OHSE Takamoto 大瀬貴元

Researcher Number	10568447
Affiliation (based on the past Project Information) *help	2015: 東京大学, 医学部附属病院, 登録診療員 2013 – 2015: 東京大学, 医学部附属病院, 臨床登録医 2014: 東京大学, 医学部附属病院, その他 2010 – 2012: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Kidney internal medicine Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator インドール / 尿毒素 / インドキシル硫酸 / 腸内細菌 / 慢性腎臓病 / 細胞増殖 / 半月体形成性腎炎 / 糸球体壁細胞 Except Principal Investigator 小胞体ストレス / 低酸素 … More / 蛋白尿 / 細胞骨格 / エピゲノム / HIF / microRNA / 酸化ストレス / 虚血再灌流モデル / 糸球体足細胞 / ATF4 / 小胞体ストレス応答 / 糸球体腎炎 / コータクチン / アクチン / ストレスシグナル / 腎臓老化 / 尿細管上皮細胞 / ポドサイト / アクチン細胞骨格 / SIRT１ / 虚血・再灌流 / オートファジー / エピジェネティクス / 腎細胞癌 / 慢性腎臓病 / ヒストン修飾 / エピジェネティックス / 腎臟病 / 酸化ストリス / UPR経路 / 腎臓病 / 翻訳制御 / 虚血 / unfolded protein response / 尿細管 / グルコース / 分子シャペロン / アポトーシス / 腎臓学 Less

Identification of microRNA that regulates renal pathophysiology related to hypoxia and ER stress
- Principal Investigator
  
  Inagi Reiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
The analysis of the pathophysiology of the Kidney- Gut interaction, the vicious cycle in Chronic kidney disease and dysbiosis.Principal Investigator
- Principal Investigator
  
  Ohse Takamoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Elucidation of the pathogenesis of kidney disease via epigenetic responses against hypoxia
- Principal Investigator
  
  NANGAKU Masaomi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Elucidation of the mechanisms of podocyte homeostasis and development of new therapeutic strategies against diabetic kidney disease
- Principal Investigator
  
  WADA Takehiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Expression profile of miRNA in chronic kidney disease and identification of miRNA regulating hypoxia and endoplasmic reticulum stress signals
- Principal Investigator
  
  INAGI Reiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Exploring the mechanism of the glomerular parietal epithelial cell proliferation in crescentic glomerulonephritis and its treatmentPrincipal Investigator
- Principal Investigator
  
  OHSE Takamoto
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Elucidation of the mechanisms underlying podocyte injury through endoplasmic reticulum stress and Development of novel therapeutic strategies for glomerular diseases
- Principal Investigator
  
  WADA Takehiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] SIRT1 maintains actin cytoskeleton by deacetylation of cortactin in injured podocytes.2015
- Author(s)
  Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R.
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390213
[Journal Article] Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.2015
- Author(s)
  Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R
- Journal Title
  
  Journal of American Society of Nephrology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591189
[Journal Article] Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation.2014
- Author(s)
  Jo-Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, Shirakawa J, Nagai R, Miyata T, Nagano T, Hirata Y, Inagi R, Nangaku M.
- Journal Title
  
  Aging Cell
  
  Volume: Epub ahead of print Issue: 3 Pages: 519-28
- DOI
  10.1111/acel.12204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300260, KAKENHI-PROJECT-24390213, KAKENHI-PROJECT-24591189, KAKENHI-PROJECT-24650482, KAKENHI-PROJECT-25461207
[Journal Article] Galacto-oligosaccharides attenuate renal injury with microbiota modification.2014
- Author(s)
  Satoshi Unuma Furuse, Takamoto Ohse, Airi Jo-Watanabe, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku
- Journal Title
  
