Sakasai Ryo 逆井良

Researcher Number	10549950
Affiliation (Current)	2025: 金沢医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 金沢医科大学, 医学部, 准教授 2017 – 2022: 金沢医科大学, 医学部, 講師 2012 – 2017: 金沢医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals Except Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals
Keywords	Principal Investigator DNA二本鎖切断 / 相同組換え / 非相同末端連結 / 転写 / 相同組換え修復 / カンプトテシン / DNA複製 / 転写ストレス / DNAトポイソメラーゼ / R-loop / 組換え修復 / ユビキチン … More Except Principal Investigator … More アポトーシス / DNA二本鎖切断修復 / 53BP1 / DNA損傷 / 相同組換え / DNA修復 / クロマチン動態 / DNA二本鎖切断 / 核内ミオシン / 相同組換え修復 / 分子生物学 / DNA損傷修復 / 細胞生物学 / DNA二重鎖切断 / ユビキチン / PARP阻害剤 / 相同組み換え / DNA損傷応答 / 合成致死 / ゲノム編集 Less

遺伝子領域に生じたDNA二本鎖切断の新規修復機構の解明
- Principal Investigator
  
  西良太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tokyo University of Technology
53BP1が制御する核断片化を伴う新規ゲノム不安定化経路の解析Principal Investigator
- Principal Investigator
  
  逆井良
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kanazawa Medical University
Mechanisms for cell surface expression of chromatin in apoptotic cells
- Principal Investigator
  
  IWABUCHI Kuniyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kanazawa Medical University
Investigation for the regulatory mechanism of DNA double-strand break repair by nuclear myosin
- Principal Investigator
  
  Nishi Ryotaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tokyo University of Technology
Cellular responses to DNA double-strand breaks caused by transcription stressPrincipal Investigator
- Principal Investigator
  
  SAKASAI Ryo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kanazawa Medical University
Analysis of the contribution of transcription to homologous recombination pathwayPrincipal Investigator
- Principal Investigator
  
  SAKASAI Ryo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kanazawa Medical University
A role of DNA-damage repair protein 53BP1 in apoptotic cells.
- Principal Investigator
  
  IWABUCHI Kuniyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kanazawa Medical University
Analysis of the mechanism of cell sensitivity against anti-cancer drug caused by ubiquitination-dependent DNA-PK activationPrincipal Investigator
- Principal Investigator
  
  SAKASAI Ryo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kanazawa Medical University
Regulation of DNA repair pathway choice and gene editing by DNA repair machinery
- Principal Investigator
  
  Nakada Shinichiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Osaka University
A DNA damage-independent role for 53BP1 in apoptotic cells
- Principal Investigator
  
  IWABUCHI Kuniyoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kanazawa Medical University
Analysis of cell death and repair pathway choice of DNA double-strand breaks caused by anti-cancer drugPrincipal Investigator
- Principal Investigator
  
  Sakasai Ryo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kanazawa Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks2023
- Author(s)
  Sakasai Ryo、Matsui Tadashi、Sunatani Yumi、Iwabuchi Kuniyoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 668 Pages: 42-48
- DOI
  10.1016/j.bbrc.2023.05.068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K12245
[Journal Article] Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair2022
- Author(s)
  Sakasai Ryo、Wakasugi Mitsuo、Matsui Tadashi、Sunatani Yumi、Saijo Masafumi、Matsunaga Tsukasa、Iwabuchi Kuniyoshi
- Journal Title
  
  DNA Repair
  
  Volume: 113 Pages: 103318-103318
- DOI
  10.1016/j.dnarep.2022.103318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265, KAKENHI-PROJECT-20K06543, KAKENHI-PROJECT-21K12245
[Journal Article] Lens-specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity2021
- Author(s)
  Shibata Teppei、Ikawa Masahito、Sakasai Ryo、Ishigaki Yasuhito、Kiyokawa Etsuko、Iwabuchi Kuniyoshi、Singh Dhirendra P、Sasaki Hiroshi、Kubo Eri
- Journal Title
  
