ONO HIRAKU 小野啓

… Alternative Names

Ono Hiraku 小野啓

ONO Hiraku 小野啓

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Researcher Number	10570616
Other IDs
Affiliation (Current)	2025: 千葉大学, 予防医学センター, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 千葉大学, 大学院医学研究院, 准教授 2017 – 2018: 千葉大学, 大学院医学研究院, 講師 2015 – 2016: 埼玉医科大学, 医学部, 講師 2010 – 2011: 埼玉医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator Akt / インスリン / 糖尿病 / 摂食 / 視床下部 / インスリン抵抗性 / FoxO / 摂食調節 / PTEN / 肝臓 … More / 寿命 / 筋肉 / マウス / 加齢 / 脂肪組織 / 糖代謝 / FoxO1 / 中枢神経 / SGLT2 / 肥満 / ブドウ糖 / 阻害薬 / グルコースクランプ法 / インスリン情報伝達 / インスリン感受性 / 糖負荷試験 / GSK3 / AMPK / S6キナーゼ / LKB1 / エネルギー・糖質代謝異常 … More Except Principal Investigator ウェルナー症候群 / 老化 / 代謝異常 / Hippoシグナル / 肥満 / Pin1 / 線維化 / 炎症 / 糖代謝異常 / プロリン異性化酵素 / 老化メカニズム / 遺伝性早老症 / Werner症候群 / 細胞老化 / マーモセット / iPS細胞 / 早老症 Less

早老症の多角的解析に基づく老化と疾患の病態解明
- Principal Investigator
  
  横手幸太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Chiba University
Hippo/YAP経路へのPin1作用と肝や脂肪組織の肥大、炎症、線維化への関与
- Principal Investigator
  
  浅野知一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hiroshima University
Roles of four FoxO isoforms on insulin resistance and longevityPrincipal Investigator
- Principal Investigator
  
  Ono Hiraku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Chiba University
Elucidation of the molecular pathogenesis of aging and related diseases through analysis of multilayered models
- Principal Investigator
  
  Yokote Koutaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Chiba University
Direct and Indirect Effects of Insulin on Target Tissues to Decrease GlucosePrincipal Investigator
- Principal Investigator
  
  Ono Hiraku
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Chiba University
Roles of Hypothalamic Akt on Food Intake and Glucose MetabolismPrincipal Investigator
- Principal Investigator
  
  Ono Hiraku
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Chiba University
  Saitama Medical University
Roles of hypothalamic S6 kinase on diabetesPrincipal Investigator
- Principal Investigator
  
  ONO Hiraku
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Saitama Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 Other

All Journal Article Presentation Book Other

[Book] 『肥満症』日常診療に活かす診療ガイドラインUP-TO-DATE 2022-20232022
- Author(s)
  落合英俊，小野啓，横手幸太郎
- Total Pages
  1096
- Publisher
  メディカルレビュー社
- ISBN
  9784779225802
- Data Source
  KAKENHI-PROJECT-21K08570
[Book] 今日の治療指針 2021年版2021
- Author(s)
  小野啓（分担執筆）
- Total Pages
  2192
- Publisher
  医学書院
- ISBN
  9784260042826
- Data Source
  KAKENHI-PROJECT-18K08502
[Book] 日常診療に活かす診療ガイドラインUPDATE　肥満症 pp413-4182020
- Author(s)
  佐藤愛，小野啓，横手幸太郎
- Total Pages
  1060
- Publisher
  メディカルレビュー社
- ISBN
  9784779222535
- Data Source
  KAKENHI-PROJECT-18K08502
[Book] 第三期特定健診・特定保健指導ガイド2018
- Author(s)
  門脇孝，津下一代，永井良三，多田羅浩三，西沢均，下村伊一郎，小野啓，横手幸太郎，崔仁哲，磯博康，鈴木隆雄，鈴木亮，佐藤大，加藤秀樹，南学正臣，三浦克之，高本偉碩，寺本民生，岡村友教，宮本恵宏，中川詩織，安田宜成，和田隆志，小久保喜弘，峰松一夫，川崎良，中山健夫，杉田由加里，武見ゆかり，林芙美，中田由夫，中村正和，他
- Total Pages
  328
- Publisher
  南山堂
- ISBN
  9784525207816
- Data Source
  KAKENHI-PROJECT-18K08502
[Book] これが知りたかった!糖尿病診療・療養指導Q&A 「インスリン分泌能とインスリン抵抗性はどのように評価し，どのように活用するのですか？」2017
- Author(s)
  小野啓（分担執筆），岩本安彦（監修），吉田洋子（編集）
- Total Pages
  299
- Publisher
  中山書店
- ISBN
  9784521745237
- Data Source
  KAKENHI-PROJECT-15K09398
[Journal Article] Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines2023
- Author(s)
  Kanna, M; Nakatsu, Y ; Yamamotoya, T, Takeshi ; Kushiyama, A ; Fujishiro, M ; Sakoda, H ; Ono, H ; Arihiro, K ; Asano, T
- Journal Title
  
