504, KAKENHI-PROJECT-17K09956, KAKENHI-PROJECT-16H05327, KAKENHI-PROJECT-17H05104, KAKENHI-PROJECT-16K18420
[Journal Article] Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava2017
- Author(s)
  Nakamura S, Kagawa K, Sumitani R, Uemura M, Takahashi M, Iwasa M, Fujii S, Miki H, Abe M
- Journal Title
  
  internal medicine
  
  Volume: 56 Pages: 2043-2047
- NAID
  130005876447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18420
[Journal Article] 多発性骨髄腫2016
- Author(s)
  安倍正博、三木浩和、中村信元
- Journal Title
  
  臨床血液
  
  Volume: 57 Pages: 260-269
- NAID
  130005145479
- Data Source
  KAKENHI-PROJECT-26830108
[Journal Article] Susceptibility to bendamustine considerably varies among myeloma cells, but is enhanced in acidic conditions2016
- Author(s)
  Nakamura S, Miki H, Oda A, Amachi R, Teramachi J, Sogabe K, Fujino H, Maruhashi T, Fujii S, Kagawa K , Abe M
- Journal Title
  
  International Journal of Myeloma.
  
  Volume: 6 Pages: 7-11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18420
[Journal Article] Susceptibility to bendamustine considerably varies among myeloma cells, but is enhanced in acidic conditions2016
- Author(s)
  Shingen NAKAMURA , Hirokazu MIKI , Asuka ODA , Ryota AMACHI , Jumpei TERAMACHI , Kimiko SOGABE , Hikaru FUJINO , Tomoko MARUHASHI , Shiro FUJII , Kumiko KAGAWA and Masahiro ABE
- Journal Title
  
  International Journal of Myeloma
  
  Volume: 6 Pages: 7-11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830108
[Journal Article] A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration.2016
- Author(s)
  Amachi R, Hiasa M, Teramachi J, Harada T, Oda A, Nakamura S, Hanson D, Watanabe K, Fujii S, Miki H, Kagawa K, Iwasa M, Endo I, Kondo T, Yoshida S, Aihara KI, Kurahashi K, Kuroda Y, Horikawa H, Tanaka E, Matsumoto T, Abe M.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Pages: 70447-70461
- NAID
  120006576954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18420
[Journal Article] Lipopolysaccharide-Induced CXCL10 mRNA Level and Six Stimulant-mRNA Combinations in Whole Blood: Novel Biomarkers for Bortezomib Responses Obtained from a Prospective Multicenter Trial for Patients with Multiple Myeloma.2015
- Author(s)
  Watanabe T, Mitsuhashi M, Sagawa M, Ri M, Suzuki K, Abe M, Ohmachi K, Nakagawa Y, Nakamura S, Chosa M, Iida S, Kizaki M.
- Journal Title
  
  PLoS One
  
  Volume: 10
- NAID
  120006871197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26830108
[Journal Article] Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.2015
- Author(s)
  Hiasa M, Teramachi J, Oda A, Amachi R, Harada T, Nakamura S, Miki H, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M
- Journal Title
  
  Leukemia
  
  Volume: 29 Pages: 207-217
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830108
[Journal Article] Induction of endoplasmic reticulum stress by bortezomib sensitizes myeloma cells to DR5-mediated cell death2015
- Author(s)
  Miki H, Nakamura S, Oda A, Amachi R, Watanabe K, Hanson D, Teramachi J, Hiasa M, Yagi H, Sogabe K, Takahashi M, Maruhashi T, Udaka K, Harada T, Fujii S, Nakano A, Kagawa K, Ri M, Iida S, Ozaki S, Matsumoto T, Abe M.
- Journal Title
  
  International Journal of Myeloma
  
  Volume: 5 Pages: 1-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830108
[Journal Article] Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma2015
- Author(s)
  Yamashita M, Fujii Y, Ozaki K, Urano Y, Iwasa M, Nakamura S, Fujii S, Abe M, Sato Y, Yoshino T
- Journal Title
  
  Diagn Pathol.
  