  Physiological Reports
  
  Volume: 2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461210
[Journal Article] Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates eytokinesis, and its expression correlates with the prognosis of renal cell earcinoma.2013
- Author(s)
  Shoji K, Mimura I, Murayama T, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 182 Issue: 6 Pages: 2191-2203
- DOI
  10.1016/j.ajpath.2013.02.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08634, KAKENHI-PROJECT-22590307, KAKENHI-PROJECT-22790781, KAKENHI-PROJECT-24390213, KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-24591189, KAKENHI-PROJECT-25290051, KAKENHI-PROJECT-25460431, KAKENHI-PROJECT-25461207
[Journal Article] Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/22012
- Author(s)
  Chang AM, Ohse T, Krofft RD, Wu JS, Eddy AA, Pippin JW, Shankland SJ.
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 27(4) Issue: 4 Pages: 1330-43
- DOI
  10.1093/ndt/gfr483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790779
[Presentation] 腸腎連関：腸内環境と腎不全の相互作用2015
- Author(s)
  大瀬貴元
- Organizer
  第24回腸内フローラシンポジウム
- Place of Presentation
  東京、新橋、ヤクルトホール
- Year and Date
  2015-10-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461210
[Presentation] 腸腎連関：腸内環境と腎不全の相互作用2015
- Author(s)
  大瀬貴元
- Organizer
  第24回腸内フローラシンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-25461210
[Presentation] Galacto-oligosaccharides modified gut microbiota and attenuated renal injury.2014
- Author(s)
  Satoshi Unuma Furuse, Takamoto Ohse, Airi Jo-Watanabe, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku
- Organizer
  The 14th Asian Pacific Congress of Nephrology.
- Place of Presentation
  東京
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25461210
[Presentation] ガラクトオリゴ糖は腸内細菌叢を変化させ，腎組織障害を改善する2014
- Author(s)
  鵜沼智、大瀬貴元、城愛理、重久晃、川上幸治、松木隆広、長南治、南学正臣
- Organizer
  第59回日本透析医学会
- Place of Presentation
  神戸
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-25461210
[Presentation] SIRT1 Maintains Podocyte Homeostasis via Regulation of Actin Fiber Formation2013
- Author(s)
  Shuta Motonishi, Reiko Inagi, Takehiko Wada, Takamoto Ohse, Akira Shimizu, Masaomi Nangaku
- Organizer
  American Society of Nephrology Annual Meeting
- Place of Presentation
  Georgia World Congress Center（米国・アトランタ）
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] 新規HIF-1ターゲット分子SPAG4は細胞質分裂を調節し、腎細胞癌の進行に重要な役割を果たす2013
- Author(s)
  正路久美, 村山尚, 三村維真理, 和田健彦, 久米春喜, 後藤明輝, 大瀬貴元, 田中哲洋, 稲城玲子, 油谷浩幸, 児玉龍彦, 南学正臣
- Organizer
  日本臨床分子医学会学術総会
- Place of Presentation
  東京国際フォーラム（東京）
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] Glyoxalase I Prevents Age-Related Endothelial Dysfunction through Modulation of eNOS Phosphorylation2013
- Author(s)
  Airi Jo, Takamoto Ohse, Hiroaki Nishimatsu, Masao Takahashi, Satoshi Unuma, Takehiko Wada, Yoichiro Ikeda, Toshio Miyata, Yasunobu Hirata, Reiko Inagi, Masaomi Nangaku
- Organizer
  American Society of Nephrology Annual Meeting
- Place of Presentation
  Georgia World Congress Center（米国・アトランタ）
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] Glyoxalase Iによる血管内皮の糖化抑制とeNOSの活性制御を介した内皮機能障害の軽減と血管老化の進行抑制2013
- Author(s)
  城愛理, 大瀬貴元, 稲城玲子, 鵜沼智, 池田洋一郎, 和田健彦, 宮田敏男, 高橋政夫, 西松寛明, 平田恭信, 南学正臣
- Organizer
  日本臨床分子医学会学術総会
- Place of Presentation
  東京国際フォーラム（東京）
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] Identification and Characterization of a Novel HIF-1 Target that Regulates Cytokinesis as a Defensive Mechanism against Polyploidy2012
- Author(s)
  Kumi Shoji, Imari Mimura, Takashi Murayama, Takehiko Wada, Tetsuhiro Tanaka, Takamoto Ohse, Reiko Inagi, Hiroyuki Aburatani, Tatsuhiko Kodama, Masaomi Nangaku
- Organizer
  American Society of Nephrology Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] 新規HIF-1ターゲット分子SPAG4は尿細管の細胞質分裂を調節する2012
- Author(s)
  正路久美, 村山尚, 三村維真理, 和田健彦, 久米春喜, 後藤明輝, 大瀬貴元, 田中哲洋, 稲城玲子, 油谷浩幸, 児玉龍彦, 南学正臣, 藤田敏郎
- Organizer
  第５５回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] Identification of a Novel Hypoxia-Inducible Factor 1 (HIF-1) Regulator, CCAAT/Enhancer-Binding Protein Delta (CEBPD) in Kidney Disease2012
- Author(s)
  Junna Yamaguchi, Tetsuhiro Tanaka, Nobuaki Eto, Takamoto Ohse, Takehiko Wada, MD, Reiko Inagi, Masaomi Nangaku
- Organizer
  American Society of Nephrology Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] microRNAによるprolyl hydroxylase domain 1(PHD1)の転写後制御を介した腎尿細管細胞のストレス応答調節機構2012
- Author(s)
  村津四葉, 南学正臣, 田中哲洋, 池田洋一郎, 和田健彦, 大瀬貴元, 藤田敏郎, 稲城玲子
- Organizer
  第５５回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] 小胞体ストレスシグナル(unfolded protein response)による低酸素応答性エリスロポエチン産生機構の破綻2012
- Author(s)
  Chiang Chih-Kang, 南学正臣, 田中哲洋, 和田健彦, 大瀬貴元, 藤田敏郎, 稲城玲子
- Organizer
  第５５回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591189
[Presentation] 糸球体壁細胞(PEC)に発現する遺伝子のマイクロアレイ法による同定2011
- Author(s)
  大瀬貴元
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-22790779
[Presentation] 糸球体壁細胞(PEC)から見たFSGS2011
- Author(s)
  大瀬貴元
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜(シンポジウム)(招待講演)
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-22790779
[Presentation] 腎炎・ネフローゼ(基礎)(4)糸球体壁細胞(PEC)に発現する遺伝子のマイクロアレイ法による同定2011
- Author(s)
  大瀬貴元
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-22790779
[Presentation] シンポジウム3FSGSを上皮細胞のバイオロジーから考える糸球体壁細胞(PEC)から見たFSGS2011
- Author(s)
  大瀬貴元
- Organizer
  第54回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-22790779
[Presentation] Identification & Characterization of a Novel OncogenicHIF-1 Target Involved in Renal Cell Carcinoma2011
- Author(s)
  Shoji K, Mimura I, Ohse T, Murayama T, Inagi R, Wada T, Tanaka T, Kume H, GotoA, Fujita T, Aburatani H, Kodama T, Nangaku M
- Organizer
  The 44th Annual Meeting of the American Society of Nephrology.
- Place of Presentation
  Philadelphia, U. S. A
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21591020
[Presentation] ボウマン嚢上皮細胞(PEC)における実験腎炎モデルでのポドサイトタンパク質の発現2010
- Author(s)
  大瀬貴元
- Organizer
  第53回日本腎臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22790779
[Presentation] Galacto-Oligosaccharides Modified Gut Microbiota and Attenuated Renal Injury.
- Author(s)
  Satoshi Unuma, Takamoto Ohse, Airi Jo, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku.
- Organizer
  The 46th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24390213
[Presentation] Galacto-Oligosaccharides Modified Gut Microbiota and Attenuated Renal Injury
- Author(s)
  Satoshi Unuma, Takamoto Ohse, Airi Jo, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku
- Organizer
  Annual meeting of American Society of Nephrology
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-25461210
[Presentation] Galacto-oligosaccharide modified gut microbiota and attenuated the renal injury
- Author(s)
  Satoshi Unuma, Takamoto Ohse, Airi Jo, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku
- Organizer
  International congress on uremia research and toxicity
- Place of Presentation
  沖縄(沖縄コンベンションセンター)
- Data Source
  KAKENHI-PROJECT-25461210
[Presentation] Glyoxalase I Prevents Age-Related Endothelial Dysfunction through Modulation of eNOS Phosphorylation.
- Author(s)
  Airi Jo, Takamoto Ohse, Hiroaki Nishimatsu, Masao Takahashi, Satoshi Unuma, Takehiko Wada, Yoichiro Ikeda, Toshio Miyata, Yasunobu Hirata, Reiko Inagi, Masaomi Nangaku.
- Organizer
  The 46th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24390213
[Presentation] SIRT1 Maintains Podocyte Homeostasis via Regulation of Actin Fiber Formation.
- Author(s)
  Shuta Motonishi, Reiko Inagi, Takehiko Wada, Takamoto Ohse, Akira Shimizu, Masaomi Nangaku.
- Organizer
  The 46th Annual Meeting of the American Society of Nephrology
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24390213

