Miyahara Yoshihiro 宮原慶裕

… Alternative Names

MIYAHARA Yoshihiro 宮原慶裕

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Researcher Number	10582083
Other IDs
Affiliation (Current)	2025: 三重大学, 医学系研究科, 産学官連携講座教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 三重大学, 医学系研究科, 産学官連携講座教授 2020: 三重大学, 医学系研究科, 産学官連携講座准教授 2016 – 2019: 三重大学, 医学系研究科, 准教授 2011 – 2013: 三重大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Tumor immunology Except Principal Investigator Basic Section 49020:Human pathology-related / Basic Section 55020:Digestive surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Respiratory organ internal medicine
Keywords	Principal Investigator TCR / 変異抗原 / 腫瘍免疫 / Hybrid-TCR / CAR-T / 固形がん / 末梢血 / 個別化 / 細胞療法 / 個別化がん免疫療法 … More / TCR-T / ワクチン / 免疫応答 / 複合免疫療法 / 免疫抑制 … More Except Principal Investigator CAR-T療法 / がん免疫療法 / 食道癌 / 免疫チェックポイント阻害剤 / ウイルス / 心筋炎 / バイオマーカー / MAGE-A4 / CAR-T細胞 / TCR遺伝子導入T細胞 / 遺伝子改変T細胞輸注療法 / T細胞治療 / GITRシグナル / 固形がん / Ｔ細胞輸注療法 / 制御性Ｔ細胞 / キメラ抗原受容体 / 喘息 / 癌胎児性抗原 / T細胞輸注療法 / 制御性T細胞 / キメラ抗原受容他 Less

固形がんを対象とした新たなCAR-T療法の創出に挑む―Rethinking of T cell receptorーPrincipal Investigator
- Principal Investigator
  
  宮原慶裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
Investigation of the control mechanisms for the precision medicine in myocarditis
- Principal Investigator
  
  吉田恭子 (今中恭子)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Mie University
Basic research toward the establishment of next-generation personalized TCR-T therapyPrincipal Investigator
- Principal Investigator
  
  宮原慶裕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Mie University
Biomarker-based manufacture of MAGE-A4/CAR-T cell in immunotherapy for esophageal cancer
- Principal Investigator
  
  Kageyama Shinichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Mie University
T cell optimization for effective CAR-T cell therapy to refractory esophageal cancer
- Principal Investigator
  
  Kageyama Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Mie University
Development of effective combined immunotherapies by using a novel immune response detection methodPrincipal Investigator
- Principal Investigator
  
  Miyahara Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Mie University
Therapeutic potintial of Tregs transduced with CEA specific CAR in sever asthma
- Principal Investigator
  
  KATO Takuma
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Mie University
Analysis of differentiation mechanism of peripherally induced Foxp3 positive T cells for application to cancer treatmentPrincipal Investigator
- Principal Investigator
  
  MIYAHARA Yoshihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor immunology
- Research Institution
  Mie University

[Book] 抗CTLA-4 抗体による免疫制御機構の解除. 臨床免疫・アレルギー科特集I;腫瘍の免疫回避機構 vol.562011
- Author(s)
  宮原慶裕、珠玖洋
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complex2024
- Author(s)
  Linan Wang, Masahiro Matsumoto, Yasushi Akahori, Naohiro Seo, Kazuko Shirakura, Takuma Kato, Yoichi Katsumoto, Yoshihiro Miyahara, Hiroshi Shiku
- Journal Title
  