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  
  Volume: 24 Issue: 10 Pages: 8847-8847
- DOI
  10.3390/ijms24108847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08077, KAKENHI-PROJECT-22K08655, KAKENHI-PROJECT-21K08570, KAKENHI-PROJECT-23K27650
[Journal Article] d-Alanine Affects the Circadian Clock to Regulate Glucose Metabolism in the Kidney2023
- Author(s)
  Sakai Shinsuke、Tanaka Youichi、Tsukamoto Yusuke、Kimura-Ohba Shihoko、Hesaka Atsushi、Hamase Kenji、Hsieh Chin-Ling、Kawakami Eiryo、Ono Hiraku、Yokote Kotaro、Yoshino Mitsuaki、Okuzaki Daisuke、Matsumura Hiroyo、Fukushima Atsuko、Mita Masashi、Nakane Maiko、Doi Masao、Isaka Yoshitaka、Kimura Tomonori
- Journal Title
  
  Kidney360
  
  Volume: 5 Issue: 2 Pages: 237-251
- DOI
  10.34067/kid.0000000000000345
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19414, KAKENHI-PROJECT-23KJ1290, KAKENHI-PROJECT-21K08570, KAKENHI-PROJECT-21K15638, KAKENHI-PROJECT-22H04987, KAKENHI-PROJECT-21H02935, KAKENHI-PROJECT-23K27671
[Journal Article] Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells2023
- Author(s)
  Akasaka Y, Hasei S, Ohata Y, Kanna M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Ono H, Matsubara A, Hinata N, Asano T, Yamamotoya T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 24(21) Issue: 21 Pages: 16011-16011
- DOI
  10.3390/ijms242116011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08580, KAKENHI-PROJECT-22K08655, KAKENHI-PROJECT-19K02314, KAKENHI-PROJECT-21K08570, KAKENHI-PROJECT-23K27650
[Journal Article] Insulin Sensitivity Initially Worsens but Later Improves With Aging in Male C57BL/6N Mice2023
- Author(s)
  Kondo Hiroya、Ono Hiraku、Hamano Hiiro、Sone-Asano Kanako、Ohno Tomohiro、Takeda Kenji、Ochiai Hidetoshi、Matsumoto Ai、Takasaki Atsushi、Hiraga Chihiro、Kumagai Jin、Maezawa Yoshiro、Yokote Koutaro
- Journal Title
  
  The Journals of Gerontology: Series A
  
  Volume: 78 Issue: 10 Pages: 1785-1792
- DOI
  10.1093/gerona/glad126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08570
[Journal Article] Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases2022
- Author(s)
  Yamamotoya Takeshi、Hasei Shun、Akasaka Yasuyuki、Ohata Yukino、Nakatsu Yusuke、Kanna Machi、Fujishiro Midori、Sakoda Hideyuki、Ono Hiraku、Kushiyama Akifumi、Misawa Hidemi、Asano Tomoichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1966-1966
- DOI
  10.1038/s41598-022-05884-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-19K02314, KAKENHI-PROJECT-21K08570, KAKENHI-PROJECT-21K08580, KAKENHI-PROJECT-19K08982, KAKENHI-PROJECT-21K19380
[Journal Article] 肥満症患者の食事指導は炭水化物制限とするべきでしょうか？2022
- Author(s)
  小野啓
- Journal Title
  
  臨床雑誌内科
  
  Volume: 130 Pages: 512-514
- Data Source
  KAKENHI-PROJECT-21K08570
[Journal Article] Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis2021
- Author(s)
  Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano
- Journal Title
  
