Gerle Christoph ＧｅｒｌｅＣｈｒｉｓｔｏｐｈ

Researcher Number	10561970
Other IDs	https://orcid.org/0000-0002-7265-2804
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 放射光科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2019: 大阪大学, 蛋白質研究所, 特任准教授(常勤) 2017: 大阪大学, たんぱく質研究所, 特任准教授(常勤) 2016: 兵庫県立大学, 生命理学研究科, 特任准教授 2015: 兵庫県立大学, 生命理学研究科, 准教授
Review Section/Research Field	Principal Investigator Structural biochemistry
Keywords	Principal Investigator cryo-EM / single particle cryo-EM / mitochondria / membrane protein / 生体分子 / 電子顕微鏡 / 蛋白質 / 分子モータ / rotary ATPase / proton transport … More / membrane biology / structural biology / bioenergetics / FoF1 ATP synthase / FoF1ATP合成 / 膜蛋白質複合体 / FoF1ATP合成酵素 / クライオ電顕 / 膜タンパク質複合体 / 高分解能電子顕微鏡解析 / channel / PTP / protein structure / supercomplex / membrane transport / membrane architecture / cristae / super complex / F-ATP synthase / image processing / single particle / protein purification / sample preparation / structural dynamics / rotational catalysis / molecular machine Less

Single particle cryoEM of mammalian FoF1 ATP synthasePrincipal Investigator
- Principal Investigator
  
  Gerle Christoph
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Investigation into Fo/F1 coupling of the FoF1 ATP synthase by time resolved single particle cryo-EMPrincipal Investigator
- Principal Investigator
  
  Gerle Christoph
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Hyogo

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] The Dual Life of Mitochondrial F-ATP Synthase.2020
- Author(s)
  Paolo, B., Szabo, I., Lippe, G., Gerle, C., and Forte, M.A.
- Journal Title
  
  Biophysical Journal
  
  Volume: 118, 3 Issue: 3 Pages: 16a-16a
- DOI
  10.1016/j.bpj.2019.11.270
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Journal Article] Purified F-ATP synthase forms a Ca2+dependent high-conductance channel matching the mitochondrial permeability transition pore.2019
- Author(s)
  Urbani A,Giorgio V,Carrer A, Franchin C,Arrigoni G, Jiko C,Abe K,Maeda S, Sginzawa-Itoh K, Bogers JF, McMillan DG, Gerle C, Szabo I, Bernardi P
- Journal Title
  
  Nature communications
  
  Volume: 4341 Issue: 1 Pages: 4341-4341
- DOI
  10.1038/s41467-019-12331-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15749, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03647, KAKENHI-PROJECT-17H03653
[Journal Article] Essay on Biomembrane Structure.2019
- Author(s)
  Christoph Gerle
- Journal Title
  
  Journal of Membrane Biology
  
  Volume: 252 Issue: 2-3 Pages: 115-130
- DOI
  10.1007/s00232-019-00061-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Journal Article] Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry2018
- Author(s)
  Dror S Chorev, Lindsay A Baker, Di Wu, Victoria Beilsten-Edmands, Sarah L Rouse, Tzviya Zeev-Ben-Mordehai, Chimari Jiko, Firdaus Samsudin, Christoph Gerle, Syma Khalid, Alastair G Stewart, Stephen J Matthews, Kay Grunewald, Carol V Robinson
- Journal Title
  
  Science
  
  Volume: 362, 6416 Issue: 6416 Pages: 829-834
- DOI
  10.1126/science.aau0976
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Journal Article] The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.2018
- Author(s)
  Ruben Quintana-Cabrera, Charlotte Quirin, Christina Glytsou, Mauro Corrado, Andrea Urbani, Anna Pellattiero, Enrique Calvo, Jesus Vazquez, Jose; Antonio Enriquez, Christoph Gerle, Maria Eugenia Soriano, Paolo Bernardi & Luca Scorrano
- Journal Title
  
  Nature communications
  
  Volume: 9 (3399) Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-018-05655-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Journal Article] RAZA: A Rapid 3D z-crossings algorithm to segment electron tomograms and extract organelles and macromolecules2017
- Author(s)
  Ali Rubbiya A.、Mehdi Ahmed M.、Rothnagel Rosalba、Hamilton Nicholas A.、Gerle Christoph、Landsberg Michael J.、Hankamer Ben
- Journal Title
  
  Journal of Structural Biology
  
  Volume: 200 Issue: 2 Pages: 73-86
- DOI
  10.1016/j.jsb.2017.10.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Journal Article] On the structural possibility of pore-forming mitochondrial FoF1 ATP synthase2016
- Author(s)
  Gerle, Christoph
- Journal Title
  
