SOHMA Youhei 相馬洋平

Researcher Number	10565518
Affiliation *help	2016 – 2018 : 東京大学, 大学院薬学系研究科(薬学部), 特任研究員 2012 : 東京大学, 薬学研究科(研究院), 研究員 2011 : 東京大学, 大学院・薬学系研究科, 特任研究員 2010 : 京都薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 阻害剤 / アミロイド / ペプチド / 凝集 / イソペプチド / クリックペプチド / 結晶 / 創薬 / 有機化学 / 触媒 … More Except Principal Investigator クリプタイド / ss-セクレターゼ / プロテアーゼ / プロテアーゼ阻害剤 / クリックペプチド / ドラッグデザイン / 基質遷移状態 / 酵素阻害剤 / β-セクレターゼ / 分子認識 Less

病原性アミロイドタンパク質に対する革新的凝集阻害戦略Principal InvestigatorOngoing
- Principal Investigator
  
  相馬洋平
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Research on pathological mechanism of amyloid beta peptide and application to the aggregation inhibitorPrincipal Investigator
- Principal Investigator
  
  YOUHEI Sohma
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
  Kyoto Pharmaceutical University
Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular Recognition
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology
  Kyoto Pharmaceutical University

All 2017 2016 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] ペプチド医薬の最前線2012
- Author(s)
  相馬洋平
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22790118
[Book] 遺伝子医学MOOK21号最新ペプチド合成技術とその創薬研究への応用(木曽良明編集)O-アシルイソペプチドの合成.2012
- Author(s)
  相馬洋平・木曽良明
- Publisher
  メディカル・ドゥ
- Data Source
  KAKENHI-PROJECT-21249007
[Book] ペプチド医薬の最前線2012
- Author(s)
  相馬洋平
- Total Pages
  240
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22790118
[Book] 最新ペプチド合成技術とその創薬研究への応用2011
- Author(s)
  相馬洋平
- Publisher
  遺伝子医学MOOK21号, メディカルドウ
- Data Source
  KAKENHI-PROJECT-22790118
[Book] Wiley Encyclopedia of Chemical Biology, Volume 1 (Tadhg P. Begley, Chief Advisor)2009
- Author(s)
  Yoshiaki Kiso, Atsuhiko Taniguchi, Youhei Sohma
- Publisher
  Click Peptides: Design and Applica- tions.
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] Scandium(III) triflate-promoted serine/threonine-selective peptide bond cleavage.2017
- Author(s)
  Jizhi Ni, Youhei Sohma, Motomu Kanai
- Journal Title
  
  Chemical Communication
  
  Volume : 53 Pages : 3311-3314
- DOI
  10.1039/c6cc10300f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06216
[Journal Article] Switchable photooxygenation catalysts that sense higher-order amyloid structures2016
- Author(s)
  Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
- Journal Title
  
  Nature Chemistry
  
  Volume : 8 Pages : 974-982
- DOI
  10.1038/nchem.2550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06216, KAKENHI-PROJECT-25460008
[Journal Article] Transition Metal-Free, Tryptophan-Selective Bioconjugation of Proteins2016
- Author(s)
  Yohei Seki, Takashi Ishiyama, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume : 138 Pages : 10798-10801
- DOI
  10.1021/jacs.6b06692
- Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06216, KAKENHI-PROJECT-15J11454, KAKENHI-PROJECT-25460008
[Journal Article] Comparative Properties of ASS1-42, ASS11-42, and [Pyr11]ASS11-42Generated from O-Acyl Isopeptides.2013
- Author(s)
  相馬洋平
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 23巻 Pages : 1326-1329
- DOI
  10.1016/j.bmcl.2012.12.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J08493, KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-25350971
[Journal Article] Synthesis of O-acyl isopeptides2013
- Author(s)
  Youhei Sohma
- Journal Title
  
  Chem. Rec.
  