  Mol Ther
  
  Volume: 32 Issue: 3 Pages: 374-348
- DOI
  10.1016/j.ymthe.2024.01.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-23K24180
[Journal Article] Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial2023
- Author(s)
  Kawai Akira, Shigehisa Kitano , et. al.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 29 Issue: 24 Pages: 5069-5078
- DOI
  10.1158/1078-0432.ccr-23-1456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08101, KAKENHI-PROJECT-23K08700, KAKENHI-PROJECT-23K24180
[Journal Article] Fully closed cell sorter for immune cell therapy manufacturing2023
- Author(s)
  Matsumoto Masahiro、Tashiro Shinji、Ito Tatsumi、Takahashi Kazuya、Hashimoto Gakuji、Kajihara Junji、Miyahara Yoshihiro、Shiku Hiroshi、Katsumoto Yoichi
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 30 Pages: 367-376
- DOI
  10.1016/j.omtm.2023.07.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24180
[Journal Article] A phase 1 trial of <scp>NY‐ESO</scp> ‐1‐specific <scp>TCR</scp> ‐engineered T‐cell therapy combined with a lymph node‐targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma2023
- Author(s)
  Ishihara Mikiya、Nishida Yoshihiro、Kitano Shigehisa、Kawai Akira、Takada Kohichi、Emori Makoto、Kageyama Shinichi、Shiku Hiroshi
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 12 Pages: 2554-2566
- DOI
  10.1002/ijc.34453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08080, KAKENHI-PROJECT-21H02995, KAKENHI-PROJECT-20K16411, KAKENHI-PROJECT-21K19561, KAKENHI-PROJECT-21K06690, KAKENHI-PROJECT-23K08700, KAKENHI-PROJECT-21K08682, KAKENHI-PROJECT-22K07277, KAKENHI-PROJECT-23K24180
[Journal Article] Exploring for the Development of Personalized Cancer Immunotherapy2023
- Author(s)
  Yoshihiro Miyahara
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 5 Pages: 567-570
- Data Source
  KAKENHI-PROJECT-23K24180
[Journal Article] NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome2022
- Author(s)
  Ishihara M, Kitano S, Kageyama S, Miyahara Y, Yamamoto N, Kato H, Mishima H, Hattori H, Funakoshi T, Kojima T, Sasada T, Sato E, Okamoto S, Tomura D, Nukaya I, Chono H, Mineno J, Kairi MF, Diem Hoang Nguyen P, Simoni Y, Nardin A, Newell E, Fehlings M, Ikeda H, Watanabe T, Shiku H.
- Journal Title
  
  J Immunother Cancer
  
  Volume: 10 Issue: 6 Pages: e003811-e003811
- DOI
  10.1136/jitc-2021-003811
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08682, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-22K19532, KAKENHI-PROJECT-21H02990, KAKENHI-PROJECT-21H02995, KAKENHI-PROJECT-23K24180
[Journal Article] Chimeric antigen receptor T-cell therapy targeting a MAGE A4 peptide and HLA-A*02:01 complex for unresectable advanced or recurrent solid cancer: protocol for a multi-institutional phase 1 clinical trial2022
- Author(s)
  Satoshi Okumura, Mikiya Ishihara, Naomi Kiyota, Kimikazu Yakushijin, Kohichi Takada, Shinichiro Kobayashi, Hiroaki Ikeda, Makoto Endo, Koji Kato, Shigehisa Kitano, Akihiko Matsumine, Yasuhiro Nagata,...Hiroshi Shiku
- Journal Title
  
  BMJ Open
  
  Volume: 12(11) Issue: 11 Pages: e065109-e065109
- DOI
  10.1136/bmjopen-2022-065109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06690, KAKENHI-PROJECT-21K08682, KAKENHI-PROJECT-22K08080, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-22K19532, KAKENHI-PROJECT-21K16400, KAKENHI-PROJECT-21H02990, KAKENHI-PROJECT-20K09731, KAKENHI-PROJECT-23K24456, KAKENHI-PROJECT-23K24180
[Journal Article] IL-17A Is the Critical Cytokine for Liver and Spleen Amyloidosis in Inflammatory Skin Disease2022
- Author(s)
  Iida S, Nakanishi T, Momose F, Ichishi M, Mizutani K, Matsushima Y, Umaoka A, Kondo M, Habe K, Hirokawa Y, Watanabe M, Iwakura Y, Miyahara Y, Imai Y, Yamanaka K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 23 Issue: 10 Pages: 5726-5726
- DOI
  10.3390/ijms23105726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08379, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-23K24180
[Journal Article] Prognostic significance of NY-ESO-1 antigen and PIGR expression in esophageal tumors of CHP-NY-ESO-1-vaccinated patients as adjuvant therapy.2022
- Author(s)
  Yasuhiro Nagata, Shinichi Kageyama, Takeshi Ishikawa, Satoshi Kokura, Tetsuya Okayama, Tetsuya Abe,...Hiroshi Shiku
- Journal Title
  