  BBA - Bioenergetics
  
  Volume: in press Issue: 8 Pages: 1191-1196
- DOI
  10.1016/j.bbabio.2016.03.008
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Journal Article] Recent advances of single particle analysis by cryo-electron microscopy and its application to membrane proteins2016
- Author(s)
  光岡薫, Gerle, Christoph
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 4 Pages: 532-536
- DOI
  10.14952/SEIKAGAKU.2016.880532
- NAID
  40020948610
- ISSN
  0037-1017
- Year and Date
  2016-08-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14464
[Journal Article] Osuda Y, Shinzawa-Itoh K, Tani K, Maeda S, Yoshikawa S, Tsukihara T, Gerle C.2016
- Author(s)
  Osuda Y, Shinzawa-Itoh K, Tani K, Maeda S, Yoshikawa S, Tsukihara T, Gerle C.
- Journal Title
  
  Microscopy
  
  Volume: 65 Issue: 3 Pages: 263-267
- DOI
  10.1093/jmicro/dfv381
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26440024, KAKENHI-PROJECT-15K14464
[Journal Article] Bovine F1FoATP synthase monomers bend the lipid bilayer in 2D membrane crystals.2015
- Author(s)
  C. Jiko, K.M. Davies, K.S. Itoh, K. Tani, S. Maeda, D.J. Mills, T. Tsukihara, Y. Fujiyoshi W. Kuehlbrandt and C. Gerle
- Journal Title
  
  eLIFE
  
  Volume: 06119 Pages: 1-36
- DOI
  10.7554/elife.06119
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22227004, KAKENHI-PROJECT-26440024, KAKENHI-PROJECT-15K14464, KAKENHI-PROJECT-13J05370
[Journal Article] GraDeR: membrane protein complex preparation for single particle cryo-EM.2015
- Author(s)
  Hauer F., Gerle C., Fischer N., Oshima A., Shinzawa-Itoh K., Shimada S., Yokoyama K., Fujiyoshi Y. & Stark H.
- Journal Title
  
