Soeda Yoshiyuki 添田義行

… Alternative Names

SOEDA Yoshiyuki 添田義行

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Researcher Number	10553836
Other IDs
Affiliation (Current)	2025: 日本大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 学習院大学, 理学部, 助教 2018 – 2019: 国立研究開発法人国立長寿医療研究センター, その他部局等, その他 2017: 学習院大学, 理学部, 助教 2016: 福島県立医科大学, 公私立大学の部局等, 助教 2012 – 2013: 独立行政法人国立長寿医療研究センター, 分子基盤研究部, 研究員 2011: 独立行政法人理化学研究所, アルツハイマー病研究チーム, 研究員
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / General pharmacology Except Principal Investigator Medium-sized Section 28:Nano/micro science and related fields / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Radiation science
Keywords	Principal Investigator 凝集 / タウタンパク質 / タウ / 相転移 / リン酸化 / 光遺伝学 / 液-液相分離 / アプタマー / 抗体 / 顆粒状タウオリゴマー … More / 中間凝集体抗体 / 神経変性疾患 / 中間凝集体 / 認知症 / 化合物 / スクリーニング / イソプロテレノール / タウ凝集阻害剤 … More Except Principal Investigator 液液相分離 / アミロイド線維 / タンパク質凝集 / １分子計測 / 光遺伝学 / iPS細胞 / タウオパチー / タウ / 薬理学 / 臨床 / トランスレーショナルリサーチ / 放射線 / 移植・再生医療 / 間葉細胞 / 腸管障害 / 放射線障害 / 臨床研究 / アニマルルール / 間葉系間質細胞 / 細胞医療 / 臨床薬理 / 急性放射線障害 Less

Multi-step kinetic analysis of protein condensate aging using microfluidics
- Principal Investigator
  
  福山真央
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Tohoku University
Study of the starting point and diversity of Tauopathy by single-molecule measurement
- Principal Investigator
  
  坂内博子
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Waseda University
神経変性型認知症の原因蛋白質「タウ」の液相→固相転換時におこる細胞内変化の探索Principal Investigator
- Principal Investigator
  
  添田義行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Gakushuin University
Elucidating the Mechanism of Dementia Caused by Tau Aggregation Using a Novel AptamerPrincipal Investigator
- Principal Investigator
  
  Soeda Yoshiyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Gakushuin University
Non-clinical evaluation of PLX-R18, Placenta-derived Mesenchymal-like Stromal Cells for GI-ARS mouse model
- Principal Investigator
  
  INANO AKIHIRO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
Screen for tau-focused drugs that inhibit tau toxicityPrincipal Investigator
- Principal Investigator
  
  SOEDA Yoshiyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  National Center for Geriatrics and Gerontology
  The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2018 2013 2012 2011

All Journal Article Presentation Patent

[Journal Article] Research on the molecular mechanism of singularity phenomenon in neurological disorders2024
- Author(s)
  Bannai Hiroko、Takashima Akihiko、Soeda Yoshiyuki、Yoshimura Hideaki、Matsumoto Gen、Sahara Naruhiko、Hiroshima Michio、Hattori Mitsuru、Nagai Takeharu
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 21 Issue: Supplemental Pages: n/a
- DOI
  10.2142/biophysico.bppb-v21.s008
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05153, KAKENHI-PROJECT-23K05993, KAKENHI-WRAPUP-23H05421
[Journal Article] Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils2023
- Author(s)
  Soeda Yoshiyuki、Yoshimura Hideaki、Bannai Hiroko、Koike Riki、Shiiba Isshin、Takashima Akihiko
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2023.09.10.557018
- Open Access
- Data Source
  KAKENHI-PROJECT-23K17364, KAKENHI-PROJECT-23K05993
[Journal Article] Path integration deficits with phosphorylated tau accumulation in the entorhinal cortex in mice and humans2022
- Author(s)
  Koike R, Soeda Y, Kasai A, Fujioka Y, Ishigaki S, Yamanaka A, Takaichi Y, Chambers JK, Uchida K, Watanabe H, Takashima A
- Journal Title
  
  Research Square
  
  Volume: -
- DOI
  10.21203/rs.3.rs-2062952/v1
- Open Access
- Data Source
  KAKENHI-PROJECT-20K06896
[Journal Article] Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3?×?Tg-AD mice2022
- Author(s)
  Konishi Fumiko、Furusho Tadasu、Soeda Yoshiyuki、Yamauchi Jun、Kobayashi Shoko、Ito Masatoshi、Araki Takuma、Kogure Sarasa、Takashima Akihiko、Takekoshi Susumu
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 996-996
- DOI
  10.1038/s41598-022-04777-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-20K06896
[Journal Article] Memory formation in old age requires GSK-3β2021
- Author(s)
  Koike Riki、Takaichi Yuta、Soeda Yoshiyuki、Takashima Akihiko
- Journal Title
  
  Aging Brain
  
  Volume: 1 Pages: 100022-100022
- DOI
  10.1016/j.nbas.2021.100022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J22779, KAKENHI-PROJECT-20K06896
[Journal Article] タウ凝集体の役割と凝集阻害剤開発2021
- Author(s)
  添田義行、高島明彦
- Journal Title
  