  Volume : 13 Pages : 218-223
- DOI
  10.1002/tcr.201200023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118
[Journal Article] Comparative Properties of AB1-42, AB11-42 and [Pyr11]AB11-42 Generated from O-Acyl Isopeptides2013
- Author(s)
  Youhei Sohma
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume : 23 Pages : 1326-1329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790118
[Journal Article] Comparative properties of A〓1〓42, A〓11〓42, and [Pyr11]A〓11〓42 generated from O-acyl isopeptides2013
- Author(s)
  Youhei Sohma, Moe Yamasaki, Hiroyuki Kawashima, Atsuhiko Taniguchi, Masayuki Yamashita, Kenichi Akaji, Hidehito Mukai, Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 23 Pages : 1326-1329
- URL
  http://dx.doi.org/10.1016/j.bmcl.2012.12.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790118
[Journal Article] Through the looking glass-a new world of proteins enabled by chemical synthesis2012
- Author(s)
  Stephen Kent, Youhei Sohma, Suhuai Liu, Duhee Bang, Brad Pentelute and Kalyaneswar Mandal
- Journal Title
  
  J. Peptide Science
  
  Volume : 18 Pages : 428-436
- DOI
  10.1002/psc.2421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790118
[Journal Article] S-Acyl isopeptide method: use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS.2011
- Author(s)
  Taku Yoshiya, Yuka Hasegawa, Wakana Kawamura, Hiroyuki Kawashima, Youhei Sohma, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  Biopolymers
  
  Volume : 96 Pages : 228-239
- DOI
  10.1002/bip.21410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790118
[Journal Article] Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element.2011
- Author(s)
  Hironobu Hojo, Hidekazu Katayama, Chiharu Tano, Yuko Nakahara, Azusa Yoneshige, Junko Matsuda, Youhei Sohma, Yoshiaki Kiso, Yoshiaki Nakahara
- Journal Title
  
  Tetrahedron Lett.
  
  Volume : 52 Pages : 635-639
- DOI
  10.1016/j.tetlet.2010.11.154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790118
[Journal Article] Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide2011
- Author(s)
  Youhei Sohma, Hitomi Kitamura, Hiroyuki Kawashima, Hironobu Hojo, Masayuki Yamashita, Kenichi Akaji, Yoshiaki Kiso
- Journal Title
  
  Tetrahedron Lett.
  
  Volume : 52(52) Pages : 7146-7148
- DOI
  10.1016/j.tetlet.2011.10.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-23380065
[Journal Article] Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors2011
- Author(s)
  Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Koushi Hidaka, Takashi Hamada, Youhei Sohma, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume : 19 Pages : 5238-5246
- DOI
  10.1016/j.bmc.2011.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-23590137
[Journal Article] 'Click peptide'using production of monomer Ab from the O-acyl isopeptide : Application to assay system of aggregation inhibitors and cellular cytotoxicity2011
- Author(s)
  Youhei Sohma
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume : 19 Pages : 1729-1733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790118
[Journal Article] Click peptide' using production of monomer Aβ from the O-acyl isopeptide : Application to assay system of aggregation inhibitors and cellular cytotoxicity.2011
- Author(s)
  Youhei Sohma
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume : 19 Pages : 1729-1733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] TEe E22Δ-type mutant of amyloid β peptide (Aβ) adopts distinct self-assembly mechanisms from wild-type Aβ2011
- Author(s)
  Youhei Sohma, Hui Wang, Atsuhiko Taniguchi, Yuta Hirayama, Taeko Kakizawa, Hidehito Mukai, Yoshiaki Kiso
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume : 19 Pages : 3787-3792
- DOI
  10.1016/j.bmc.2011.04.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-22790119
[Journal Article] "Click Peptide" Concept : O-Acyl isopeptide of Islet Amyloid Polypeptide As a non-aggregative precursor molecule2011
- Author(s)
  Taku Yoshiya, Ayano Higa, Naoko Abe, Fukue Fukao, Tomomi Kuruma, Youhei Sohma, Yoshiaki Kiso
- Journal Title
  
  ChemBioChem
  
  Volume : 12(8) Pages : 1216-1222
- DOI
  10.1002/cbic.201100025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118
[Journal Article] Click peptide' using production of monomer A. from the O-acyl isopeptide : Application to assay system of aggregation inhibitors and cellular cytotoxicity2011
- Author(s)
  Youhei Sohma, Yuta Hirayama, AtsuhikoTaniguchi, Hidehito Mukai, Yoshiaki Kiso
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume : 19 Pages : 1729-1733
- DOI
  10.1016/j.bmc.2011.01.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014, KAKENHI-PROJECT-22790118
[Journal Article] Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method.2010
- Author(s)
  Taku Yoshiya, Hiroyuki Kawashima, Yuka Hasegawa, Kazuhiro Okamoto, Tooru Kimura, Youhei Sohma, Yoshiaki Kiso
- Journal Title
  
