Ainai Akira 相内章

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AINAI Akira 相内章

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Researcher Number	10572133
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所感染病理部, 室長
Affiliation (based on the past Project Information) *help	2023: 国立感染症研究所, 感染病理部, 室長 2016 – 2022: 国立感染症研究所, 感染病理部, 主任研究官 2015: 国立感染症研究所, 感染病理部, 研究員 2014: 国立感染症研究所, インフルエンザ研究センター, 研究員 2013: 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 2012: 国立感染症研究所, インフルエンザウイルス研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 49030:Experimental pathology-related / Biomedical engineering/Biomaterial science and engineering / Infectious disease medicine Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Biological pharmacy
Keywords	Principal Investigator ワクチン / 経鼻接種 / 膜小胞 / 百日咳 / 免疫学的指標 / 相関 / 感染防御能 / 母子免疫 / HTLV-1 / 抗体 … More / B細胞 / ヒト抗体 / 感染症 / 経鼻インフルエンザワクチン / アジュバント / 合成二本鎖RNA … More Except Principal Investigator 粘膜免疫 / ワクチン / 歯周病 / 細菌膜小胞 / 細菌由来膜小胞 / 膜小胞 / 薬学 / 免疫学 / 糖鎖 / 感染症 / ウイルス / 免疫ノグロブリン / 樹状細胞 / インフルエンザ / レクチン Less

Analysis of immune responses induced by intranasal administration of B. pertussis vaccine candidatesPrincipal Investigator
- Principal Investigator
  
  相内章
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Infectious Diseases
Acceleration of unexplored periodontal disease vaccine development by intranasal administration of bacterial membrane vesicles
- Principal Investigator
  
  中尾龍馬
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  National Institute of Infectious Diseases
Investigation of a vaccine to prevent HTLV-1 infection by mother-to-child immunizationPrincipal Investigator
- Principal Investigator
  
  Ainai Akira
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Institute of Infectious Diseases
Convenient isolation and generation of fully human antibodiesPrincipal Investigator
- Principal Investigator
  
  Ainai Akira
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  National Institute of Infectious Diseases
Regulation of IgA responses against influenza virus
- Principal Investigator
  
  IRIMURA Tatsuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  St. Luke's International University
  The University of Tokyo
The mechanism for secretory IgA antibody induction by TLR3 ligandPrincipal Investigator
- Principal Investigator
  
  AINAI Akira
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  National Institute of Infectious Diseases

All 2023 2019 2018 2014 2013 2012

All Journal Article Presentation

[Journal Article] Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults2013
- Author(s)
  Ainai A, Tamura S, Suzuki T, van Riet E, Ito R, Odagiri T, Tashiro M, Kurata T, Hasegawa H
- Journal Title
  
  Hum Vaccin Immunother
  
  Volume: 9(9) Pages: 1962-70
- Data Source
  KAKENHI-PROJECT-24791035
[Journal Article] Analysis of bronchoalveolar lavage fluid in a mouse model of bronchial asthma and H1N1 2009 infection2013
- Author(s)
  Okada S, Hasegawa S, Hasegawa H, Ainai A, Atsuta R, Ikemoto K, Sasaki K, Toda S, Shirabe K, Takahara M, Harada S, Morishima T, Ichiyama T
- Journal Title
  
  Cytokine
  
  Volume: 63(2) Pages: 194-200
- Data Source
  KAKENHI-PROJECT-24791035
[Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012
- Author(s)
  Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T
- Journal Title
  
  Blood
  
  Volume: 120(24) Pages: 4733-43
- Data Source
  KAKENHI-PROJECT-24791035
[Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012
- Author(s)
  Ainai A, Tamura S, Suzuki T, Ito R, Asanuma H, Tanimoto T, Gomi Y, Manabe S, Ishikawa T, Okuno Y, Odagiri T, Tashiro M, Sata T, Kurata T, Hasegawa H
- Journal Title
  
  J Med Virol
  
  Volume: 84(2) Pages: 336-44
- Data Source
  KAKENHI-PROJECT-24791035
[Journal Article] Mucosal IgA responses in influenza virus infections; thoughts for vaccine design2012
- Author(s)
  van Riet E, Ainai A, Suzuki T, Hasegawa H
- Journal Title
  