  Mechanisms of Ageing and Development
  
  Volume: 196 Pages: 111492-111492
- DOI
  10.1016/j.mad.2021.111492
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21K12245, KAKENHI-PROJECT-21K16886
[Journal Article] USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX92020
- Author(s)
  Matsui M, Sakasai R, Abe M, Kimura Y, Kajita S, Torii W, Katsuki Y, Ishiai M, Iwabuchi K, Takata M, Nishi R.
- Journal Title
  
  Oncogenesis
  
  Volume: 9 Issue: 6 Pages: 60-60
- DOI
  10.1038/s41389-020-00244-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11642, KAKENHI-PROJECT-20K12161, KAKENHI-PROJECT-18K11648
[Journal Article] Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase- activated DNase2018
- Author(s)
  1.Sunatani Y, Kamdar RP, Sharma MK, Matsui T, Sakasai R, Hashimoto M, Ishigaki Y, Matsumoto Y, Iwabuchi K
- Journal Title
  
  Exp Cell Res
  
  Volume: 362 Issue: 2 Pages: 450-460
- DOI
  10.1016/j.yexcr.2017.12.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12210, KAKENHI-PROJECT-26281025, KAKENHI-PROJECT-15K16127, KAKENHI-PROJECT-15H02817
[Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes.2018
- Author(s)
  Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 46(6) Issue: 6 Pages: 2932-2944
- DOI
  10.1093/nar/gky058
- NAID
  120006488604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-26291018, KAKENHI-PLANNED-17H06380, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-16H07295, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-15K16127, KAKENHI-PROJECT-18K11648, KAKENHI-PUBLICLY-18H04719, KAKENHI-PUBLICLY-18H05097, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-15H04403, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-17H03711, KAKENHI-PROJECT-16K18477
[Journal Article] Aquarius is required for proper CtIP expression and homologous recombination repair2017
- Author(s)
  2.Sakasai R, Isono M, Wakasugi M, Hashimoto M, Sunatani Y, Matsui T, Shibata A, Matsunaga T, Iwabuchi K
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-13695-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K12210, KAKENHI-PROJECT-26281025, KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-15K00534, KAKENHI-PROJECT-16K15118, KAKENHI-PROJECT-15K16127, KAKENHI-PROJECT-26241014
[Journal Article] Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.2016
- Author(s)
  Iimori M, Watanabe S, Kiyonari S, Matsuoka K, Sakasai R, Saeki H, Oki E, Kitao H, Maehara Y:
- Journal Title
  
  Nature Communications
  
  Volume: [Epub ahead of print] Issue: 1 Pages: 11117-11117
- DOI
  10.1038/ncomms11117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462024, KAKENHI-PROJECT-24390321, KAKENHI-PROJECT-15H05792, KAKENHI-PROJECT-26281025, KAKENHI-PROJECT-26430116
[Journal Article] The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription2015
- Author(s)
  Sakasai R, Iwabuchi K.
- Journal Title
  
  Genes Genet. Syst.
  