  Cancer immunology, immunotherapy : CII
  
  Volume: CII 71(11) Issue: 11 Pages: 2743-2755
- DOI
  10.1007/s00262-022-03194-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06690, KAKENHI-PROJECT-21K08682, KAKENHI-PROJECT-22K19532, KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21K16400, KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-21H02990, KAKENHI-PROJECT-23K24180
[Journal Article] Safety and antibody immune response of CHP-NY-ESO-1 vaccine combined with poly-ICLC in advanced or recurrent esophageal cancer patients2021
- Author(s)
  Ishikawa T, Kageyama S, Miyahara Y, Okayama T, Kokura S, Wang L, Sato E, Yagita H, Itoh Y, Shiku H.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: Online ahead of print Issue: 11 Pages: 3081-3091
- DOI
  10.1007/s00262-021-02892-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22655
[Journal Article] First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors.2020
- Author(s)
  Ishihara M, Tono Y, Miyahara Y, Muraoka D, Harada N, Kageyama S, Sasaki T, Hori Y, Soga N, Uchida K, Shiraishi T, Sato E, Kanda H, Mizuno T, Webster GA, Ikeda H, Katayama N, Sugimura Y, Shiku H.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 69 Issue: 4 Pages: 663-675
- DOI
  10.1007/s00262-020-02483-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-19K21599, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-17K09923, KAKENHI-PROJECT-19K22655, KAKENHI-PROJECT-19H03729
[Journal Article] MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours2020
- Author(s)
  Ishihara Mikiya、Kageyama Shinichi、Miyahara Yoshihiro、Ishikawa Takeshi、Ueda Shugo、Soga Norihito、Naota Hiroaki、Mukai Katsumi、Harada Naozumi、Ikeda Hiroaki、Shiku Hiroshi
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Issue: 1 Pages: 606-606
- DOI
  10.1186/s12885-020-07098-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21599, KAKENHI-PROJECT-19K22655, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-18K19584
[Journal Article] Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance2019
- Author(s)
  Muraoka Daisuke、Seo Naohiro、Hayashi Tae、Tahara Yoshiro、Fujii Keisuke、Tawara Isao、Miyahara Yoshihiro、Okamori Kana、Yagita Hideo、Imoto Seiya、Yamaguchi Rui、Komura Mitsuhiro、Miyano Satoru、Goto Masahiro、Sawada Shin-ichi、Asai Akira、Ikeda Hiroaki、Akiyoshi Kazunari、Harada Naozumi、Shiku Hiroshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 3 Pages: 1278-1294
- DOI
  10.1172/jci97642
- NAID
  120006987781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07222, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-18K19474, KAKENHI-PROJECT-16H06369, KAKENHI-PROJECT-16K07168
[Journal Article] Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.2018
- Author(s)
  Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H.
- Journal Title
  
  Blood. 2018 Sep 13;132(11):
  
  Volume: 132 Issue: 11 Pages: 1134-1145
- DOI
  10.1182/blood-2017-08-802926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08341, KAKENHI-PROJECT-18K08361, KAKENHI-PROJECT-18K19474, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-16K09533
[Journal Article] Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors2017
- Author(s)
  Fujii K, Miyahara Y, Harada N, Muraoka D, Komura M, Yamaguchi R, Yagita H, Nakamura J, Sugino S, Okumura S, Imoto S, Miyano S, Shiku H
- Journal Title
  
  OncoImmunology
  
  Volume: 印刷中 Issue: 5 Pages: e1306617-e1306617
- DOI
  10.1080/2162402x.2017.1306617
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02775, KAKENHI-PROJECT-16K07168
[Journal Article] Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions2014
- Author(s)
  Khattar M, Miyahara Y, Schroder PM, Xie A, Chen W, Stepkowski SM
- Journal Title
  
  PLoS One
  
  Volume: 9(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells2013
- Author(s)
  Guo Z, Khattar M, Schroder PM, Miyahara Y, Wang G, He X, Chen W, Stepkowski SM
- Journal Title
  
  J Immunol
  
  Volume: 190(7) Pages: 3153-3162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients2013
- Author(s)
  Kageyama S, Wada H, Muro K, Niwa Y, Ueda S, Miyata H, Takiguchi S, Sugino SH, Miyahara Y, Ikeda H, Imai N, Sato E, Yamada T, Osako M, Ohnishi M, Harada N, Hishida T, Doki Y, Shiku H
- Journal Title
  
  J Transl Med
  
  Volume: 11 Pages: 246-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients2013
- Author(s)
  Kageyama S, Wada H, Muro K, Niwa Y, Ueda S, Miyata H, Takiguchi S, Sugino SH, Miyahara Y, Ikeda H, Imai N, Sato E, Yamada T, Osako M, Ohnishi M, Harada N, Hishida T, Doki Y, Shiku H
- Journal Title
  