  Metabolism
  
  Volume: 15 Pages: 154459-154459
- DOI
  10.1016/j.metabol.2020.154459
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08982, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-18K08502
[Journal Article] Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping?2021
- Author(s)
  Ono Hiraku、Yokote Koutaro
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 12 Issue: 11 Pages: 1942-1943
- DOI
  10.1111/jdi.13640
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08570
[Journal Article] Serum HDL-C values: An extremely useful marker for differentiating homozygous lipoprotein lipase deficiency from severe hypertriglyceridemia with other causes in Japan2021
- Author(s)
  Kobayashi Junji、Minamizuka Takuya、Koshizaka Masaya、Maezawa Yoshiro、Ono Hiraku、Yokote Koutaro
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 521 Pages: 85-89
- DOI
  10.1016/j.cca.2021.07.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08570
[Journal Article] Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats2021
- Author(s)
  Takeda Kenji、Ono Hiraku、Ishikawa Ko、Ohno Tomohiro、Kumagai Jin、Ochiai Hidetoshi、Matumoto Ai、Yokoh Hidetaka、Maezawa Yoshiro、Yokote Koutaro
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 9 Issue: 1 Pages: e002104-e002104
- DOI
  10.1136/bmjdrc-2020-002104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-21K08570
[Journal Article] Pathological Role of Pin1 in the Development of DSS-Induced Colitis2021
- Author(s)
  Matsunaga Yasuka、Hasei Shun、Yamamotoya Takeshi、Honda Hiroaki、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Ito Hisanaka、Okabe Takayoshi、Asano Tomoichiro、Nakatsu Yusuke
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 5 Pages: 1230-1230
- DOI
  10.3390/cells10051230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-19K02314, KAKENHI-PROJECT-19K08982, KAKENHI-PROJECT-21K08570, KAKENHI-PROJECT-21K08580
[Journal Article] Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes2021
- Author(s)
  Fujishiro Midori、Ishihara Hisamitsu、Ogawa Katsuhiko、Murase Takayo、Nakamura Takashi、Watanabe Kentaro、Sakoda Hideyuki、Ono Hiraku、Yamamotoya Takeshi、Nakatsu Yusuke、Asano Tomoichiro、Kushiyama Akifumi
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 8 Pages: 1052-1052
- DOI
  10.3390/biomedicines9081052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-19K02314, KAKENHI-PROJECT-20K08918, KAKENHI-PROJECT-21K08570, KAKENHI-PROJECT-21K08580
[Journal Article] Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency - Effects of pemafibrate treatment2020
- Author(s)
  Minamizuka T, Kobayashi J, Tada H, Miyashita K, Koshizaka M, Maezawa Y, Ono H, Yokote K
- Journal Title
  
  CLINICA CHIMICA ACTA
  
  Volume: 510 Pages: 216-219
- DOI
  10.1016/j.cca.2020.07.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07484, KAKENHI-PROJECT-18K08502
[Journal Article] Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells2020
- Author(s)
  Nakatsu Yusuke、Yamamotoya Takeshi、Ueda Koji、Ono Hiraku、Inoue Masa-Ki、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Matsubara Akio、Asano Tomoichiro
- Journal Title
  
  Cancer Letters
  
  Volume: 470 Pages: 106-114
- DOI
  10.1016/j.canlet.2019.10.043
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-19K08982, KAKENHI-PROJECT-20H03732
[Journal Article] Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins2019
- Author(s)
  Inoue Masa-Ki、Nakatsu Yusuke、Yamamotoya Takeshi、Hasei Shun、Kanamoto Mayu、Naitou Miki、Matsunaga Yasuka、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Kushiyama Akifumi、Asano Tomoichiro
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 12 Pages: 1545-1545
- DOI
  10.3390/cells8121545
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-17K16150
[Journal Article] 肥満症の栄養管理2019
- Author(s)
  中野香名，野本尚子，小野啓，横手幸太郎
- Journal Title
  