  Vaccine
  
  Volume: 30(40) Pages: 5893-900
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 百日咳菌の外膜小胞を用いた経鼻ワクチンによる抗体応答評価2023
- Author(s)
  石川青空、相内　章、小林万倫、坂本玲奈、中尾龍馬、田村浩二、鈴木忠樹
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K08596
[Presentation] 組換えHTLV-1 Envタンパク質のマウスにおける抗体誘導能の検討2019
- Author(s)
  相内　章、齋藤訓平、鈴木忠樹、長谷川秀樹
- Organizer
  第23回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07054
[Presentation] バキュロウイルス発現系による組換えHTLV-1 Envタンパク質はワクチン抗原として特異的抗体応答を誘導する2019
- Author(s)
  齋藤訓平、相内　章、鈴木忠樹、西山千春、長谷川秀樹
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07054
[Presentation] The immunogenicity of recombinant HTLV-1 envelope protein purified from a baculoviral expression system in mice2019
- Author(s)
  Ainai A, Saito K, Suzuki T, Hasegawa H
- Organizer
  13th Vaccine Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07054
[Presentation] 組換えHTLV-1 Envタンパク質の免疫で誘導された移行抗体の評価2019
- Author(s)
  相内　章、齋藤訓平、鈴木忠樹、長谷川秀樹
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07054
[Presentation] Immunogenicity of recombinant HTLV-1 Env protein puri ed from a baculoviral expression system as a vaccine antigen in mice2018
- Author(s)
  Akira Ainai，Kumpei Saito，Tadaki Suzuki，Hideki Hasegawa
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07054
[Presentation] Impact of the quaternary structure of human Secretory-IgA on neutralization potency to Influenza A virus in upper respiratory tract2014
- Author(s)
  Suzuki T, Kawaguchi A, Ainai A, Tamura S, Ito R, Tashiro M, Hasegawa H
- Organizer
  Keystone Symposia 2014
- Place of Presentation
  CO, USA
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Antibody responses induced by intranasal vaccination of a whole inactivated influenza virus in mice previously infected or vaccinated2014
- Author(s)
  Ikeda K, Ito R, Ainai A, Suzuki T, Tamura S, Arao Y, Tashiro M, Asanuma H, Hasegawa H
- Organizer
  Keystone Symposia 2014
- Place of Presentation
  CO, USA
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Antibody responses in serum and nasal mucus induced by the intranasal vaccination with a whole-virion inactivated vaccine of A(H5N1) virus in healthy naïve human adults2014
- Author(s)
  Hasegawa H, Ainai A, Suzuki T, van Riet E, Tamura S, Ikeda K, Odagiri T, Tashiro M, Kurata T
- Organizer
  Keystone Symposia 2014
- Place of Presentation
  CO, USA
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] マウスモデルを用いた細胞培養型インフルエンザワクチンの有効性の解析2014
- Author(s)
  原田勇一, 中村一哉, 浜本いつき, 榎本匡志, 浅沼秀樹, 相内章, 田代眞人, 山本典生
- Organizer
  第17回日本ワクチン学会学術集会
- Place of Presentation
  津
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 経鼻インフルエンザワクチンにおけるワクチンの組み合せが抗体応答に与える影響2013
- Author(s)
  相内章, 浅沼秀樹, 鈴木忠樹, 原田勇一, 田村愼一, 田代眞人, 長谷川秀樹
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] マウスにおける細胞培養型インフルエンザワクチンの有効性の解析2013
- Author(s)
  原田勇一, 中村一哉, 浜本いつき, 浅沼秀樹, 相内章, 田代眞人, 奥野良信, 山本典夫
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Nc/Nga マウスを用いた喘息発作によるインフルエンザ感染症重症化モデルの作製2013
- Author(s)
  川口晶, 鈴木忠樹, 相内章, 佐藤由子, 永田典代, 田代眞人, 長谷川秀樹
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 母子免疫によるインフルエンザウイルス感染防御効果の解析2013
- Author(s)
  泉地恭輔, 相内章, 鈴木忠樹, 浅沼秀樹, 梁明秀, 長谷川秀樹
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 経鼻インフルエンザワクチンにより鼻腔粘膜上に誘導される多量体IgA 抗体のウイルス感染防御における役割2013
- Author(s)
  鈴木忠樹, 川口晶, 相内章, 田村愼一, 小田切孝人, 田代眞人, 長谷川秀樹
- Organizer
  第17回日本ワクチン学会学術集会
- Place of Presentation
  津
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 経鼻インフルエンザワクチンにより誘導される抗体応答に年齢, 性別あるいは副反応が与える影響2013
- Author(s)
  相内章, 田村愼一, 鈴木忠樹, 小田切孝人, 田代眞人, 倉田毅, 長谷川秀樹
- Organizer
  第17回日本ワクチン学会学術集会
- Place of Presentation
  津
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 高病原性鳥インフルエンザウイルスA(H5N1)全粒子不活化ワクチンを用いた経鼻インフルエンザワクチンの効果2013
- Author(s)
  長谷川秀樹, 相内章, 田村愼一, 鈴木忠樹, 浅沼秀樹, 小田切孝人, 田代眞人, 倉田毅
- Organizer
  第17回日本ワクチン学会学術集会
- Place of Presentation
  津
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Impact of the quaternary structure of human secretory-IgA on viral neutralization activity in upper respiratory tract2013
- Author(s)
  Suzuki T, Kawaguchi A, Ainai A, Tamura S, Ito R, Tashiro M, Hasegawa H
- Organizer
  7th Vaccine & ISV
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Antibody responses in serum and nasal mucus induced by the intranasal vaccination with a whole-virion inactivated vaccine of A(H5N1) virus in healthy human adults2013
- Author(s)
  Ainai A, van Riet E, Tamura S, Suzuki T, Kawaguchi A, Ito R, Ikeda K, Senchi K, Asanuma H, Odagiri T, Tashiro M, Kurata T, Hasegawa H
- Organizer
  7th Vaccine & ISV
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 経鼻インフルエンザワクチンで誘導される抗体応答に基礎免疫が与える影響2013
- Author(s)
  池田千将, 伊藤良, 相内章, 鈴木忠樹, 田村愼一, 荒尾雄二郎, 田代眞人, 浅沼秀樹, 長谷川秀樹
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Analysis of protective immune responses after intranasal administration of an inactivated whole-virion influenza vaccine in human2012
- Author(s)
  Hasegawa H, Ainai A, Suzuki T, Tamura S, Tashiro M, Kurata T
- Organizer
  第16回日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 喘息発作誘発モデルを用いたインフルエンザウイルス感染症の病態解析2012
- Author(s)
  川口晶, 鈴木忠樹, 相内章, 佐藤由子, 信澤枝里, 田代眞人, 長谷川秀樹
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 基礎免疫を有する個体に対する経鼻投与型インフルエンザワクチン効果2012
- Author(s)
  池田千将, 伊藤良, 相内章, 鈴木忠樹, 田村愼一, 田代眞人, 浅沼秀樹, 長谷川秀樹
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 経鼻投与型インフルエンザワクチンによるマウス母子免疫の解析2012
- Author(s)
  泉地恭輔, 相内章, 鈴木忠樹, 浅沼秀樹, 長谷川秀樹
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 野外株より細胞培養インフルエンザワクチンの種候補株を選定する基準の検討2012
- Author(s)
  浅沼秀樹, 相内章, 佐藤佳代子, 許斐奈美, 岸田典子, 長谷川秀樹, 山本典生, 田代眞人
- Organizer
  第16回日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] Characteristics of IgA versus IgG human monoclononal antibodies cloned from human plasma cells induced upon intranasal H5N1 vaccination2012
- Author(s)
  van Riet E, Ainai A, Ito R, Senchi K, Suzuki T, Tamura S, Tashiro M, Hasegawa H
- Organizer
  第16回日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 細胞培養もしくは鶏卵で製造されたインフルエンザワクチンの品質管理試験および免疫応答への影響2012
- Author(s)
  山本典生, 浅沼秀樹, 佐藤佳代子, 中内美奈, 高橋仁, 許斐奈美, 相内章, 長谷川秀樹, 田代眞人
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] インフルエンザワクチン経鼻接種により鼻腔内に誘導される分泌型IgA 抗体の性状解析2012
- Author(s)
  鈴木忠樹, 川口晶, 相内章, 田村愼一, 伊藤良, 小田切孝人, 田代眞人, 長谷川秀樹
- Organizer
  第16回日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791035
[Presentation] 感染あるいはワクチン接種歴が経鼻投与型インフルエンザワクチンにより誘導される抗体応答に対して与える影響2012
- Author(s)
  相内章, 池田千将, 伊藤良, 鈴木忠樹, 泉地恭輔, 田村愼一, 田代眞人, 浅沼秀樹, 長谷川秀樹
- Organizer
  第16回日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24791035