  Volume: 90 Issue: 4 Pages: 187-194
- DOI
  10.1266/ggs.15-00023
- NAID
  130005118395
- ISSN
  1341-7568, 1880-5779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12210, KAKENHI-PROJECT-15K16127, KAKENHI-PROJECT-24710061, KAKENHI-PROJECT-26281025
[Presentation] DNA複製を介したDNA二本鎖切断の修復機構とその破綻による核の断片化2023
- Author(s)
  逆井良、松井理、砂谷優実、岩淵邦芳
- Organizer
  第96回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K12245
[Presentation] BRCA2 prevents nuclear fragmentation mediated by LINC-lamina-53BP1 axis in response to one-ended DNA double-strand breaks2023
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Kuniyoshi Iwabuchi
- Organizer
  The 19th Ataxia-Telangiectasia workshop
- Data Source
  KAKENHI-PROJECT-21K12245
[Presentation] DNA 複製を介したDNA二本鎖切断に対し、BRCA2は53BP1-核ラミナ-LINC複合体を介した核の断片化を抑制する2023
- Author(s)
  逆井良、松井理、砂谷優実、岩淵邦芳
- Organizer
  第27回 DNA 複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-21K12245
[Presentation] 53BP1- and BRCA2-dependent biphasic repair of replication-mediated one-ended DSBs2022
- Author(s)
  逆井良、岩淵邦芳
- Organizer
  第9回DNA損傷応答ワークショップ
- Data Source
  KAKENHI-PROJECT-21K12245
[Presentation] 53BP1- and BRCA2-dependent biphasic repair of replication-mediated one-ended DSBs2022
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Kuniyoshi Iwabuchi
- Organizer
  日本放射線影響学会　第65回大会
- Data Source
  KAKENHI-PROJECT-21K12245
[Presentation] カンプトテシンはDNA損傷後の転写の回復を阻害しシスプラチンに対する殺細胞効果を増強する2021
- Author(s)
  逆井良、若杉光夫、松井理、砂谷優実、西條将文、松永司、岩淵邦芳
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K12245
[Presentation] Top1-DNAクロスリンクによる転写ストレス応答とその破綻2020
- Author(s)
  逆井良、松井理、砂谷優実、篠原彰、岩淵邦芳
- Organizer
  日本放射線影響学会第63回大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K11648
[Presentation] 転写を介したDNA鎖切断に対するRecQL5の機能解析2019
- Author(s)
  逆井　良、松井　理、砂谷優実、篠原　彰、岩淵邦芳
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-18K11648
[Presentation] カンプトテシンによる転写ストレスに対するRecQL5の機能解析2019
- Author(s)
  逆井　良、松井　理、砂谷優実、篠原　彰、岩淵邦芳
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11648
[Presentation] Repair pathways for one-ended DNA double-strand breaks caused by camptothecin2018
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Kuniyoshi Iwabuchi
- Organizer
  Gordon Research Conference, Genome Instability
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11648
[Presentation] One-ended DSBの修復経路の解析2018
- Author(s)
  逆井　良、砂谷優実、松井　理、岩淵邦芳
- Organizer
  第90回日本遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K11648
[Presentation] One-ended DNA二本鎖切断の修復経路解析2018
- Author(s)
  逆井　良、松井　理、砂谷優実、岩淵邦芳
- Organizer
  日本放射線影響学会　第61回大会
- Data Source
  KAKENHI-PROJECT-18K11648
[Presentation] ユビキチン化因子UBE2E2によるDNAトポイソメラーゼIIの制御2017
- Author(s)
  逆井良、砂谷優実、松井理、岩淵邦芳
- Organizer
  第24回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] PARP- and TDP1-dependent repair pathways of one-ended DNA double-strand breaks caused by camptothecin2017
- Author(s)
  逆井良, 砂谷優実, 松井理, 岩淵邦芳
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Repair pathways for one-ended DNA double-strand breaks caused by camptothecin.2017
- Author(s)
  Sakasai R, Sunatani Y, Matsui T, Iwabuchi K.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26241014
[Presentation] ユビキチン化因子UBE2E2によるDNAトポイソメラーゼIIの制御2017
- Author(s)
  逆井良, 砂谷優実, 松井理, 岩淵邦芳
- Organizer
  第24回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Analysis of repair pathway for one-ended DNA double-strand breaks2017
- Author(s)
  Sakasai R, Sunatani Y, Matsui T, Iwabuchi K
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] PARP inhibition disrupts repair of one-ended DNA double-strand breaks2017
- Author(s)
  Ryo Sakasai, Kuniyoshi Iwabuchi
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] NA二本鎖切断修復タンパク質53BP1を介した神経前駆細胞の未分化性維持機構2017
- Author(s)
  砂谷優実, 逆井良, 松井理, 橋本光正, 岩淵邦芳
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Analysis of repair pathway for one-ended DNA double-strand breaks2017
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Kuniyoshi Iwabuchi
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] RNAヘリカーゼAquariusはDNA-RNAハイブリッドを解消して相同組換え修復を促進する2016
- Author(s)
  逆井良, 磯野真由, 若杉光夫, 橋本光正, 砂谷優実, 松井理, 柴田淳史, 松永司, 岩淵邦芳
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] RNAヘリカーゼAquariusはDNA-RNAハイブリッドを解消して相同組換え修復を促進する2016
- Author(s)
  逆井良　磯野真由　若杉光夫　橋本光正　砂谷優実　松井理　柴田淳史　松永司　岩淵邦芳
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市西区）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] DNA二本鎖切断修復タンパク質53BP1を介した神経前駆細胞の分化抑制効果2016
- Author(s)
  砂谷優実, 辰野貴則, 中村有香, 逆井　良, 松井　理, 橋本光正, 石垣靖人, 岩淵邦芳