  臨床栄養臨時増刊号高齢者の栄養管理パーフェクトガイド
  
  Volume: 135 Pages: 506-512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08502
[Journal Article] Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice2019
- Author(s)
  Inoue Masa-Ki、Matsunaga Yasuka、Nakatsu Yusuke、Yamamotoya Takeshi、Ueda Koji、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Iwashita Misaki、Sano Tomomi、Nishimura Fusanori、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Asano Tomoichiro
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 11 Issue: 1 Pages: 57-57
- DOI
  10.1186/s13098-019-0454-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K02314, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K16150
[Journal Article] Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice2019
- Author(s)
  Mizuno Yu、Yamamotoya Takeshi、Nakatsu Yusuke、Ueda Koji、Matsunaga Yasuka、Inoue Masa-Ki、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Kikuchi Takako、Takahashi Masahiro、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Asano Tomoichiro、Kushiyama Akifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 19 Pages: 4680-4680
- DOI
  10.3390/ijms20194680
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-17K16150
[Journal Article] 高度肥満を認める1型糖尿病の患者2019
- Author(s)
  小野啓
- Journal Title
  
  臨床雑誌内科診療力を上げる！症例問題集
  
  Volume: 123 Pages: 999-1000
- Data Source
  KAKENHI-PROJECT-18K08502
[Journal Article] Molecular Mechanisms of Hypothalamic Insulin Resistance2019
- Author(s)
  Ono Hiraku
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 6 Pages: 1317-1317
- DOI
  10.3390/ijms20061317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08502
[Journal Article] CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet2019
- Author(s)
  Kurita Kenichi、Ishikawa Ko、Takeda Kenji、Fujimoto Masanori、Ono Hiraku、Kumagai Jin、Inoue Hiromi、Yokoh Hidetaka、Yokote Koutaro
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 6165-6165
- DOI
  10.1038/s41598-019-42127-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K19643, KAKENHI-PROJECT-17H01558
[Journal Article] Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation2019
- Author(s)
  Ueda Koji、Nakatsu Yusuke、Yamamotoya Takeshi、Ono Hiraku、Inoue Yuki、Inoue Masa-Ki、Mizuno Yu、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Takahashi Shin-Ichiro、Matsubara Akio、Asano Tomoichiro
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 17 Pages: 1637-1648
- DOI
  10.18632/oncotarget.26691
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-25221204
[Journal Article] Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.2019
- Author(s)
  Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
- Journal Title
  
  Cell Rep.
  
  Volume: 26 Issue: 12 Pages: 3221-3230
- DOI
  10.1016/j.celrep.2019.02.066
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K11670, KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16H06226, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-16K11503, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-19K17951, KAKENHI-PROJECT-17H01565, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-17K11644
[Journal Article] The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model2018
- Author(s)
  Inoue Masa-Ki、Yamamotoya Takeshi、Nakatsu Yusuke、Ueda Koji、Inoue Yuki、Matsunaga Yasuka、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Suzuki Yusuke、Asano Tomoichiro、Kushiyama Akifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 12 Pages: 3967-3967
- DOI
  10.3390/ijms19123967
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791
[Journal Article] Development of Pin1 inhibitors and their potential as therapeutic agents.2018
- Author(s)
  Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T.
- Journal Title
  
  Curr Med Chem
  
  Volume: - Issue: 20 Pages: 1-1
- DOI
  10.2174/0929867325666181105120911
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16K09791
[Journal Article] 12年にわたる内科的治療にて治療効果が不十分であり肥満外科手術を施行した2型糖尿病の症例2018
- Author(s)
  小野啓
- Journal Title
  
  Medical Practice
  
  Volume: 35 Pages: 304-308
- Data Source
  KAKENHI-PROJECT-18K08502
[Journal Article] Gut microbiota as a　therapeutic target for metabolic disorders.2018
- Author(s)
  Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue MK,　Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T.
- Journal Title
  
  Curr Med Chem.
  