1. 中尾龍馬 (10370959)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. IRIMURA Tatsuro (80092146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HASEGAWA Hideki (30301790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DENDA Kaori (00313122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 泉福英信 (20250186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 佐々木永太 (40762216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 野村暢彦 (60292520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 井上智 (90213157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山口雄大 (40726080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ainai Akira 相内 章

AINAI Akira 相内 章

Research Projects

Research Products

Co-Researchers

Analysis of immune responses induced by intranasal administration of B. pertussis vaccine candidatesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Acceleration of unexplored periodontal disease vaccine development by intranasal administration of bacterial membrane vesicles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of a vaccine to prevent HTLV-1 infection by mother-to-child immunizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Convenient isolation and generation of fully human antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of IgA responses against influenza virus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism for secretory IgA antibody induction by TLR3 ligandPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intranasal vaccination with an inactivated whole influenza virus vaccine induces strong antibody responses in serum and nasal mucus of healthy adults2013

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of bronchoalveolar lavage fluid in a mouse model of bronchial asthma and H1N1 2009 infection2013

Author(s)

Journal Title

Data Source

[Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012

Author(s)

Journal Title

Data Source

[Journal Article] Mucosal IgA responses in influenza virus infections; thoughts for vaccine design2012

Author(s)

Journal Title

Data Source

[Presentation] 百日咳菌の外膜小胞を用いた経鼻ワクチンによる抗体応答評価2023

Author(s)

Organizer

Data Source

[Presentation] 組換えHTLV-1 Envタンパク質のマウスにおける抗体誘導能の検討2019

Author(s)

Organizer

Data Source

[Presentation] バキュロウイルス発現系による組換えHTLV-1 Envタンパク質はワクチン抗原として特異的抗体応答を誘導する2019

Author(s)

Organizer

Data Source

[Presentation] The immunogenicity of recombinant HTLV-1 envelope protein purified from a baculoviral expression system in mice2019

Author(s)

Organizer

Data Source

[Presentation] 組換えHTLV-1 Envタンパク質の免疫で誘導された移行抗体の評価2019

Author(s)

Organizer

Ainai Akira 相内章

AINAI Akira 相内章