  Journal of translational medicine
  
  Volume: 5;11 Issue: 1 Pages: 246-246
- DOI
  10.1186/1479-5876-11-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284, KAKENHI-PROJECT-24390300, KAKENHI-PROJECT-24591939, KAKENHI-PROJECT-24591965, KAKENHI-PROJECT-24650259
[Journal Article] A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells2013
- Author(s)
  Guo Z, Khattar M, Schroder PM, Miyahara Y, Wang G, He X, Chen W, Stepkowski SM
- Journal Title
  
  Journal of immunology
  
  Volume: 190(7) Issue: 7 Pages: 3153-3162
- DOI
  10.4049/jimmunol.1200751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells2012
- Author(s)
  Miyahara Y, Khattar M, Schroder PM, Mierzejewska B, Deng R, Han R, Hancock WW, Chen W, Stepkowski SM
- Journal Title
  
  Am J Transplant
  
  Volume: 12(6) Pages: 1409-1418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] anti-TCRβ mAb Induces Long-Term Allograft Survival by Reducing Antigen-Reactive T Cells and Sparing Regulatory T Cells2012
- Author(s)
  Y. Miyahara, M. Khattar, P. M. Schroder, B. Mierzejewska, R. Deng, R. Han, W. W. Hancock, W. Chen, S. M. Stepkowski
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 12(6) Issue: 6 Pages: 1409-1418
- DOI
  10.1111/j.1600-6143.2012.04006.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions2012
- Author(s)
  Iwamura K, Kato T, Miyahara Y, Naota H, Mineno J, Ikeda H, Shiku H
- Journal Title
  
  Gene Ther
  
  Volume: 19(10) Pages: 959-966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] H.Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses2011
- Author(s)
  Tsuda K, Yamanaka K, Linan W, Miyahara Y, Akeda T, Nakanishi T, Kitagawa H, Kakeda M, Kurokawa I, Shiku H, Gabazza EC, Mizutani
- Journal Title
  
  PLoS One
  
  Volume: 6(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Journal Article] Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses2011
- Author(s)
  K Tsuda, K Yamanaka, W ang L,Y Miyahara, T Akeda, T Nakanishi, H Kitagawa, M Kakeda, I Kurokawa, H Shiku, E C. Gabazza, and H Mizutani
- Journal Title
  