  Volume: 25 Issue: 9 Pages: 984-1001
- DOI
  10.2174/0929867324666171009121702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K19538, KAKENHI-PROJECT-18K08502
[Journal Article] Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.2017
- Author(s)
  Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-017-13432-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
[Journal Article] The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.2017
- Author(s)
  Yusuke Nakatsu, Hiroki Kokubo, Batmunkh Bumdelger, Masao Yoshizumi, Takeshi Yamamotoya, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Hideyuki Sakoda, and Tomoichiro Asano
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18(8) Issue: 8 Pages: 1704-1717
- DOI
  10.3390/ijms18081704
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08443, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
[Journal Article] The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion2017
- Author(s)
  Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 28 Pages: 11886-11895
- DOI
  10.1074/jbc.m117.780726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
[Journal Article] Effects of the activations of three major hepatic Akt substrates on glucose metabolism in male mice.2017
- Author(s)
  Sakai G, Inoue I, Suzuki T, Sumita T, Inukai K, Katayama S, Awata T, Yamada T, Asano T, Katagiri H, Noda M, Shimada A, Ono H.
- Journal Title
  
  Endocrinology.
  
  Volume: 158 Issue: 8 Pages: 2659-2671
- DOI
  10.1210/en.2016-1969
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293215, KAKENHI-PROJECT-17H01565, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K15486
[Journal Article] Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.2016
- Author(s)
  Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 2016 Pages: 8603164-8603164
- DOI
  10.1155/2016/8603164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06427, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K09791
[Journal Article] Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine2016
- Author(s)
  Nakano T, Inoue I, Takenaka Y, Ono H, Katayama S, Awata T, Murakoshi T.
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 3 Pages: e0152207-e0152207
- DOI
  10.1371/journal.pone.0152207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09398
[Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.2016
- Author(s)
  Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 17 (9) Issue: 9 Pages: 1495-1495
- DOI
  10.3390/ijms17091495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06427, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791
[Journal Article] Influence of Treatment with Extracts of <i>Hypsyzigus marmoreus</i> Mushroom on Body Composition during Obesity Development in KK-A<sup>y</sup> Mice2015
- Author(s)
  Iuchi T, Hosaka T, Shiroishi M, Ono H, Inukai K, Sumita T, Sakai G, Katayama S, Awata T
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 61 Issue: 1 Pages: 96-100
- DOI
  10.3177/jnsv.61.96
- NAID
  130005070827
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09398
[Journal Article] Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit2015
- Author(s)
  Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 40 Pages: 24255-24266
- DOI
  10.1074/jbc.m115.658559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-26660287, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25253067, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670447, KAKENHI-PROJECT-26252064, KAKENHI-PROJECT-16H05220
[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
- Author(s)
  Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 23 Pages: 20812-20822
- DOI
  10.1074/jbc.m110.206904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390556, KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022
[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
- Author(s)
  Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Asano T
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790869
[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
- Author(s)
  Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 300(5) Issue: 5 Pages: 1047-54
- DOI
  10.1152/ajpcell.00416.2010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047
[Journal Article] Separation of the gluconeogenic and mitochondrial functions of PGC-1αthrough S6 kinase2011
- Author(s)
  Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM
- Journal Title
  
  Genes Dev
  
  Volume: 25 Issue: 12 Pages: 1232-44
- DOI
  10.1101/gad.2054711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790869
[Journal Article] 中枢神経のインスリン作用と糖尿病2011
- Author(s)
  小野啓
- Journal Title
  
  International Review of Diabetes
  
  Volume: 3 Pages: 28-31
- Data Source
  KAKENHI-PROJECT-22790869
[Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010
- Author(s)
  Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 33018-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790869
[Journal Article] Effects of telmisartan on insulin resistance in Japanese type 2 diabetic patients2010
- Author(s)
  Watanabe M, Inukai K, Sumita T, Ikebukuro K, Ito D, Kurihara S, Ono H, Awata T, Katayama S
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 1843-7
- NAID
  130000336862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790869
[Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010
- Author(s)
  Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T
- Journal Title
  
