Okuno Yosuke 奥野陽亮

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OKUNO Yosuke 奥野陽亮

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Researcher Number	10534513
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 助教 2016 – 2021: 大阪大学, 医学系研究科, 助教 2010 – 2011: 東京大学, 分子細胞生物学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Keywords	Principal Investigator ARMC5 / 糖尿病 / 酸化ストレス / SREBP1 / 脂肪細胞 / 肥満 / Armc5 / Srebp1 / クッシング症候群 / 医学 … More / インスリン抵抗性 / 脂肪組織 / 代謝 / 発現制御 / 転写 … More Except Principal Investigator 脂肪細胞 / ケトン体 / 乳酸 / アディポサイトカイン / 栄養シグナル / グルタミン / ケモカイン / 脂肪組織 / インスリンシグナル / 前駆脂肪細胞 / インスリン抵抗性 / 糖尿病 / 肥満 / IRS-1 / インスリン / SDF-1 Less

ARMC5によるインスリン抵抗性・分泌の両面制御機構の解明Principal Investigator
- Principal Investigator
  
  奥野陽亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Osaka University
脂肪細胞栄養シグナルの解明と肥満病態への治療応用
- Principal Investigator
  
  福原淳範
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Osaka University
Significance of novel ubiqutin ligase of SREBP in obesity, diabetes and Cushing syndromePrincipal Investigator
- Principal Investigator
  
  Okuno Yosuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Osaka University
Clarification of the mechanism maintaining metabolic homeostasis by nutrition signaling in adipocytes
- Principal Investigator
  
  Fukuhara Atsunori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Osaka University
Analysis of Srebf1 transcriptional coregulator in adipose oxidative stress and healthy adipose expansionPrincipal Investigator
- Principal Investigator
  
  Okuno Yosuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Osaka University
Physiological and pathological roles of SDF-1 in adipocytes
- Principal Investigator
  
  Fukuhara Atusnori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Role of adipocyte oxidative stress in obesityPrincipal Investigator
- Principal Investigator
  
  Okuno Yosuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Analysis of the physiological roles of PHF2/ARID5B, a novel fasting-responsive transcription complexPrincipal Investigator
- Principal Investigator
  
  OKUNO Yosuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2011

All Journal Article Presentation

[Journal Article] ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors2022
- Author(s)
  Okuno Yosuke、Fukuhara Atsunori、Otsuki Michio、Shimomura Iichiro
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 16
- DOI
  10.1172/jci.insight.151390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08905
[Journal Article] Ketone body 3-hydroxybutyrate enhances adipocyte function.2022
- Author(s)
  Shigeki Nishitani, Atsunori Fukuhara, Issei Tomita, Shinji Kume, Jihoon Shin, Yosuke Okuno, Michio Otsuki, Hiroshi Maegawa, Iichiro Shimomura
- Journal Title
  
  Scientific Reports
  
  Volume: 12 (1) Issue: 1 Pages: 10080-10080
- DOI
  10.1038/s41598-022-14268-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16369, KAKENHI-PROJECT-20K08905
[Journal Article] Glutamine deficiency induces lipolysis in adipocytes2021
- Author(s)
  Okuro Kenta、Fukuhara Atsunori、Minemura Tomomi、Hayakawa Tomoaki、Nishitani Shigeki、Okuno Yosuke、Otsuki Michio、Shimomura Iichiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 585 Pages: 155-161
- DOI
  10.1016/j.bbrc.2021.11.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08905
[Journal Article] Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway2018
- Author(s)
  Okuno Y, Fukuhara A, Hashimoto E, Kobayashi H, Kobayashi S, Otsuki M, Shimomura I
- Journal Title
  