1. NANGAKU Masaomi (90311620)

# of Collaborated Projects: 6 results

# of Collaborated Products: 20 results
2. WADA Takehiko (90447409)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
3. INAGI Reiko (50232509)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
4. TANAKA Tetsuhiro (90508079)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. JO Airi

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. KODAMA Tatsuhiko (90170266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Hirata Yoshihiro (10529192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MOTONISHI Shuta

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIMOTO Yu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OKADA Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Unuma Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 永井竜児

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHSE Takamoto 大瀬 貴元

Research Projects

Research Products

Co-Researchers

Identification of microRNA that regulates renal pathophysiology related to hypoxia and ER stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of the pathophysiology of the Kidney- Gut interaction, the vicious cycle in Chronic kidney disease and dysbiosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the pathogenesis of kidney disease via epigenetic responses against hypoxia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanisms of podocyte homeostasis and development of new therapeutic strategies against diabetic kidney disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression profile of miRNA in chronic kidney disease and identification of miRNA regulating hypoxia and endoplasmic reticulum stress signals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring the mechanism of the glomerular parietal epithelial cell proliferation in crescentic glomerulonephritis and its treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanisms underlying podocyte injury through endoplasmic reticulum stress and Development of novel therapeutic strategies for glomerular diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SIRT1 maintains actin cytoskeleton by deacetylation of cortactin in injured podocytes.2015

Author(s)

Journal Title

Data Source

[Journal Article] Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.2015

Author(s)

Journal Title

Data Source

[Journal Article] Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Galacto-oligosaccharides attenuate renal injury with microbiota modification.2014

Author(s)

Journal Title

Data Source

[Journal Article] Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates eytokinesis, and its expression correlates with the prognosis of renal cell earcinoma.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/22012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 腸腎連関：腸内環境と腎不全の相互作用2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 腸腎連関：腸内環境と腎不全の相互作用2015

OHSE Takamoto 大瀬貴元