  Diabetes Res Clin Pract
  
  Volume: 87 Pages: 57-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] 3T3-L1脂肪細胞においてインスリン刺激による糖取り込みと脂肪合成にAkt2は不要である2023
- Author(s)
  松本愛，小野啓，平賀千尋，髙崎敦史，落合英俊，大野友寛，熊谷仁，横手幸太郎
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 成熟脂肪細胞において FoxO1 の活性化は細胞増殖効果をもたらさずにインスリンの代謝作用を模倣する2023
- Author(s)
  大野友寛，小野啓，近藤寛也，濱野陽彩，田村みなみ，髙崎敦史，平賀千尋，落合英俊，松本愛，熊谷仁，前澤善朗，横手幸太郎
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 診療端末上のグラフ付き体重管理アプリケーションの作成とそれを用いた肥満症診療2023
- Author(s)
  小野啓
- Organizer
  第43回医療情報学連合大会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] C57BL/6Nマウスにおいて1 年齢以降では加齢に伴いインスリン抵抗性が改善する2023
- Author(s)
  近藤寛也，小野啓，濱野陽彩，曽根加菜子，大野友寛，落合英俊，松本愛，髙崎敦史，平賀千尋，熊谷仁，横手幸太郎
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 高度肥満症の最新の治療とマジンドール2023
- Author(s)
  小野啓
- Organizer
  第43回日本肥満学会・第40回日本肥満症治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 肥満外科手術後の食材調達困難の高齢の高度肥満患者に対して栄養指導により支援を行った一例2023
- Author(s)
  野本尚子，小野啓，林愛子，大塚将之，横手幸太郎
- Organizer
  第44回日本肥満学会・第41回日本肥満症治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 脂肪細胞において FoxO1 の活性化は細胞増殖効果をもたらさずにインスリンの糖・脂質代謝作用を模倣する2022
- Author(s)
  大野友寛，小野啓　他
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] C57/Bl6N マウスにおいて 1 年齢以降では加齢に伴いインスリン抵抗性が改善する2022
- Author(s)
  近藤寛也，小野啓　他
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 運動による減量に乏しい経過からKlinefelter症候群の診断に至った高度肥満症の一例2021
- Author(s)
  佐藤愛，小野啓，落合英俊，大野友寛，武田健治，熊谷仁，林愛子，横手幸太郎
- Organizer
  第41回日本肥満学会・第38回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 肥満症治療のためのセマグルチド投与に伴う体重減少と嘔気について2021
- Author(s)
  横手幸太郎, 小野啓, Wharton Sean, Birkenfeld Andreas L, McGowan Barbara, Carson Charlotte G, Jepsen Cecilie H, Endahl Lars, Pedersen Sue D
- Organizer
  第41回日本肥満学会・第38回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 腹壁蜂窩織炎の治療後，LSGにて減量を得るも余剰皮膚切除後に皮膚創離開と感染により創傷治癒遅延が生じた一例2021
- Author(s)
  小野啓，野本尚子，岩立康男，横手幸太郎
- Organizer
  第41回日本肥満学会・第38回日本肥満症治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes2021
- Author(s)
  TOMOHIRO OHNO, HIRAKU ONO, KENJI TAKEDA, KOUTARO YOKOTE
- Organizer
  第81回米国糖尿病学会年次学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] Laparoscopic Sleeve Gastrectomy（LSG）後の嘔吐を多職種による介入で改善した一例2021
- Author(s)
  矢野周子、野本尚子、松本泰典、加野将之、林秀樹、林愛子、小野啓、岩立康男、横手幸太郎、松原久裕
- Organizer
  第42回日本肥満学会・第39回日本肥満症治療学会合同学術集会
- Data Source
  KAKENHI-PROJECT-21K08570
[Presentation] 当院肥満外来通院１年間における内科的治療の減量効果2021
- Author(s)
  林愛子，前澤善朗，前田祐香里，越坂理也，北原綾，小野啓，林秀樹，横手幸太郎
- Organizer
  第41回日本肥満学会・第38回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究（続報）2020
- Author(s)
  櫛山暁史，小川克彦，渡邉健太郎，江頭富士子，岡本真由美，村瀬貴代，中村敬志，赤利精悟，迫田秀之，小野啓，山本屋武，中津祐介，浅野知一郎，石原寿光
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] Mechanisms and Roles of FoxO1-Akt Negative Feedback Pathway in Adipocytes2020
- Author(s)
  Tomohiro Ohno, Hiraku Ono, Koutaro Yokote
- Organizer
  American Diabetes Association 80th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 脂肪細胞におけるFoxO1-Aktフィードバック機構の機序と役割2020
- Author(s)
  大野友寛，小野啓，濱野陽彩，佐藤愛，落合英俊，武田健治，熊谷仁，横尾英孝，前澤善朗，藤代緑，片桐秀樹，浅野知一郎，横手幸太郎
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 内科治療の現状と今後2020
- Author(s)
  小野啓
- Organizer
  第63回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 脂肪細胞におけるFoxO1-Aktフィードバック機構の機序と役割2019
- Author(s)
  大野友寛、小野啓、浜野陽彩、武田健治、藤城緑、前澤善朗、片桐秀樹、浅野知一郎、横手幸太郎
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 高度肥満症患者における性格や過食症状，不安・うつ尺度について2019
- Author(s)
  佐藤愛，小野啓，北原綾，松本淳子，林愛子，横手幸太郎
- Organizer
  第40回日本肥満学会・第37回日本肥満症治療学会合同学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 肝臓および脂肪組織におけるFoxO1-Aktフィードバック機構の機序と役割2018
- Author(s)
  大野友寛, 小野啓, 濱野陽彩, 武田武治, 栗田健市, 藤城緑, 石川耕, 前澤善朗, 片桐秀樹, 浅野知一郎, 横手幸太郎
- Organizer
  第55回臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 脂肪組織におけるFoxO1-Aktフィードバック機構の機序と役割2018
- Author(s)
  大野友寛、小野啓、浜野陽彩、武田健治、藤城緑、石川耕、前澤善朗、片桐秀樹、浅野知一郎、横手幸太郎
- Organizer
  第23回アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 高度肥満症専門外来における治療法の選択と予後；千葉大学におけるチーム医療2018
- Author(s)
  小野啓
- Organizer
  第39回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 県民公開シンポジウム「メタボで何が悪い!?」2018
- Author(s)
  小野啓
- Organizer
  千葉県医師会医学会第19回学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 脂肪細胞におけるFoxO1-Aktフィードバック機構の機序と役割2018
- Author(s)
  大野友寛, 小野啓, 横手幸太郎
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-18K08502
[Presentation] 肝Foxo1は糖新生律速酵素と独立してインスリンによる糖代謝を制御する2017
- Author(s)
  酒井豪太，小野啓，鈴木徳子，犬飼浩一，住田崇，片山茂裕，粟田卓也，井上郁夫，野田光彦，島田朗
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] 視床下部弓状核のAktは摂食調節とは独立してインスリン感受性を調節する2017
- Author(s)
  小野啓，横手幸太郎
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] DPP-4阻害薬/少量SU薬併用およびSU薬増量の膵β細胞機能に及ぼす影響：3S（Saitama Sitagliptin Study）無作為化比較試験2016
- Author(s)
  小野啓, 栗原進, 松田昌文, 加計正文, 豊島秀男, 犬飼敏彦, 麻生好正, 粟田卓也, 片山茂裕, 3S研究グループ