  J. Peptide Sci.
  
  Volume : 16(8) Pages : 437-442
- DOI
  10.1002/psc.1261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118
[Journal Article] Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.2010
- Author(s)
  Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Takashi Hamada, Hamdy Abdel-Rahman, Abdellah Yamani, Ayaka Nagamine, Hayato Ikari, Naoto Igawa, Koushi Hidaka, Youhei Sohma, Tooru Kimura, Yo shiaki Kiso
- Journal Title
  
  Bioorg.Med. Chem.
  
  Volume : 18(9)
- DOI
  10.1016/j.bmc.2010.03.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Journal Article] efficient synthesis of isopeptide segment and application to racemization-free segment condensation.2009
- Author(s)
  Taku Yoshiya, Hiroyuki Kawashima, YouheiSohma, Tooru Kimura, Yoshiaki Kiso: O-Acylisopeptide method
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume : 7(14) Pages : 2894-2904
- DOI
  10.1039/B903624E
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] Biocompatible Photooxygenation Catalyst that Targets Amyloid Aggregation2017
- Author(s)
  Youhei Sohma
- Organizer
  23rd Peptide Forum
- Place of Presentation
  東京大学（東京都・文京区）
- Year and Date
  2017-01-15
- Invited
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] アミロイドタンパク質に対する革新的凝集阻害戦略の開発2017
- Author(s)
  相馬洋平
- Organizer
  日本薬学会　第１３７年会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Synthesis of Amyloid-β Oligomer Models Possessing Various Numbers of Amyloid-β Segment Chains2016
- Author(s)
  Kiyomichi Shinoda, Youhei Sohma, Motomu Kanai
- Organizer
  Molecular Chirality Asia
- Place of Presentation
  コングレコンベンションセンター（大阪府・大阪市）
- Year and Date
  2016-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] アミロイド疾患の治療を指向した選択的光酸素化触媒の開発2016
- Author(s)
  相馬洋平，谷口敦彦，倪　積智，清水裕介，生長幸之助，小澤　柊太、堀由起子、富田泰輔、金井求
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Amyloid-selective catalytic photooxygenation with long-wavelength light irradiation2016
- Author(s)
  Atsuhiko Taniguchi, Jizhi Ni, Yusuke Shimizu, Shuta Ozawa, Yukiko Hori, Taisuke Tomita, Kounosuke Oisaki, Yoichiro Kuninobu, Youhei Sohma, Motomu Kanai
- Organizer
  Peptide and Protein Society in Singapore Symposium
- Place of Presentation
  南洋（シンガポール）
- Year and Date
  2016-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] ペプチド由来ファーマコフォアを有する新規アミロイドβ凝集阻害低分子化合物の創成2016
- Author(s)
  新谷卓士, 城野柳人，西光海，藤後貴也，國信洋一郎，相馬洋平，金井求
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] アミロイドタンパク質に対する革新的凝集阻害戦略の開発2016
- Author(s)
  相馬洋平
- Organizer
  明治薬科大学認知症創薬資源研究開発センター講演会
- Place of Presentation
  明治薬科大学（東京都・清瀬市）
- Year and Date
  2016-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] アミロイドペプチドの凝集を標的とした機能分子設計2016
- Author(s)
  相馬洋平
- Organizer
  第８９回日本生化学会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Serine-Selective Aerobic Cleavage of Peptides and a Protein Using Water-Soluble Copper-Organoradical Conjugate2016
- Author(s)
  Yohei Seki, Kana Tanabe, Daisuke Sasaki, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
- Organizer
  17th Tetrahedron Symposium
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] In vivo への適用を目指したアミロイドβ選択的光酸素化触媒の開発2016
- Author(s)
  谷口敦彦、清水裕介、倪　積智、生長幸之助、國信洋一郎、相馬洋平、金井　求
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Rational design and synthesis of non-peptidic aggregation inhibitors based on primary structure of amyloid β2016
- Author(s)
  Takushi Araya, Ryuto Kkino, Youhei Sohma, Motomu Kanai
- Organizer
  French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  京王プラザホテル多摩（東京都・多摩）
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Development of near-infrared photoactivatable oxygenation catalysts that sense amyloid structure2016
- Author(s)
  Atsuhiko Taniguchi, Jizhi Ni, Youhei Sohma, Motomu Kanai
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Synthesis of Amyloid-β Oligomer Models Possessing Various Numbers of Amyloid-β Segment Chains2016
- Author(s)
  Kiyomichi Shinoda, Youhei Sohma, Motomu Kanai
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins2016
- Author(s)
  Takashi Ishiyama, Yohei Seki, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki, Motomu Kanai
- Organizer
  第33回有機合成化学セミナー
- Place of Presentation
  ヒルトンニセコビレッジ（北海道・虻田郡ニセコ町）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] ペプチド由来ファーマコフォアを有する新規アミロイドβ凝集阻害低分子化合物の創成2016
- Author(s)
  新谷卓士、城野柳人、相馬洋平、金井求
- Organizer
  第４６回複素環化学討論会
- Place of Presentation
  金沢歌劇座（石川県・金沢市）