  Volume: 10 Pages: 8-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26830108
[Journal Article] Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.2015
- Author(s)
  Hanson DJ, Nakamura S, Amachi R, Hiasa M, Oda A1, Tsuji D, Itoh K, Harada T, Horikawa K, Teramachi J, Miki H, Matsumoto T, Abe M.
- Journal Title
  
  oncotarget
  
  Volume: 6 Pages: 33568-33586
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830108
[Presentation] Mature osteoblasts reduce Pim-2 to cause an energy crisis in myeloma cells2017
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Keiichiro Watanabe, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Yusaku Maeda, Masahiro Oura, Mamiko Takahashi, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Masahiro Abe
- Organizer
  日本骨髄腫学会
- Data Source
  KAKENHI-PROJECT-16K18420
[Presentation] Restoration of bone formation induces an energy crisis in myeloma cells2017
- Author(s)
  Ryota Amachi, Shingen Nakamura, Hirokazu Miki, ,Hirofumi Tenshin, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Masami Iwasa, Shiro Fujii,Kumiko Kagawa, Masahiro Abe
- Organizer
  日本骨髄腫学会2017
- Place of Presentation
  日本赤十字看護大学　（東京都　渋谷区）
- Data Source
  KAKENHI-PROJECT-16K18420
[Presentation] Osteoblast creates a non-permissive niche for myeloma2017
- Author(s)
  Ryota Amachi, Masahiro Hiasa , Jumpei Teramachi, Asuka Oda, Ariunzaya Bat-Erdene, Hirofumi Tenshin, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Shiro Fujii, Eiji Tanaka , Toshio Matsumoto , Masahiro Abe
- Organizer
  IADR/AADR/CADR General Session & Exhibition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18420
[Presentation] Mature osteoblasts reduce Pim-2 to cause an energy crisis in myeloma cells2017
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Keiichiro Watanabe, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Yusaku Maeda, Masahiro Oura, Mamiko Takahashi, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Masahiro Abe
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-16K18420
[Presentation] Creation of a non-permissive niche for myeloma by bone formation2016
- Author(s)
  Ryota Amachi, Jumpei Teramachi，Masahiro Hiasa，Takeshi Harada，Asuka Oda，Shingen Nakamura，Keiichiro Watanabe，Shiro Fujii，Hirokazu Miki，Kumiko Kagawa，Itsuro Endo，Eiji Tanaka，Toshio Matsumoto，Masahiro Abe
- Organizer
  日本血液学会総会2016
- Place of Presentation
  パシフィコ横浜(神奈川県　横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18420
[Presentation] Alteration of Pim-2 synthesis and degradation in myeloma cells by anti-myeloma agents.2016
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Ariunzaya BAT-ERDENE,Hirofumi Tenshin, Ryota Amachi, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Masami Iwasa, Shiro Fujii,Kumiko Kagawa, Masahiro Abe
- Organizer
  日本血液学会総会2016
- Place of Presentation
  パシフィコ横浜(神奈川県　横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18420
[Presentation] Cytotoxic efficacy of Pim inhibitors and anti-myeloma agents in combination2015
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe
- Organizer
  日本血液学会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、ほか　（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26830108
[Presentation] Alteration of Pim-2 expression by clinically available anti-myeloma agents: combinatory anti-myeloma effects with Pim inhibition2015
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe
- Organizer
  international myeloma workshop
- Place of Presentation
  Rome（Italy）
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830108
[Presentation] Cytotoxic efficacy of Pim inhibitors and anti-myeloma agents in combination2015
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe
- Organizer
  日本骨髄腫学会
- Place of Presentation
  くまもと森都心プラザ（熊本県熊本市）
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26830108
[Presentation] Combinatory effects of Pim inhibitor with clinically available anti-myeloma agents2015
- Author(s)
  Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe
- Organizer
  日本骨髄腫学会
- Place of Presentation
  くまもと森都心プラザ　（熊本県熊本市）
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26830108

1. 日浅雅博 (90511337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 田中栄二 (40273693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 村上圭史 (10335804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 日野出大輔 (70189801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐藤陽一 (10363160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TERAMACHI Jyumpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 三木浩和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中村教泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamura Shingen 中村 信元

NAKAMURA Shingen 中村 信元

Research Projects

Research Products

Co-Researchers

ALアミロイドーシスにおける単球に着目した疾患関連遺伝子と新規治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of Fusobacterium nucleatum in Systemic Inflammations by Cancer ChemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of activated osteoblast-induced myeloma death through mitochondrial impairment and metabolic perturbationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of mechanism of drug resisitance in cancer acidic condition and development of novel therapeutic drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨形成誘導と骨破壊性腫瘍の進展抑制を併せ持つ新たな分子標的薬の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Steroid pulse therapy in patients with encephalopathy associated with severe fever with thrombocytopenia syndrome2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effective impairment of myeloma cells and their progenitors by hyperthermia.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Multiple myeloma with high adenosine deaminase expression2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Pim-2 is a critical target for treatment of osteoclastogenesis enhanced in myeloma.2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 多発性骨髄腫2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Susceptibility to bendamustine considerably varies among myeloma cells, but is enhanced in acidic conditions2016

Author(s)

Journal Title

Nakamura Shingen 中村信元

NAKAMURA Shingen 中村信元