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  みやこめっせ（京都）
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] 3種のAkt基質の糖代謝における役割2016
- Author(s)
  小野啓
- Organizer
  第30回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  大宮ソニックシティ(埼玉県大宮市）
- Year and Date
  2016-03-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] 3種のAkt基質と迷走神経肝臓枝の糖代謝における役割2016
- Author(s)
  酒井豪太，小野啓，鈴木徳子，住田崇，井上郁夫，片山茂裕，粟田卓也，野田光彦，島田朗
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  みやこめっせ（京都）
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] Aｋｔ基質と迷走神経肝臓枝の肝糖代謝における役割2015
- Author(s)
  小野啓, 酒井豪太, 住田崇, 犬飼浩一, 片山茂裕, 粟田卓也, 井上郁夫
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] インスリンの血糖低下機序と最新の糖尿病治療2015
- Author(s)
  小野啓
- Organizer
  第19回日本適応医学会
- Place of Presentation
  一橋大学（東京都千代田区）
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] Differential roles of three Akt substrates in the liver and vagal hepatic branch on insulin sensitivity2015
- Author(s)
  Gota Sakai, Hiraku Ono, Tokuko Suzuki, Takashi Sumita, Kouichi Inukai, Shigehiro Katayama, Takuya Awata, Ikuo Inoue
- Organizer
  Keystone Symposia's Third Conference in Japan
- Place of Presentation
  ウェスティン都ホテル（京都府京都市）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09398
[Presentation] 視床下部PTEN/Aktの摂食とインスリン感受性に対する影響2012
- Author(s)
  住田崇, 小野啓, 犬飼浩一, 片山茂裕, 粟田卓也
- Organizer
  第26回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  愛知県
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] ラット視床下部PTEN/Aktの摂食とインスリン感受性に対する影響2012
- Author(s)
  住田崇, 小野啓, 犬飼浩一, 片山茂裕, 粟田卓也
- Organizer
  第26回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  愛知県産業労働センター(愛知県)
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] 視床下部PTENの摂食およびインスリン感受性調節における役割2011
- Author(s)
  小野啓, 住田崇, 犬飼浩一, 片山茂裕, 粟田卓也
- Organizer
  第25回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  東京大学工学部武田先端知ビル「武田ホール」(東京都)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] Acute suppression of hypothalamic PTEN reduces food intake and improves insulin resistance2011
- Author(s)
  Sumita T, Ono H, Inukai K, Awata T, Kayamama S
- Organizer
  40th Keystone Symposia ; Type 2 Diabetes, Insulin Resistance and Metabolis Dysfunction
- Place of Presentation
  Keystone, Colorado USA
- Year and Date
  2011-01-16
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] 視床下部PTENの摂食およびインスリン感受性調節における役割2011
- Author(s)
  小野啓, 住田崇, 犬飼浩一, 片山茂裕, 粟田卓也
- Organizer
  第25回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  東京都
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] 視床下部PTENの摂食およびインスリン感受性調節における役割2011
- Author(s)
  住田崇, 小野啓, 犬飼浩一, 片山茂裕, 粟田卓也
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌市教育文化会館(北海道)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] 視床下部PTENの摂食およびインスリン感受性調節における役割2011
- Author(s)
  住田崇, 小野啓, 犬飼浩一, 片山茂裕, 粟田卓也
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  北海道
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] Role of Hepatic LKB1 in the pathophysiology of diabetes in obese diabetic mouse.2010
- Author(s)
  Sumita T, Ono H, Inukai K, Awata T, Katayama S
- Organizer
  FASEB summer research conference
- Place of Presentation
  Kyoto Japan
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-22790869
[Presentation] 肝S6キナーゼの活性化はインスリンの肝糖産生抑制効果を傷害する2010
- Author(s)
  住田崇, 小野啓, 犬飼浩一, 粟田卓也, 片山茂裕
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山県
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22790869
[]
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1. Yokote Koutaro (20312944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 前澤善朗 (80436443)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 鈴木佐和子 (60400892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 黒滝陽子 (80771229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 加藤尚也 (90841974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 浅野知一郎 (70242063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 神名麻智 (10619365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 中津祐介 (20452584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 迫田秀之 (50376464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 山本屋武 (50760013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. KUSHIYAMA Akifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. YOSHIZUMI Masao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小久保博樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 西村英紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 木村友則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 片桐秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 小林淳二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 多田隼人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 山田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ONO HIRAKU 小野 啓