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-16H06216
[Presentation] エステル含有ペプチドを基盤とした生物有機化学研究2011
- Author(s)
  相馬洋平
- Organizer
  第46回天然物化学談話会
- Place of Presentation
  熱川
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] アミロイドベータペプチドおよびアミリンの凝集機構解明を目指したO-アシルイソペプチドの利用2011
- Author(s)
  相馬洋平Hui Wang山崎萌,平山雄太,谷口敦彦,川島浩之,比嘉彩乃,吉矢拓,向井秀仁,木曽良明
- Organizer
  第9回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] ネイティブケミカルライゲーション法を利用したO-アシルイソペプチドの合成2011
- Author(s)
  相馬洋平、北村仁美、川島浩之、北條裕信、赤路健一、木曽良明
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] Use of ester-containing peptides toward understanding the functions of amyloid beta peptide and human insulin.2010
- Author(s)
  Y.Sohma
- Organizer
  31st European Peptide Symposium
- Place of Presentation
  コペンハーゲン、デンマーク
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] Use of ester-containing peptides for identifying the functions of human insulin and amyloid peptide2010
- Author(s)
  Youhei Sohma
- Organizer
  大阪大学蛋白質研究所セミナーNew Trend of Peptide Science in Asia and Oceania
- Place of Presentation
  大阪
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] アミロイドβペプチドおよびインスリンの機能解明を目指したエステル含有ペプチドの利用2010
- Author(s)
  相馬洋平、谷口敦彦、向井秀仁、Stephen B. H. Kent、木曽良明
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  横浜
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] Use of O-acyl isopeptides to identify new functions of amyloid beta peptides2010
- Author(s)
  Youhei Sohma, Atsuhiko Taniguchi, Yuta Hirayama, Hui Wang, Moe Yamazaki, Hidehito Mukai, Yoshiaki Kiso
- Organizer
  31st European Peptides Symposium
- Place of Presentation
  Copenhagen,Denmark
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] In situ production of Alzheimer's Aβ mutants from water-soluble click peptide precursors.2010
- Author(s)
  Hui Wang, Taeko Kakizawa, Atsuhiko Taniguchi, Takaaki Mizuguchi, Youhei Sohma, Hidehito Mukai, Tooru Kimura, Yoshiaki Kiso
- Organizer
  11th Chinese International Peptide Symposium
- Place of Presentation
  Lanzhou, China
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] アミロイドベータペプチドの機能解明を目指したO-アシルイソペプチドの利用.2010
- Author(s)
  相馬洋平、平山雄太、谷口敦彦、向井秀仁、木曽良明
- Organizer
  第36回反応と合成の進歩シンポジウム-ライフサイエンスを志向した理論、反応および合成-
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] Use of ester-containing peptides toward understanding the functions of amyloid beta peptide and human insulin.2010
- Author(s)
  Youhei Sohma
- Organizer
  31st European Peptides Symposium
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] Use of O-Acyl isopeptides to identify new functions of amyloid beta peptides.2010
- Author(s)
  Youhei Sohma
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] エルテルまたはチオエステルを含むペプチド合成法開発とその生物研究への応用2010
- Author(s)
  相馬洋平,Stephen B. H. Kent,木曽良明
- Organizer
  第8回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] アミロイドβペプチドおよびインスリンの機能解明を目指したエステル含有ペプチドの利用2010
- Author(s)
  相馬洋平
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] Use of ester-containing peptides for identifying the functions of human insulin and amyloid peptide.2010
- Author(s)
  Youhei Sohma
- Organizer
  大阪大学蛋白質研究所セミナーNew Trend of Peptide Science in Asia and Oceania
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] Use of O-acyl isopeptides to identify new functions of amyloid beta peptides2010
- Author(s)
  Youhei Sohma, Atsuhiko Taniguchi, Yuta Hirayama, Hui Wang, Moe Yamazaki, Hidehito Mukai, Yoshiaki Kiso
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] アミロイドβペプチドおよびインスリンの機能解明を目指したエステル含有ペプチドの利用.2010
- Author(s)
  相馬洋平、谷口敦彦、向井秀仁、StephenKent、木曽良明
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] "クリックペプチド":水溶性プレカーサーによるアルツハイマー病関連Aβ変異体の産生.2010
- Author(s)
  王惠、柿澤多惠子、谷口敦彦、水口貴章、相馬洋平、向井秀仁、木村徹、木曽良明
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249007
[Presentation] エルテルまたはチオエステルを含むペプチド合成法開発とその生物研究への応用2010
- Author(s)
  相馬洋平
- Organizer
  第8回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790118
[Presentation] In situ production of Alzheimer's disease-related amyloid s peptide from water- soluble precursor analogs.2009
- Author(s)
  Atsuhiko Taniguchi, Youhei Sohma, Mariusz Skwarczynski, Yuta Hirayama, Takuma Okada, Keisuke Ikeda, Halan Prakash, Hidehito Mukai, Tooru Kimura, Yoshio Hayashi, Shun Hirota, Katsumi Matsuzaki, Yoshiaki Kiso: Click peptide
- Organizer
  238th American Chemical Society National Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21249007