  Structure
  
  Volume: 23 Issue: 9 Pages: 1769-1775
- DOI
  10.1016/j.str.2015.06.029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464, KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-26650039, KAKENHI-PROJECT-26840019
[Presentation] In and out of the membrane: cryo-EM of membrane proteins.2019
- Author(s)
  Christoph Gerle
- Organizer
  Asian Crystallographic Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore.2019
- Author(s)
  Christoph Gerle
- Organizer
  Cold Spring Harbor Asia conference on Mitochondria
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Membrane bending & more - in vitro studies of membrane protein supercomplexes.2019
- Author(s)
  Christoph Gerle
- Organizer
  Institute for Plant Biotechnology and Biology, University of Munster, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Mitochondrial F-ATP synthase: an old machine with new tricks.2019
- Author(s)
  Christoph Gerle
- Organizer
  Kluyver Colloquium, TU Delft, The Netherlands
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Is mammalian FoF1 ATP synthase the mitochondrial permeability transition pore?2018
- Author(s)
  Christoph Gerle
- Organizer
  EBEC
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Cryo electron tomography of in vitro membrane systems.2018
- Author(s)
  Christoph Gerle
- Organizer
  KEK Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Membrane protein sample preparation for single-particle cryo-EM and more.2018
- Author(s)
  Christoph Gerle
- Organizer
  生理研研究会「クライオ電子顕微鏡によるタンパク質の高分解能単粒子構造解析」～これであなたも高分解能～
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] 牛心筋シトクロム-c酸化酵素二量体か？単量体か？2018
- Author(s)
  Christoph Gerle
- Organizer
  日本生体エネルギー研究会第44回討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] GraDeR: detergent free membrane protein preparation.2018
- Author(s)
  Christoph Gerle
- Organizer
  Oxford Talks
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Membrane bending and more - cryo-EM of integral membrane complexes.2018
- Author(s)
  Christoph Gerle
- Organizer
  Departmental Talk, Ruh University Bochum, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Mammalian FoF1 ATP synthase as the mitochondrial permeability transition pore -? new drug targets in old proteins.2018
- Author(s)
  Christoph Gerle
- Organizer
  CeSPI Talk
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] GraDeR: micelle free membrane protein preparation.2017
- Author(s)
  Christoph Gerle
- Organizer
  The 55th Annual Meeting of Biophysical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] Cryo-EM 2.02017
- Author(s)
  Christoph Gerle
- Organizer
  ConBio
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] 哺乳動物F-ATP合成酵素はptp?2017
- Author(s)
  Christoph Gerle
- Organizer
  日本生体エネルギー研究会第43回討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] The intermembrane space domain of mammalian FoF1 ATP synthase and its potential role in ptp formation.2017
- Author(s)
  Christoph Gerle
- Organizer
  Cold Spring Harbor Asia conference on Mitochondria
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03647
[Presentation] GraDeR:単粒子解析等の膜タンハク質資料調整2016
- Author(s)
  Christoph Gerle, Florian Hauer, Niels Fischer, Kyoko Shinzawa-Itoh, Satoru Shimada, Ken Yokoyama, Atsunori Oshima, Yoshinori Fujiyoshi, Holger Stark
- Organizer
  日本生物物理学会
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] In & out of the membrane: cryoEM of bovine FoF1 ATP synthase.2016
- Author(s)
  Gerle, C.
- Organizer
  Minisymposium on Structure-Based Bioenergetics
- Place of Presentation
  Spring-8 (兵庫県、佐用郡）
- Invited
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] On the structural possibility of pore forming mitochondrial FoF1 ATP synthase.2016
- Author(s)
  Gerle, C.
- Organizer
  EBEC
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2016-07-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] Electron crystallography of tomographic volumes.2016
- Author(s)
  Kazutoshi Tani, Karen Davies, Chimari Jiko, Shintaro Maeda, Kyoko Shinzawa-Itoh, Deryck Mills, Tomitake Tsukihara, Yoshinori Fujiyoshi, Werner Kuhlbrandt, Christoph Gerle
- Organizer
  3DEM Gordon Research Conference
- Place of Presentation
  Hong Kong University, Hong Kong
- Year and Date
  2016-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] Membrane bending and more: cryoEM of the mammalian F-ATP synthase2016
- Author(s)
  Gerle, C.
- Organizer
  Mitochondrial bASiCs: ATP, Signaling and Calcium symposium
- Place of Presentation
  University of Padua, Italy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] Looking at a cellular machine in & out of the membrane: cryo-EM of the mammalian FoF1 ATP synthase.2016
- Author(s)
  Christoph Gerle
- Organizer
  IPR Seminar 'Introduction and overview of cryo-electron microscopy'
- Place of Presentation
  大阪大学 (大阪府吹田市)
- Year and Date
  2016-02-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] CryoEM of the mammalian F-ATP synthase: possible implications for the mitochondrial permeability transition pore.2016
- Author(s)
  Gerle, C.
- Organizer
  departmental seminar
- Place of Presentation
  University of Padua, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] GraDeR: membrane protein complex preparation for single particle cryo-EM.2015
- Author(s)
  Christoph Gerle
- Organizer
  71st annual meeting of the Japanese Society of Microscopy
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2015-05-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] In & Out of the Membrane: EM structure of the mammalian FoF1 ATP synthase2015
- Author(s)
  Christoph Gerle
- Organizer
  Cold Spring Harbor Asia conference on Mitochondria
- Place of Presentation
  Suzhou, China
- Year and Date
  2015-10-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] Looking at "bad" 2D crystals can be good.2015
- Author(s)
  Christoph Gerle
- Organizer
  Seminar Talk, LMB, Cambridge, U.K.
- Place of Presentation
  Cambridge, U.K.
- Year and Date
  2015-07-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] GraDeR: membrane protein complex preparation for single particle cryo-EM.2015
- Author(s)
  Gerle C., Hauer F., Fischer N., Oshima A., Shinzawa-Itoh K., Shimada S., Yokoyama K., Fujiyoshi Y. & Stark H.
- Organizer
  3DEM Gordon Research Conference
- Place of Presentation
  Colby-Sawyer College, New London. NH, U.S.A.
- Year and Date
  2015-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464
[Presentation] Novel sample preparation for cryo-EM: in silico & in aqua.2015
- Author(s)
  Christoph Gerle
- Organizer
  Young Scientists Satellite Meeting - Toward Next Generation of Microscopic Sciences - in The 2nd East-Asia Microscopy Conference
- Place of Presentation
  淡路夢舞台（兵庫県淡路市）
- Year and Date
  2015-11-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14464

1. 森本幸生 (80200450)

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2. 慈幸千真理

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3. 藤吉好則

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4. 吉川信也

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5. 新沢伊藤恭子

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Gerle Christoph Ｇｅｒｌｅ Ｃｈｒｉｓｔｏｐｈ

Research Projects

Research Products

Co-Researchers

Single particle cryoEM of mammalian FoF1 ATP synthasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation into Fo/F1 coupling of the FoF1 ATP synthase by time resolved single particle cryo-EMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Dual Life of Mitochondrial F-ATP Synthase.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purified F-ATP synthase forms a Ca2+dependent high-conductance channel matching the mitochondrial permeability transition pore.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essay on Biomembrane Structure.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RAZA: A Rapid 3D z-crossings algorithm to segment electron tomograms and extract organelles and macromolecules2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] On the structural possibility of pore-forming mitochondrial FoF1 ATP synthase2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent advances of single particle analysis by cryo-electron microscopy and its application to membrane proteins2016

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Osuda Y, Shinzawa-Itoh K, Tani K, Maeda S, Yoshikawa S, Tsukihara T, Gerle C.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bovine F1FoATP synthase monomers bend the lipid bilayer in 2D membrane crystals.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GraDeR: membrane protein complex preparation for single particle cryo-EM.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] In and out of the membrane: cryo-EM of membrane proteins.2019

Author(s)

Organizer

Data Source

[Presentation] Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore.2019

Gerle Christoph ＧｅｒｌｅＣｈｒｉｓｔｏｐｈ

[Presentation] 牛心筋シトクロム-c酸化酵素二量体か？単量体か？2018