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ（広島県・広島市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] RNAヘリカーゼAquariusはR-loopを解消して相同組換え修復を促進する2016
- Author(s)
  逆井良, 磯野真由, 若杉光夫, 橋本光正, 砂谷優実, 松井理, 柴田淳史, 松永司, 岩淵邦芳
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ（広島県・広島市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] RNAヘリカーゼAquariusはR-loopを解消して相同組換え修復を促進する2016
- Author(s)
  逆井良　磯野真由　若杉光夫　橋本光正　砂谷優実　松井理　柴田淳史　松永司　岩淵邦芳
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  ＪＭＳアステールプラザ（広島県広島市）
- Year and Date
  2016-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] Topoisomerase II switching is regulated by ubiquitination2016
- Author(s)
  Sakasai R, Sunatani Y, Matsui T, Iwabuchi K
- Organizer
  Gordon Research Conference, DNA Topoisomerase in Biology & Medicine
- Place of Presentation
  Sunday River, Newry, ME, USA
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Topoisomerase II switching is regulated by ubiquitination2016
- Author(s)
  Sakasai R, Sunatani Y, Matsui T, Iwabuchi K
- Organizer
  Gordon Research Conference, DNA Topoisomerase in Biology & Medicine
- Place of Presentation
  メーン州　米国
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] Ubiquitine-dependent Activation of DNA-PKcs Leads to Chromosomal Aberration in Response to One-ended DNA Double Strand Breaks2015
- Author(s)
  Sakasai R, Sunatani Y, Matsui T, Hashimoto M, Iwabuchi K
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center (Kyoto)
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Top2-poisonに対する主要調節因子であるユビキチン化酵素の同定2015
- Author(s)
  逆井　良, 砂谷優実, 松井　理, 橋本光正, 岩淵邦芳
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートピア（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Phosphorylatio-mediated Regulation of Apoptosis By NHEJ-protein XRCC4Phosphorylatio-mediated Regulation of Apoptosis By NHEJ-protein XRCC42015
- Author(s)
  Sunatani Y, Sharma MK, Kamdar RP, Matsui T, Sakasai R, Hashimoto M, Matsumoto Y, Iwabuchi K
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto International Conference Center (Kyoto)
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] p53標的遺伝子発現における53BP1の機能的役割2015
- Author(s)
  松井　理, 逆井　良, 砂谷優実, 橋本光正, 岩淵邦芳
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートピア（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Ubiquitin-dependent activation of DNA-PKcs leads to chromosomal aberration in response to one-ended DNA double strand breaks2015
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi
- Organizer
  ICRR2015
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24710061
[Presentation] Ubiquitin-dependent activation of DNA-PKcs leads to chromosomal aberration in response to one-ended DNA double strand breaks2015
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi
- Organizer
  ICRR2015
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16127
[Presentation] DNA修復タンパク質XRCC4のカスパーゼ依存性切断によるスプライシング調節を介したアポトーシスの促進2015
- Author(s)
  砂谷優実, Kamdar RP, Sharma MK, 松井　理, 逆井　良, 橋本光正, 松本義久, 岩淵邦芳
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートピア（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] 抗ガン剤トポイソメラーゼ阻害剤が引き起こす二次的DNA損傷に対する細胞応答2014
- Author(s)
  逆井　良, 砂谷　優実, 松井　理, 橋本　光正, 岩淵　邦芳.
- Organizer
  金沢医科大学医学会学術集会
- Place of Presentation
  金沢医科大学（石川県・河北郡）
- Year and Date
  2014-07-19
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] ユビキチン化を介したDNA-PKcs 活性化機構
- Author(s)
  逆井　良, 松井　理, 砂谷　優実, 橋本　光正, 岩淵　邦芳.
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] XRCC4のカスパーゼ依存的な切断によって引き起こされるアポトーシス促進の機構
- Author(s)
  砂谷　優実, Radhika Pankaj Kamdar, Mukesh Kumar Sharma, 松井　理, 逆井　良, 橋本　光正, 松本　義久, 岩淵　邦芳.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Ubiquitin-dependent activation of DNA-PKcs in response to DNA replication-mediated DNA double strand breaks.
- Author(s)
  Sakasai R, Sunatani Y, Matsui T, Hashimoto M, Iwabuchi K.
- Organizer
  The 9th 3R Symposium Together with National Institute of Genetics 2014 International Symposium.
- Place of Presentation
  御殿場高原ホテル・時之栖（静岡県・御殿場市）
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26281025
[Presentation] Ubiquitin-dependent activation of DNA-PKcs in response to DNA replication-mediated DNA double strand breaks
- Author(s)
  Ryo Sakasai, Yumi Sunatani, Tadashi Matsui, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi
- Organizer
  The 9th 3R Symposium
- Place of Presentation
  御殿場高原ホテル時之栖（静岡県御殿場市）
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24710061
[Presentation] ユビキチン化を介したDNA-PKcs活性化機構
- Author(s)
  逆井良、松井理、砂谷優実、橋本光正、岩淵邦芳
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24710061