1. KISO Yoshiaki (40089107)

# of Collaborated Projects : 1results

# of Collaborated Products : 16results
2. KIMURA Tooru (70204980)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
3. MUKAI Hidehito (20251027)

# of Collaborated Projects : 1results

# of Collaborated Products : 8results
4. HIDAKA Koushi (30445960)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
5. HAMADA Yoshio

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
6. KAKIZAWA Taeko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. 生長幸之助

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
8. 北條裕信

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

SOHMA Youhei 相馬 洋平

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病原性アミロイドタンパク質に対する革新的凝集阻害戦略Principal InvestigatorOngoing

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Research on pathological mechanism of amyloid beta peptide and application to the aggregation inhibitorPrincipal Investigator

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Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular Recognition

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[Book] ペプチド医薬の最前線2012

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[Book] 遺伝子医学MOOK21号最新ペプチド合成技術とその創薬研究への応用(木曽良明編集)O-アシルイソペプチドの合成.2012

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[Book] ペプチド医薬の最前線2012

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[Book] 最新ペプチド合成技術とその創薬研究への応用2011

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[Book] Wiley Encyclopedia of Chemical Biology, Volume 1 (Tadhg P. Begley, Chief Advisor)2009

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[Journal Article] Scandium(III) triflate-promoted serine/threonine-selective peptide bond cleavage.2017

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[Journal Article] Switchable photooxygenation catalysts that sense higher-order amyloid structures2016

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[Journal Article] Transition Metal-Free, Tryptophan-Selective Bioconjugation of Proteins2016

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[Journal Article] Comparative Properties of ASS1-42, ASS11-42, and [Pyr11]ASS11-42Generated from O-Acyl Isopeptides.2013

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[Journal Article] Synthesis of O-acyl isopeptides2013

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[Journal Article] Comparative Properties of AB1-42, AB11-42 and [Pyr11]AB11-42 Generated from O-Acyl Isopeptides2013

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[Journal Article] Comparative properties of A〓1〓42, A〓11〓42, and [Pyr11]A〓11〓42 generated from O-acyl isopeptides2013

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[Journal Article] Through the looking glass-a new world of proteins enabled by chemical synthesis2012

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SOHMA Youhei 相馬洋平