  Diabetes
  
  Volume: 印刷中 Issue: 6 Pages: 1113-1127
- DOI
  10.2337/db17-1032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19536, KAKENHI-PROJECT-18H02863
[Presentation] Glutamine欠乏は脂肪細胞における中性脂肪分解を促進する2022
- Author(s)
  大畔健太, 福原淳範, 峰村友美, 西谷重紀, 奥野陽亮, 大月道夫, 下村伊一郎
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08905
[Presentation] ケトン体による脂肪細胞機能制御2020
- Author(s)
  西谷重紀, 福原淳範, 申智勲, 奥野陽亮, 大月道夫, 下村伊一郎
- Organizer
  第93回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08905
[Presentation] 脂肪細胞におけるグルココルチコイドの新たな役割 - 脂肪細胞特異的GR欠損マウス、副腎不全患者の解析から -2019
- Author(s)
  林令子、奥野陽亮、福原淳範、大月道夫、下村伊一郎
- Organizer
  第24回アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] SGLT2阻害薬とケトン体による脂肪細胞機能制御2019
- Author(s)
  西谷重紀、福原淳範、申智勲、奥野陽亮、大月道夫、下村伊一郎
- Organizer
  第24回アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] 脂肪細胞におけるMineralocorticoid receptorのノックアウトマウスを用いた解析2019
- Author(s)
  早川友朗、峰村友美、小野寺俊晴、佐伯絢、豊田新一郎、林令子、西谷重紀、向井康祐、申智勲、小林祥子、奥野陽亮、福原淳範、大月道夫、下村伊一郎
- Organizer
  第24回アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] クッシング症候群における脂肪細胞GRの病態学的意義解明2019
- Author(s)
  林令子, 奥野陽亮, 向井康祐, 福原淳範, 大月道夫, 下村伊一郎
- Organizer
  第40回肥満学会
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] 脂肪細胞における核内SREBP1結合因子の探索2019
- Author(s)
  奥野陽亮
- Organizer
  第９２回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08513
[Presentation] 脂肪細胞特異的MR欠損マウスの解析2019
- Author(s)
  早川友朗, 峰村友美, 小野寺俊晴, 佐伯絢, 豊田新一郎, 林令子, 西谷重紀, 向井康祐, 申智勳, 小林祥子, 奥野陽亮, 福原淳範, 大月道夫, 下村伊一郎
- Organizer
  第62回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] 脂肪組織・血管由来分泌因子Favineの機能探索2019
- Author(s)
  小林祥子, 早川友朗, 林令子, 奥野陽亮, 福原淳範, 大月道夫, 森井英一, 下村伊一郎
- Organizer
  第62回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] インスリン抵抗性の病態から治療への展開脂肪組織酸化ストレスとSDF-1によるインスリン感受性制御2018
- Author(s)
  福原淳範, Shin Jihoon, 奥野陽亮, 大月道夫, 下村伊一郎
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09829
[Presentation] 脂肪細胞酸化ストレスはde novo lipogenesisを介して異所性脂肪蓄積・インスリン感受性を調節する2017
- Author(s)
  奥野陽亮、福原淳範、大月道夫、下村伊一郎
- Organizer
  第６０回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19536
[Presentation] 脂肪細胞酸化ストレスはadipose healthy expansionを抑制する2017
- Author(s)
  奥野陽亮、福原淳範、大月道夫、下村伊一郎
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K19536
[Presentation] Adipose oxidative stress augments insulin resistance through suppression of de novo lipogenesis2016
- Author(s)
  奥野陽亮、福原淳範、大月道夫、下村伊一郎
- Organizer
  第２１回アディポサイエンス・シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2016-08-20
- Data Source
  KAKENHI-PROJECT-16K19536
[Presentation] 脂肪細胞酸化ストレスは脂質合成抑制を介してインスリン抵抗性を増悪させる2016
- Author(s)
  奥野陽亮、福原淳範、大月道夫、下村伊一郎
- Organizer
  第３７回日本肥満学会
- Place of Presentation
  東京
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K19536
[Presentation] 脂肪細胞酸化ストレスの除去は、脂質合成及びbeneficial adipose expansionを誘導し、インスリン抵抗性を改善する2016
- Author(s)
  奥野陽亮、福原淳範、松田守弘、橋本恵里香、小林宏規、宮田佑吾、大月道夫、下村伊一郎
- Organizer
  第５９回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K19536
[Presentation] Physiological role of a histone demethylase PHF2 in the regulation ofenergy metabolism2011
- Author(s)
  奥野陽亮、大竹史明、今井祐記、加藤茂明
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22790848
[Presentation] 新規ヒストン脱メチル化酵素PHF2の生体内高次機能解明2011
- Author(s)
  奥野陽亮、大竹史明、今井祐記、加藤茂明
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22790848

1. Fukuhara Atusnori (00437328)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. 大月道夫 (00403056)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
3. 西谷重紀 (30889407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Okuno Yosuke 奥野 陽亮

OKUNO Yosuke 奥野 陽亮

Research Projects

Research Products

Co-Researchers

ARMC5によるインスリン抵抗性・分泌の両面制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪細胞栄養シグナルの解明と肥満病態への治療応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of novel ubiqutin ligase of SREBP in obesity, diabetes and Cushing syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the mechanism maintaining metabolic homeostasis by nutrition signaling in adipocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Srebf1 transcriptional coregulator in adipose oxidative stress and healthy adipose expansionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological and pathological roles of SDF-1 in adipocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of adipocyte oxidative stress in obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the physiological roles of PHF2/ARID5B, a novel fasting-responsive transcription complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ketone body 3-hydroxybutyrate enhances adipocyte function.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutamine deficiency induces lipolysis in adipocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Glutamine欠乏は脂肪細胞における中性脂肪分解を促進する2022

Author(s)

Organizer

Data Source

[Presentation] ケトン体による脂肪細胞機能制御2020

Author(s)

Organizer

Okuno Yosuke 奥野陽亮

OKUNO Yosuke 奥野陽亮

[Presentation] インスリン抵抗性の病態から治療への展開脂肪組織酸化ストレスとSDF-1によるインスリン感受性制御2018