  月刊細胞 THE CELL
  
  Volume: 53 Pages: 17-21
- Data Source
  KAKENHI-PROJECT-20K06896
[Journal Article] Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)2021
- Author(s)
  Takaichi Yuta、Chambers James K.、Takahashi Kei、Soeda Yoshiyuki、Koike Riki、Katsumata Etsuko、Kita Chiaki、Matsuda Fuko、Haritani Makoto、Takashima Akihiko、Nakayama Hiroyuki、Uchida Kazuyuki
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 9 Issue: 1 Pages: 10-10
- DOI
  10.1186/s40478-020-01104-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02338, KAKENHI-PROJECT-19J22779, KAKENHI-PROJECT-20K06896
[Journal Article] New Insights Into Drug Discovery Targeting Tau Protein2020
- Author(s)
  Yoshiyuki Soeda, Akihiko Takashima
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 13 Pages: 590896-590896
- DOI
  10.3389/fnmol.2020.590896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06896, KAKENHI-PLANNED-18H05414
[Journal Article] SH2-containing inositol 5'-phosphatase 2 (SHIP2) selectively impaired hypothalamic insulin signalling and regulation of food intake in mice.2013
- Author(s)
  Ichihara Y, Wada T, Soeda Y, Ishii Y, Sasahara M, Tsuneki H, Sasaoka T.
- Journal Title
  
  J Neuroendocrinol.
  
  Volume: 25 Issue: 4 Pages: 372-382
- DOI
  10.1111/jne.12014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590444, KAKENHI-PROJECT-23659774, KAKENHI-PROJECT-23790313, KAKENHI-PROJECT-24390056, KAKENHI-PROJECT-25293093
[Journal Article] Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes2012
- Author(s)
  Yoshiike Y, Yamashita S, Mizoroki T, Maeda S, Murayama M, Kimura T, Sahara N, Soeda Y, Takashima A
- Journal Title
  