  PLoS One
  
  Volume: 6(12) Issue: 12 Pages: e29020-e29020
- DOI
  10.1371/journal.pone.0029020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284
[Patent] 腫瘍反応性T細胞の製造方法2022
- Inventor(s)
  宮原慶裕、珠玖　洋、山根真妃子
- Industrial Property Rights Holder
  宮原慶裕、珠玖　洋、山根真妃子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-114657
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] Development of CAR-T therapy for solid tumors2024
- Author(s)
  宮原慶裕
- Organizer
  第21回日本臨床腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] 固形腫瘍を対象としたCAR-T療法の開発2023
- Author(s)
  宮原慶裕
- Organizer
  第6回日本サルコーマ治療研究学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] 固形腫瘍を対象とした細胞療法の開発2023
- Author(s)
  宮原慶裕
- Organizer
  第27回がん免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] Aiming for the development of effective cell therapy for solid tumors2022
- Author(s)
  宮原慶裕
- Organizer
  日本免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] 個別化がん免疫療法の確立へ向けた取り組み2022
- Author(s)
  宮原慶裕
- Organizer
  日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] Tetraspanin molecule CD9 as a novel marker of tumor-reactive T cells2022
- Author(s)
  宮原慶裕
- Organizer
  第37回米国免疫療法学会（SITC）総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24180
[Presentation] Promising use of gene-modified γδ T cells for Cancer Immunotherapy2018
- Author(s)
  Okumura S, Kato T, Wang Y, Hayashi T, Shirakura K, Ikeda H, Wang L, Miyahara Y, Tanaka Y, Shiku H.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Anti-tumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination2018
- Author(s)
  Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] Anti-tumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination2018
- Author(s)
  Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H.
- Organizer
  日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-16K09533
[Presentation] マウス腫瘍細胞株をモデルとした高免疫原性変異抗原の同定とワクチン治療への応用2018
- Author(s)
  宮原　慶裕
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K07168
[Presentation] Analysis of TCR repertoire usage and identification of antigens recognized by CT26 tumor-infiltrating CD8+ T cells2016
- Author(s)
  藤井啓介、宮原慶裕、村岡大輔、下岡清美、浜名洋、岸裕幸、珠玖　洋
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K07168
[Presentation] CT26 腫瘍局所浸潤CD8+T 細胞のTCRレパトア解析と認識エピトープの同定2016
- Author(s)
  藤井　啓介、宮原　慶裕、村岡　大輔、下岡　清美、浜名　洋、岸　裕幸、珠玖　洋
- Organizer
  日本がん免疫学
- Place of Presentation
  ひめぎんホール（愛媛県・松山市）
- Year and Date
  2016-07-30
- Data Source
  KAKENHI-PROJECT-16K07168
[Presentation] Determining CD8+ T cell immune responses against the tumor“mutanome”using CXCR3 ligand mRNAs as sensors2016
- Author(s)
  宮原　慶裕、藤井　啓介、村岡　大輔、上村　光弘、山口　類、井元　清哉、宮野　悟、珠玖　洋
- Organizer
  日本がん免疫学
- Place of Presentation
  ひめぎんホール（愛媛県・松山市）
- Year and Date
  2016-07-30
- Data Source
  KAKENHI-PROJECT-16K07168
[Presentation] Adoptive transfer of wild-type TCR-gene transduced T lymphocytes targeting MAGE-A4 antigen to patients with refractory esophageal cancer2014
- Author(s)
  S Kageyama, H Ikeda, N Imai, M Ishihara, Y Miyahara, S Ueda, T Ishikawa, H Naota, K Ohishi, T Shiraishi, N Inoue, M Tanabe, T Kidokoro, H Yoshioka, D Tomura, I Nukaya, J Mineno, K Takesako, N Katayama, H Shiku
- Organizer
  American Assosication for Cancer Research Annual meeting
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2014-04-05
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Adoptive transfer of TCR gene-transduced lymphocytes targeting MAGE-A4 for refractory esophageal cancer2014
- Author(s)
  Y Miyahara, S Kageyama, H Ikeda, M Ishihara, N Katayama, D Tomura, I Nukaya, J Mineno, K Takesako, H Shiku
- Organizer
  ITOC-1 Immunotherapy of Cancer Conference
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-03-12
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Adoptive transfer of TCR gene-transduced lymphocytes targeting MAGE-A4 for refractory esophageal cancer2014
- Author(s)
  Yoshihiro Miyahara, Shinichi Kageyama, Hiroaki Ikeda, Mikiya Ishihara, Naoyuki Katayama, Daisuke Tomura, Ikuei Nukaya, Junichi Mineno, Kazuto Takesako, Hiroshi Shiku
- Organizer
  ITOC-1 Immunotherapy of Cancer Conference
- Place of Presentation
  ミュンヘン　ドイツ
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 進行・再発固形癌に対するCHP-MAGE-A4 がんワクチン療法第 I 相臨床試験2013
- Author(s)
  上田修吾、影山慎一、宮原慶裕、珠玖洋
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 化療・放射線療法後、胃全摘、膵尾部切除、脾摘、右腎摘、横行結腸部分切除、脳転移2回、肺転移で活性化リンパ輸注療法を続けているQOL 良好な長期生存例2013
- Author(s)
  片平智行、坂本英至、関行雄、三村三喜男、吉岡洋、都築豊徳、二村舞子、金田次弘、宮原慶裕、珠玖洋
- Place of Presentation
  盛岡
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] HLA-A0206+ NY-ESO-1+ tumor cell lines can be recognized by HLA-A0201 restricted-NY-ESO-1(p157-165) specific TCRs2013
- Author(s)
  Yoshihiro Miyahara, Sahoko Sugino, Linan Wang, Kiyotaka Kuzushima, Tomonobu Fujita, Yutaka Kawakami, Sachiko Okamoto, Yasunori Amaishi, Junichi Mineno, Hiroshi Shiku