Ono Hiraku 小野 啓

ONO Hiraku 小野 啓

Research Projects

Research Products

Co-Researchers

早老症の多角的解析に基づく老化と疾患の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Hippo/YAP経路へのPin1作用と肝や脂肪組織の肥大、炎症、線維化への関与

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of four FoxO isoforms on insulin resistance and longevityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular pathogenesis of aging and related diseases through analysis of multilayered models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Direct and Indirect Effects of Insulin on Target Tissues to Decrease GlucosePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of Hypothalamic Akt on Food Intake and Glucose MetabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of hypothalamic S6 kinase on diabetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 『肥満症』日常診療に活かす 診療ガイドラインUP-TO-DATE 2022-20232022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 今日の治療指針 2021年版2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 日常診療に活かす診療ガイドラインUPDATE 肥満症 pp413-4182020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 第三期 特定健診・特定保健指導ガイド2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] これが知りたかった!糖尿病診療・療養指導Q&A 「インスリン分泌能とインスリン抵抗性はどのように評価し，どのように活用するのですか？」2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines2023

Author(s)

ONO HIRAKU 小野啓

Ono Hiraku 小野啓

ONO Hiraku 小野啓

[Book] 『肥満症』日常診療に活かす診療ガイドラインUP-TO-DATE 2022-20232022

[Book] 日常診療に活かす診療ガイドラインUPDATE　肥満症 pp413-4182020

[Book] 第三期特定健診・特定保健指導ガイド2018