  Aging Cell
  
  Volume: 11 Issue: 1 Pages: 51-62
- DOI
  10.1111/j.1474-9726.2011.00756.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790313
[Patent] タウ凝集阻害剤2013
- Inventor(s)
  宮坂知宏、杉本八郎、時實梨衣、新崎由紀、大江洋平、太田哲男、高島明彦、添田義行、井原康夫
- Industrial Property Rights Holder
  宮坂知宏、杉本八郎、時實梨衣、新崎由紀、大江洋平、太田哲男、高島明彦、添田義行、井原康夫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-076614
- Filing Date
  2013-04-02
- Overseas
- Data Source
  KAKENHI-PROJECT-23790313
[Patent] タウ凝集阻害剤2013
- Inventor(s)
  宮坂知宏, 添田義行, 他
- Industrial Property Rights Holder
  宮坂知宏, 添田義行, 他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-076614
- Filing Date
  2013-04-02
- Data Source
  KAKENHI-PROJECT-23790313
[Patent] タウ凝集阻害剤2012
- Inventor(s)
  高島明彦、添田義行、長田裕之、井原康夫、宮坂智宏、杉本八郎
- Industrial Property Rights Holder
  高島明彦、添田義行、長田裕之、井原康夫、宮坂智宏、杉本八郎
- Industrial Property Rights Type
  特許
- Filing Date
  2012-10-03
- Overseas
- Data Source
  KAKENHI-PROJECT-23790313
[Patent] タウ凝集阻害剤2012
- Inventor(s)
  高島明彦、添田義行、長田裕之、井原康夫、宮坂智宏、杉本八郎
- Industrial Property Rights Holder
  高島明彦、添田義行、長田裕之、井原康夫、宮坂智宏、杉本八郎
- Industrial Property Rights Type
  特許
- Filing Date
  2012-10-03
- Data Source
  KAKENHI-PROJECT-23790313
[Presentation] タウオリゴマー光誘導モデル細胞を用いた不溶性タウ凝集の誘導2024
- Author(s)
  内田智也、加藤尚己、櫻木繁雄、服部精人、添田義行、吉村英哲、高島昭彦、坂内博子
- Organizer
  第13回日本生物物理学会関東支部会
- Data Source
  KAKENHI-PROJECT-23K18116
[Presentation] ゲノム編集によるタウ標識とタウ凝集過程の生細胞観察2023
- Author(s)
  片山維央名、櫻木繁雄, 添田義行、高島明彦、坂内博子
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K18116
[Presentation] Aggresomeへの移動が制限されたタウの凝集能2023
- Author(s)
  添田義行、吉村英哲、坂内博子、高島明彦
- Organizer
  第42回日本認知症学会学術集会(2023年11月24日-26日）奈良
- Data Source
  KAKENHI-PROJECT-23K05993
[Presentation] 青色光照射により細胞内Tau凝集を制御する手法の検証2023
- Author(s)
  坂田佳大、櫻木繁雄、高島明彦、添田義行、吉田英哲、坂内博子
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K18116
[Presentation] タウのN末端切断によって生じる細胞内タウ液滴はタウ線維形成の種となり得る2023
- Author(s)
  添田義行、吉村英哲、坂内博子、高島明彦
- Organizer
  第46回日本分子生物学会年会 (2023年12月7日)神戸
- Data Source
  KAKENHI-PROJECT-23K05993
[Presentation] 経路統合能測定法の開発2022
- Author(s)
  小池力、山下真央、高市雄太、添田義行、高島明彦
- Organizer
  第45回日本神経科学大会/第65回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-20K06896
[Presentation] タウ凝集を見る2022
- Author(s)
  添田義行
- Organizer
  タウ研究会2022
- Data Source
  KAKENHI-PROJECT-20K06896
[Presentation] 抗タウオパチー薬開発とタウオリゴマー2021
- Author(s)
  添田義行
- Organizer
  第64回日本神経化学会大会、シンポジウム11「ヒトと社会に役立つタウバイオロジー」
- Data Source
  KAKENHI-PROJECT-20K06896
[Presentation] 認知症最初期に起こる嗅内野機能低下を検出するVR-ゴーグルの開発2020
- Author(s)
  添田義行　笠井淳史　源田公平　甲斐英隆　高島明彦
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06896
[Presentation] PLX-R18- Placenta-derived Mesenchymal-like Stromal Cells are efficacious in reducing lethality in Gastrointestinal Acute Radiation Syndrome (GI-ARS) Mouse Model2018
- Author(s)
  添田義行、稲野彰洋
- Organizer
  the 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10357
[Presentation] PLX-R18- Placenta-derived Mesenchymal-like Stromal Cells are efficacious in reducing lethality in Gastrointestinal Acute Radiation Syndrome (GI-ARS) Mouse Model2018
- Author(s)
  Yoshiyuki Soeda, Racheli Ofir, Noa Sher, Yoshiyuki Suzuki, Zami Aberman, Akihiro Inano
- Organizer
  18th world congress of basic and clinical pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10357
[Presentation] タウ凝集阻害剤2013
- Author(s)
  添田義行
- Organizer
  タウ研究ミーティング
- Place of Presentation
  愛知県大府市
- Year and Date
  2013-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-23790313
[Presentation] 新時代に向けたタウオパチー研究集中講座2013
- Author(s)
  添田義行、高島明彦
- Organizer
  第32回に本認知症学会学術集会
- Place of Presentation
  茨城県つくば市
- Year and Date
  2013-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-23790313
[Presentation] 新時代に向けたタウオパチー研究集中講座2013
- Author(s)
  添田義行, 高島明彦
- Organizer
  第３２回日本認知症学会学術集会
- Place of Presentation
  長野県松本市
- Invited
- Data Source
  KAKENHI-PROJECT-23790313
[Presentation] in vitroおよびin vivoにおける低分子化合物によるタウ凝集抑制作用の検討2011
- Author(s)
  添田義行、吉池裕二、前田純宏、木村哲也、村山美由紀、溝呂木達也、柳下聡介、斉藤臣雄、長田裕之、高島明彦
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京都江戸川区(学会奨励賞受賞)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23790313
[Presentation] in vitroおよびin vivoおける低分子化合物によるタウ凝集抑制作用の検討2011
- Author(s)
  添田義行、吉池裕二、前田純宏、木村哲也、村山美由紀、溝呂木達也、山下俊治、柳下聡介、斎藤臣雄、長田裕之、高島明彦
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23790313

1. 坂内博子 (40332340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. INANO AKIHIRO (30437933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 織内昇 (40292586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 鈴木義行 (60334116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 長谷川有史 (70404879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 原孝光 (70464542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 前田純宏 (70443025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉村英哲 (90464205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 福山真央 (40754429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 菅井祥加 (10905566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中島吉太郎 (20867337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ISHII Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 笹原正清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 内田和幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. チェンバーズジェームズ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Soeda Yoshiyuki 添田 義行

SOEDA Yoshiyuki 添田 義行

Research Projects

Research Products

Co-Researchers

Multi-step kinetic analysis of protein condensate aging using microfluidics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the starting point and diversity of Tauopathy by single-molecule measurement

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経変性型認知症の原因蛋白質「タウ」の液相→固相転換時におこる細胞内変化の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the Mechanism of Dementia Caused by Tau Aggregation Using a Novel AptamerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Non-clinical evaluation of PLX-R18, Placenta-derived Mesenchymal-like Stromal Cells for GI-ARS mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screen for tau-focused drugs that inhibit tau toxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Research on the molecular mechanism of singularity phenomenon in neurological disorders2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Path integration deficits with phosphorylated tau accumulation in the entorhinal cortex in mice and humans2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3?×?Tg-AD mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Memory formation in old age requires GSK-3β2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] タウ凝集体の役割と凝集阻害剤開発2021

Author(s)

Journal Title

Data Source

[Journal Article] Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Insights Into Drug Discovery Targeting Tau Protein2020

Author(s)

Journal Title

Soeda Yoshiyuki 添田義行

SOEDA Yoshiyuki 添田義行