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] HLA-A0206+NY-ESO-1+tumor cell lines can be recognized by HLA-A0201 restricted-NY-ESO-1(p157-165) specific TCRs2013
- Author(s)
  宮原慶裕、杉野早穂子、王立楠、葛島清隆、藤田知信、河上裕、岡本幸子、天石泰典、峰野純一、珠玖洋
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 食道癌を対象にしたMAGE-A4 特異的TCR 遺伝子導入リンパ球輸注における輸注細胞の体内動態と臨床評価2013
- Author(s)
  影山慎一、池田裕明、今井奈緒子、石原幹也、斉藤佳菜子、上田修吾、石川剛、古倉聡、直田浩明、宮原慶裕、城所知秀、井上直樹、田辺雅茂、吉岡広文、戸村大助、糠谷育衛、岡本幸子、峰野純一、白石泰三、大石晃嗣、片山直之、珠玖洋
- Organizer
  第17回日本がん免疫学会総会
- Place of Presentation
  宇部
- Year and Date
  2013-07-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] ANTIGEN RECEPTOR GENE-MODIFIED LYMPHOCYTES : HARNESSING T CELLS FOR EFFECTIVE CANCER TREATMENT WITH NOVEL VECTORS AND MANIPULATIONS2013
- Author(s)
  H Ikeda, S Kageyama, N Imai, Y Miyahara, M Ishihara, A Kawamura, M Yamane, D Tomura, S Okamoto, I Nukaya, J Mineno, K Takesako, N Katayama, H Shiku
- Organizer
  American Assosication for Cancer Research Annual meeting
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2013-04-05
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 子宮平滑筋肉腫長期生存例における活性化リンパ球輸注療法の効果2013
- Author(s)
  片平智行、長谷川正規、金田次弘、二村舞子、原田智子、細井延行、倉内修、藤田興一、青田泰博、宮原慶裕、珠玖洋
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-09-19
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] MAGE-A4 発現食道癌における抗原特異的 TCR 遺伝子導入リンパ球輸注後の in vivo 血中持続2013
- Author(s)
  影山慎一、池田裕明、今井奈緒子、上田修吾、石川剛、直田浩明、宮原慶裕、吉岡広文、戸村大助、糠谷育衛、峰野純一、片山直之、珠玖洋
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] MAGE-A4 特異的 T 細胞受容体を用いた遺伝子免疫治療における免疫モニタリング2013
- Author(s)
  杉野早穂子、宮原慶裕、上田修吾、石川剛、古倉聡、池田裕明、影山慎一、糠谷育衛、戸村大助、吉岡広文、峰野純一、珠玖洋
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation]2013
- Author(s)
  H Ikeda, S Kageyama, N Imai, Y Miyahara, M Ishihara, N Katayama, H Yoshioka, D Tomura, I Nukaya, J Mineno, K Takesako, H Shiku
- Organizer
  28^<th> Annual Meeting of Society for Immunotherapy of Cancer
- Place of Presentation
  National Harbor, MD, USA
- Year and Date
  2013-11-07
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Serological analysis of "antigen spreading" induced by cholesteryl pullulan (CHP)-MAGEA4 vaccination2013
- Author(s)
  堀早穂子、宮原慶裕、影山慎一、池田裕明、藤田知信、河上裕、上田修吾、宮本正樹、土川貴裕、平野聡、川上和孝、五島直樹、珠玖洋
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-09-19
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Immuno-monitoring of adoptive immunotherapy using patient’s autologous T cells redirected by MAGE-A4 specific TCR gene transduction2013
- Author(s)
  Sahoko Sugino, Yoshihiro Miyahara, Shugo Ueda, Takeshi Ishikawa, Satoshi Kokura, Hiroaki Ikeda, Shinichi Kageyama, Ikuei Nukaya, Daisuke Tomura, Hirofumi Yoshioka, Junichi Mineno, Hiroshi Shiku
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 食道癌を対象にしたTCR 遺伝子導入リンパ球輸注療法における輸注細胞の血中動態2013
- Author(s)
  影山慎一、池田裕明、宮原慶裕、今井奈緒子、石原幹也、斉藤佳菜子、片山直之、上田修吾、戸村大助、糠谷育衛、峰野純一、竹迫一任、珠玖洋
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-09-19
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 遺伝子改変T 細胞の臨床応用2012
- Author(s)
  池田裕明、影山慎一、宮原慶裕、今井奈緒子、石原幹也、岡本幸子、糠谷育衛、峰野純一、竹迫一任、珠玖洋
- Organizer
  第16回日本癌免疫学会総会
- Place of Presentation
  札幌
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] ヒト腫瘍抗原特異的T 細胞へのPD-L1/PD-L2 siRNA 導入によるT 細胞機能の増強2011
- Author(s)
  岩村康一、加藤琢磨、宮原慶裕、直田浩明、峰野純一郎、池田浩明、竹迫一任、珠玖洋
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Protein array-based serological analysis of immune responses induced by cholesteryl pullulan (CHP)-MAGEA4 vaccination2011
- Author(s)
  Y Miyahara, S　Hori, A　Yamamoto, K　Shirakura, Y　Maeda, H　Nishikawa, S Ueda, et.al.
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Protein array-based serological analysis of immune responses induced by cholesteryl pullulan (CHP)-MAGEA4 vaccination2011
- Author(s)
  宮原慶裕、堀早穂子、山本明美、白倉和子、前田優香、西川博嘉、上田修吾、宮本正樹、川上和孝、五島直樹、村岡大輔、原田直純、藤田知信、河上裕、池田裕明、影山慎一、珠玖洋
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] 食道癌症例を対象にしたTCR 遺伝子導入リンパ球輸注後の血中細胞動態2011
- Author(s)
  影山慎一、池田裕明、宮原慶裕、堀早穂子、斉藤佳菜子、今井奈緒子、岡本幸子、戸村大助、糠谷育衛、峰野純一、竹迫一任、片山直之、珠玖洋
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] ヒト腫瘍抗原特異的T 細胞へのPD-L1/PD-L2 siRNA 導入によるT 細胞機能の増強2011
- Author(s)
  岩村康一、加藤琢磨、宮原慶裕、直田浩明、峰野純一郎、池田浩明、竹迫一任、珠玖洋
- Organizer
  第15回日本がん免疫学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23501284
[Presentation] Clinical application of TCR gene-transduced lymphocytes for patients with epitherial cancer and other types of malignancy: In vivo persistence of adoptively transferred TCR gene-transduced lymphocytes with anti-tumor reactivity in patients
- Author(s)
  H Ikeda, S Kageyama, N Imai, Y Miyahara, M Ishihara, N Katayama, H Yoshioka, D Tomura, I Nukaya, J Mineno, K Takesako, H Shiku
- Organizer
  2013 European society of gene & cell therapy (ESGCT) and SETGyC Collaborative Congress
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-23501284