1. Nishi Ryotaro (80446525)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. IWABUCHI Kuniyoshi (10232696)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
3. 砂谷優実 (70581057)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
4. SHIBATA Atsushi (30707633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 松井理 (60288272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Nakada Shinichiro (70548528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMURA Akira (20344723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 寺尾由里 (80466846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石垣靖人 (20232275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 若杉光生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 松永司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石合正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 佐伯浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 北尾洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 沖英次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 河合秀彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakasai Ryo 逆井 良

Research Projects

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Co-Researchers

遺伝子領域に生じたDNA二本鎖切断の新規修復機構の解明

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53BP1が制御する核断片化を伴う新規ゲノム不安定化経路の解析Principal Investigator

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Mechanisms for cell surface expression of chromatin in apoptotic cells

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Investigation for the regulatory mechanism of DNA double-strand break repair by nuclear myosin

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Cellular responses to DNA double-strand breaks caused by transcription stressPrincipal Investigator

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Analysis of the contribution of transcription to homologous recombination pathwayPrincipal Investigator

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A role of DNA-damage repair protein 53BP1 in apoptotic cells.

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Analysis of the mechanism of cell sensitivity against anti-cancer drug caused by ubiquitination-dependent DNA-PK activationPrincipal Investigator

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Regulation of DNA repair pathway choice and gene editing by DNA repair machinery

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A DNA damage-independent role for 53BP1 in apoptotic cells

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Analysis of cell death and repair pathway choice of DNA double-strand breaks caused by anti-cancer drugPrincipal Investigator

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[Journal Article] UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks2023

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[Journal Article] Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair2022

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Sakasai Ryo 逆井良