1. KATO Takuma (60224515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Kageyama Shinichi (80194695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 原田直純 (40520961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 王立楠 (00589484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 吉田恭子 (00242967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 丸山和晃 (90821984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鈴木忠樹 (30527180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田尻和子 (60633914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 田村雄一 (00468498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 問山裕二 (00422824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 百瀬文康 (20798326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAGATA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. KITANO Shigehisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. IKEDA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 村岡大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 影山慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 山中恵一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 波部幸司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 近藤誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 井元清哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 赤塚美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 高田弘一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 曽我倫久人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyahara Yoshihiro 宮原 慶裕

MIYAHARA Yoshihiro 宮原 慶裕

Research Projects

Research Products

Co-Researchers

固形がんを対象とした新たなCAR-T療法の創出に挑む―Rethinking of T cell receptorーPrincipal Investigator

Principal Investigator

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Investigation of the control mechanisms for the precision medicine in myocarditis

Principal Investigator

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Review Section

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Basic research toward the establishment of next-generation personalized TCR-T therapyPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Biomarker-based manufacture of MAGE-A4/CAR-T cell in immunotherapy for esophageal cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

T cell optimization for effective CAR-T cell therapy to refractory esophageal cancer

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of effective combined immunotherapies by using a novel immune response detection methodPrincipal Investigator

Principal Investigator

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Research Institution

Therapeutic potintial of Tregs transduced with CEA specific CAR in sever asthma

Principal Investigator

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Analysis of differentiation mechanism of peripherally induced Foxp3 positive T cells for application to cancer treatmentPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 抗CTLA-4 抗体による免疫制御機構の解除. 臨床免疫・アレルギー科 特集I;腫瘍の免疫回避機構 vol.562011

Author(s)

Data Source

[Journal Article] Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A*02:01 complex2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fully closed cell sorter for immune cell therapy manufacturing2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A phase 1 trial of <scp>NY‐ESO</scp> ‐1‐specific <scp>TCR</scp> ‐engineered T‐cell therapy combined with a lymph node‐targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma2023

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[Journal Article] Exploring for the Development of Personalized Cancer Immunotherapy2023

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Miyahara Yoshihiro 宮原慶裕

MIYAHARA Yoshihiro 宮原慶裕

[Book] 抗CTLA-4 抗体による免疫制御機構の解除. 臨床免疫・アレルギー科特集I;腫瘍の免疫回避機構 vol.562011